WO2017091520A1 - Toric small aperture intraocular lens with extended depth of focus - Google Patents

Toric small aperture intraocular lens with extended depth of focus Download PDF

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Publication number
WO2017091520A1
WO2017091520A1 PCT/US2016/063181 US2016063181W WO2017091520A1 WO 2017091520 A1 WO2017091520 A1 WO 2017091520A1 US 2016063181 W US2016063181 W US 2016063181W WO 2017091520 A1 WO2017091520 A1 WO 2017091520A1
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WO
WIPO (PCT)
Prior art keywords
mask
intraocular lens
eye
meridian
iol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2016/063181
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English (en)
French (fr)
Inventor
William J. Link
R. Kyle Webb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acufocus Inc
Original Assignee
Acufocus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acufocus Inc filed Critical Acufocus Inc
Priority to US15/775,158 priority Critical patent/US11464625B2/en
Priority to KR1020187016476A priority patent/KR102407311B1/ko
Priority to EP16869140.0A priority patent/EP3384342B1/en
Priority to CA3005891A priority patent/CA3005891C/en
Priority to CN201680075406.3A priority patent/CN108431676B/zh
Priority to JP2018545572A priority patent/JP7055747B2/ja
Publication of WO2017091520A1 publication Critical patent/WO2017091520A1/en
Anticipated expiration legal-status Critical
Priority to US17/886,849 priority patent/US20230078298A1/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1637—Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
    • A61F2/1645—Toric lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2002/1696—Having structure for blocking or reducing amount of light transmitted, e.g. glare reduction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2002/16965—Lens includes ultraviolet absorber
    • A61F2002/1699—Additional features not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0071—Additional features; Implant or prostheses properties not otherwise provided for breakable or frangible

Definitions

  • Tl is application is directed to ophthalmic devices that can be used to improve vision in patients suffering from astigmatism.
  • the human eye functions to provide vision by transmitting and focusing light through the cornea and through the crystalline lens in the eye to form a focused image on a retina.
  • the quality of the focused image depends on many factors including the size and shape of the eye, the transparency of the cornea and the lens, as well as the capability of the lens to accommodate.
  • the optical power of the eye is a function of the optical power of the cornea and the crystalline lens.
  • sharp images of distant objects are formed on the retina. This vision state is called emmetropia.
  • images of distant objects are either formed at a location in front of the retina. This may be because the eye is abnormally long or the cornea is abnormally steep.
  • images are formed at a location behind the retina. This may be because the eye is abnormally short or the cornea is abnormally flat.
  • the focusing effect of the eye may be rotationaliy asymmetric, resulting in an uncompensated cylindrical refractive error referred to astigmatism.
  • IOL intraocular lens
  • This application is directed to providing a better outcome for patients undergoing intraocular refractive vision correction .
  • This application discloses devices that can simplify treatment of complex cases, such as patients who have a lack of accommodation, cataract, and/or astigmatism,
  • an intraocular lens in one embodiment, includes a refractive element and a mask.
  • the refractive element has a first power in a first meridian and a second power greater than the first power in a second meridian.
  • a magnitude of the first and second powers and a location of the first and second meridians are configured to correct astigmatism in a human eye.
  • the mask is configured to block a substantial portion of light from passing through an annular region thereof and to permit a substantial portion of light to pass through a central aperture thereof to enhance an astigmatism correction rotational misplacement range.
  • an intraocular lens in another embodiment, includes a refractive element that is adapted to counter astigmatism in a human eye and a mask.
  • the mask is configured to prevent light from passing through an annular region tliereof.
  • the mask is configured to permit a light to pass through a central aperture thereof to increase depth of focus and to increase tolerance to rotational misplacement within the eye by as much as 15 degrees.
  • a method of correcting astigmatism is provided.
  • an intraocular lens is placed into an eye of a patient.
