WO2023137341A1 - Devices for removing clot material from intravascularly implanted devices, and associated systems and methods - Google Patents

Devices for removing clot material from intravascularly implanted devices, and associated systems and methods Download PDF

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Publication number
WO2023137341A1
WO2023137341A1 PCT/US2023/060502 US2023060502W WO2023137341A1 WO 2023137341 A1 WO2023137341 A1 WO 2023137341A1 US 2023060502 W US2023060502 W US 2023060502W WO 2023137341 A1 WO2023137341 A1 WO 2023137341A1
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WIPO (PCT)
Prior art keywords
treatment device
end portion
clot
clot treatment
elongate member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2023/060502
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English (en)
French (fr)
Other versions
WO2023137341A8 (en
Inventor
Taylor SCHEINBLUM
Derek Hauschka
Hieu Minh Luong
John Coleman THRESS
Philippe Marchand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inari Medical Inc
Original Assignee
Inari Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inari Medical Inc filed Critical Inari Medical Inc
Priority to EP23740802.6A priority Critical patent/EP4463083A4/en
Priority to CA3247294A priority patent/CA3247294A1/en
Priority to AU2023208030A priority patent/AU2023208030A1/en
Priority to CN202380023646.9A priority patent/CN118804718A/zh
Priority to JP2024541650A priority patent/JP2025502163A/ja
Publication of WO2023137341A1 publication Critical patent/WO2023137341A1/en
Anticipated expiration legal-status Critical
Publication of WO2023137341A8 publication Critical patent/WO2023137341A8/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
    • A61B17/320725—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with radially expandable cutting or abrading elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22031—Gripping instruments, e.g. forceps, for removing or smashing calculi
    • A61B2017/22034—Gripping instruments, e.g. forceps, for removing or smashing calculi for gripping the obstruction or the tissue part from inside
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22031—Gripping instruments, e.g. forceps, for removing or smashing calculi
    • A61B2017/22035—Gripping instruments, e.g. forceps, for removing or smashing calculi for retrieving or repositioning foreign objects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
    • A61B2017/2212—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions having a closed distal end, e.g. a loop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
    • A61B2017/2217—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions single wire changing shape to a gripping configuration

Definitions

  • the present technology generally relates to devices for cleaning stents, embolic protection devices, other implants, and/or bare vessels and, more particularly, for example, to devices for intravascularly removing clot and/or other material from stents implanted in the vasculature of a patient (e.g., the venous vasculature).
  • Stents are tubes or similar structures that can be implanted within a blood vessel of a patient to mechanically keep the vessel open, restore flow, and/or bypass a diseased region of the blood vessel.
  • Stents are typically made of metal or plastic, and can be crimped or packed down into a delivery catheter before being intravascularly delivered to a target location within the blood vessel.
  • unwanted material can form around and/or adhere to the stent.
  • clot material can form and adhere to an inner surface of the stent.
  • vascular wall cells can abnormally accumulate within the stent (e.g., intimal hyperplasia).
  • Physicians are currently limited in their abilities to remove adherent clot or intimal hyperplasia from implanted stents and, in particular, venous stents.
  • aspiration mechanisms exist to remove clot material from venous stents
  • these aspiration mechanisms are limited to non-adherent, acute clot, and cannot treat chronic adherent clot or intimal hyperplasia.
  • mechanical clot treatment devices exist to target adherent clot material, many such devices are currently contraindicated for removing clot material from stents because the mechanical clot treatment devices can catch on the stent, causing damage.
  • tissue plasminogen activator tPA
  • Other methods of medical management such as ballooning or re-stenting do not remove the clot that has been formed, likely causing additional clot to form.
  • Pharmacological methods such as administering tissue plasminogen activator (tPA) — do not work on aged, more adherent clot, and also carry other risks such as systemic bleeding. Surgery carries risks of adverse events and is more invasive than transcatheter methods.
  • Figure 1A is a side view of a stent cleaning system in accordance with embodiments of the present technology.
  • Figures IB and 1C are an enlarged side view and an enlarged proximally-facing view, respectively, of a distal portion of the system of Figure 1A including a clot treatment device in accordance with embodiments of the present technology.
  • Figures 2A-2C are enlarged proximally-facing views of a distal portion of the system of Figure 1A including the clot treatment device in accordance with additional embodiments of the present technology.
  • Figures 3A-3D are enlarged side views of a distal portion of the system of Figure 1A including the clot treatment device in accordance with additional embodiments of the present technology.
  • Figures 4A ⁇ 4C are enlarged isometric views of a distal portion of the system of Figure 1A including the clot treatment device in accordance with additional embodiments of the present technology.
  • Figure 5 is a partially cut-away view of a handle of the system of Figure 1A in accordance with embodiments of the present technology.
  • Figures 6A and 6B are side views of a distal portion of the system of Figure 1A including the clot treatment device in a first position and a second position, respectively, in accordance with embodiments of the present technology.
  • Figure 7 is a flow diagram of a process or method for operating the system of Figure 1 A during an intravascular procedure to remove clot material from an implanted stent in accordance with embodiments of the present technology.
  • Figure 8 is a distally-facing perspective view of a distal portion of the system of Figure 1A including the clot treatment device expanded within a stent implanted in a vessel in accordance with embodiments of the present technology.
  • Figures 9A and 9B are distally-facing perspective views of a distal portion of the system of Figure 1 A including the clot treatment device positioned within the stent of Figure 6 in accordance with embodiments of the present technology.
  • Figures 10A-10C are distally-facing perspective views of a distal portion of the system of Figure 1A including the clot treatment device deployed within an implant with differing amounts of radial expansion in accordance with embodiments of the present technology.
  • Figure 11A is a side view of a stent cleaning system in accordance with embodiments of the present technology.
  • Figures 11B and 11C are side views of a distal portion of the system of Figure 11 A including a clot treatment device in a first position and a second position, respectively, in accordance with embodiments of the present technology.
  • Figure 12 is a side view of a clot treatment device in accordance with embodiments of the present technology.
  • Figure 13 is a side view of a clot treatment device in accordance with embodiments of the present technology.
  • Figure 14 is a side view of a clot treatment device in accordance with embodiments of the present technology.
  • Figure 15 is a side view of a clot treatment device in accordance with embodiments of the present technology.
  • Figures 16A-16C are side views of a clot treatment device in accordance with embodiments of the present technology.
  • Figures 17A and 17B are side views of a distal portion of a stent cleaning system in accordance with embodiments of the present technology.
  • Figure 18 illustrates several different chamfers that can be used in a clot treatment device in accordance with embodiments of the present technology.
  • Figure 19 is an enlarged side view of a pair of struts of a clot treatment device in accordance with embodiments of the present technology.
  • Figure 20 is a side cross-sectional view of a handle in accordance with additional embodiments of the present technology that can be used in the system of Figure 1 A.
  • Figure 21 is a side cross-sectional view of a handle in accordance with additional embodiments of the present technology that can be used in the system of Figure 1 A.
  • Figure 22 is a side cross-sectional view of an actuation mechanism of a handle in accordance with embodiments of the present technology that can be used in the system of Figure 1A.
  • Figure 23 is a side cross-sectional view of a handle in accordance with additional embodiments of the present technology that can be used in the system of Figure 1 A.
  • Figure 24 is a side cross-sectional view of a handle in accordance with additional embodiments of the present technology that can be used in the system of Figure 1 A.
  • Figures 25A-25C are an enlarged perspective view, an enlarged side view, and an enlarged cross-sectional side view, respectively, of a handle in accordance with additional embodiments of the present technology that can be used in the system of Figure 1 A.
  • Figure 26 is an enlarged cross-sectional side view of a handle in accordance with additional embodiments of the present technology that can be used in the system of Figure 1 A.
  • Figure 27 is an enlarged cross-sectional side view of a handle in accordance with additional embodiments of the present technology that can be used in the system of Figure 1 A.
  • Figure 28 is a side view of a distal portion of a clot removal system positioned within a vessel to treat clot material in accordance with embodiments of the present technology.
  • the present technology is generally directed to devices for mechanically removing clot and/or other material from the vasculature of a patient, and associated systems and methods.
  • some of the embodiments are directed to devices for mechanically removing clot and/or other material from implants implanted in the vasculature of the patient, such as stents implanted within the venous vasculature.
  • a system for removing clot material from an implant — such as a venous stent — includes a (i) clot treatment device, (ii) a handle, and (iii) a first elongate member and a second elongate member coupling the clot treatment device to the handle.
  • the clot treatment device is configured to be deployed within the implant, and includes a first end portion, a second end portion, and a plurality of struts extending between the first and second end portions.
  • the first elongate member couples the first end portion of the clot treatment device to the handle
  • the second elongate member couples the second end portion of the clot treatment device to the handle (e.g., to an actuator of the handle).
  • Actuation of the actuator in a first direction is configured to move the second elongate member relative to the first elongate member and/or the first elongate member relative to the second elongate member to move the first and second end portions toward one another to radially expand the struts.
  • the actuator can be actuated in a second direction (e.g., opposite the first direction) to move the second elongate member relative to the first elongate member and/or the first elongate member relative to the second elongate member to move the first and second end portions away from one another to radially collapse the struts.
  • the clot treatment device When expanded within the implant, the clot treatment device can be (i) translated proximally and/or distally through the implant by translating the handle and (ii) rotated within the implant by rotating the handle. Such movements can mechanically engage the clot treatment device with clot material adhered to the implant to dislodge the clot material.
