MX2015003021A - Derivados de acido glicirretinico y metodos de uso de los mismos. - Google Patents

Derivados de acido glicirretinico y metodos de uso de los mismos.

Info

Publication number
MX2015003021A
MX2015003021A MX2015003021A MX2015003021A MX2015003021A MX 2015003021 A MX2015003021 A MX 2015003021A MX 2015003021 A MX2015003021 A MX 2015003021A MX 2015003021 A MX2015003021 A MX 2015003021A MX 2015003021 A MX2015003021 A MX 2015003021A
Authority
MX
Mexico
Prior art keywords
acid derivatives
inflammatory activity
glycyrrhetinic acid
salts
compounds
Prior art date
Application number
MX2015003021A
Other languages
English (en)
Inventor
Rolf Wagner
Hui-Ju Chen
Jason Shanley
Andrew Bogdan
Jasmina Marjanovic
Xiu Wang
Diana Donnelly-Roberts
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2015003021A publication Critical patent/MX2015003021A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C261/00—Derivatives of cyanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La solicitud actual se refiere a: (a) compuestos de la Fórmula (I) (ver Fórmula) y sales de los mismos, en donde Y, y Z son como se define en la especificación; (b) composiciones que comprenden tales compuestos y sales; y (c) métodos de uso de tales compuestos, sales, y composiciones, particularmente útiles para el tratamiento y prevención de enfermedades tales como aquellas asociadas con tensión oxidante e inflamación.
MX2015003021A 2012-09-10 2013-09-10 Derivados de acido glicirretinico y metodos de uso de los mismos. MX2015003021A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261699123P 2012-09-10 2012-09-10
PCT/US2013/059008 WO2014040052A2 (en) 2012-09-10 2013-09-10 Glycyrrhetinic acid derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2015003021A true MX2015003021A (es) 2015-11-09

Family

ID=49213164

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015003021A MX2015003021A (es) 2012-09-10 2013-09-10 Derivados de acido glicirretinico y metodos de uso de los mismos.

Country Status (7)

Country Link
US (1) US20140073700A1 (es)
EP (1) EP2892910B1 (es)
JP (1) JP2015527407A (es)
CN (1) CN104936972A (es)
CA (1) CA2884400A1 (es)
MX (1) MX2015003021A (es)
WO (1) WO2014040052A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS58486B1 (sr) 2008-01-11 2019-04-30 Reata Pharmaceuticals Inc Sintetički triterpenoidi i metode njihove upotrebe u tretmanu bolesti
JP5529851B2 (ja) 2008-04-18 2014-06-25 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーター：ｃ−１７においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体
MX2010011435A (es) 2008-04-18 2011-01-25 Reata Pharmaceuticals Inc Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso.
SI2841445T1 (sl) 2012-04-27 2017-12-29 Reata Pharmaceuticals, Inc. 2,2-difluoropropionamidni derivati bardoksolon metila, njihove polimorfne oblike in postopki za njihovo uporabo
WO2013188818A1 (en) 2012-06-15 2013-12-19 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
PT2892912T (pt) 2012-09-10 2019-07-12 Reata Pharmaceuticals Inc Derivados c17-alcanodiilo e alcenodiilo de ácido oleanólico e métodos de utilização dos mesmos
WO2014040073A1 (en) 2012-09-10 2014-03-13 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
TW201936625A (zh) 2013-04-24 2019-09-16 美商艾伯維有限公司 甲基巴多索龍之2,2-二氟丙醯胺衍生物、其多晶形及其使用方法
MX2019005401A (es) 2016-11-08 2019-08-05 Reata Pharmaceuticals Inc Metodos para tratar el sindrome de alport con bardoxolona metilo o analogos de la misma.
CA3114354A1 (en) * 2018-09-28 2020-04-02 Sichuan Haisco Pharmaceutical Co., Ltd. Terpinoid derivatives and uses thereof
CN115697319A (zh) * 2020-04-01 2023-02-03 四川海思科制药有限公司 三萜系化合物nrf2抑制剂的用途
CN115677813A (zh) * 2021-03-25 2023-02-03 河北中医学院 化合物在tmem16a激动剂中的应用
CN113698447A (zh) * 2021-09-24 2021-11-26 河北维达康生物科技有限公司 一种18β-甘草次酸甲酯的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025395A (en) * 1994-04-15 2000-02-15 Duke University Method of preventing or delaying the onset and progression of Alzheimer's disease and related disorders
US6326507B1 (en) * 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
AU2003303128A1 (en) * 2002-05-13 2004-08-13 Trustees Of Dartmouth College Inhibitors and methods of use thereof
CN100417660C (zh) * 2004-12-29 2008-09-10 浙江海正药业股份有限公司 一类含异环共轭烯酮的齐墩果烷三萜衍生物及其医药用途
US8088824B2 (en) * 2007-08-15 2012-01-03 Reata Pharmaceuticals Inc. Forms of CDDO methyl ester
RS58486B1 (sr) * 2008-01-11 2019-04-30 Reata Pharmaceuticals Inc Sintetički triterpenoidi i metode njihove upotrebe u tretmanu bolesti
JP5529851B2 (ja) * 2008-04-18 2014-06-25 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーター：ｃ−１７においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体
RS55631B1 (sr) * 2008-04-18 2017-06-30 Reata Pharmaceuticals Inc Antioksidansni modulatori upale: c-17 homologisani derivati oleanolinske kiseline
EP2279197B1 (en) * 2008-04-18 2014-11-05 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
JP5990160B2 (ja) 2010-04-12 2016-09-07 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーターを使用して肥満を処置する方法
US8828329B2 (en) * 2010-10-01 2014-09-09 Church & Dwight, Co., Inc. Electronic analyte assaying device
EP2683731B1 (en) * 2011-03-11 2019-04-24 Reata Pharmaceuticals, Inc. C4-monomethyl triterpenoid derivatives and methods of use thereof

Also Published As

Publication number Publication date
EP2892910B1 (en) 2016-09-07
US20140073700A1 (en) 2014-03-13
CA2884400A1 (en) 2014-03-13
WO2014040052A2 (en) 2014-03-13
CN104936972A (zh) 2015-09-23
WO2014040052A3 (en) 2014-05-22
EP2892910A2 (en) 2015-07-15
JP2015527407A (ja) 2015-09-17

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