ZA200708262B - Process for production of 1-(3-(2-(1-benzothiophen-5-yl)-ethoxy)propyl)azetidin-3-ol or salts thereof - Google Patents
Process for production of 1-(3-(2-(1-benzothiophen-5-yl)-ethoxy)propyl)azetidin-3-ol or salts thereofInfo
- Publication number
- ZA200708262B ZA200708262B ZA200708262A ZA200708262A ZA200708262B ZA 200708262 B ZA200708262 B ZA 200708262B ZA 200708262 A ZA200708262 A ZA 200708262A ZA 200708262 A ZA200708262 A ZA 200708262A ZA 200708262 B ZA200708262 B ZA 200708262B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzothiophen
- azetidin
- ethoxy
- propyl
- salts
- Prior art date
Links
- HQNACSFBDBYLJP-UHFFFAOYSA-N 1-[3-[2-(1-benzothiophen-5-yl)ethoxy]propyl]azetidin-3-ol Chemical compound C1C(O)CN1CCCOCCC1=CC=C(SC=C2)C2=C1 HQNACSFBDBYLJP-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- GEZDICNOLPTCMD-UHFFFAOYSA-N 3-[2-(1-benzothiophen-5-yl)ethoxy]-1-(3-hydroxyazetidin-1-yl)propan-1-one Chemical compound C1C(O)CN1C(=O)CCOCCC1=CC=C(SC=C2)C2=C1 GEZDICNOLPTCMD-UHFFFAOYSA-N 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005090831 | 2005-03-28 | ||
| JP2005174738 | 2005-06-15 | ||
| JP2005206808 | 2005-07-15 | ||
| JP2005230666 | 2005-08-09 | ||
| JP2006006127 | 2006-03-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200708262B true ZA200708262B (en) | 2009-01-28 |
Family
ID=37053344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200708262A ZA200708262B (en) | 2005-03-28 | 2006-03-27 | Process for production of 1-(3-(2-(1-benzothiophen-5-yl)-ethoxy)propyl)azetidin-3-ol or salts thereof |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7951963B2 (ja) |
| EP (4) | EP1864978A4 (ja) |
| JP (1) | JP5031554B2 (ja) |
| KR (2) | KR101337382B1 (ja) |
| CN (1) | CN101151257B (ja) |
| AT (2) | ATE557020T1 (ja) |
| AU (1) | AU2006229271B2 (ja) |
| BR (1) | BRPI0609496C8 (ja) |
| CA (2) | CA2799659C (ja) |
| CY (3) | CY1112956T1 (ja) |
| DK (2) | DK2248809T3 (ja) |
| ES (3) | ES2380443T3 (ja) |
| IL (2) | IL186044A (ja) |
| MX (1) | MX2007011938A (ja) |
| NO (3) | NO340071B1 (ja) |
| NZ (2) | NZ561672A (ja) |
| PL (3) | PL2210884T3 (ja) |
| PT (3) | PT2210884E (ja) |
| SG (1) | SG155251A1 (ja) |
| SI (3) | SI2210884T1 (ja) |
| WO (1) | WO2006104088A1 (ja) |
| ZA (1) | ZA200708262B (ja) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101643470B (zh) | 2001-10-19 | 2012-08-01 | 富山化学工业株式会社 | 烷基醚衍生物或其盐 |
| CA2799659C (en) * | 2005-03-28 | 2014-12-02 | Toyama Chemical Co., Ltd. | Process for production of 1-(3-(2-(1-benzothiophen-5-yl) ethoxy)propyl) azetidin-3-ol or salts thereof |
| JP4902247B2 (ja) * | 2005-04-08 | 2012-03-21 | 富山化学工業株式会社 | ２−（１−ベンゾチオフェン−５−イル）エタノールの新規製造法およびその中間体 |
| US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| PL3327016T3 (pl) | 2006-04-07 | 2021-10-04 | Vertex Pharmaceuticals Incorporated | Wytwarzanie modulatorów transporterów posiadających kasetę wiążącą ATP |
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| CA2659835A1 (en) * | 2006-08-04 | 2008-02-07 | Toyama Chemical Co., Ltd. | Protein kinase c activity enhancer containing alkyl ether derivative or salt thereof |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| JP5592205B2 (ja) * | 2009-09-03 | 2014-09-17 | 富山化学工業株式会社 | （１−ベンゾチオフェン−５−イル）酢酸またはその塩の製造法 |