  • the intraocular lens has a cylinder power component aligned with a meridian tliereof and a mask comprising a small aperture surrounded by an opaque member. It is then confirmed that the meridian of the intraocular lens is aligned within a range exceeding five degrees of a locally minimum power of the eye to reduce astigmatism in the eye such that the eye achieves functional acuity.
  • Figure 1 schematically illustrates uncorrected and corrected focusing effect along a horizontal meridian of an eye with astigmatism in which the lowest power meridian of the eye is aligned with the horizontal meridian.
  • Figure 2 schematically illustrates uncorrected and corrected focusing effect along a vertical meridian of an ey e with astigmatism in which the highest power meridian of the eye is aligned with the vertical meridian.
  • Figure 3 illustrates a power distribution of a refractive element of an intraocular lens (IOL) configured to correct for rotationally asymmetric refractive error illustrated in Figures 1 and 2.
  • IOL intraocular lens
  • Figures 4A-4D illustrate an embodiment of an IOL having a refractive element and a mask coupled with the refractive element.
  • Figure 5 A illustrates an embodiment of a mask.
  • Figure 5B illustrates another embodiment of the mask.
  • Figure 6 schematically illustrates the depth of focus extending effect of the masks of Figures 5 A and 5B.
  • Figure 7 shows simulated defocus performance of a monofocal IOL with corneal aberration correction compared with the same IOL additionally incorporating a small aperture optic.
  • Figure 8 shows simulated cylinder performance of a monofocal IOL with corneal aberration correction compared with the same IOL additionally incorporating a small aperture optic.
  • Figure 9 shows simulated defocus performance of a monofocal toric IOL in an eye system with cylinder cornea compared with the same IOL additionally incorporating a small aperture optic
  • Figure 10 shows simulated cylinder performance of a monofocal toric IOL in an eye system with cylinder at the cornea and additional cylinder at the IOL plane compared with the same IOL additionally incorporating a small aperture optic.
  • Figure 11 shows simulated rotational misalignment performance of a monofocal toric TOL in an eye system with cylinder at the cornea compared with the same IOL additionally incorporating a small aperture optic.
  • Figure 12 is a schematic diagram of an eye showing increased tolerance to misplacement as provided by certain embodiments herein.
  • a patient with astigmatism has unequal optical power at different rotational positions of the eye.
  • the power of the eye is greater in some meridians of the eye than in other meridians.
  • Patients who undergo IOL implantation surgery may suffer from astigmatism. This may be because even if the IOL has perfectly symmetric optics, the cornea of the eye in which the IOL is placed may be formed in a way providing uneven, rotationally asymmetric powers.
  • Figures 1 and 2 illustrate a simple example of how an astigmatic eye 10 converges light passing through the lens.
  • Figure 1 illustrates a horizontal meridian H of the eye 10. Light incident on the horizontal meridian passes through the crystalline lens 18 and converges behind the retina 14. The solid lines show that the light passing along the horizontal meridian H is focused at a location rearward of the retina 14 by a first amount.
  • Figure 2 illustrates a vertical meridian V of the eye 10. In Figure 2, solid lines illustrate that light passing along the vertical meridian V is focused at a location rearward of the retina 14 by a second amount greater than the first amount, which is the optical effect of astigmatism.
  • FIG 3 shows a refractive element 100 that can correct for the rotational asymmetry of refractive power in an eye that causes astigmatism.
  • the refractive element 100 includes a surface 104 that has a refractive power. That is, the surface 104 is configured to cause rays being refracted in an astigmatic eye and through the element 100 to converge at a common focal point.
  • the surface 104 can have a refractive index that causes such convergence, can be curved to cause such convergence or can combine refractive index and curvature together or with other optical effects to cause such convergence.
  • the surface 104 has a first curvature 108 and a second curvature 112. The first curvature 108 is less than the second curvature 112.
  • the first curvature 1 8 has less optical power than the second curvature 1 12,
  • the second curvature 1 12 induces more convergence of the rays that are incident on the surface 104 along a line of the second curvature 112 than the first curvature 108, [0028] If the refractive element 100 is properly placed in the astigmatic eye 10 illustrated in Figures 1 and 2, the refractive element 100 can correct the astigmatism.
