WO2008111497A1 - トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤 - Google Patents

トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤 Download PDF

Info

Publication number
WO2008111497A1
WO2008111497A1 PCT/JP2008/054119 JP2008054119W WO2008111497A1 WO 2008111497 A1 WO2008111497 A1 WO 2008111497A1 JP 2008054119 W JP2008054119 W JP 2008054119W WO 2008111497 A1 WO2008111497 A1 WO 2008111497A1
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic agent
prophylactic
oxidative stress
retinal
disease associated
Prior art date
Application number
PCT/JP2008/054119
Other languages
English (en)
French (fr)
Inventor
Shinichiro Hirai
Atsushi Yoshida
Original Assignee
Santen Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co., Ltd. filed Critical Santen Pharmaceutical Co., Ltd.
Publication of WO2008111497A1 publication Critical patent/WO2008111497A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

　本発明は、酸化ストレスが関連する眼疾患の新たな予防又は治療剤を提供する。下記一般式（Ｉ）で表される化合物又はその塩は、神経網膜、網膜色素上皮、網脈絡膜といった後眼部組織において、優れた異物代謝系第２相酵素の誘導能を発揮するので、加齢黄斑変性、糖尿病網膜症、糖尿病黄斑浮腫、網膜色素変性症、増殖性硝子体網膜症、網膜動脈閉塞症、網膜静脈閉塞症、ぶどう膜炎、レーベル病、未熟児網膜症、網膜剥離、網膜色素上皮剥離、これらの疾患に起因する視神経障害、緑内障に起因する視神経障害、虚血性視神経障害、白内障などの酸化ストレスが関連する眼疾患の予防又は治療剤として有用である。 　　【化１】
PCT/JP2008/054119 2007-03-08 2008-03-07 トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤 WO2008111497A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007058764 2007-03-08
JP2007-058764 2007-03-08

Publications (1)

Publication Number Publication Date
WO2008111497A1 true WO2008111497A1 (ja) 2008-09-18

Family

ID=39759436

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/054119 WO2008111497A1 (ja) 2007-03-08 2008-03-07 トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤

Country Status (2)

Country Link
JP (1) JP2008247898A (ja)
WO (1) WO2008111497A1 (ja)

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009089545A1 (en) * 2008-01-11 2009-07-16 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
US7678830B2 (en) 2002-01-15 2010-03-16 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US7714012B2 (en) 2006-11-17 2010-05-11 Trustees Of Dartmouth University Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
US7795305B2 (en) 2000-11-28 2010-09-14 Board Of Regents, The University Of Texas System CDDO-compounds and combination therapies thereof
US7863327B2 (en) 1998-06-19 2011-01-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7915402B2 (en) 2008-04-18 2011-03-29 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
US7943778B2 (en) 2008-04-18 2011-05-17 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives
WO2010093944A3 (en) * 2009-02-13 2011-08-11 Reata Pharmaceuticals, Inc. Delayed release, oral dosage compositions that contain amorphous cddo-me
US8071632B2 (en) 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
US8124799B2 (en) 2008-04-18 2012-02-28 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
US8258329B2 (en) 2008-04-18 2012-09-04 Reata Pharmaceuticals, Inc. Dehydroandrosterone analogs including an anti-inflammatory pharmacore and methods of use
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US8314137B2 (en) 2008-07-22 2012-11-20 Trustess Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
JP2013544838A (ja) * 2010-12-03 2013-12-19 アラーガン インコーポレイテッド 網膜の疾患を治療するための方法
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US8993640B2 (en) 2012-04-27 2015-03-31 Reata Pharmaceuticals, Inc. 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof
US9174941B2 (en) 2010-12-17 2015-11-03 Reata Pharmaceuticals, Inc. Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
US9205113B2 (en) 2012-05-08 2015-12-08 Trustees Of Dartmouth College Synthetic triterpenoids and methods for modulating stem/progenitor cell gene expression
US9278912B2 (en) 2012-09-10 2016-03-08 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
US9290536B2 (en) 2011-03-11 2016-03-22 Reata Pharmaceuticals, Inc. C4 monomethyl triterpenoid derivatives and methods of use thereof
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
US9556222B2 (en) 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
US9593074B2 (en) 2012-09-10 2017-03-14 Reata Pharmaceuticals, Inc. C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof
WO2017121766A1 (en) 2016-01-12 2017-07-20 Kaleyde Pharmaceuticals Ag Pharmaceutical formulations and their use for the treatment of retinitis pigmentosa
US10105372B2 (en) 2010-04-12 2018-10-23 Reata Pharmaceuticals, Inc. Methods of treating obesity using antioxidant inflammation modulators
US10953020B2 (en) 2016-11-08 2021-03-23 Reata Pharmaceuticals, Inc. Methods of treating Alport syndrome using bardoxolone methyl or analogs thereof
US11117927B2 (en) 2013-04-24 2021-09-14 Abbvie Inc. 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof
US11584775B2 (en) 2015-09-23 2023-02-21 Reata Pharmaceuticals, Inc. C4-modified oleanolic acid derivatives for inhibition of IL-17 and other uses

