ZA200800440B - Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin - Google Patents

Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

Info

Publication number
ZA200800440B
ZA200800440B ZA200800440A ZA200800440A ZA200800440B ZA 200800440 B ZA200800440 B ZA 200800440B ZA 200800440 A ZA200800440 A ZA 200800440A ZA 200800440 A ZA200800440 A ZA 200800440A ZA 200800440 B ZA200800440 B ZA 200800440B
Authority
ZA
South Africa
Prior art keywords
norepinephrine
serotonin
dopamine
heteroaryl
aryl
Prior art date
Application number
ZA200800440A
Other languages
English (en)
Inventor
Bruce F Molino
Shuang Liu
Aruna Sambandam
Peter R Guzzo
Min Hu
Congxiang Zha
Kassoum Nacro
David D Manning
Matthew L Isherwood
Kristen N Fleming
Wenge Cui
Richard E Olson
Original Assignee
Amr Technology Inc
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amr Technology Inc, Bristol Myers Squibb Co filed Critical Amr Technology Inc
Publication of ZA200800440B publication Critical patent/ZA200800440B/xx

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    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
ZA200800440A 2005-07-15 2006-07-17 Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin ZA200800440B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70005705P 2005-07-15 2005-07-15

Publications (1)

Publication Number Publication Date
ZA200800440B true ZA200800440B (en) 2009-12-30

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ID=37669440

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ZA200800440A ZA200800440B (en) 2005-07-15 2006-07-17 Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

Country Status (17)

Country Link
US (4) US7956050B2 (fr)
EP (1) EP1904069B1 (fr)
JP (2) JP5258561B2 (fr)
KR (3) KR101594898B1 (fr)
CN (1) CN101495184A (fr)
AU (1) AU2006270071B2 (fr)
BR (1) BRPI0613403A2 (fr)
CA (1) CA2615403C (fr)
EA (1) EA019115B1 (fr)
GE (1) GEP20125566B (fr)
IL (3) IL188758A (fr)
MX (1) MX2008000717A (fr)
NZ (1) NZ565111A (fr)
PH (1) PH12014501033A1 (fr)
UA (1) UA95454C2 (fr)
WO (1) WO2007011820A2 (fr)
ZA (1) ZA200800440B (fr)

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US7956050B2 (en) * 2005-07-15 2011-06-07 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
WO2007137968A1 (fr) 2006-05-29 2007-12-06 High Point Pharmaceuticals, Llc Benzodioxolylcyclopropylpipérazinylpyridazines
KR20090009275A (ko) * 2006-05-31 2009-01-22 에프. 호프만-라 로슈 아게 모노아민 재흡수 억제제로서 벤즈아제핀 유도체
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BRPI0811200A8 (pt) 2007-05-10 2015-09-22 Bristol Myers Squibb Co Tetra-hidrobenzapinas arilóxi- e heteroarilóxi-substituídas e uso das mesmas para bloquear percepção de norepinefrina, dopamina, e serotonina
EP2014656A3 (fr) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC Nouveaux antagonistes d'hétéocycliques h3
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AR071997A1 (es) * 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
FR2932800B1 (fr) * 2008-06-20 2015-02-20 Servier Lab Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
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