MX2020007948A - Medicamento para prevenir o tratar una enfermedad oftalmica asociada con neovascularizacion intraocular mejorada y/o permeabilidad vascular intraocular. - Google Patents

Medicamento para prevenir o tratar una enfermedad oftalmica asociada con neovascularizacion intraocular mejorada y/o permeabilidad vascular intraocular.

Info

Publication number
MX2020007948A
MX2020007948A MX2020007948A MX2020007948A MX2020007948A MX 2020007948 A MX2020007948 A MX 2020007948A MX 2020007948 A MX2020007948 A MX 2020007948A MX 2020007948 A MX2020007948 A MX 2020007948A MX 2020007948 A MX2020007948 A MX 2020007948A
Authority
MX
Mexico
Prior art keywords
intraocular
vascular permeability
neovascularization
preventing
activity
Prior art date
Application number
MX2020007948A
Other languages
English (en)
Inventor
Rie Yamamoto
Tomohiro Aoki
Hideaki Hara
Shuh Narumiya
Ichiro Aramori
Original Assignee
Univ Kyoto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kyoto filed Critical Univ Kyoto
Publication of MX2020007948A publication Critical patent/MX2020007948A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se proporciona un producto farmacéutico para prevenir o tratar una enfermedad oftálmica asociada con la neovascularización intraocular y/o el aumento de la permeabilidad vascular intraocular. Los inventores de la presente invención han realizado investigaciones sobre un producto farmacéutico para prevenir o tratar una enfermedad oftálmica asociada con la neovascularización intraocular y/o el aumento de la permeabilidad vascular intraocular, y han confirmado que un agonista selectivo del receptor S1P que tiene actividad agonista en un receptor S1P1 tiene una acción reductora de la neovascularización intraocular y una acción reductora de la permeabilidad vascular intraocular, completando así la presente invención. Un compuesto o una sal farmacéuticamente aceptable del mismo de la presente invención, que sirve como el agonista selectivo del receptor S1P que tiene actividad agonista en el receptor S1P1, tiene una acción reductora de la neovascularización intraocular y una acción reductora de la permeabilidad vascular intraocular, y puede usarse como un agente preventivo y/o terapéutico para, por ejemplo, la degeneración macular exudativa relacionada con la edad, retinopatía diabética, edema macular diabético, neovascularización coroidea de la miopía, oclusión arterial retiniana, oclusión venosa retiniana o glaucoma neovascular.
MX2020007948A 2018-02-02 2019-02-01 Medicamento para prevenir o tratar una enfermedad oftalmica asociada con neovascularizacion intraocular mejorada y/o permeabilidad vascular intraocular. MX2020007948A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018016911 2018-02-02
PCT/JP2019/003573 WO2019151470A1 (ja) 2018-02-02 2019-02-01 眼内血管新生及び／又は眼内血管透過性亢進を伴う眼科疾患の予防又は治療のための医薬

Publications (1)

Publication Number Publication Date
MX2020007948A true MX2020007948A (es) 2020-12-10

Family

ID=67479734

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020007948A MX2020007948A (es) 2018-02-02 2019-02-01 Medicamento para prevenir o tratar una enfermedad oftalmica asociada con neovascularizacion intraocular mejorada y/o permeabilidad vascular intraocular.

Country Status (17)