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3318264A1 (en) * 2009-08-24 2018-05-09 Stealth Peptides International, Inc. Methods ans compositions for preventing or treating opthalmic conditions

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003051313A2 (en) * 2001-12-18 2003-06-26 Brassica Foundation For Chemoprotection Research, Inc. Prevention and treatment of oxidative stress disorders by glutathione and phase ii detoxification enzymes
WO2005063295A1 (en) * 2003-12-22 2005-07-14 Alcon, Inc. Agents for treatment of glaucomatous retinopathy and optic neuropathy
WO2005063249A1 (en) * 2003-12-22 2005-07-14 Alcon, Inc. Agents for treatment of diabetic retinopathy and drusen formation in macular degeneration
WO2008016095A1 (fr) * 2006-08-02 2008-02-07 Santen Pharmaceutical Co., Ltd. REMÈDE PRÉVENTIF OU CURATIF POUR LES KÉRATOCONJONCTIVITES CONTENANT UN ACTIVATEUR DE Nrf2 EN TANT QUE MATIÈRE ACTIVE

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003051313A2 (en) * 2001-12-18 2003-06-26 Brassica Foundation For Chemoprotection Research, Inc. Prevention and treatment of oxidative stress disorders by glutathione and phase ii detoxification enzymes
WO2005063295A1 (en) * 2003-12-22 2005-07-14 Alcon, Inc. Agents for treatment of glaucomatous retinopathy and optic neuropathy
WO2005063249A1 (en) * 2003-12-22 2005-07-14 Alcon, Inc. Agents for treatment of diabetic retinopathy and drusen formation in macular degeneration
WO2008016095A1 (fr) * 2006-08-02 2008-02-07 Santen Pharmaceutical Co., Ltd. REMÈDE PRÉVENTIF OU CURATIF POUR LES KÉRATOCONJONCTIVITES CONTENANT UN ACTIVATEUR DE Nrf2 EN TANT QUE MATIÈRE ACTIVE

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DINKOVA-KOSTOVA A.T. ET AL.: "Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress", PROC. NATL. ACAD. SCI. U.S.A., vol. 102, no. 12, 22 March 2005 (2005-03-22), pages 4584 - 4589, XP055117477, DOI: doi:10.1073/pnas.0500815102 *
GAO X. ET AL.: "Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage", PROC. NATL. ACAD. SCI. U.S.A., vol. 101, no. 28, 13 July 2004 (2004-07-13), pages 10446 - 10451, XP002993321 *
LIBY K. ET AL.: "The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling", CANCER RES., vol. 65, no. 11, 1 June 2005 (2005-06-01), pages 4789 - 4798, XP003020927 *
YATES M.S. ET AL.: "Pharmacodynamic characterization of chemopreventive triterpernoids as exceptionally potent inducers of Nrf2-regulated genes", MOL. CANCER THER., vol. 6, no. 1, 1 January 2007 (2007-01-01), pages 154 - 162, XP002456640 *
YATES M.S. ET AL.: "Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-12-diooxoleana-1,9(11)-dien-28-oyl]imidazole", CANCER RES., vol. 66, no. 4, 15 February 2005 (2005-02-15), pages 2488 - 2494 *