  • the refractive element 100 can be placed in the eye 10 such that the first curvature 108 is aligned with the horizontal meridian H which is illustrated in Figure 1. When so placed, the first curvature 108 corrects the relatively smaller hyperopic error on the horizontal meridian H of the eye 10 by a first amount.
  • the refractive element 100 can be placed in the eye 10 such that the second curvature 112, is aligned with the vertical meridian V which is illustrated in Figure 2.
  • the relatively larger hyperopic error is corrected by a larger amount than was corrected in the horizontal meridian H.
  • the rays on both meridians are brought into focus at the same location.
  • An additional power can be provided if needed to shift the focal plane to the retina as illustrated by the solid converging lines in Figures 1 and 2.
  • Figure 3 shows the refractive element 100 surrounded by dashed lines.
  • other components of an IOL incorporating the refractive element 100 can be coupled with the refractive element 100 either prior to implantation or during the course of the useful life of the IOL incorporating the refractive element 100.
  • an intraocular lens 1000 includes an optic 1004 and a mask 1012.
  • the optic 1004 can be formed from an optically transmissive material, while the mask 1012 can be formed from an opaque material.
  • the optic 1004 can include the refractive element 100 to correct refractive errors, such as rotationally asymmetric power, e.g., astigmatism.
  • the optic 1004 can include other structures to improve the overall visual performance of the IOL 1000 in addition to the refractive element 100.
  • the optic 1004 can be monofocal or multifocal and it can have positive or negative optical power.
  • the optic 1004 may be aspheric or any other configuration as the context may dictate.
  • the optic 1004 has a cylinder power or other rotationally asymmetric power such that the optic 1004 can correct for astigmatism of an eye as discussed above.
  • the greatest thickness of the optic 1004 is at the center of the optic 1004.
  • the optic 1004 may have a reduced thickness at its center, which is further described in U.S. Publication No. 201 1/0040376, filed August 13, 2010, which is hereby incorporated by reference in its entirety herein.
  • the optic 1004 may be substantially circular with an outer diameter between about 5.0 mm and about 8.0 mm, such as about 6.0 mm .
  • a central thickness of the optic 1004 can be less than or equal to about 1.0 mm, such as between about 0.75 mm and about 1.0 mm.
  • the intraocular lens 1000 may include one or more haptics 1008 (e.g., one, two, three, four, or more) to prevent the intraocular lens 1000 from moving or rotating within the eye.
  • haptics e.g., one, two, three, four, or more
  • the haptics 1008 can be a variety of shapes and sizes depending on the location the intraocular lens 1000 is implanted in the eye.
  • the haptics 1008 may be C-shaped, J-shaped, plate design, or any other design.
  • the haptics 1008 may be manufactured substantially flat or vaulted with respect to the optic. Variations on the shape of the optic and the haptics can be found in U.S. Publication No. 2011/0040376, filed August 13, 2010, which is hereby incorporated by reference in its entirety herein.
  • the mask 1012 can be formed on an anterior surface 1016 of the optic 1004 (see Figures 4A-4D), on a posterior surface 1020 of the optic 1004, or embedded within the optic 1004.
  • the mask 1012 can be formed substantially at the midway line between the posterior 1020 and anterior surfaces 1016 of the optic 1004. But the mask 1012 can also be formed at other locations within the optic 1004. Additional information regarding the manufacturing of such intraocular lenses can be found in PCT/US2016/055207, filed October 3, 2016, which is hereby incorporated by reference in its entirety herein.
  • Figure 5A illustrates a mask 2034a having an annular region 2036a surrounding an aperture 2038a substantially centrally located on the mask 2034a.
  • An anterior surface of the annular region 2036a can have a curvature from the outer periphery to the inner periphery of the annular region 2036a, and the posterior surface of the annular region 2036a can have a similar curvature.