| JP5763313B2 (ja) * | 2009-09-03 | 2015-08-12 | 富山化学工業株式会社 | ２−（１−ベンゾチオフェン−５−イル）エタノールの製造法 |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| KR101984225B1 (ko) * | 2010-04-22 | 2019-05-30 | 버텍스 파마슈티칼스 인코포레이티드 | 시클로알킬카르복스아미도-인돌 화합물의 제조 방법 |
| JP6004307B2 (ja) * | 2010-07-26 | 2016-10-05 | 富山化学工業株式会社 | ３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピオン酸の塩またはその水和物およびその製造法 |
| BR112013022282B1 (pt) * | 2011-03-02 | 2019-03-26 | Bayer Intellectual Property Gmbh | Processo para a preparação de derivados de ácidos aril- e heteroaril acético |
| EP2762225B1 (en) | 2011-09-30 | 2018-09-12 | Mitsubishi Chemical Corporation | Polymerizable inorganic particle-dispersing agent, inorganic/organic composite particles containing said polymerizable inorganic particle-dispersing agent, and inorganic/organic resin composite |
| KR102070581B1 (ko) | 2012-02-22 | 2020-01-29 | 후지필름 도야마 케미컬 가부시키가이샤 | 1－(3－(2－(1－벤조티오펜－5－일)에톡시)프로필)아제티딘－3－올 또는 그 염을 함유하는 고형 의약 조성물 |
| AU2013290444B2 (en) | 2012-07-16 | 2018-04-26 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof |
| ES2792950T3 (es) | 2014-01-31 | 2020-11-12 | Fujifilm Toyama Chemical Co Ltd | Agente potenciador del efecto de rehabilitación después de una lesión nerviosa que comprende un derivado alquil éter o una sal del mismo |
| PT3925607T (pt) | 2014-04-15 | 2023-09-26 | Vertex Pharma | Composições farmacêuticas para o tratamento de doenças mediadas pelo regulador de condutância transmembranar da fibrose quística |
| EP3444243B1 (en) | 2016-03-31 | 2020-09-02 | FUJIFILM Toyama Chemical Co., Ltd. | Method for producing 5-(bromomethyl)-1-benzothiophene |
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| ZA844616B (en) | 1983-06-20 | 1986-02-26 | Merck & Co Inc | 2-sulfamoylbenzo(b)thiophene derivatives for the treatment of elevated intraocular pressure |
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| CH673100A5 (ja) | 1987-08-10 | 1990-02-15 | Josef Paul Huser | |
| JPH04182463A (ja) | 1990-11-17 | 1992-06-30 | Sumitomo Seika Chem Co Ltd | ハロゲノチオフェノール類およびその誘導体の製造方法 |
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| JPH1143455A (ja) | 1997-07-25 | 1999-02-16 | Mitsubishi Chem Corp | ハロゲン化アルコールの製造方法 |
| AU1506499A (en) | 1997-12-12 | 1999-07-05 | Toyama Chemical Co. Ltd. | Alkyl ether derivatives or salts thereof and calcium antagonists containing the same |
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| CN101643470B (zh) | 2001-10-19 | 2012-08-01 | 富山化学工业株式会社 | 烷基醚衍生物或其盐 |
| KR101096528B1 (ko) * | 2003-04-17 | 2011-12-20 | 토야마 케미칼 컴퍼니 리미티드 | 알킬에테르 유도체 또는 그 염을 함유하는 망막신경질환의예방·치료제 |
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| WO2005019200A2 (en) * | 2003-08-14 | 2005-03-03 | Icos Corporation | Aryl piperidine derivatives as vla-1 integrin antagonists and uses thereof |
| CA2799659C (en) | 2005-03-28 | 2014-12-02 | Toyama Chemical Co., Ltd. | Process for production of 1-(3-(2-(1-benzothiophen-5-yl) ethoxy)propyl) azetidin-3-ol or salts thereof |
| CN101432280B (zh) | 2006-04-26 | 2012-11-21 | 富山化学工业株式会社 | 包括烷基醚衍生物或其盐的神经形成诱导剂或神经病变治疗剂 |