Cited By (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8034955B2 (en) 1998-06-19 2011-10-11 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US8586775B2 (en) 1998-06-19 2013-11-19 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7863327B2 (en) 1998-06-19 2011-01-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7795305B2 (en) 2000-11-28 2010-09-14 Board Of Regents, The University Of Texas System CDDO-compounds and combination therapies thereof
US8067465B2 (en) 2002-01-15 2011-11-29 The Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US7678830B2 (en) 2002-01-15 2010-03-16 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US8067394B2 (en) 2006-11-17 2011-11-29 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
US7714012B2 (en) 2006-11-17 2010-05-11 Trustees Of Dartmouth University Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
EA022166B1 (ru) * 2008-01-11 2015-11-30 Ритэ Фамэсутиклс, Инк. Синтетические тритерпеноиды и их применение в лечении заболеваний
AU2009203941B2 (en) * 2008-01-11 2015-03-12 Reata Pharmaceuticals Holdings, LLC Synthetic triterpenoids and methods of use in the treatment of disease
US9757359B2 (en) 2008-01-11 2017-09-12 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
EP3492077A1 (en) * 2008-01-11 2019-06-05 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
US8129429B2 (en) 2008-01-11 2012-03-06 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
WO2009089545A1 (en) * 2008-01-11 2009-07-16 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
US8455544B2 (en) 2008-01-11 2013-06-04 Reata Pharmaecuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
US8338618B2 (en) 2008-04-18 2012-12-25 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
USRE45288E1 (en) 2008-04-18 2014-12-09 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
US9249089B2 (en) 2008-04-18 2016-02-02 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives
US9233998B2 (en) 2008-04-18 2016-01-12 Reata Pharmaceuticals, Inc. Natural product analogs including an anti-inflammatory cyanoenone pharmacore and methods of use
US8394967B2 (en) 2008-04-18 2013-03-12 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives
US8440820B2 (en) 2008-04-18 2013-05-14 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
US8440854B2 (en) 2008-04-18 2013-05-14 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino acid and other modifications at C-17
US10556858B2 (en) 2008-04-18 2020-02-11 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
US11091430B2 (en) 2008-04-18 2021-08-17 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17
US8124656B2 (en) 2008-04-18 2012-02-28 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
US10093614B2 (en) 2008-04-18 2018-10-09 Reata Pharmaceuticals, Inc. Antioxidant Inflamation modulators: oleanolic acid derivatives with amino and other modifications at C-17
US8258329B2 (en) 2008-04-18 2012-09-04 Reata Pharmaceuticals, Inc. Dehydroandrosterone analogs including an anti-inflammatory pharmacore and methods of use
US8124799B2 (en) 2008-04-18 2012-02-28 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
USRE45325E1 (en) 2008-04-18 2015-01-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
US8071632B2 (en) 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
US9796668B2 (en) 2008-04-18 2017-10-24 Reata Pharmaceuticals, Inc. Natural product analogs including an anti-inflammatory cyanoenone pharmacore and methods of use
US7915402B2 (en) 2008-04-18 2011-03-29 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
US11919838B2 (en) 2008-04-18 2024-03-05 Reata Pharmaceuticals Holdings, LLC Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
US9090574B2 (en) 2008-04-18 2015-07-28 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
US9102681B2 (en) 2008-04-18 2015-08-11 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
US7943778B2 (en) 2008-04-18 2011-05-17 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives
US9670147B2 (en) 2008-04-18 2017-06-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
US9000188B2 (en) 2008-07-22 2015-04-07 Trustees Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
US8314137B2 (en) 2008-07-22 2012-11-20 Trustess Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
US9155721B2 (en) 2009-02-13 2015-10-13 Reata Pharmaceuticals, Inc. Delayed release, oral dosage compositions that contain amorphous CDDO-Me
EP3254675A1 (en) * 2009-02-13 2017-12-13 Reata Pharmaceuticals, Inc. Delayed release, oral dosage compositions that contain amorphous cddo-me
WO2010093944A3 (en) * 2009-02-13 2011-08-11 Reata Pharmaceuticals, Inc. Delayed release, oral dosage compositions that contain amorphous cddo-me
CN102387789A (zh) * 2009-02-13 2012-03-21 瑞阿特制药公司 含有无定形cddo-me的延迟释放口服组合物
EA023652B1 (ru) * 2009-02-13 2016-06-30 Реата Фармасьютикалз, Инк. Композиции с отсроченным высвобождением для перорального применения, содержащие аморфный бардоксолон метил (cddo-me)
JP2012518008A (ja) * 2009-02-13 2012-08-09 リアタ ファーマシューティカルズ，インク 非晶質ｃｄｄｏ−ｍｅを含有する遅延放出性経口投薬組成物
US8747901B2 (en) 2009-02-13 2014-06-10 Reata Pharmaceuticals, Inc. Delayed release, oral dosage compositions that contain amorphous CDDO-Me
CN105232471A (zh) * 2009-02-13 2016-01-13 瑞阿特制药公司 含有无定形cddo-me的延迟释放口服组合物
US11911395B2 (en) 2010-04-12 2024-02-27 Reata Pharmaceuticals Holdings, LLC Methods of treating obesity using antioxidant inflammation modulators
US10105372B2 (en) 2010-04-12 2018-10-23 Reata Pharmaceuticals, Inc. Methods of treating obesity using antioxidant inflammation modulators
JP2013544838A (ja) * 2010-12-03 2013-12-19 アラーガン インコーポレイテッド 網膜の疾患を治療するための方法
US9174941B2 (en) 2010-12-17 2015-11-03 Reata Pharmaceuticals, Inc. Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
US9884809B2 (en) 2010-12-17 2018-02-06 Reata Pharmaceuticals, Inc. Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
US11814338B2 (en) 2010-12-17 2023-11-14 Reata Pharmaceuticals, Inc. Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
US11192852B2 (en) 2010-12-17 2021-12-07 Reata Pharmaceuticals, Inc. Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
US9290536B2 (en) 2011-03-11 2016-03-22 Reata Pharmaceuticals, Inc. C4 monomethyl triterpenoid derivatives and methods of use thereof
US11078230B2 (en) 2012-04-27 2021-08-03 Reata Pharmaceuticals, Inc. 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof
JP2015521166A (ja) * 2012-04-27 2015-07-27 リアタ ファーマシューティカルズ インコーポレイテッド バルドキソロンメチルの２，２−ジフルオロプロピオンアミド誘導体、その多形体および使用方法
US8993640B2 (en) 2012-04-27 2015-03-31 Reata Pharmaceuticals, Inc. 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof
US9701709B2 (en) 2012-04-27 2017-07-11 Reata Pharmaceuticals, Inc. 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof
US9205113B2 (en) 2012-05-08 2015-12-08 Trustees Of Dartmouth College Synthetic triterpenoids and methods for modulating stem/progenitor cell gene expression
US9539287B2 (en) 2012-05-08 2017-01-10 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
US9556222B2 (en) 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
US10898499B2 (en) 2012-09-10 2021-01-26 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
US11406648B2 (en) 2012-09-10 2022-08-09 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
US9889143B2 (en) 2012-09-10 2018-02-13 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
US10501489B2 (en) 2012-09-10 2019-12-10 Reata Pharmaceuticals, Inc. C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof
US9278912B2 (en) 2012-09-10 2016-03-08 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
US10398711B2 (en) 2012-09-10 2019-09-03 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
US9593074B2 (en) 2012-09-10 2017-03-14 Reata Pharmaceuticals, Inc. C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof
US11873320B2 (en) 2013-04-24 2024-01-16 Reata Pharmaceuticals Holdings, LLC 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof
US11117927B2 (en) 2013-04-24 2021-09-14 Abbvie Inc. 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof
US11584775B2 (en) 2015-09-23 2023-02-21 Reata Pharmaceuticals, Inc. C4-modified oleanolic acid derivatives for inhibition of IL-17 and other uses
WO2017121766A1 (en) 2016-01-12 2017-07-20 Kaleyde Pharmaceuticals Ag Pharmaceutical formulations and their use for the treatment of retinitis pigmentosa
US11446313B2 (en) 2016-11-08 2022-09-20 Reata Pharmaceuticals Holdings, LLC Methods of treating Alport syndrome using bardoxolone methyl or analogs thereof
US10953020B2 (en) 2016-11-08 2021-03-23 Reata Pharmaceuticals, Inc. Methods of treating Alport syndrome using bardoxolone methyl or analogs thereof

