PL1643983T3 - Sposoby hamowania przepuszczalności naczyń krwionośnych i apoptozy - Google Patents

Sposoby hamowania przepuszczalności naczyń krwionośnych i apoptozy

Info

Publication number
PL1643983T3
PL1643983T3 PL04776717T PL04776717T PL1643983T3 PL 1643983 T3 PL1643983 T3 PL 1643983T3 PL 04776717 T PL04776717 T PL 04776717T PL 04776717 T PL04776717 T PL 04776717T PL 1643983 T3 PL1643983 T3 PL 1643983T3
Authority
PL
Poland
Prior art keywords
sphingosine
methods
vascular endothelial
vascular permeability
apoptosis
Prior art date
Application number
PL04776717T
Other languages
English (en)
Inventor
Timothy Hla
Teresa Sanchez
Ji-Hye Paik
Kevin P Claffey
Original Assignee
Univ Connecticut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Connecticut filed Critical Univ Connecticut
Publication of PL1643983T3 publication Critical patent/PL1643983T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL04776717T 2003-06-24 2004-06-18 Sposoby hamowania przepuszczalności naczyń krwionośnych i apoptozy PL1643983T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48223403P 2003-06-24 2003-06-24
EP04776717A EP1643983B1 (en) 2003-06-24 2004-06-18 Methods of inhibiting vascular permeability and apoptosis
PCT/US2004/019420 WO2005002559A2 (en) 2003-06-24 2004-06-18 Methods of inhibiting vascular permeability and apoptosis

Publications (1)

Publication Number Publication Date
PL1643983T3 true PL1643983T3 (pl) 2010-10-29

Family

ID=33563841

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04776717T PL1643983T3 (pl) 2003-06-24 2004-06-18 Sposoby hamowania przepuszczalności naczyń krwionośnych i apoptozy

Country Status (14)

Country Link
US (3) US7838562B2 (pl)
EP (1) EP1643983B1 (pl)
JP (2) JP2007523858A (pl)
CN (2) CN100431534C (pl)
AT (1) ATE466572T1 (pl)
AU (1) AU2004253473B2 (pl)
BR (1) BRPI0411831A (pl)
CA (3) CA2529318C (pl)
DE (1) DE602004027045D1 (pl)
ES (1) ES2342396T3 (pl)
MX (1) MXPA05014216A (pl)
PL (1) PL1643983T3 (pl)
PT (1) PT1643983E (pl)
WO (1) WO2005002559A2 (pl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003094965A2 (en) 2002-05-08 2003-11-20 Neuronova Ab Modulation of neural stem cells with s1p or lpa receptor agonists
GB0329498D0 (en) 2003-12-19 2004-01-28 Novartis Ag Organic compounds
EP1845971A4 (en) * 2005-01-21 2009-12-30 Medvet Science Pty Ltd METHOD FOR THE TREATMENT OF CELL DAMAGE
KR100773765B1 (ko) 2005-11-24 2007-11-12 재단법인서울대학교산학협력재단 개선된 스핑고신 유사체의 제조 방법
EP1905434A1 (en) * 2006-09-26 2008-04-02 Novartis AG Organic compounds comprising an S1P receptor agonist and their therapeutic use
CN102579387A (zh) * 2006-09-26 2012-07-18 诺瓦提斯公司 包含s1p调节剂的药物组合物
CA2670116C (en) 2006-11-22 2015-03-10 Seaside Therapeutics, Llc Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism
EP3120833A1 (en) 2007-10-12 2017-01-25 Novartis Ag Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators
CN102464590B (zh) * 2010-11-18 2013-10-23 中国科学院上海药物研究所 一类免疫调节剂及其制备方法和用途
ES2388273B1 (es) * 2011-03-16 2013-10-01 Consejo Superior De Investigaciones Científicas (Csic) Uso de inhibidores de receptores de s1p para el tratamiento de la estenosis aórtica calcificada
EP2831072B1 (en) 2012-03-26 2017-04-19 Arroyo BioSciences L.L.C. Novel sphingosine 1-phosphate receptor antagonists
WO2013181488A2 (en) * 2012-06-01 2013-12-05 The Ohio State University Research Foundation Inhibition of leukemic stem cells by pp2a activating agents
WO2014043334A1 (en) * 2012-09-12 2014-03-20 Oklahoma Medical Research Foundation Modulation of podoplanin mediated platelet activation
EP2990055B1 (en) * 2013-04-26 2019-06-05 Kyoto University Composition comprising a sphingosine-1-phosphate receptor 1 agonist for inhibiting formation and/or enlargement of cerebral aneurysm or for shrinking it
US10574647B2 (en) * 2014-09-01 2020-02-25 Passlogy Co., Ltd. User authentication method and system for implementing same
WO2016115092A1 (en) * 2015-01-12 2016-07-21 La Jolla Institute For Allergy And Immunology Methods for targeting host vascular mechanism for therapeutic protection against hemorrhagic fever
US10111841B2 (en) 2015-06-19 2018-10-30 University Of South Florida Stabilization of alcohol intoxication-induced cardiovascular instability
CN105395530A (zh) * 2015-11-27 2016-03-16 天津医科大学总医院 芬戈莫德的新用途
CN105640928A (zh) * 2016-02-26 2016-06-08 南京医科大学 Fty720在制备预防与治疗缺血性脑卒药物中的应用
CN115120724A (zh) * 2017-05-22 2022-09-30 北京蔚蓝之源医药科技有限公司 治疗再生障碍性贫血的方法和药物组合物
SG11202006255UA (en) * 2018-02-02 2020-07-29 Univ Kyoto Medicine for preventing or treating ophthalmic disease associated with enhanced intraocular neovascularization and/or intraocular vascular permeability
EP3677259A1 (en) * 2019-01-07 2020-07-08 Mosaiques Diagnostics And Therapeutics AG Use of arachidonyl trifluoromethyl ketone

