ZA201808534B - Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide - Google Patents

Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide

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Publication number
ZA201808534B
ZA201808534B ZA2018/08534A ZA201808534A ZA201808534B ZA 201808534 B ZA201808534 B ZA 201808534B ZA 2018/08534 A ZA2018/08534 A ZA 2018/08534A ZA 201808534 A ZA201808534 A ZA 201808534A ZA 201808534 B ZA201808534 B ZA 201808534B
Authority
ZA
South Africa
Prior art keywords
difluorophenyl
pyrrolidin
formula
pyrimidin
pyrazolo
Prior art date
Application number
ZA2018/08534A
Other languages
English (en)
Inventor
Reynolds Mark
Spencer Stacey
Juengst Derrick
Hache Bruno
Jiang Yutong
Haas Julia
W Andrews Steven
Original Assignee
Loxo Oncology Inc
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58794189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA201808534(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Loxo Oncology Inc, Array Biopharma Inc filed Critical Loxo Oncology Inc
Publication of ZA201808534B publication Critical patent/ZA201808534B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA2018/08534A 2016-05-18 2018-12-18 Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide ZA201808534B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662338359P 2016-05-18 2016-05-18
PCT/US2017/033257 WO2017201241A1 (en) 2016-05-18 2017-05-18 Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide

Publications (1)

Publication Number Publication Date
ZA201808534B true ZA201808534B (en) 2024-04-24

Family

ID=58794189

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2018/08534A ZA201808534B (en) 2016-05-18 2018-12-18 Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide

Country Status (27)

Country Link
US (1) US11214571B2 (https=)
EP (2) EP3458456B1 (https=)
JP (1) JP7443057B2 (https=)
KR (1) KR102566858B1 (https=)
CN (1) CN110049987B (https=)
AU (1) AU2017268371B2 (https=)
CA (1) CA3024603A1 (https=)
CL (1) CL2018003264A1 (https=)
CO (1) CO2018013015A2 (https=)
DK (2) DK3800189T3 (https=)
ES (2) ES2836222T3 (https=)
FI (1) FI3800189T3 (https=)
HR (2) HRP20230704T1 (https=)
HU (2) HUE063877T2 (https=)
IL (1) IL262964B (https=)
LT (2) LT3458456T (https=)
MX (1) MX392604B (https=)
PE (1) PE20190437A1 (https=)
PL (2) PL3458456T3 (https=)
PT (2) PT3458456T (https=)
RS (2) RS64698B1 (https=)
RU (1) RU2745953C2 (https=)
SG (1) SG11201810245WA (https=)
SI (2) SI3458456T1 (https=)
UA (1) UA127826C2 (https=)
WO (1) WO2017201241A1 (https=)
ZA (1) ZA201808534B (https=)

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CN115872905B (zh) * 2021-09-29 2024-08-09 凯特立斯（深圳）科技有限公司 一种拉罗替尼中间体的制备方法
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