ME02751B - Antioksidansni modulatori upale: c-17 homologisani derivati oleanolinske kiseline - Google Patents

Antioksidansni modulatori upale: c-17 homologisani derivati oleanolinske kiseline

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Publication number
ME02751B
ME02751B MEP-2017-27A MEP2717A ME02751B ME 02751 B ME02751 B ME 02751B ME P2717 A MEP2717 A ME P2717A ME 02751 B ME02751 B ME 02751B
Authority
ME
Montenegro
Prior art keywords
compound
disease
substituted
acyloxy
acyl
Prior art date
Application number
MEP-2017-27A
Other languages
German (de)
English (en)
French (fr)
Inventor
Xin Jiang
Melean Visnick
Jack Greiner
Xiaofeng Liu
Stephen S Szucs
Original Assignee
Reata Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reata Pharmaceuticals Inc filed Critical Reata Pharmaceuticals Inc
Publication of ME02751B publication Critical patent/ME02751B/me

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Claims (1)

  1. 3. Jedinjenje iz Patentnog zahteva 2, pri čemu Y predstavlja -CH2-; i/ili pri čemu Rapredstavlja hidroksi, cijano, acil(C�8), supstituisani acil(C�8), aciloksi(C�8), supstituisani aciloksi(C�8), amido (C�8), ili supstituisani amido(C�8); ili njihovu farmaceutski prihvatljivu so, ili njihov tautomer.
    4. Jedinjenje iz patentnog zahteva 2, je još definisano kao pri čemu Ra jeste hidroksi, cijano, acil(C�8), supstituisani acil(C�8), aciloksi(C�8), ili supstituisani aciloksi(C�8); ili njihova farmaceutski prihvatljiva so ili njihov tautomer.
    5. Jedinjenje iz patentnog zahteva 2, je još definisano kao pri čemu Ra jeste hidroksi, cijano, acil(C�8), supstituisani acil(C�8), aciloksi(C�8), ili supstituisani aciloksi(C�8); ili njihova farmaceutski prihvatljiva so ili njihov tautomer.
    6. Jedinjenje iz Patentnog zahteva 1, pri čemu Y jeste -C(OH)HCH2-.
    7. Jedinjenje prema bilo kom od patentnih zahteva 1-2, pri čemu Ra jeste -OH, -Cl, -Br ili -H.
    8. Jedinjenje prema bilo kom od patentnih zahteva 1-5, pri čemu Ra jeste -OH.
    9. Jedinjenje prema bilo kom od patentnih zahteva 1-5, pri čemu: Ra jeste acil(C1-3) ili supstituisani acil(C1-3) ili Ra jeste aciloksi(C1-8) ili supstituisani aciloksi(C1-3)
    10. Jedinjenje prema bilo kom od patentnih zahteva 1-2, pri čemu Ra jeste alkilamino(C�12), dialkilamino(C�12), alkenilamino(C�12), alkinilamino(C�12), arilamino(C�12), aralkilamino(C�12), heteroarilamino(C�12), heteroaralkilamino(C�12), alkilsulfonilamino(C�12), ili amido(C�12), ili supstituisana verzija bilo koje od ovih grupa.
    11. Jedinjenje iz patentnog zahteva 1, se još definiše kao: Ili
    12.Jedinjenje iz formule:
    13. Farmaceutska supstanca koja obuhvata kao aktivni sastojak jedinjenje prema bilo kom od patentnih zahteva 1-12 i farmaceutski prihvatljiv nosač.
    14. Jedinjenje za koje se traži zaštita patentom u bilo kom od patentnih zahteva 1-12 za upotrebu kao lek.
    15. Jedinjenje za koje se traži zaštita patentom u bilo kom od Patentnih zahteva 1-12 za upotrebu u lečenju kancera, npr. karcinoma, sarkoma, limfoma, leukemije, melanoma, mezotelioma, višestrukog mijeloma, ili seminoma i/ili je to kancer bešike, krvi, kosti, mozga, dojke, centralnog nervnog sistema, debelog creva, endometrijuma, ezofagusa, genitourinarnog trakta, glave, grla, jetre, pluća, vrata, jajnika, pankreasa, prostate, slezine, tankog creva, velikog creva, želuca, ili testisa.
    16. Jedinjenje za koje se zaštita patentom traži u bilo kom od Patentnih zahteva 1-12 za upotrebu u lečenju bolesti ili stanja sa komponentom upale kod ispitanika, na primer, pri čemu ova bolest jeste lupus, reumatoidni artritis, inflamatorna bolest creva, kardiovaskularna bolest, dijabetes, metabolički sindrom, metabolički sindrom (X sindrom), psorijaza, akne, ili atopični dermatitis.
    17. Jedinjenje za koje se traži zaštita patentom u bilo kom od Patentnih zahteva 1-12 za upotrebu za lečenje neurodegenerativne bolesti kod ispitanika, na primer, pri čemu je ta bolest Parkinsonova bolest, Alchajmerova bolest, multipla skleroza (MS), Hantingtonova bolest ili amiotrofična lateralna skleroza
    18.Jedinjenje za koje se traži zaštita patentom u bilo kom od Patentnih zahteva 1-12 za upotrebu u lečenju renalne/bubrežne bolesti kod ispitanika.
    19. Komplet obuhvata: jedinjenje iz bilo kog od patentnih zahteva 1-12; i uputstva koja obuhvataju jedan ili više oblika informacije izabrane iz grupe koja obuhvata označavanje stanja bolesti za koje jedinjenje treba da bude primenjeno, informaciju o skladištenju za ovo jedinjenje, informaciju o doziranju i uputstva o načinu kako primeniti jedinjenje. Triterpenoid u mozgu, nM etil amid Slika 7 Slika 8
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