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960703597A (ko) * 1993-07-23 1996-08-31 데이비드 엘 토메이 아폽토시스 및 관련 상태의 치료방법(methods of treating apoptosis and associated conditions)
US5948820A (en) * 1994-08-22 1999-09-07 Yoshitomi Pharmaceutical Industries, Ltd. Benzene compound and pharmaceutical use thereof
US6476004B1 (en) * 1996-07-18 2002-11-05 Mitsubishi Pharma Corporation Pharmaceutical composition
EP1006798A4 (en) * 1996-09-05 2003-03-05 Massachusetts Inst Technology COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS AND NEURODEGENERATIVE DISEASES
GB9624038D0 (en) * 1996-11-19 1997-01-08 Sandoz Ltd Organic compounds
JPH1180026A (ja) * 1997-09-02 1999-03-23 Yoshitomi Pharmaceut Ind Ltd 新規免疫抑制剤、その使用方法およびその同定方法
JPH11246434A (ja) * 1998-02-25 1999-09-14 Sumitomo Pharmaceut Co Ltd ｂａｘの低下及び／又はｂｃｌ−２の増加誘導剤
JP2002505868A (ja) * 1998-03-09 2002-02-26 スミスクライン・ビーチャム・コーポレイション ヒトＥＤＧ−１ｃポリヌクレオチドおよびポリペプチドおよびその使用法
JP4627356B2 (ja) * 1999-06-30 2011-02-09 松森　　昭 ウイルス性心筋炎の予防または治療薬剤
IL156304A0 (en) * 2000-12-11 2004-01-04 Tularik Inc Cxcr3 antagonists
US6471980B2 (en) * 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
EP1426762A4 (en) * 2001-08-08 2007-05-09 Chugai Pharmaceutical Co Ltd DRUGS FOR CARDIAC DISEASES
US20040058894A1 (en) * 2002-01-18 2004-03-25 Doherty George A. Selective S1P1/Edg1 receptor agonists
EP1469863A2 (en) * 2002-01-18 2004-10-27 Merck & Co., Inc. Selective s1p1/edg1 receptor agonists
GB0217152D0 (en) 2002-07-24 2002-09-04 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
DE602004027045D1 (de) 2010-06-17
US9101575B2 (en) 2015-08-11
EP1643983B1 (en) 2010-05-05
AU2004253473A1 (en) 2005-01-13
MXPA05014216A (es) 2006-03-13
US7838562B2 (en) 2010-11-23
PT1643983E (pt) 2010-06-18
WO2005002559A3 (en) 2005-04-14
JP2007523858A (ja) 2007-08-23
CA2778309A1 (en) 2005-01-13
WO2005002559A2 (en) 2005-01-13
ATE466572T1 (de) 2010-05-15
JP2014088421A (ja) 2014-05-15
CN101518524A (zh) 2009-09-02
EP1643983A2 (en) 2006-04-12
CA2529318C (en) 2013-09-17
CN1826104A (zh) 2006-08-30
CA2778126A1 (en) 2005-01-13
ES2342396T3 (es) 2010-07-06
CA2778309C (en) 2014-12-02
US20080039530A1 (en) 2008-02-14
BRPI0411831A (pt) 2006-08-08
CA2529318A1 (en) 2005-01-13
US20150283154A1 (en) 2015-10-08
AU2004253473B2 (en) 2010-03-04
CN100431534C (zh) 2008-11-12
US20110015159A1 (en) 2011-01-20

Similar Documents

Publication Publication Date Title
PL1643983T3 (pl) Sposoby hamowania przepuszczalności naczyń krwionośnych i apoptozy
UA98629C2 (ru) Соединения и способ модуляции киназ
TW200634006A (en) Tetrahydroquinoline analogues as muscarinic agonists
MX2009008253A (es) Derivados de 2-aminopiridina utiles como inhibidores de cinasa.
WO2008063842A3 (en) Methods of treating neuropathic pain with agonists of ppar-gamma
MX2009006345A (es) Compuestos utiles como inhibidores de proteina cinasa.
TW200639163A (en) RAF inhibitor compounds and methods
MXPA05012678A (es) Forma cristalina del agonista del receptor adrenergico beta2.
WO2008060907A3 (en) Pyrrolo-pyridine kinase inhibitors
EA200970447A1 (ru) Соединения и композиции в качестве ингибиторов протеинкиназы
UA111933C2 (uk) Піролопіридини як інгібітори кінази
EP2111107A4 (en) HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS
WO2007098474A8 (en) Phenyl-cycloalkyl and phenyl-heterocyclic derivatives as s1p receptor agonists
WO2004010987A3 (en) Use of s1p receptor agonists in heart diseases
TNSN08140A1 (pl)
MY159955A (en) Certain chemical entities, compositions and methods
EA201000130A1 (ru) Бициклические гетероарильные соединения и их применение в качестве ингибиторов киназы
MX2009001062A (es) Agonistas de ep2.
WO2007100640A3 (en) Growth hormone receptor antagonist cancer treatment
HK1139705A1 (en) Growth medium for c. histolyticum without ingredients of mamalian sources
EA201100255A1 (ru) 5-алкинилпиримидины
RU2014124430A (ru) Средство для лечения фиброза кишечника
AU2010236734A8 (en) 5-HT4 receptor agonist compounds for treatment of cognitive disorders
EA201100254A1 (ru) Новые соединения
WO2007109288A3 (en) Enantiomerically pure r-etifoxine, pharmaceutical compositions thereof and methods of their use