  • the clot treatment device is configured to be translated and/or rotated within the implant without catching on the implant, avoiding potential damage, deformation, movement, and/or migration of the implant.
  • the struts can extend generally axially between the first and second end portions — and not include any cross-members connected therebetween that are configured to contact the implant — to reduce the likelihood of the struts damaging the implant.
  • clot material e.g., clot material adhered to an implant
  • present technology can be used to remove and/or treat other unwanted material in addition or alternatively to clot material, such as thrombi, emboli, plaque, intimal hyperplasia, post- thrombotic scar tissue, etc.
  • clot and “clot material” as used herein can refer to any of the foregoing materials.
  • distal and proximal within this description, unless otherwise specified, the terms can reference a relative position of the portions of a catheter subsystem with reference to an operator and/or a location in the vasculature.
  • the designations “rearward,” “forward,” “upward,” “downward,” and the like are not meant to limit the referenced component to a specific orientation. It will be appreciated that such designations refer to the orientation of the referenced component as illustrated in the Figures; the systems of the present technology can be used in any orientation suitable to the user. To the extent any materials incorporated herein by reference conflict with the present disclosure, the present disclosure controls.
  • Figure 1A is a side view of a stent cleaning system 100 (“system 100”) in accordance with embodiments of the present technology.
  • Figures IB and 1C are an enlarged side view and an enlarged proximally-facing view, respectively, of a distal portion of the system 100 including a clot treatment device 130 in accordance with embodiments of the present technology.
  • the stent cleaning system 100 can be used to remove clot material from (e.g., adhered to) the implant, to clean clot material from a native vessel in which the implant is implanted, and/or to remove clot material from a native vessel in which no implants are implanted.
  • the system 100 can also be referred to as a clot treatment system, a clot removal system, a thrombectomy system, and/or the like.
  • the clot treatment device 130 can also be referred to as a clot removal device, a coring element, a clot engagement member, a thrombectomy device, and/or the like.
  • the system 100 includes a proximal handle 110 operably coupled to a clot treatment device 130 via an inner elongate member 102 (obscured in Figure 1A; e.g., a second elongate member) and a middle elongate member 104 (e.g., a first elongate member).
  • the inner elongate member 102 can extend through a lumen of the middle elongate member 104 such that the inner and middle elongate members 102, 104 (collectively “elongate members 102, 104”) are coaxial.
  • the system 100 can further include an outer elongate member 106 (e.g., a third elongate member, a guide catheter), and the elongate members 102, 104 can at least partially extend through the outer elongate member 106 such that the inner, middle, and outer elongate members 102, 104, 106 (collectively “elongate members 102-106”) are coaxial.
  • the elongate members 102, 104 are not coaxial and can instead extend side-by-side and/or through separate lumens of the outer elongate member 106.
  • the elongate members 102-106 can comprise catheters, tubes (e.g., hypotubes), sheathes, shafts, and/or the like and can be formed from metal (e.g., stainless steel, nitinol), plastic, fluoropolymers (e.g., polytetrafluoroethylene (PTFE)), polymers, and/or other suitable materials.
  • the outer elongate member 106 can comprise a guide catheter.
  • the outer elongate member 106 can include a distal end portion 107a and a proximal end portion 107b.
  • the proximal end portion 107b can be coupled to a tubing assembly 101 (e.g., including one or more tubes, fluid control devices, and/or the like) via a valve device 109.
  • the tubing assembly 101 can be used to flush the lumen of the outer elongate member 106.
  • the handle 110 is movable (translatable, rotatable) relative to the valve device 109 and the outer elongate member 106.
  • the handle 110 has been advanced toward the valve device 109 such that the clot treatment device 130 extends from the distal end portion 107a of the outer elongate member 106.
  • the handle 110 can be retracted away from the outer elongate member 106 and/or the outer elongate member 106 can be advanced away from the handle 110 such that the clot treatment device 130 is captured/positioned within the outer elongate member 106.
  • the clot treatment device 130 is captured within the lumen of the outer elongate member 106, the clot treatment device 130 is in a radially-compressed state.
  • the clot treatment device 130 can be positioned within the outer elongate member 106 during delivery of the system 100 through the vasculature.
  • the system 100 includes a tip 108 coupled to the clot treatment device 130 and/or the inner elongate member 102 ( Figure IB).
  • the tip 108 can have an atraumatic shape configured to minimize or even prevent damage to the vasculature as the system 100 is advanced therethrough. In other embodiments, the tip 108 can have other shapes or can be omitted entirely.
  • the tip 108 when the clot treatment device 130 is constrained within the outer elongate member 106, the tip 108 can engage the distal end portion 107a of the outer elongate member 106 and can be shaped and sized to seal the lumen of the outer elongate member 106.
  • the tip 108 and the inner elongate member 102 can define a lumen configured (e.g., shaped and sized) to receive a guidewire (not shown) therethrough.
  • the system 100 can be advanceable/trackable over the guidewire.
  • the inner elongate member 102 includes a distal end portion 103a coupled to a distal end portion 131a of the clot treatment device 130.
  • the middle elongate member 104 includes a distal end portion 105a coupled to a proximal end portion 131b of the clot treatment device 130. Accordingly, as described in detail below with reference to Figures 6A and 6B, relative movement of the elongate members 102, 104 can longitudinally shorten/lengthen and radially expand/compress the clot treatment device 130 via the relative movement of the end portions 131a-b.
  • the end portions 131a-b of the clot treatment device 130 can be identical and can have a cylindrical or hub-like shape.
  • the end portions 131a-b are secured to the elongate members 102, 104, respectively, via adhesive (e.g., glue bonds), welding, fasteners, crimping (e.g., via a crimp tube), and/or the like.
  • one or both of the end portions 131a- b of the clot treatment device 130 can be directly welded to the elongate members 102, 104, or one or both of the end portions 13 la-b can be crimped via a crimp tube to the elongate members 102, 104 (e.g., the proximal end portion 131b can be crimped to the middle elongate member 104).
  • the distal end portion 131a includes/defines a distal window 132a extending therethrough
  • the proximal end portion 131b includes/defines a proximal window 132b extending therethrough.
  • Coupling members such as steel discs, can be placed in one or both of the windows 132a-b and welded, soldered, crimped, or otherwise fastened to the elongate members 102, 104, respectively, to secure the end portions 131a-b to the elongate members 102, 104 via a rivet-like lock.
  • the end portions 131a-b can include multiple ones of the windows 132a-b extending circumferentially thereabout, each configured to receive a corresponding coupling member.
  • the elongate members 102, 104 can comprise (i) metal, polymeric, and/or metallic (e.g., solid stainless steel, cobalt chrome, nitinol) tubes, (ii) metal, polymeric, and/or metallic (e.g., solid stainless steel, cobalt chrome, nitinol) tubes with relief cuts (e.g., laser-cuts) for flexibility, (iii) hollow helical spirals (e.g., including one or more axial metal (e.g., stainless- steel, cobalt chrome, nitinol) wires turned to create a closed-pitch coil with a hollow central lumen), (iv) reinforced polymeric shafts, and/or (v) the like.
  • metal, polymeric, and/or metallic (e.g., solid stainless steel, cobalt chrome, nitinol) tubes with relief cuts (e.g., laser-cuts) for flexibility
  • hollow helical spirals e.g., including one or
  • the inner elongate member 102 comprises a solid nitinol tube and the middle elongate member 104 comprises a hollow helical spiral (HHS).
  • the hollow helical spiral can be a single layer spiral, or a multilayer spiral (e.g., two-layer, three-layer, or more layer spiral) to provide greater torque and/or tensile response.
  • a hollow helical spiral allows the overall system 100 to be more flexible such that the system 100 can, for example, be inserted to treat clot material in more tortuous anatomies with less biasing of the clot treatment device 130 (e.g., to one side of an implant or vessel).
  • the elongate members 102, 104 can have a relatively high tensile, compression, and/or torque capability/response that allow for the controlled expansion and movement of the clot treatment device 130 during a procedure to remove clot material from an implanted stent, embolic protection device, other implant, and/or bare vessel, as described in greater detail below.
  • the clot treatment device 130 includes a plurality of beams or struts 133 extending between the end portions 131a-b and generally axially relative to a longitudinal axis L of the clot treatment device 130. More specifically, the struts
  • 133 can be generally similar or identical to one another and can each include: (i) a distal portion
  • proximal portion 136 extending from the middle portion 135 to the proximal end portion 131b in a direction toward the longitudinal axis L (e.g., at an angle relative to the longitudinal axis L).
  • the clot treatment device 130 does not include any cross struts or other cross-members extending between (e.g., circumferentially between) the struts 133. That is, the struts 133 can each extend separately in a generally axial direction between the end portions 131a-b. In some aspects of the present technology, this absence of cross struts can permit the clot treatment device 130 to be advanced and retracted through an implanted stent (or other implant) without catching on the stent (e.g., catching on apices or ends of the stent), which could potentially damage, disrupt, and/or move the stent.
  • the clot treatment device 130 can include one or more cross-members between the struts 133 — but that are not configured to contact the implanted stent when the clot treatment device 130 is expanded.
  • crossmembers can be positioned near the end portions 131a-b.
  • the struts 133 each have an undulating (e.g., wave-like, sawtooth-like, periodic) pattern.
  • the undulating pattern of the struts 133 can create an abrasive surface for disrupting/engaging with clot and/or other material adhered to an implanted stent.
  • each of the struts 133 can include one or circumferential portions 137 that extend at least partially circumferentially relative to the longitudinal axis L.