  • Figure 5B shows that the mask 2034b can be flat in some embodiments.
  • the mask 2034b can include an annular region 2034b surrounding an aperture 2038b substantially centered on the optical axis 2039b of the mask 2034b.
  • the outer periphery of the mask 2034a is generally circular with an outer diameter of at least about 3 mm and less than about 6 mm. In some embodiments, the diameter of the outer periphery of the mask 2034a is at least about 3 mm and less than or equal to about 4 mm.
  • a thickness of the mask 2034a can be constant or can vary between the inner periphery (near the aperture) and the outer periphery. For example, the thickness may increase from an outer periphery and/or inner periphery of the mask 2034a and toward a radial midline of the annular region 2036a. In general, the thickness at any location of the mask 2034a can be less than or equal to about 200 microns, or less than or equal to about 100 microns, but preferably between about 1 micron and about 20 microns.
  • the thickness of the mask 2034a can be within the range: from about 1 micron to about 40 microns, from about 5 microns to about 20 microns, from about 5 microns to about 15 microns. In some implementations, the thickness of the mask 2034a can be within about two microns of: about 15 microns, about 10 microns, about 8 microns, or about 5 microns.
  • the aperture 2038a can transmit substantially all incident visible light along the optical axis 2039a.
  • the aperture 2038a can be a through-hole in the annular region 2036a or a substantially light transmissive (e.g., transparent to visible light) portion thereof.
  • the aperture 2038a can be substantially circular and/or substantially centered around the optical axis 2039a of the mask 2034a.
  • the size of the aperture 2038a can be any size that is effective to increase the depth of focus of an eye of a patient with presbyopia.
  • the size of the aperture 2038a can be dependent on die location of the mask 2034a within the eye (e.g., distance from the retina).
  • the aperture 2038a can have a diameter of at least about 0.85 mm and less than or equal to about 2.8 mm, at least about 1.1 mm and less than or equal to about 1.6 mm, or at least about 1.3 mm and less than or equal to about 1.4 mm.
  • the annular region 2036a can prevent transmission of substantially all or at least a portion of the spectrum of the incident visible light (e.g., radiant energy in the electromagnetic spectrum that is visible to the human eye) and/or the spectrum of non- visible light (e.g., radiant energy outside the range visible to humans). Preventing transmission of visible light through the annular region 2036a can block light that would not converge at the retina and fovea to form a sharp image.
  • Figure 6 illustrates this effect, in particular, the TOL 1000 is placed in the capsular bag of the eye 10.
  • the mask 1012 is centered on the optical axis of the eye 10. Rays that would not converge on the retina 14 are illustrated by the dash lines.
  • the annular region 2036a can prevent transmission of at least about: 90 percent of incident visible light, 92 percent of incident visible light, 95 percent of incident visible light, 98 percent of all incident visible light, or 99 percent of all incident visible light.
  • the annular region 2036a can transmit no more than about: 10 percent of incident visible light, 8 percent of incident visible light, 5 percent of incident visible light, 3 percent of incident visible light, 2 percent of incident visible light, or 1 percent of incident visible light.
  • opacity of the annular region 2036a is achieved because the material used to make mask 2034a is naturally opaque.
  • the material used to make the mask 2034a may be naturally substantially clear but treated with a dye or other pigmentation agent (e.g., carbon black).
  • the mask is made of the same material as the lens body, with the addition of dye or other pigmentation agent. In otlier embodiments, the mask is made of a different material from the lens body.
  • Figure 7 is a Zemax optical simulation of the optical performance of a 21 diopter monofocal IOL.
  • corneal aberration is corrected and the simulation assumes a realistic polychromatic model eye, with a 3 mm pupil.
  • the left-most box shows the visual acuity for 0 diopter defocus.
  • the acuity illustrated is acceptable at 20/20 or greater.
  • the second box from the left shows the visual acuity for a -0.5 diopter defocus using the same lens and model used in the leftmost box.
  • the threshold acuity level is still at about 20/20.