Country Link
US (1) US20210113529A1 (es)
EP (1) EP3747471A4 (es)
JP (1) JPWO2019151470A1 (es)
KR (1) KR20200116953A (es)
CN (1) CN111683682A (es)
AU (1) AU2019214265A1 (es)
BR (1) BR112020015567A2 (es)
CA (1) CA3089952A1 (es)
IL (1) IL275603A (es)
JO (1) JOP20200186A1 (es)
MA (1) MA53098A (es)
MX (1) MX2020007948A (es)
PH (1) PH12020551015A1 (es)
RU (1) RU2020128700A (es)
SG (1) SG11202006255UA (es)
WO (1) WO2019151470A1 (es)
ZA (1) ZA202004327B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021148439A1 (en) * 2020-01-21 2021-07-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for stimulating cerebrovascular function
WO2021163355A1 (en) * 2020-02-11 2021-08-19 Arena Pharmaceuticals, Inc. Formulations and methods of treating conditions related to the s1p1 receptor
CN113082031A (zh) * 2021-03-09 2021-07-09 温州医科大学附属眼视光医院 一种多巴胺d1和d2受体非选择性激动剂在作为制备治疗眼部病理性血管新生药物的应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1643983T3 (pl) 2003-06-24 2010-10-29 Univ Connecticut Sposoby hamowania przepuszczalności naczyń krwionośnych i apoptozy
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
CN1993333B (zh) 2004-08-04 2012-08-01 大正制药株式会社 三唑衍生物
GB0504544D0 (en) * 2005-03-04 2005-04-13 Novartis Ag Organic compounds
US8022091B2 (en) 2006-02-03 2011-09-20 Taisho Pharmaceutical Co., Ltd. Triazole derivative
EP1988081B1 (en) 2006-02-06 2012-10-17 Taisho Pharmaceutical Co., Ltd Binding inhibitor of sphingosine-1-phosphate
ES2453372T3 (es) 2006-04-03 2014-04-07 Astellas Pharma Inc. Derivados de oxadiazol como agonistas de S1P1
WO2008055072A2 (en) 2006-10-27 2008-05-08 Lpath, Inc. Compositions and methods for treating ocular diseases and conditions
WO2008063932A2 (en) 2006-11-10 2008-05-29 Genentech, Inc. Method for treating age-related macular degeneration
EP2014653A1 (en) * 2007-06-15 2009-01-14 Bioprojet Novel dicarboxylic acid derivatives as S1P1 receptor agonists
WO2009017219A1 (ja) 2007-08-01 2009-02-05 Taisho Pharmaceutical Co., Ltd. Ｓ１ｐ1結合阻害物質
BRPI0922135B1 (pt) 2008-12-05 2021-07-13 Astellas Pharma Inc Composto de 2h-cromeno ou um sal do mesmo, composição farmacêutica compreendendo dito composto e uso do mesmo para prevenir ou tratar uma doença induzida por infiltração de linfócito indesejável associada com s1p1
CN102686574A (zh) 2009-10-23 2012-09-19 阿勒根公司 作为具有治疗应用的受体调节剂的香豆素化合物
CA2780908A1 (en) 2009-11-24 2011-06-03 Allergan, Inc. Novel compounds as receptor modulators with therapeutic utility
BR112012017071A2 (pt) 2010-01-14 2016-04-12 Univ Nagoya City produto farmacêutico para prevenir ou tratar distúrbios acompanhados da agiogênese ocular e/ou do aumento da permeabilidade vascular ocular
US8273776B2 (en) 2010-04-16 2012-09-25 Allergan, Inc Biphenyl oxadiazole derivatives as sphingosine-1-phosphate receptors modulators
CN103380112A (zh) 2010-11-24 2013-10-30 阿勒根公司 作为s1p受体调节剂的吲哚衍生物
CN103402986A (zh) 2010-11-24 2013-11-20 阿勒根公司 S1p受体的调节剂
RU2013129484A (ru) 2010-12-03 2015-01-10 Аллерган, Инк. Алкиновые и алкеновые производные в качестве модуляторов рецептора сфингозин 1-фосфата-1
CN103391782A (zh) 2011-02-02 2013-11-13 公立大学法人名古屋市立大学 用于预防或治疗伴有眼内血管新生及/或眼内血管渗透性过高的疾病的药物
AU2012242807A1 (en) 2011-04-14 2013-11-07 Allergan, Inc. Phenyl bicyclic methyl azetidine derivatives as sphingosine-1 phosphate receptors modulators
CN103781766A (zh) 2011-04-18 2014-05-07 阿勒根公司 用作鞘氨醇-1磷酸酯受体调节剂的取代的双环甲胺衍生物
US9000016B2 (en) 2012-11-05 2015-04-07 Allergan, Inc. 1,3,4-Oxadiazoles-2-thio derivatives as sphingosine-1 phosphate receptors modulators
US8735433B1 (en) 2012-11-14 2014-05-27 Allergan, Inc. Aryl oxadiazole derivatives as sphingosine 1-phosphate (S1P) receptor modulators
WO2014130565A1 (en) 2013-02-20 2014-08-28 Allergan, Inc. Substituted diaryl azetidine derivatives as sphingosine receptor modulators
EP2990055B1 (en) * 2013-04-26 2019-06-05 Kyoto University Composition comprising a sphingosine-1-phosphate receptor 1 agonist for inhibiting formation and/or enlargement of cerebral aneurysm or for shrinking it
JP2018016911A (ja) 2016-07-28 2018-02-01 村田機械株式会社 解析装置