  • the circumferential portions 137 can together define the abrasive surface for disrupting the clot material.
  • the undulations are relatively small such to reduce the likelihood of the struts 133 catching on the stent when the clot treatment device 130 is advanced and retracted through the implanted stent.
  • each of the struts 133 can curve radially at least partially back toward the longitudinal axis L in the middle portion 135 (and/or at a transition region between the middle portion 135 and distal and proximal portions 134, 136) such that the struts 133 have a wave- like or hook- like shape when viewed along the longitudinal axis L. In some embodiments, this shape can help facilitate the uniform collapse of the clot treatment device 130.
  • the hook- like shape of the struts 133 can improve the ability of the clot treatment device 130 to engage and disrupt clot material within an implant while still being atraumatic to regions of the native vessel outside the implant (e.g., proximal and distal of the implant).
  • the clot treatment device 130 has nine of the struts 133 in Figure IB and six of the struts 133 in Figure 1C for illustration.
  • the clot treatment device 130 can include any number of the struts 133 (e.g., one, two, three, four, five, seven, eight, ten, or more than ten) and the struts 133 can be positioned symmetrically or asymmetrically about the longitudinal axis L.
  • the struts 133 can be asymmetrically positioned about the longitudinal axis L to facilitate targeted engagement of the struts 133 with a region of adherent clot and/or to inhibit or even prevent catching of the clot treatment device 130 on bent portions of an implant (e.g., when the implant is positioned within tortuous anatomy).
  • the distal portions 134 of the struts 133 can be circumferentially offset from the proximal portions 136 of the struts 133 — either permanently or via differential rotation of the elongate members 102, 104 — to cause the struts 133 to assume a “scoop-like” shape when radially compressed, as described in greater detail below with reference to Figures 10A-10C.
  • each of the struts 133 can connect to the distal end portion 131a at a different circumferential position (e.g., relative to the longitudinal axis L) than the proximal portion 136 of the strut 133 connects to the proximal end portion 131b.
  • the clot treatment device 130 is an integral/continuous structure, such as a laser-cut metal (e.g., nitinol, cobalt chrome, stainless steel) element.
  • the clot treatment device 130 is configured (e.g., heat set) to self-expand from a compressed delivery state (e.g., when the clot treatment device 130 is positioned within the outer elongate member 106) to the expanded deployed state illustrated in Figures IB and 1C.
  • the clot treatment device 130 is configured (e.g., heat set) to collapse to the compressed delivery state from the expanded state.
  • biasing the clot treatment device 130 to collapse can help ensure that the clot treatment device 130 can be removed from the patient if one of the struts 133 or a connection point breaks during operation, as the clot treatment device 130 will automatically collapse for removal.
  • the struts 133 can curve more or less back toward the longitudinal axis L.
  • Figures 2A-2C are enlarged proximally-facing views of a distal portion of the system 100 including the clot treatment device 130 in accordance with additional embodiments of the present technology.
  • the middle portion 135 of each of the struts 133 of the clot treatment device 130 has (i) a relatively flat profile in the embodiment of Figure 2A, (ii) a hook-shaped profile in the embodiment of Figure 2B, and (iii) a further hook-shaped profile in the embodiment of Figure 2C.
  • the flatter profile shown in Figure 2A can provide a longer cutting edge for engaging clot material adhered to an implant
  • the more hook-shaped profile shown in Figure 2B can provide for a smaller contact area between the clot treatment device 130 and an implant that can reduce the likelihood of the clot treatment device 130 damaging the implant and that can be more atraumatic to a native vessel when the clot treatment device 130 is deployed at least partially outside the implant
  • the further hook-shaped profile shown in Figure 2C can provide an even smaller cutting surface than the profile shown in Figure 2B to further reduce the likelihood of implant or native vessel damage as compared to the profile of Figure 2B.
  • the flatter profile shown in Figure 2 A can be utilized to treat adherent clot material that is firmly attached to the implant.
  • one or more of the struts 133 can have different shapes and/or profiles.
  • Figures 3A-3D are enlarged side views of a distal portion of the system 100 including the clot treatment device 130 in accordance with additional embodiments of the present technology.
  • the tip 108 Figure 3B
  • the struts 133 can extent to and past the distalmost end of the inner elongate member 102 in the expanded position.
  • one or more of the struts 133 can have a profile including multiple (e.g., two) bumps or peaks between the end portions 131a-b.
  • one or more of the struts 133 can have an axial apex positioned near the distal end portion 131a (e.g., including a proximal tapered portion).
  • one or more of the struts 133 can have an axial apex positioned near the proximal end portion 131b (e.g., including a distal tapered portion).
  • Figures 4A-4C are enlarged isometric views of a distal portion of the system 100 including one of the struts 133 of the clot treatment device 130 in accordance with additional embodiments of the present technology.
  • one or more of the struts 133 can have a profile including multiple (e.g., two) bumps or peaks between the end portions 131a-b and that does not extend radially about the longitudinal axis L and the inner elongate member 102 ( Figure IB).
  • one or more of the struts 133 can have a profile including a smoothly sloping shape between the distal and proximal end portions 131a-b.
  • FIG. 5 is a partially cut-away view of the handle 110 of Figure 1 A in accordance with embodiments of the present technology.
  • the handle 110 includes a housing 514 having a distal portion 515a and a proximal portion 515b and defining an internal chamber or lumen 516.
  • the housing 514 is shown as partially-cut away in Figure 5 for clarity.
  • a proximal portion 105b of the middle elongate member 104 can be fixedly coupled to the distal portion 515a of the housing 514.
  • the handle 110 includes a flush port 517 operably (e.g., fluidly) coupled to the lumen of the middle elongate member 104.
  • the inner elongate member 102 can extend through the lumen of the middle elongate member 104, past the proximal portion 105b of the middle elongate member 104, and into the lumen 516 of the housing 514.
  • the inner elongate member 102 can extend entirely through the housing 514 to a flush port 518 coupled to the proximal portion 515 of the housing 514.
  • the handle 110 further comprises a leadscrew 520 attached to the inner elongate member 102 and movably positioned within the lumen 516 over one or more guiderails 522 (e.g., a pair of guiderails 522).
  • the leadscrew 520 can have a threaded outer surface configured to mate with a threaded inner surface of the actuator 112 (shown as partially transparent in Figure 5 for clarity).
  • the leadscrew 520 can have a threaded inner surface configured to mate with a threaded outer surface of the actuator 112 as described, for example, in detail below with reference to Figure 26.
  • the actuator 112 can extend out of the housing 514 from one or more openings 519 therein (e.g., a pair of openings on opposing sides of the housing 514) such that the actuator 112 is accessible outside the housing 514 by a user of the handle 110 (e.g., a physician).
  • the handle 110 further includes a leadscrew knob 521 (shown as partially transparent in Figure 2 for clarity) coupled to the actuator 112 and configured to threadably engage the leadscrew 520 over an entire range of movement of the actuator 112.
  • Rotation of the actuator 112 relative to the housing 514 can drive the leadscrew 520 to translate proximally and/or distally (e.g., between the distal and proximal portions 515a-b of the housing 514) to thereby drive the attached inner elongate member 102 to translate relative to the middle elongate member 104.
  • This relative movement of the elongate members 102, 104 lengthens/shortens the clot treatment device 130 ( Figures 1A-1C) to radially compress/expand the clot treatment device 130.
  • Figures 6A and 6B are side views of a distal portion of the system 100 including the clot treatment device 130 in a first position (e.g., a radially-expanded position) and a second position (e.g., a radially-compressed position), respectively, in accordance with embodiments of the present technology.
  • a first position e.g., a radially-expanded position
  • a second position e.g., a radially-compressed position
  • the user can rotate the actuator 112 in a first direction to drive the leadscrew 520 distally through the housing 514.
  • This movement drives the inner elongate member 102 distally through the lumen of the middle elongate member 104, thereby driving the distal end portion 131a of the clot treatment device 130 distally relative to the proximal end portion 131b to radially compress the clot treatment device 130 while lengthening the clot treatment device 130.
  • the user can rotate the actuator 112 in a second direction opposite the first direction to drive the leadscrew 520 proximally through the housing 514.
  • This movement drives the inner elongate member 102 proximally through the lumen of the middle elongate member 104, thereby driving the distal end portion 131a of the clot treatment device 130 proximally relative to the proximal end portion 131b to radially expand the clot treatment device 130 while shortening the clot treatment device 130.
  • the clot treatment device can be expanded to any number of continuous positions therebetween, to a position further radially expanded than the first position, and/or to a position less radially expanded than the second position.
  • the middle elongate member 104 can be operably coupled to the leadscrew 520 and the actuator 112 instead of or in addition to the inner elongate member 102 such that actuation of the actuator 112 drives the middle elongate member 104 relative to the inner elongate member 102, or both the inner elongate member 102 and the middle elongate member 104 relative to the handle 110, to radially expand/compress the clot treatment device 130.
  • the handle 110 can further include an indicator 111, such as a slider, configured to provide a visual indication of an amount of radial expansion of the clot treatment device 130.
  • the indicator 111 can, for example, indicate whether the clot treatment device 130 is in the first position or the second position.
  • the indicator 111 includes detents and/or other features that provide an indication (e.g., a “clicking” sound) as the clot treatment device 130 is incrementally expanded/collapsed (e.g., millimeter by millimeter).
  • the indicator 111 can include markings that indicate an expanded size of the clot treatment device 130 as described in, for example, detail below with reference to Figures 25A-26.