  • the third box from the left shows the visual acuity for a -1.0 diopter defocus using the same lens and simulation model used in generating the left-most box.
  • This box does not register any level of visual acuity and thus the IOL is completely ineffective at this and greater defocus amounts.
  • Figure 7 is a Zemax optical simulation of the optical performance of an IOL that has a small aperture mask disposed therein for extended depth of focus.
  • the small aperture optic can have a 1.36 mm working aperture.
  • the IOL had optimal focus.
  • the simulation used a realistic polychromatic model eye with a 3 mm pupil.
  • the left-most box shows the visual acuity for 0 diopter defocus, which is acceptable at 20/20 or greater.
  • each of the defocus positions m the lower row from the left most box toward the right from -0.5 diopter, -1.0 diopter, - 1.5 diopter and -2.0 diopter defocus show a 20/20 visual acuity or better.
  • This simulation confirms the effectiveness of the small aperture optic illustrated in Figure 6.
  • Figure 8 upper row, is a Zemax optical simulation of the optical performance of a 21 diopter monofocal IOL correcting corneal aberration using a realistic polychromatic model eye, with a 3 mm pupil.
  • the left-most box shows the visual acuity for 0 diopter added cylinder power. The acuity illustrated is acceptable at 20/20 or greater.
  • the third box from the left shows the visual acuity for a -0.5 diopter addition of cylinder power using the same lens and model used in the left-most box.
  • the fifth box from the left shows the visual acuity for a -1.0 diopter addition of cylinder power using the same lens and model used in the left-most box.
  • This box does not register any useful level of visual acuity and thus the IOL is completely- ineffective at this and greater amounts of cylinder.
  • Figure 8 lower row, is a Zemax optical simulation of an 10L with a small aperture mask that provides extended depth of focus. The mask was provided with a 1.36 working aperture and the IOL with optimal focus. The model again was constructed using a realistic polychromatic model eye with a 3 nm pupil.
  • the left-most box shows the visual acuity for 0 added cylinder power and in this box the acuity illustrated is acceptable at 20/20 or greater.
  • the third and fifth boxes from the left show the visual acuity for a -0.5 and -1.0 diopter added cylinder power using the same lens and model used in the left-most box, lower row.
  • the threshold acuity level is still at about 20/20.
  • the performance of the small aperture IOL remains acceptable even to the right-most box which illustrates performance with -1.5 diopter of cylinder.
  • Figure 8 thus shows that a small aperture IOL can provide vision correction for small amounts of astigmatism even up to -1.5 diopters of added cylinder.
  • Figure 9 show s the performance of a tone IOL.
  • Figure 9, upper row is a Zemax optical simulation of the optical performance of a 3 diopter toric monofocal IOL using a realistic polychromatic model eye, with a 3 mm pupil and with a toric cornea.
  • the performance of the toric IOL is similar to that of the monofocal IOL illustrated in Figure 7. That is, it can tolerate about -0.5 diopter defocus. But greater amounts of defocus degrade the visual acuity too much for the tone IOL to provide functional visual acuity.
  • Figure 9 shows that astigmatism in an eye can be more robustly corrected by a 3 diopter tone IOL with a small aperture optic, e.g., having a 1.36 mm working aperture with the IOL having optimal focus.
  • the lower row shows that the toric IOL with small aperture optic can still perform well at up to -2.0 diopters of defocus.
  • Figure 10 shows a further comparison of the performance of a 21 diopter monofocal toric IOL and the same IOL with a small aperture optic, e.g., an optic having a 1.36 mm working aperture.
  • Figure 10 shows the ability of these two lOLs to sustain visual acuity when working with progressively more additional cylinder power.
  • the upper row shows that a toric IOL can sustain acceptable visual acuity up to an additional -0.5 diopter of cylinder.
