ZA201007589B - Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives - Google Patents
Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivativesInfo
- Publication number
- ZA201007589B ZA201007589B ZA2010/07589A ZA201007589A ZA201007589B ZA 201007589 B ZA201007589 B ZA 201007589B ZA 2010/07589 A ZA2010/07589 A ZA 2010/07589A ZA 201007589 A ZA201007589 A ZA 201007589A ZA 201007589 B ZA201007589 B ZA 201007589B
- Authority
- ZA
- South Africa
- Prior art keywords
- acid derivatives
- oleanolic acid
- antioxidant inflammation
- inflammation modulators
- homologated oleanolic
- Prior art date
Links
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 title 1
- 206010061218 Inflammation Diseases 0.000 title 1
- 239000003963 antioxidant agent Substances 0.000 title 1
- 230000003078 antioxidant effect Effects 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
Classifications
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- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
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- C07—ORGANIC CHEMISTRY
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- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4636608P | 2008-04-18 | 2008-04-18 | |
| US11129408P | 2008-11-04 | 2008-11-04 | |
| PCT/US2009/041176 WO2009129548A1 (en) | 2008-04-18 | 2009-04-20 | Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201007589B true ZA201007589B (en) | 2013-09-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2010/07589A ZA201007589B (en) | 2008-04-18 | 2010-10-25 | Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives |
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| US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| ZA200706804B (en) | 2005-02-03 | 2008-10-29 | Gen Hospital Corp | Method for treating gefitinib resistant cancer |
| CA2626326C (en) | 2005-11-04 | 2021-02-16 | Wyeth | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
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| MX2010011437A (es) | 2008-04-18 | 2010-12-20 | Reata Pharmaceuticals Inc | Moduladores antioxidantes de inflamacion: derivados del acido oleanolico con saturacion en el anillo c. |
| WO2009146216A2 (en) | 2008-04-18 | 2009-12-03 | Reata Pharmaceuticals. Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| KR101665042B1 (ko) * | 2008-04-18 | 2016-10-11 | 리타 파마슈티컬스 잉크. | 소염성 골격군을 포함하는 화합물 및 사용 방법 |
| AU2009274037B2 (en) | 2008-07-22 | 2015-07-09 | Trustees Of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
| WO2010053817A1 (en) | 2008-11-04 | 2010-05-14 | Trustees Of Dartmouth College | Betulinic acid derivatives and methods of use thereof |
| JP5775464B2 (ja) | 2009-02-13 | 2015-09-09 | リアタ ファーマシューティカルズ,インク | 非晶質cddo−meを含有する遅延放出性経口投薬組成物 |
| RU2401273C1 (ru) | 2009-03-30 | 2010-10-10 | Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) (статус государственного учреждения) | Противоопухолевое средство тритерпеновой природы, полученное путем модификации глицирретовой кислоты |
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| MA34909B1 (fr) | 2011-01-31 | 2014-02-01 | Bristol Myers Squibb Co | Triterpénoïdes modifi2s en c-17 et c-3 presentant une activité inhibitrice de la maturation du vih |
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| CN208692323U (zh) | 2018-08-13 | 2019-04-05 | 深圳市优维尔科技有限公司 | 一种抽吸装置 |
| US11133308B2 (en) | 2019-05-03 | 2021-09-28 | International Business Machines Corporation | Uniform work function metal recess for vertical transistor complementary metal oxide semiconductor technology |
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