Also Published As

Publication number Publication date
JP2008247898A (ja) 2008-10-16

Similar Documents

Publication Publication Date Title
WO2008111497A1 (ja) トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤
RU2009145939A (ru) Профилактическое или терапевтическое средство, применяемое при заболеваниях заднего отдела глаза
Kerr et al. Intraocular pressure during femtosecond laser pretreatment of cataract
JP2008538215A5 (ja)
Tu Balancing antimicrobial efficacy and toxicity of currently available topical ophthalmic preservatives
EP4302829A3 (en) Peptide for use in preventing or treating macular degeneration
NZ588938A (en) Sustained release delivery of active agents to treat glaucoma and ocular hypertension
CA2582316A1 (en) Use of inhibitors of jun n-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
WO2007075720A8 (en) Topical mecamylamine formulations for ocular administration and uses thereof
WO2008019417A3 (en) Treatment of ocular diseases
MX2020007948A (es) Medicamento para prevenir o tratar una enfermedad oftalmica asociada con neovascularizacion intraocular mejorada y/o permeabilidad vascular intraocular.
GB2432526A (en) Use of ifenprodil for the treatment of ophthalmic diseases
Ellies et al. Macular hemorrhage after laser in situ keratomileusis for high myopia
Helbig Surgery for diabetic retinopathy
WO2021220061A3 (en) Heterodimer compositions and methods for the treatment of ocular disorders
WO2019054960A3 (en) Improving ophthalmic telomerase activity via topical and local ocular applications and preventing, delaying and / or treating impairments or diseases experienced due to degenerative processes (such as aging)
FI3720428T3 (fi) Dobesiliinihappoa käsittävä oftalminen paikalliskoostumus silmän takasegmentin sairauksien hoitoon
JP2013513606A5 (ja)
CA2453442A1 (en) Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases
Cheung et al. Stabilization of anterior chamber depth during phacoemulsification cataract surgery in vitrectomized eyes
Yates et al. Scleral rupture during intraoperative silicone oil injection in pars plana vitrectomy
Watanabe et al. Cystoid macular edema associated with latanoprost use in a pseudophakic eye with a history of surgical complications
Friberg et al. Migration of intravitreal silicone oil through a Baerveldt tube into the subconjunctival space
TWI766565B (zh) 用於治療眼疾的組合物及其用途
Dervenis et al. Anterior segment approach for the surgical management of aqueous misdirection syndrome

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08721537

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08721537

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP