BRPI0911422A2 - moduladores inflamatórios derivados do ácido oleanólico homolgados para c-17 - Google Patents
moduladores inflamatórios derivados do ácido oleanólico homolgados para c-17Info
- Publication number
- BRPI0911422A2 BRPI0911422A2 BRPI0911422A BRPI0911422A BRPI0911422A2 BR PI0911422 A2 BRPI0911422 A2 BR PI0911422A2 BR PI0911422 A BRPI0911422 A BR PI0911422A BR PI0911422 A BRPI0911422 A BR PI0911422A BR PI0911422 A2 BRPI0911422 A2 BR PI0911422A2
- Authority
- BR
- Brazil
- Prior art keywords
- homolgated
- acid derived
- oleanolic acid
- derived inflammatory
- inflammatory modulators
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
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- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4636608P | 2008-04-18 | 2008-04-18 | |
US61/046,366 | 2008-04-18 | ||
US11129408P | 2008-11-04 | 2008-11-04 | |
US61/111,294 | 2008-11-04 | ||
PCT/US2009/041176 WO2009129548A1 (en) | 2008-04-18 | 2009-04-20 | Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0911422A2 true BRPI0911422A2 (pt) | 2017-12-05 |
BRPI0911422B1 BRPI0911422B1 (pt) | 2021-02-02 |
BRPI0911422B8 BRPI0911422B8 (pt) | 2021-05-25 |
Family
ID=40852224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0911422A BRPI0911422B8 (pt) | 2008-04-18 | 2009-04-20 | compostos moduladores inflamatórios antioxidantes, composição farmacêutica e usos dos mesmos |
Country Status (28)
Country | Link |
---|---|
US (3) | US7943778B2 (pt) |
EP (1) | EP2271658B1 (pt) |
JP (2) | JP5588966B2 (pt) |
KR (2) | KR20110010611A (pt) |
CN (2) | CN104250280A (pt) |
AU (2) | AU2009237581C1 (pt) |
BR (1) | BRPI0911422B8 (pt) |
CA (1) | CA2721666C (pt) |
CO (1) | CO6311107A2 (pt) |
CY (1) | CY1118475T1 (pt) |
DK (1) | DK2271658T3 (pt) |
EA (1) | EA020156B1 (pt) |
ES (1) | ES2613964T3 (pt) |
HK (2) | HK1152713A1 (pt) |
HR (1) | HRP20170102T1 (pt) |
HU (1) | HUE033288T2 (pt) |
IL (1) | IL208759B (pt) |
LT (1) | LT2271658T (pt) |
ME (1) | ME02751B (pt) |
MX (1) | MX2010011439A (pt) |
NZ (1) | NZ588711A (pt) |
PL (1) | PL2271658T3 (pt) |
PT (1) | PT2271658T (pt) |
RS (1) | RS55631B1 (pt) |
SI (1) | SI2271658T1 (pt) |
TW (1) | TWI584808B (pt) |
WO (1) | WO2009129548A1 (pt) |
ZA (1) | ZA201007589B (pt) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
CN102886045A (zh) | 2005-02-03 | 2013-01-23 | 综合医院公司 | 治疗吉非替尼耐药性癌症的方法 |
KR101354828B1 (ko) | 2005-11-04 | 2014-02-18 | 와이어쓰 엘엘씨 | mTOR 저해자, 헤르셉틴, 및/또는 HKI-272의항신생물성 조합 |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
MX356760B (es) | 2008-01-11 | 2018-06-12 | Dartmouth College | Triterpenoides sinteticos y metodos de uso en el tratamiento de enfermedad. |
US7915402B2 (en) | 2008-04-18 | 2011-03-29 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring |
CN102066397B (zh) | 2008-04-18 | 2013-09-11 | 里亚塔医药公司 | 包含抗炎症药效团的化合物以及使用方法 |
AU2009237579C1 (en) | 2008-04-18 | 2016-05-12 | Reata Pharmaceuticals Holdings, LLC | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17 |
WO2009129548A1 (en) | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives |
US8071632B2 (en) | 2008-04-18 | 2011-12-06 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
EP3135285B1 (en) | 2008-06-17 | 2018-08-15 | Wyeth LLC | Antineoplastic combinations containing hki-272 and vinorelbine |
EP2309860B1 (en) * | 2008-07-22 | 2014-01-08 | Trustees of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
EP2326329B1 (en) | 2008-08-04 | 2017-01-11 | Wyeth LLC | Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine |
DK3000467T3 (da) | 2009-04-06 | 2023-03-27 | Wyeth Llc | Behandling med neratinib mod brystkræft |
PL2558105T3 (pl) | 2010-04-12 | 2020-04-30 | Reata Pharmaceuticals, Inc. | Metylowany bardoksolon do leczenia otyłości |
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