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2006
- 2006-03-27 CA CA2799659A patent/CA2799659C/en active Active
- 2006-03-27 PL PL10002020T patent/PL2210884T3/pl unknown
- 2006-03-27 DK DK10007872.4T patent/DK2248809T3/da active
- 2006-03-27 EP EP06730075A patent/EP1864978A4/en not_active Withdrawn
- 2006-03-27 ES ES10002020T patent/ES2380443T3/es active Active
- 2006-03-27 DK DK10002020.5T patent/DK2210884T3/da active
- 2006-03-27 ZA ZA200708262A patent/ZA200708262B/xx unknown
- 2006-03-27 PL PL10007872T patent/PL2248809T3/pl unknown
- 2006-03-27 SG SG200905724-1A patent/SG155251A1/en unknown
- 2006-03-27 WO PCT/JP2006/306127 patent/WO2006104088A1/ja active Application Filing
- 2006-03-27 BR BRPI0609496A patent/BRPI0609496C8/pt active IP Right Grant
- 2006-03-27 EP EP11002265A patent/EP2348022B1/en active Active
- 2006-03-27 AT AT10007872T patent/ATE557020T1/de active
- 2006-03-27 CN CN2006800102653A patent/CN101151257B/zh active Active
- 2006-03-27 NZ NZ561672A patent/NZ561672A/en unknown
- 2006-03-27 PT PT10002020T patent/PT2210884E/pt unknown
- 2006-03-27 ES ES10007872T patent/ES2384312T3/es active Active
- 2006-03-27 PL PL11002265T patent/PL2348022T3/pl unknown
- 2006-03-27 CA CA2600381A patent/CA2600381C/en active Active
- 2006-03-27 AU AU2006229271A patent/AU2006229271B2/en active Active
- 2006-03-27 EP EP10007872A patent/EP2248809B1/en active Active
- 2006-03-27 PT PT10007872T patent/PT2248809E/pt unknown
- 2006-03-27 PT PT110022654T patent/PT2348022E/pt unknown
- 2006-03-27 AT AT10002020T patent/ATE546443T1/de active
- 2006-03-27 JP JP2007510482A patent/JP5031554B2/ja active Active
- 2006-03-27 KR KR1020127032936A patent/KR101337382B1/ko active IP Right Grant
- 2006-03-27 EP EP10002020A patent/EP2210884B1/en active Active
- 2006-03-27 NZ NZ583580A patent/NZ583580A/en unknown
- 2006-03-27 SI SI200631324T patent/SI2210884T1/sl unknown
- 2006-03-27 SI SI200631383T patent/SI2248809T1/sl unknown
- 2006-03-27 ES ES11002265T patent/ES2398934T3/es active Active
- 2006-03-27 MX MX2007011938A patent/MX2007011938A/es active IP Right Grant
- 2006-03-27 KR KR1020077024039A patent/KR101283930B1/ko active IP Right Grant
- 2006-03-27 SI SI200631556T patent/SI2348022T1/sl unknown
- 2006-03-27 US US11/909,809 patent/US7951963B2/en active Active
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2007
- 2007-09-12 NO NO20074618A patent/NO340071B1/no unknown
- 2007-09-18 IL IL186044A patent/IL186044A/en active IP Right Grant
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2011
- 2011-01-06 US US12/985,616 patent/US8273902B2/en active Active
- 2011-07-21 IL IL214245A patent/IL214245A/en active IP Right Grant
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2012
- 2012-05-08 CY CY20121100434T patent/CY1112956T1/el unknown
- 2012-06-27 CY CY20121100566T patent/CY1112885T1/el unknown
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2013
- 2013-01-25 CY CY20131100075T patent/CY1113571T1/el unknown
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2016
- 2016-09-07 NO NO20161418A patent/NO340366B1/no unknown
- 2016-09-07 NO NO20161419A patent/NO340420B1/no unknown
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