Also Published As

Publication number Publication date
SG11202006255UA (en) 2020-07-29
BR112020015567A2 (pt) 2021-02-02
JOP20200186A1 (ar) 2020-07-29
EP3747471A4 (en) 2021-10-27
WO2019151470A1 (ja) 2019-08-08
US20210113529A1 (en) 2021-04-22
RU2020128700A (ru) 2022-03-02
RU2020128700A3 (es) 2022-03-02
KR20200116953A (ko) 2020-10-13
CN111683682A (zh) 2020-09-18
JPWO2019151470A1 (ja) 2021-02-25
ZA202004327B (en) 2022-01-26
CA3089952A1 (en) 2019-08-08
EP3747471A1 (en) 2020-12-09
IL275603A (en) 2020-08-31
MA53098A (fr) 2021-05-12
PH12020551015A1 (en) 2021-09-06
AU2019214265A1 (en) 2020-07-23

Similar Documents

Publication Publication Date Title
PH12020551015A1 (en) Medicine for preventing or treating ophthalmic disease associated with enhanced intraocular neovascularization and/or intraocular vascular permeability
Sallam et al. Repeat intravitreal triamcinolone acetonide injections in uveitic macular oedema
JP2015528454A5 (es)
MX2013007847A (es) Uso de un antagonista de factor de crecimiento endotelial vascular para tratar transtornos oculares angiogenicos.
JP2008538215A5 (es)
RU2009145939A (ru) Профилактическое или терапевтическое средство, применяемое при заболеваниях заднего отдела глаза
MY176525A (en) Therapeutic agent for ocular disease or prophylactic agent for ocular disease
MX2022001433A (es) Tratamiento personalizado de enfermedades oftalmologicas.
HRP20192256T1 (hr) Uporaba kabergolina u liječenju očnih bolesti uzrokovanih povišenim čimbenikom vaskularnog endotelnog rasta
MX2019011242A (es) Farmacos y composiciones para el tratamiento de trastornos oculares.
Eibenberger et al. Effects of intravitreal dexamethasone implants on retinal oxygen saturation, vessel diameter, and retrobulbar blood flow velocity in ME secondary to RVO
AU2017261303A1 (en) Ophthalmic compositions
CL2020001426A1 (es) Composición tópica oftálmica que comprende ácido dobesilico para tratar enfermedades del segmento posterior del ojo.
JP2013513606A5 (es)
Ayhan Tuzcu et al. Bilateral serous detachment associated with latanoprost/timolol fixed combination use: a report of one phakic case
Wasik et al. Bevacizumab in conjunction with panretinal photocoagulation for neovascular glaucoma
NZ594728A (en) Use of deferiprone for treatment and prevention of iron-related eye disorders
AU2019478778B2 (en) Use of naphthylurea compound
Malisa et al. Dramatic response of iris and retinal neovascularisation following usage of intravitreal ranibizumab as pre-operative adjunct in vitrectomy for advanced proliferative diabetic retinopathy
Shaheen Comparison of ParsPlanaVitrectomy WithAnti VEGF Injection As A primary Management ForDiabetic Macular Edema
Casati Increased introcular pressure, retinal and vitreous haemorrhage leading to decreased visual acuity caused by device malfunction: case report
Matsubara Aflibercept/ranibizumab
Semeraro Acute uveitis following intravitreal administration in elderly patients: 4 case reports
Bui Dexamethasone/iodine-125
Orssaud Urrets-Zavalia syndrome as a complication of ocular hypotonia and bilateral anterior uveitis: case report