  • the lower row shows that the toric IOL with a small aperture optic can perform well even when subject to up to -1.5 diopter of cylinder. This means that even in a patient with progressively worsening astigmatism, the toric IOL with small aperture optic can continue to provide good vision without additional lenses or procedures for much longer than the standard toric IOL,
  • Figure 1 1 shows a further comparison of the performance of a 21 diopter monofocal toric IOL and the same IOL with a small aperture optic, e.g., an optic having a 1.36 mm working aperture.
  • Figure 11 shows the ability of these two IOLs to sustain rotational misplacement.
  • the upper row shows that a toric IOL can sustain a 5 degree rotational misplacement or misalignment. Beyond this amount, the visual acuity delivered by the standard toric IOL is insufficient.
  • the lower row shows that the toric IOL with a small aperture optic can perform well at up to 15 degrees of rotational misplacement or misalignment.
  • Figure 12 schematically illustrates aspects of certain embodiments.
  • a cylinder power exists in the eye 10 prior to correction causing astigmatism.
  • the power in the vertical meridian V is noticeably less than in the horizontal meridian H.
  • the IOL 1000 including the refractive element 100 is provided and is placed in the eye 10.
  • the refractive element 100 has different powers in different portions.
  • a meridian of the refractive element 100 can have the first curvature 108 and another meridian of the element 100 can have the second curvature 1 12 larger than the first curvature.
  • the curvatures 108, 112 are along perpendicular meridians, but could be at other angles to each other as a function of the power profile of the eye. As discussed above, the steeper second curvature 112 induces more convergence. Accordingly, the second curvature 112 should optimally be aligned with the vertical meridian V of the eye 10 so that the locally lower power of the eye 10 is compensated by the second curvature 112 to enable the vertical and horizontal meridians V, H to converge at the same location. However, as shown, the refractive element 100 is rotationally offset from the optimal aligned position.
  • the IOL 1000 is enabled by the combination of a toric configuration of the refractive element 100 and the mask 1012 to have a much larger than conventional acceptable rotational offset from the optimal position.
  • Figure 12 shows in the shaded pie-shaped region that there is an acceptable acuity over a large IOL placement range.
  • the range extends on both sides, e.g., symmetrically, of the optimal (vertical) position.
  • IOL 1000 provides an increase in tolerance to rotational misplacement.
  • the range extends beyond the angle of misplacement of the IOL 1000.
  • the range would be much less, for example between the position of the second curvature 112 and the vertical meridian V preventing the convention IOL when placed as shown in Figure 12 from providing functional visual acuity.
  • Conditional language such as “can,” “could,” “might,” or “may,” unless specifically stated othenvise, or otherwise understood within the context as used, is generally intended to convey that certain embodiments include, while other embodiments do not include, certain features, elements, and/or steps. I bus. such conditional language is not generally intended to imply that features, elements, and/or steps are in any way required for one or more embodiments or that one or more embodiments necessarily include logic for deciding, with or without user input or prompting, whether these features, elements, and/or steps are included or are to be performed in any particular embodiment.

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EP16869140.0A EP3384342B1 (en) 2015-11-24 2016-11-21 Toric small aperture intraocular lens with extended depth of focus
CA3005891A CA3005891C (en) 2015-11-24 2016-11-21 Toric small aperture intraocular lens with extended depth of focus
CN201680075406.3A CN108431676B (zh) 2015-11-24 2016-11-21 具有延伸的焦深的复曲面小孔口人工晶状体
JP2018545572A JP7055747B2 (ja) 2015-11-24 2016-11-21 焦点深度の拡張を伴うトーリック小開口眼内レンズ
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EP3384342A4 (en) 2019-08-14
CN108431676A (zh) 2018-08-21
KR102407311B1 (ko) 2022-06-10
US20180338826A1 (en) 2018-11-29
CA3005891A1 (en) 2017-06-01
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US11464625B2 (en) 2022-10-11
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CA3005891C (en) 2023-12-12
US20230078298A1 (en) 2023-03-16
JP7055747B2 (ja) 2022-04-18
KR20180087285A (ko) 2018-08-01

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