  • a handle of the system 100 can include a first member coupled to the inner elongate member 102 and a second member coupled to the middle elongate member 104.
  • One or both of the first and second members can be manually moved relative to one another (e.g., without any mechanical advantage provided by a leadscrew, gear, or the like) to radially expand/compress the clot treatment device 130 as shown in Figures 6 A and 6B.
  • Figure 7 is a flow diagram of a process or method 740 for operating the system 100 during an intravascular procedure to remove material from an implant with a patient in accordance with embodiments of the present technology. Although some features of the method 740 are described in the context of the embodiments shown in Figures 1A-6B for the sake of illustration, one skilled in the art will readily understand that the method 740 can be carried out using other suitable systems and/or devices described herein.
  • the method 740 can include advancing the system 100 through the vasculature of a patient to at or proximate the implant implanted within the patient.
  • the implant can be identified as having clot material or other unwanted material (e.g., intimal hyperplasia) adhered thereto that would be beneficial to remove.
  • the implant is a stent implanted within the venous vasculature of the patient.
  • the implant can be a graft, embolic filter, inferior vena cava (IVC) filter, and/or other type of implant.
  • the method 740 can be used to clean and remove clot material from a bare vessel of the patient.
  • the elongate members 102-106 can be advanced together through the vasculature with the clot treatment device 130 constrained within the outer elongate member 106.
  • the tip 108 can provide for atraumatic advancement of the system 100 through the vasculature to the implant.
  • the outer elongate member 106 can be positioned within the vasculature first, and the clot treatment device 130 can then be advanced through the vasculature to the implant.
  • the method 740 can include deploying the clot treatment device 130 within the implant.
  • the handle 110 can be advanced distally (e.g., pushed by a physician) relative to the outer elongate member 106 to advance the elongate members 102, 104 and the coupled clot treatment device 130 distally from the distal end portion 107a of the outer elongate member 106.
  • the clot treatment device 130 can at least partially radially expand (e.g., self-expand) when the clot treatment device 130 is no longer constrained by the outer elongate member 106.
  • the method 740 can include further radially expanding the clot treatment device 130.
  • the clot treatment device 130 can be radially expanded by actuating the actuator 112 of the handle 110 to drive the inner elongate member 102 proximally relative to the middle elongate member 104 to thereby move the distal end portion 131a of the clot treatment device 130 toward the proximal end portion 131b — thereby causing the struts 133 to flex radially outwardly away from the longitudinal axis L.
  • the clot treatment device 130 is radially expanded outwardly to contact the clot material adhered to the implant or the implant itself.
  • such radial expansion can comprise a mechanical “ballooning” effect of the clot treatment device 130.
  • the clot treatment device 130 can be expanded within a deformed or compressed stent to balloon open the stent and/or to disrupt clot material, intimal hyperplasia, and/or other material within the stent such that clot treatment device 130 can more effectively engage and disrupt clot material within the stent (block 744).
  • the clot treatment device 130 can be expanded within a bare vessel (e.g., outside a stent) to perform angioplasty.
  • the clot treatment device 130 can provide a radial outward mechanical force (e.g., pressure) of between about 0.1- 30 atmospheres, between about 0.1-6 atmospheres, etc.
  • the outward mechanical force can be determined by the width and thickness of the struts 133 and/or the amount the clot treatment device 130 can be expanded (e.g., how far the leadscrew 520 can travel) — with greater strut thickness, strut width, and/or device expansion causing a greater outward mechanical force (and vice versa)
  • the clot treatment device advantageously does not include a burst failure mode like many conventional balloon treatment devices.
  • the method 740 includes mechanically engaging the clot treatment device 130 with the clot material within the implant to at least partially dislodge the clot material.
  • the clot treatment device 130 can be rotated, translated, and/or radially compressed/expanded within the implant to engage and dislodge the clot material.
  • the clot treatment device 130 can function similarly to a mechanical scoring balloon.
  • Figure 8 is a distally-facing perspective view of a distal portion of the system 100 including the clot treatment device 130 expanded within an implant 850 (e.g., a stent) implanted in a vessel V in accordance with embodiments of the present technology.
  • an implant 850 e.g., a stent
  • the implant 850 can comprise a plurality of interconnected struts, graft material, a mesh, and/or other components know in the art of intravascularly implantable medical devices (e.g., stents).
  • the clot treatment device 130 is expanded within a lumen 852 of the implant 850 such that the struts 133 contact an inner surface of the implant 850.
  • the struts 133 are the only part of the clot treatment device 130 that contacts the implant 850 when the clot treatment device 130 is expanded.
  • the clot treatment device 130 can be (i) translated distally or proximally within the implant 850 (e.g., as indicated by arrow A in Figure 8) by moving the handle 110 distally or proximally and/or (ii) rotated clockwise or counterclockwise within the implant 850 (e.g., as indicated by arrows C and CC, respectively, in Figure 8) by rotating the handle 110.
  • the elongate members 102, 104 can be formed to be highly torqueable and to have high compression/tension resistance such that the movements of the handle 110 are translated without much loss to the clot treatment device 130.
  • the struts 133 are configured not to catch, grab, or damage the implant 850 when the clot treatment device 130 is moved relative to the implant 850 as, for example, the struts 133 extend generally axially along the direction of translation and do not include any crossmembers or open cells. Additionally, the undulating shapes of the struts 133 (e.g., the circumferential portions 137) together define an abrasive surface for disrupting, cutting, and/or dislodging the clot material adhered to the implant 850. Accordingly, in some aspects of the present technology the system 100 can be used to remove chronic adherent clot while significantly reducing the risk of damaging the implant 850.
  • the method 740 optionally includes collapsing and repositioning the clot treatment device 130.
  • the clot treatment device 130 can be radially compressed (e.g., from the first position to the second position shown in Figures 6A and 6B, respectively) to disengage the implant.
  • Figures 9A and 9B are distally-facing perspective views of a distal portion of the system 100 including the clot treatment device 130 positioned within the implant 850 in the vessel V in accordance with embodiments of the present technology.
  • Figure 9A illustrates the clot treatment device 130 in a radially-expanded position and at least partially entangled with an end portion 954 of the implant 850. If such entanglement occurs, the clot treatment device 130 can be radially compressed as shown in Figure 9B to free the struts 133 from the implant 850. In some aspects of the present technology, because the clot treatment device 130 does not include any cross-members between the struts 133, radially compressing the clot treatment device 130 can disengage the struts 133 from the implant 850 without catching or pulling the implant 850 therewith.
  • the method 740 can include at least partially capturing the dislodged clot material within, for example, the outer elongate member 106.
  • the clot material dislodged from the implant (block 744) can flow into the outer elongate member 106 via the blood pressure within the vessel.
  • the clot treatment device 130 can be retracted proximally into the outer elongate member 106 to pull the clot material into the outer elongate member 106.
  • the system 100 can be withdrawn from the patient.
  • the clot treatment device 130 can be retracted proximally into the outer elongate member 106 (e.g., by proximally withdrawing the handle 110 relative to the outer elongate member 106) and radially constrained therein.
  • the outer elongate member 106 and the constrained clot treatment device 130 can then be withdrawn together from the patient.
  • Figures 10A-10C are distally-facing perspective views of a distal portion of the system 100 including the clot treatment device 130 expanded within an implant 1050 with differing amounts of radial expansion in accordance with embodiments of the present technology. More specifically, Figures 10A-10C illustrate progressively increasing amounts of radial expansion caused by for, example, further actuation of the actuator 112 of the handle 110 to move the distal end portion 131a of the clot treatment device 130 proximally toward proximal end portion 131b of the clot treatment device as shown in and described in detail with reference to Figures 1A-6B. Alternatively, Figures 10A-10C illustrate the same amount of radial expansion of the clot treatment device 130 where the implant 1050 has a progressively decreasing diameter E1-E3.
  • the struts 133 can progressively flex inward and turn to each have a scoop-like shape. More specifically, the distal and proximal portions 134, 136 of each strut can flex to be circumferentially offset relative to the longitudinal axis L ( Figure IB) of the clot treatment device 130. Such radial offset can be facilitated by the different properties of the elongate members 104, 106.
  • the inner elongate member 102 can comprise a solid tube while the middle elongate member 104 can comprise a hollow helical spiral such that there is more rotational give in the middle elongate member 104. Accordingly, when the clot treatment device 130 is rotated when it is engaged with a stent or other implant, the friction/engagement forces on the clot treatment device 130 can cause the relatively more flexible middle elongate member 104 to rotate less than the inner elongate member 102 — thereby rotating the distal end portion 131a ( Figures 6 A and 6B) of the clot treatment device 130 more than the proximal end portion 131b ( Figures 6A and 6B) and causing the scoop-like shape.
  • the scoop-like shape of the struts 133 shown in Figures 10B and 10C can facilitate a more effective removal of clot material from implant 1050.
  • the elongate members 104, 106 can be coupled to a handle configured to rotate the elongate members 104, 106 at different speeds to circumferentially offset the distal and proximal end portions of the struts 133 to thereby facilitate the scoop-like shape.
  • FIG 11A is a side view of a stent cleaning system 1100 (“system 1100”) in accordance with embodiments of the present technology.
  • the system 1100 can include some features that are at least generally similar in structure and function, or identical in structure and function, to the corresponding features of the system 1100 described in detail above with reference to Figures 1A-10C, and can operate in a generally similar or identical manner to the system 100.
  • the system 1100 includes a clot treatment device 1130 having a distal end portion 1131a coupled to the inner elongate member 102 and a proximal end portion 1131b coupled to the middle elongate member 104.
  • the elongate members 102, 104 extend through the outer elongate member 106 and are operably coupled to a handle 1110 configured to radially expand/compress the clot treatment device 1130.
  • the system 1100 is configured for use in the peripheral vasculature to treat chronic peripheral clot either within a stent or other implant, or within a bare vessel.
  • Figures 1 IB and 11C are side views of a distal portion of the system 1100 including the clot treatment device 1130 in a first position (e.g., a radially-expanded position) and a second position (e.g., a radially-compressed position), respectively, in accordance with embodiments of the present technology.
  • the clot treatment device 1130 includes a plurality of interconnected struts 1133 that extend between the distal and proximal end portions 1131a-b.
  • the struts 1133 define a plurality of proximal cells 1160 and a plurality of distal cells 1162.
  • the proximal cells 1160 are larger than the distal cells 1162. That is, the clot treatment device 1130 can have fewer of the struts 1133 near the proximal end portion 1131b than near the distal end portion 1131a.
  • the clot treatment device 1130 can be formed of a self-expanding material, such as nitinol, and can be a unitary /integral structure. In some embodiments, the clot treatment device 1130 can be at least generally similar in structure and function, or identical in structure and function, to any of the clot treatment devices disclosed in U.S. Patent Application No. 17/072,909, titled “SYSTEMS, DEVICES, AND METHODS FOR TREATING VASCULAR OCCLUSIONS,” and filed October 16, 2020, which is incorporated herein by reference in its entirety.
  • the handle 1110 can include a first actuator 1112 coupled to one of the elongate members 102, 104 (e.g., the inner elongate member 102).
  • the other one of the elongate members 102, 104 e.g., the middle elongate member 104) can be fixedly coupled to the handle 1110.
  • the first actuator 1112 is a pull member configured to be pulled proximally or advanced distally to move the elongate members 102, 104 relative to one another to radially compress or expand the clot treatment device 1130.
  • the handle 1110 further includes a second actuator 1119 operably coupled to both of the elongate members 102, 104 and configured to be rotated to rotate the elongate members 102, 104 together to rotate the clot treatment device 1130.
  • the handle 1110 can be advanced distally and withdrawn proximally relative to the outer elongate member 106 to advance the clot treatment device 1130 from within the outer elongate member 106 and/or to withdraw the clot treatment device 1130 into the outer elongate member 106.
  • the clot treatment device 1130 can self-expand within, for example, a stent or other implant to be cleaned.
  • the first actuator 1112 can be pulled/withdrawn to move the clot treatment device 1130 between the first and second positions shown in Figures 11B and 11C.
  • the first actuator 1112 when the first actuator 1112 is coupled to the inner elongate member 102, the first actuator 1112 can be advanced distally to drive the inner elongate member 102 distally relative to the middle elongate member 104 to drive the distal end portion 1131a of the clot treatment device 1130 distally relative to the proximal end portion 1131b to compress the clot treatment device 1130 (e.g., to move the clot treatment device 1130 from the first position to the second position).
  • the first actuator 1112 can be retracted proximally to drive the inner elongate member 102 proximally relative to the middle elongate member 104 to drive the distal end portion 113 la of the clot treatment device 1130 proximally relative to the proximal end portion 1131b to expand the clot treatment device 1130 (e.g., to move the clot treatment device 1130 from the second position to the first position).
  • the second actuator 1119 can be rotated to rotate elongate members 102, 104 together to rotate the clot treatment device 1130 in either the first or second positions.
  • the system 1100 when expanded within a stent or other implant, is operable to radially expand, translate, and/or rotate the clot treatment device 1130 within the stent to mechanically engage and dislodge clot or other material adhered thereto.
  • Figure 12 is a side view of a clot treatment device 1230 in accordance with embodiments of the present technology.
  • the clot treatment device 1230 can include some features that are at least generally similar in structure and function, or identical in structure and function, to the corresponding features of the clot treatment devices 130 and/or 1130 described in detail above with reference to Figures 1A-11C, and can be employed within a clot treatment system (e.g., the systems 100 or 110) in a generally similar or identical manner to mechanically engage and dislodge clot material within an implanted stent or other implant.
  • a clot treatment system e.g., the systems 100 or 110
  • the clot treatment device 1230 includes a plurality of interconnected struts extending between a distal end portion 1231a and a proximal end portion 1231b. More specifically, the clot treatment device 1230 can include (i) distal struts 1264 that extend from the distal end portion 1231a generally axially relative to a longitudinal axis L of the clot treatment device 1230, (ii) proximal struts 1266 that extend from the proximal end portion 1231b generally axially relative to the longitudinal axis L of the clot treatment device 1230, and (iii) bracing struts 1265 connecting the distal struts 1264 to the proximal struts 1266.
  • the bracing struts 1265 can extend at least partially circumferentially relative to the longitudinal axis L in a middle region of the clot treatment device 1230 and can have a chevron- or ring-like pattern. In some aspects of the present technology, the bracing struts 1265 can facilitate an increased torque response of the clot treatment device 1230, while the distal and proximal struts 1264, 1266 extend generally axially to allow the clot treatment device 1230 to be advanced and retracted through an implanted stent without catching on the stent, which could potentially damage or move the stent.
  • Figure 13 is a side view of a clot treatment device 1330 in accordance with embodiments of the present technology.
  • the clot treatment device 1330 can include some features that are at least generally similar in structure and function, or identical in structure and function, to the corresponding features of the clot treatment devices 130, 1130, and/or 1230 described in detail above with reference to Figures 1A-12, and can be employed within a clot treatment system (e.g., the systems 100 or 1100) in a generally similar or identical manner to mechanically engage and dislodge clot material within an implanted stent or other implant.
  • a clot treatment system e.g., the systems 100 or 1100
  • the clot treatment device 1330 includes a plurality of interconnected struts extending between a distal end portion 1331a and a proximal end portion 1331b. More specifically, the clot treatment device 1330 can include (i) distal struts 1364 extending from the distal end portion 1331a, (ii) proximal struts 1366 extending from the proximal end portion 1331b, and (iii) middle struts 1365 (e.g., spanning struts, axial struts) extending between the distal and proximal struts 1364, 1366.
  • middle struts 1365 e.g., spanning struts, axial struts
  • the clot treatment device 1330 includes fewer of the middle struts 1365 than the distal and proximal struts 1364, 1366, and the middle struts 1365 can be longer than the distal and proximal struts 1364, 1366.
  • the middle struts 1365 extend in a spiral or helical pattern relative to a longitudinal axis L of the clot treatment device 1330.
  • the distal and proximal struts 1364, 1366 can have a chevron- or ring-like pattern.
  • the spiral shape of middle struts 1365 can facilitate an increased torque response of the clot treatment device 1330 while also reducing engagement of the clot treatment device 1330 with an implanted stent.
  • the clot treatment device 1330 can be rotated such that the middle struts 1365 turn away from the ends of an implanted stent (e.g., by rotating the distal and proximal end portions 1331a-b in opposite directions) to further reduce stent engagement.
  • Figure 14 is a side view of a clot treatment device 1430 in accordance with embodiments of the present technology.
  • the clot treatment device 1430 can include some features that are at least generally similar in structure and function, or identical in structure and function, to the corresponding features of the clot treatment devices 130, 1130, 1230, and/or 1330 described in detail above with reference to Figures 1A-13, and can be employed within a clot treatment system (e.g., the systems 100 or 1100) in a generally similar or identical manner to mechanically engage and dislodge clot material within an implanted stent or other implant.
  • a clot treatment system e.g., the systems 100 or 1100
  • the clot treatment device 1430 includes a plurality of interconnected struts extending between a distal end portion 1431a and a proximal end portion 1431b. More specifically, the clot treatment device 1430 can include (i) distal struts 1464 extending from the distal end portion 1431a, (ii) proximal struts 1466 extending from the proximal end portion 1431b, and (iii) middle struts 1465 (e.g., spanning struts, axial struts) extending between the distal and proximal struts 1464, 1466 and generally axially relative to a longitudinal axis L of the clot treatment device 1430.
  • middle struts 1465 e.g., spanning struts, axial struts
  • the clot treatment device 1430 includes fewer of the middle struts 1465 than the distal and proximal struts 1464, 1466, and the middle struts 1465 can be longer than the distal and proximal struts 1464, 1466.
  • the distal and proximal struts 1464, 1466 can facilitate an increased torque response of the clot treatment device 1430, while the axially-extending middle struts 1465 reduce engagement of the clot treatment device 1430 with an implanted stent.
  • the clot treatment device 1430 further includes bumps 1467 (e.g., radially-extending portions) on the middle struts 1465 configured to increase the radial force of the clot treatment device 1430 for, for example, engaging and dislodging the most adhered clot or other material within the implanted stent.
  • bumps 1467 e.g., radially-extending portions
  • Figure 15 is a side view of a clot treatment device 1570 in accordance with embodiments of the present technology.
  • the clot treatment device 1570 can include some features that are at least generally similar in structure and function, or identical in structure and function, to the corresponding features of the clot treatment devices 130, 1130, 1230, 1330, and/or 1430 described in detail above with reference to Figures 1A-14, and can be employed within a clot treatment system (e.g., the systems 100 or 1100) in a generally similar or identical manner to mechanically engage and dislodge clot material within an implanted stent or other implant.
  • a clot treatment system e.g., the systems 100 or 1100
  • the clot treatment device 1570 includes an inner clot treatment device 1530 and an outer clot treatment device 1572 (e.g., a stent protection element) that houses the inner clot treatment device 1530.
  • the inner clot treatment device 1530 can be identical to any of the clot treatment devices 130, 1130, 1230, 1330, and/or 1430 described in detail above with reference to Figures 1A-14 and, in the illustrated embodiment, is identical to the clot treatment devices 1330 of Figure 13.
  • the outer clot treatment device 1572 includes a distal end portion 1571a, a proximal end portion 1571b, and a plurality of struts 1573 extending (e.g., axially) between the distal and proximal end portions 1571a-b.
  • the proximal end portion 1571b can be coupled to an elongate member 1574, and the inner clot treatment device 1530 can be advanceable through a lumen of the elongate member 1574 or fixed relative to the elongate member 1574.
  • the outer clot treatment device 1572 is configured to be radially expanded and/or compressed via movement of the inner clot treatment device 1530.
  • the outer clot treatment device 1572 can be formed of nitinol or another relatively flexible material such that expansion (e.g., via any of the handles described above) of the inner clot treatment device 1530 also expands the outer clot treatment device 1572.
  • the outer clot treatment device 1572 can directly engage an implanted stent while the inner clot treatment device 1530 is rotated therein and/or while the clot treatment device 1570 is translated distally and/or proximally within the implanted stent.
  • the outer clot treatment device 1572 can be fixed so that it does not rotate with the inner clot treatment device 1530 via its connection to the elongate member 1574.
  • the outer clot treatment device 1572 can partially or fully protect the implanted stent from being directly contacted by the inner clot treatment device 1530 — thereby reducing stent engagement that might damage or disrupt the stent. Further, the outer clot treatment device 1572 can still provide a large inner diameter that allows the inner clot treatment device 1530 to engage and disrupt clot or other material adhered to the stent.
  • Figures 16A-16C are side views of a clot treatment device 1630 in accordance with embodiments of the present technology.
  • the clot treatment device 1630 can include some features that are at least generally similar in structure and function, or identical in structure and function, to the corresponding features of the clot treatment devices 130, 1130, 1230, 1330, 1430, and/or 1530 described in detail above with reference to Figures 1A-15, and can be employed within a clot treatment system (e.g., the systems 100 or 1100) in a generally similar or identical manner to mechanically engage and dislodge clot material within an implanted stent or other implant.
  • a clot treatment system e.g., the systems 100 or 1100
  • the clot treatment device 1630 includes a plurality of struts 1633 extending between a distal end portion 1631a and a proximal end portion 1631b.
  • the clot treatment device 1630 can include a distal clot collection member 1678.
  • the clot collection member 1678 can comprise a plurality of dense cells formed by the struts 1633, or a separate member attached to the struts 1633, such as a bag (e.g., a mesh bag, a short nitinol bag, and/or the like).
  • the clot collection member 1678 can capture clot material as the clot treatment device 1630 is moved (e.g., translated, rotated) within an implanted stent.
  • the clot treatment device 1630 can further include an expandable member 1679, such as a balloon, positioned radially within the struts 1633.
  • the expandable member 1679 can be expanded to force the struts 1633 radially outward to, for example, provide additional support for dislodging adherent clot material from an implanted stent.
  • the expandable member 1679 is positioned only within a proximal portion of the clot treatment device 1630.
  • the expandable member 1679 can be positioned along the entire length of the clot treatment device 1630, or in a different portion of the clot treatment device 1630 (e.g., a distal portion). For example, as shown in Figure 16C, the expandable member 1679 is positioned along an entire length of the clot treatment device 1630. Moreover, in the illustrated embodiment the clot collection member 1678 is omitted.
  • Figures 17A and 17B are side views of a distal portion of a stent cleaning system 1700 (“system 1700”) in accordance with embodiments of the present technology.
  • the system 1700 includes an elongate member 1706 and a clot treatment device 1780 advanceable through the elongate member 1706.
  • the clot treatment device 1780 includes a pair of expandable arms 1782 that can be formed of nitinol or similar materials.
  • the clot treatment device 1780 is constrained within the elongate member 1706 such that the arms 1782 extend generally linearly through the lumen of the elongate member 1706.
  • Figure 17B illustrates the clot treatment device 1780 after advancement of the clot treatment device 1780 from the elongate member 1706.
  • the arms 1782 are configured to expand radially and curve back proximally (e.g., each forming a U-like shape) when unconstrained by the elongate member 1706.
  • the clot treatment device 1780 can be deployed within an implanted stent and rotated to engage and dislodge (e.g., cut) clot or other material adhered to the stent.
  • the arms 1782 can each have a tapered end portion 1784 configured to inhibit the arms 1782 from interacting with or damaging the stent.
  • a clot treatment device can include struts with a chamfer or angle to improve the ability of the clot treatment device to cut through adhered clot surfaces. At the same time, such a chamfer can allow the struts to be made relatively thick to increase their radial force. More specifically, for example, Figure 18 illustrates several struts having different chamfers that can be used in a clot treatment device in accordance with embodiments of the present technology. Figure 19 is and enlarged side view of a pair of struts 1933 of a clot treatment device each having a chamfered edge 1986 in accordance with embodiments of the present technology.
  • a handle in accordance with the present technology can have other configurations for (i) driving a pair of elongate members (e.g., the elongate members 102, 104 of Figures 1A-1C) relative to one another to radially expand/compress a clot treatment device (e.g., the clot treatment device 130) and/or (ii) rotating the clot treatment device.
  • Figures 21-27 illustrate handles and/or handle components in accordance with embodiments of the present technology that can be incorporated into the system 100, the system 1100, and/or another suitable system instead of or in addition to the handle 110 and/or the handle 1110.
  • the various handles can include some features that are at least generally similar in structure and function, or identical in structure and function, to the corresponding features of one another, the handle 110 described in detail above with reference to Figures 1A-C and 5, and/or the handle 1110 described in detail above with reference to Figures 11A-11C, and can operate in a generally similar or identical manner to one another, the handle 110, and/or the handle 1110.
  • the handles of the present technology can be used to manipulate/control any of the clot treatment devices of the present technology.
  • Figure 20 is a side cross-sectional view of a handle 2010 in accordance with embodiments of the present technology that can be incorporated into (e.g., used in) the system 100 (e.g., instead of the handle 110).
  • the handle 2010 includes a housing 2014 and a leadscrew 2020 movably positioned within the housing 2014 and constrained by/over one or more guiderails 2022 (e.g., a pair of the guiderails 2022).
  • the leadscrew 2020 can have a threaded outer surface configured to mate with a threaded inner surface of an actuator 2012, which extends out of the housing 2014 such that the actuator 2012 is accessible outside the housing 2014 by a user of the handle 2010 (e.g., a physician).
  • the inner elongate member 102 can be fixed to the leadscrew 2020, and the middle elongate member 104 (not shown) can be fixed to the housing 2014. Accordingly, actuation (e.g., rotation) of the actuator 2012 can drive the leadscrew 2020 proximally/distally through the housing 2014 to drive the inner elongate member 102 relative to the middle elongate member 104 to radially compress/expand the clot treatment device 130 as shown in Figures 6A and 6B.
  • the handle 2010 further includes a lock mechanism 2024 coupled to the housing 2014.
  • the lock mechanism 2024 can include a lock member 2025 configured to engage the leadscrew 2020 and/or the actuator 2012 to inhibit movement of the leadscrew 2020 through the housing 2014.
  • the lock mechanism 2024 is in a locked position in which the lock member 2025 engages the actuator 2012 to inhibit movement of the actuator 2012 and the leadscrew 2020.
  • the user can actuate (e.g., push, translate, rotate, depress) the lock mechanism 2024 to withdraw the lock member 2025 away from the actuator 2012 to allow the leadscrew 2020 to move through the housing 2014.
  • Figure 21 is a side cross-sectional view of a handle 2110 in accordance with additional embodiments of the present technology that can be incorporated into the system 100 (e.g., instead of the handle 110).
  • the handle 2110 includes a housing 2114 containing a working fluid 2180.
  • a fluid port 2182 is coupled to the housing 2114 and configured to remove/insert the working fluid 2180 into the housing 2114 via a fluid control system (not shown).
  • the inner elongate member 102 can be coupled to a flange 2181 positioned within the housing 2114 and configured to sealingly engage the housing 2114 such that the working fluid 2180 is positioned only between the flange 2181 and the fluid port 2182. Accordingly, in operation, the working fluid 2180 can be pumped into/out of the housing 2114 to drive the flange 2181 distally/proximally through the housing 2114 to drive the inner elongate member 102 relative to the middle elongate member 104 to radially expand/compress the clot treatment device 130 as shown in Figures 3 A and 3B. Therefore, in some aspects of the present technology the handle 2110 can be a pneumatically and/or hydraulically operated handle.
  • FIG. 22 is an isometric view of an actuation mechanism 2290 of a handle that can be incorporated into the system 100 in accordance with embodiments of the present technology.
  • the actuation mechanism 2290 includes an actuator 2212 that is operably coupled to a housing or other component of the handle (not shown) via one or more biasing members 2291, such as coil springs.
  • the actuator 2212 can be operably coupled to (e.g., integrally formed with) a gear rack 2292 having a plurality of teeth configured to engage a first gear 2293 mounted on a first shaft 2294.
  • a second gear 2295 can be mounted on the first shaft 2294, coupled to the first gear 2293, and configured to engage a third gear 2297 mounted on a second shaft 2296.
  • the second gear 2295 is larger than the first gear 2293.
  • the second shaft 2296 is coupled to a unidirectional ratchet mechanism 2298 including, for example, a tooth 2286 that interfaces with circumferentially disposed indents 2288 to allow only counterclockwise rotation.
  • a user can press the actuator 2212 linearly against the biasing force of the biasing members 2291 to drive the gear rack 2292 linearly relative to the first gear 2293.
  • the movement of the gear rack 2292 rotates the first gear 2293 via the engagement of the gear rack 2292 and the first gear 2293.
  • the rotation of the first gear 2293 rotates the coupled second gear 2295, which in turn rotates the third gear 2297 via the engagement of the second and third gears 2295, 2297.
  • the larger size of the second gear 2295 steps up the rotation speed of the first gear 2293.
  • the second gear can 2295 can be omitted and the first gear 2293 can directly engage the third gear 2297 or the first shaft 2294 can directly engage the ratchet mechanism 2298.
  • the ratchet mechanism 2298 inhibits or even prevents the third gear 2297 from rotating in multiple directions, such as when the biasing members 2291 return the actuator 2212 to an initial position after being depressed. Accordingly, the actuation mechanism 2290 translates the linear motion of the actuator 2212 to unidirectional rotation of the ratchet mechanism 2298 and the third gear 2297.
  • the ratchet mechanism 2298 and/or the third gear 2297 can be coupled directly to one or both of the elongate members 102, 104 ( Figures 1 A-1C) such that the actuation mechanism 2290 is configured to rotate the elongate members 102, 104, or the ratchet mechanism 2298 and/or the third gear 2297 can be coupled to a leadscrew or other device such that the actuation mechanism 2290 is configured to drive the elongate members 102, 104 relative to one another to radially expand/compress the clot treatment device 130 as shown in Figures 3 A and 3B, as described in detail above.
  • a handle coupled to a clot treatment device can include one or more features for inhibiting or even preventing over expansion and/or over torquing of the clot treatment device.
  • Figure 23, for example, is a side view of a handle 2310 in accordance with additional embodiments of the present technology that can be incorporated into the system 100 (e.g., instead of the handle 110).
  • the handle 2310 includes a distal handle portion 2370 and a proximal handle portion 2372.
  • the distal handle portion 2370 can be coupled to a leadscrew 2320 that is coupled to one of the elongate members 102, 104 (e.g., the inner elongate member 102).
  • the distal handle portion 2370 is coupled to the proximal handle portion 2372 via a plurality of balls 2371, such as spring- loaded ball bearings, positioned in corresponding detents formed between the distal and proximal handle portions 2370, 2372. Accordingly, in operation, rotation of the proximal handle portion 2372 below a predetermined torque level determined by the balls 2371 and associated detents rotates the distal handle portion 2370 and the leadscrew 2320 to advance one of the elongate members 102, 104 (e.g., the inner elongate member 102) relative to the other one of the elongate members 102, 104 and radially compress/expand the attached clot treatment device 130.
  • balls 2371 such as spring- loaded ball bearings
  • the handle 2310 is configured to maintain a torque level of the clot treatment device 130 and associated force on an implant below a predetermined level.
  • some or all of the balls 2371 and corresponding detents can be replaced with other mechanisms for inhibiting over torquing of the clot treatment device 130.
  • some or all of the balls 2371 can be replaced with pairs of magnets including a first one of the pair coupled to the distal handle portion 2370 and a second one of the pair coupled to the proximal handle portion 2372.
  • the magnets can be selected such that, when the handle 2310 is over torqued, the pairs of magnets disengage (e.g., shear apart) from one another to permit the proximal handle portion 2372 to rotate relative to the distal handle portion 2370 without rotating the distal handle portion 2370.
  • Figure 24 is a side view of a handle 2410 in accordance with additional embodiments of the present technology that can be incorporated into the system 100 (e.g., instead of the handle 110).
  • the handle 2410 includes a leadscrew 2420 coupled to an intermediary shaft 2474 having a first stop 2475. Rotation of the leadscrew 2420 in a first direction can drive the intermediary shaft 2474 to translate distally, and rotation of the leadscrew 2420 in a second direction can drive the intermediary shaft 2474 to translate proximally.
  • the inner elongate member 102 is configured to at least partially telescope within the intermediary shaft 2474 and includes a second stop 2476.
  • a biasing member 2477 (e.g., a coil spring) can extend between the first stop 2475 and the second stop 2476 to couple the inner elongate member 102 to the intermediary shaft 2474.
  • the biasing member 2477 pulls the inner elongate member 102 proximally to radially expand the clot treatment device 130.
  • the proximal movement also forces the biasing member 2477 to elongate — reducing the proximal movement of the inner elongate member 102 compared to, for example, embodiments where the inner elongate member 102 is directly coupled to the leadscrew 2420.
  • the biasing member 2477 can limit the radial expansion of the clot treatment device 130 to inhibit over expansion that may damage an implant.
  • Figures 25A-25C are an enlarged perspective view, an enlarged side view, and an enlarged cross-sectional side view, respectively, of a handle 2510 in accordance with additional embodiments of the present technology that can be incorporated into the system 100 (e.g., instead of the handle 110).
  • the handle 2510 includes a housing 2514 (shown as partially transparent in Figures 25 A and 25B for clarity) defining an internal chamber or lumen 2516 ( Figure 25C).
  • the middle elongate member 104 can be fixedly coupled to the housing 2514.
  • the inner elongate member 102 (not shown; Figures 1 A-1C) can extend through the lumen of the middle elongate member 104 into the lumen 2516 of the housing 2514.
  • the handle 2510 can further comprise a leadscrew 2520 attached to the inner elongate member 102 and an actuator 2512 (e.g., a rotatable knob).
  • the leadscrew 2520 is movably positioned within the lumen 2516 and can have a threaded outer surface configured to mate with a threaded inner surface of the actuator 2512.
  • the actuator 112 can extend out of the housing 2514 from one or more first openings 2519 therein (e.g., a pair of openings on opposing sides of the housing 2514) such that the actuator 2512 is accessible outside the housing 2514 by a user of the handle 2510 (e.g., a physician).
  • the actuator 2512 can be rotated relative to the housing 2514 to drive the leadscrew 2520 proximally and/or distally through the housing 2514 to thereby drive the attached inner elongate member 102 to translate relative to the middle elongate member 104 and thereby radially expand/collapse the clot treatment device 130.
  • the handle 2510 further comprises an indicator 2511 coupled to the leadscrew 2520.
  • the indicator 2511 can be coupled to (e.g., integrally formed with, rotatably mounted to) the leadscrew 2520 and can project into and/or otherwise be visible through one or more second openings 2518 (e.g., slots) in the housing 2514 (e.g., a pair of openings on opposing sides of the housing 2514).
  • the housing 2514 can further include one or more markings 2517 ( Figures 25 A and 25B) adjacent to one or more of the second openings 2518 that indicate an amount of expansion of the clot treatment device 130 (e.g., a measurement of the radial expansion of the clot treatment device 130, a state of the clot treatment device 130, a position of the clot treatment device 130, and/or the like).
  • markings 2517 Figures 25 A and 25B
  • the indicator 2511 can move with the leadscrew 2520 through and/or along the second openings 2518, and the one of the markings 2517 adjacent the indicator 2511 can indicate the amount of expansion (e.g., in millimeters).
  • the indicator 2511 with the leadscrew 2520 in such a manner allows to indicator 2511 to more accurately indicate the amount of radial expansion of the clot treatment device 130 because additional component attachment and manufacturing steps for forming the indicator are not needed.
  • FIG. 26 is an enlarged cross-sectional side view of a handle 2610 in accordance with additional embodiments of the present technology that can be incorporated into the system 100 (e.g., instead of the handle 110).
  • the handle 2610 includes a housing 2614 defining an internal chamber or lumen 2616.
  • the middle elongate member 104 can be fixedly coupled to the housing 2614.
  • the inner elongate member 102 can extend through the lumen of the middle elongate member 104 into the lumen 2616 of the housing 2614.
  • the handle 2610 can further comprise a leadscrew 2620 attached to the inner elongate member 102 and an actuator 2612 (e.g., a rotatable knob).
  • the leadscrew 2620 is movably positioned within the lumen 2616 and, in the illustrated embodiment, has a threaded inner surface configured to mate with a threaded outer surface of the actuator 2612. That is, the threaded surfaces of the leadscrew 2620 and the actuator 2612 are opposite those shown in Figures 5 and 25A-25C.
  • the actuator 112 can extend out of the housing 2614 such that a user can rotate the actuator 2612 relative to the housing 2614 to drive the leadscrew 2620 to proximally and/or distally through the housing 2614 to thereby drive the attached inner elongate member 102 to move relative to the middle elongate member 104 and radially expand/collapse the clot treatment device 130.
  • the handle 2610 further comprises an indicator 2611 coupled to the leadscrew 2620 and that is visible through one or more slot/openings in the housing 2614 to provide an indication of an amount of radial expansion of the clot treatment device 130.
  • an indicator 2611 coupled to the leadscrew 2620 and that is visible through one or more slot/openings in the housing 2614 to provide an indication of an amount of radial expansion of the clot treatment device 130.
  • forming the outer surface of the actuator 2612 and the corresponding inner surface of the leadscrew 2620 to be threaded can allow for easier visualization of the indicator 2611, as the actuator 2612 does not block the view of the indicator 2611 and the leadscrew 2620 anywhere along the path of the leadscrew 2620.
  • FIG. 27 is an enlarged cross-sectional side view of a handle 2710 in accordance with additional embodiments of the present technology that can be incorporated into the system 100 (e.g., instead of the handle 110).
  • the handle 2710 includes a housing 2714 defining an internal chamber or lumen 2716.
  • the middle elongate member 104 can be rotatably coupled to the housing 2714 via a first adaptor 2790 (e.g., a mid-adaptor).
  • the first adaptor 2790 comprises a flange 2791 configured (e.g., shaped, sized, positioned) to be positioned in and rotatably retained within a corresponding circumferential groove or recess 2792 in the housing 2714.
  • the inner elongate member 102 can extend through the lumen of the middle elongate member 104 into the lumen 2716 of the housing 2714.
  • the handle 2710 can further comprise a leadscrew 2720 rotatably coupled to the inner elongate member 102 via a second adaptor 2794 and an actuator 2712 (e.g., a rotatable knob).
  • the second adaptor 2794 comprises a flange 2795 configured (e.g., shaped, sized, positioned) to be positioned in and rotatably retained within a corresponding circumferential groove or recess 2796 in the leadscrew 2720.
  • the first adaptor 2790 can be fixedly attached to the middle elongate member 104, and the second adaptor 2794 can be fixedly attached to the inner elongate member 102 such that rotation of the elongate guide members 2784 rotates the elongate members 102, 104 together to rotate the clot treatment device 130 attached thereto.
  • the leadscrew 2720 is movably positioned within the lumen 2716 and, in the illustrated embodiment, has a threaded outer surface configured to mate with a threaded inner surface of the actuator 2712.
  • the actuator 2712 can be rotated relative to the housing 2714 to drive the leadscrew 2720 proximally and/or distally through the housing 2714 to thereby drive the attached inner elongate member 102 to move relative to the middle elongate member 104 and radially expand/collapse the clot treatment device 130.
  • the handle 2710 further comprises one or more elongate guide members 2784 (e.g., torque guide pins) coupling the first adaptor 2790 to the second adaptor 2740 and a rotary motor 2782.
  • the rotary motor 2782 can be operably coupled to an actuator 2780 (e.g., a switch, a button), a power source, a controller, and/or the like, and is actuatable to cause the rotary motor 2782 to rotate the elongate guide members 2784 to thereby rotate the first and second adaptors 2790, 2794 to thereby rotate the elongate members 102, 104.
  • the handle 2710 is motorized to rotate the clot treatment device 130 (e.g., via actuation of the actuator 2780 and operation of the rotary motor 2782) while still being manually actuatable by a user (e.g., via actuation of the actuator 2712 and corresponding movement of the leadscrew 2720) to radially expand the clot treatment device 130.
  • the rotary motor 2782 is configured to fully rotate (e.g., 360°) the clot treatment device 130 in one or both of the clockwise and counterclockwise directions. In some embodiments, the rotary motor 2782 is configured to only partially rotate the clot treatment device 130 (e.g., by about 10°-60°) in the clockwise and/or counterclockwise directions. In some embodiments, of the rotary motor 2782 (e.g., a controller operably coupled thereto) and/or other aspects of the present technology described herein may take the form of computer- or machine- or controller-executable instructions, including routines executed by a programmable computer or controller.
  • the technology can be practiced on computer/controller systems other than those shown and described below.
  • the technology can be embodied in a special-purpose computer, controller or data processor that is specifically programmed, configured or constructed to perform one or more of the computer-executable instructions described below.
  • the terms “computer” and “controller” as generally used herein refer to any data processor and can include Internet appliances and hand-held devices (including palm-top computers, wearable computers, cellular or mobile phones, multi-processor systems, processor-based or programmable consumer electronics, network computers, mini computers and the like). Information handled by these computers can be presented at any suitable display medium, including a liquid crystal display (LCD).
  • LCD liquid crystal display
  • the technology can also be practiced in distributed environments, where tasks or modules are performed by remote processing devices that are linked through a communications network.
  • program modules or subroutines may be located in local and remote memory storage devices.
  • aspects of the technology described below may be stored or distributed on computer-readable media, including magnetic or optically readable or removable computer disks, as well as distributed electronically over networks. Data structures and transmissions of data particular to aspects of the technology are also encompassed within the scope of the embodiments of the technology.
  • Figure 28 is a side view of a distal portion of a clot removal system 2800 (“system 2800”) positioned within a vessel V to treat clot material C in accordance with embodiments of the present technology.
  • the system 2800 can include some features that are at least generally similar in structure and function, or identical in structure and function, to the corresponding features of the system 100 described in detail above with reference to Figures 1A-10C, and can operate in a generally similar or identical manner to the system 100.
  • the system 2800 includes the clot treatment device 130, the inner elongate member 102 (obscured in Figure 28), the middle elongate member 104, the outer elongate member 106, and the tip 108.
  • the system 2800 further includes a first balloon 2870 coupled to the outer elongate member 106 (e.g., coupled to a distal portion thereof) and a second balloon 2872 coupled to an innermost (e.g., fourth) elongate member 2807.
  • the innermost elongate member 2807 can be moved (e.g., advanced and/or retracted) through the lumen in the tip 108 and the inner elongate member 102.
  • the first and second balloons 2870, 2872 can be inflated via one or more components of the handle 110 ( Figure 5), a separate handle, and/or a different inflation component to an inflated state shown in Figure 28 in which the balloons at least partially engage the wall of the vessel V.
  • the outer elongate member 106, the innermost elongate member 2807, and/or other components of the system 2800 can include one or more inflation lumens (not shown) for inflating the first and second balloons 2870, 2872.
  • the system 2800 can be used to treat the clot material C when the clot material C is positioned within a bare vessel and/or an implant.
  • the clot material C can be chronic or adherent clot material that may otherwise be difficult to treat and remove.
  • the outer elongate member 106 can be positioned proximal to the clot material C such that the first balloon 2870 is positioned proximal to the clot material C within the vessel V.
  • the innermost elongate member 2807 can be positioned such that the second balloon 2872 is distal to the clot material C within the vessel V.
  • the clot treatment devices 130 can be deployed between the first and second balloons 2870, 2872 within the clot material C. With the first and second balloons 2870, 2872 inflated, the clot treatment device 130 can be translated and/or rotated through the clot material C to treat and remove the clot material C as described in detail above with reference to, for example, Figure 7.
  • the first and second balloons 2870, 2872 can help stabilize the vessel V — inhibiting or even prohibiting it from moving — when the clot treatment device 130 is moved to treat the clot material C. This can help improve the treatment efficiency of the system 2800.
  • the first balloon 2870 and/or the second balloon 2872 can provide embolic protection during a clot treatment procedure with the clot treatment device 130 in addition to or alternatively to vessel stabilization.
  • a system for removing clot material from an implant positioned within a body vessel comprising: a clot treatment device configured to be deployed within the implant, wherein the clot treatment device includes a first end portion, a second end portion, and a plurality of struts extending between the first end portion and the second end portion; a handle including an actuator; a first elongate member coupling the first end portion of the clot treatment device to the handle; and a second elongate member coupling the second end portion of the clot treatment device to the handle, wherein actuation of the actuator is configured to move the second elongate member relative to the first elongate member to reduce a distance between the first end portion and the second end portion to radially expand the struts.
  • a method of removing clot material from an implant positioned within a body vessel comprising: positioning a clot treatment device at least partially within the implant, wherein the clot treatment device has (a) a first end portion, (b) a second end portion, and (c) a plurality of struts extending between the first end portion and the second end portion; moving the second elongate member relative to the first elongate member to reduce a distance between the first end portion and the second end portion to radially expand the struts; and after radially expanding the struts, rotating and/or translating the clot treatment device within the implant to materially engage the clot material with at least a portion of the struts.
  • a clot treatment device compressing: a proximal end portion; a distal end portion; and a plurality of struts extending generally axially along a longitudinal axis between the proximal end portion and the distal end portion, wherein — movement of the first end portion toward the second end portion is configured to radially expand the struts; individual ones of the struts include a proximal portion extending from the proximal end portion, a distal portion extending from the distal end portion, and a middle portion (a) extending between the proximal portion and the distal portion and (b) having a hook- like shape in a direction about the longitudinal axis; and individual ones of the struts have an undulating shape in a direction along the longitudinal axis.

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PCT/US2023/060502 2022-01-11 2023-01-11 Devices for removing clot material from intravascularly implanted devices, and associated systems and methods Ceased WO2023137341A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP23740802.6A EP4463083A4 (en) 2022-01-11 2023-01-11 DEVICES FOR REMOVING CLOT MATERIAL FROM INTRAVASCULARLY IMPLANTED DEVICES, AND ASSOCIATED SYSTEMS AND METHODS
CA3247294A CA3247294A1 (en) 2022-01-11 2023-01-11 Devices for removing clot material from intravascularly implanted devices, and associated systems and methods
AU2023208030A AU2023208030A1 (en) 2022-01-11 2023-01-11 Devices for removing clot material from intravascularly implanted devices, and associated systems and methods
CN202380023646.9A CN118804718A (zh) 2022-01-11 2023-01-11 用于从血管内植入装置去除凝块物质的装置以及相关的系统和方法
JP2024541650A JP2025502163A (ja) 2022-01-11 2023-01-11 血管内に埋め込まれたデバイスから凝塊物質を除去するためのデバイス、並びに関連するシステム及び方法

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US12364496B2 (en) 2025-07-22
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