CN108431676A - 具有延伸的焦深的复曲面小孔口人工晶状体 - Google Patents

具有延伸的焦深的复曲面小孔口人工晶状体 Download PDF

Info

Publication number
CN108431676A
CN108431676A CN201680075406.3A CN201680075406A CN108431676A CN 108431676 A CN108431676 A CN 108431676A CN 201680075406 A CN201680075406 A CN 201680075406A CN 108431676 A CN108431676 A CN 108431676A
Authority
CN
China
Prior art keywords
mask
intraocular lens
eyes
meridian
iol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201680075406.3A
Other languages
English (en)
Other versions
CN108431676B (zh
Inventor
威廉·J·林克
R·凯尔·韦布
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acufocus Inc
Original Assignee
Acufocus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acufocus Inc filed Critical Acufocus Inc
Publication of CN108431676A publication Critical patent/CN108431676A/zh
Application granted granted Critical
Publication of CN108431676B publication Critical patent/CN108431676B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1637—Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
    • A61F2/1645—Toric lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2002/1696—Having structure for blocking or reducing amount of light transmitted, e.g. glare reduction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2002/16965—Lens includes ultraviolet absorber
    • A61F2002/1699—Additional features not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0071—Additional features; Implant or prostheses properties not otherwise provided for breakable or frangible

Abstract

提供了包括屈光元件和掩模的人工晶状体。屈光元件具有第一子午线中的第一焦度以及第二子午线中的大于第一焦度的第二焦度。第一焦度和第二焦度的大小以及第一子午线和第二子午线的位置被配置成矫正人眼中的散光。掩模被配置成阻挡大部分光穿过其环形区域并且允许大部分光穿过其中心孔口，以增大散光矫正旋转错位范围和焦深。

Description

具有延伸的焦深的复曲面小孔口人工晶状体
相关申请
本申请要求于2015年11月24日提交的美国临时申请第62/259,524号的权益，其全部内容由此通过引用并入本文中。
技术领域
本申请涉及可以用于改善患有散光的患者的视力的眼科装置。
背景技术
人眼的功能是通过经由角膜并且经由眼睛中的晶状体透射和聚焦光以在视网膜上形成聚焦图像来提供视力。聚焦图像的质量取决于很多因素，包括眼睛的尺寸和形状、角膜和晶状体的透明度以及晶状体调节的能力。
眼睛的光焦度(optical power)是角膜和晶状体的光焦度的函数。在正常健康的眼睛中，远处物体的清晰图像形成在视网膜上。该视力状态称为正视。在近视眼中，远处物体的图像或者形成在视网膜前方的位置处。这可能是因为眼睛异常长或角膜异常陡。在远视眼中，图像形成在视网膜后方的位置处。这可能是因为眼睛异常短或角膜异常平。眼睛的聚焦效果可能是旋转非对称的，导致被称为散光的未补偿的柱面屈光不正。
一些人患有晶状体丧失了透明度的白内障。在这样的情况下，可以移除晶状体并且用人工晶状体(intraocular lens，IOL)替换。然而，商业认可的人工晶状体不能恢复全部的视力功能，并且即使在眼睛中出现小的错位也可能导致次优的视力矫正。因此，许多患者经历了不便的手术后应对策略。
发明内容
本申请涉及为经历眼内屈光视力矫正的患者提供更好的结果。本申请公开了可以简化对复杂病例(例如缺乏调节、具有白内障和/或散光的患者)的治疗的装置。
在一个实施方式中，提供了包括屈光元件和掩模的人工晶状体。屈光元件具有第一子午线中的第一焦度以及第二子午线中的大于第一焦度的第二焦度。第一焦度和第二焦度的大小以及第一子午线和第二子午线的位置被配置成矫正人眼中的散光。掩模被配置成阻挡大部分光穿过其环形区域并且允许大部分光穿过其中心孔口以增大散光矫正旋转错位范围。
在另一实施方式中，提供了包括适合于对抗人眼中的散光的屈光元件和掩模的人工晶状体。掩模被配置成防止光穿过其环形区域。掩模被配置成允许光穿过其中心孔口以增加焦深并且将对眼睛内的旋转错位的容忍度增加多达15度。
在另一实施方式中，提供了矫正散光的方法。在该方法中，将人工晶状体放入到患者的眼睛中。该人工晶状体具有与其子午线对准的柱面焦度部件和包括由不透明构件包围的小孔口的掩模。然后，确认人工晶状体的子午线在超过眼睛的局部最小焦度的5度的范围内被对准以减少眼睛中的散光，使得眼睛达到功能性敏度。
本文中公开的任何特征、结构或步骤可以使用本文中公开的任何其他特征、结构或步骤替换或与本文中公开的任何其他特征、结构或步骤组合或省略。此外，为了概述本公开内容的目的，本文中已经描述了本发明的某些方面、优点和特征。应当理解，并非任何或全部这样的优点都根据本文中公开的本发明的任何特定实施方式来实现。本公开内容的任何方面都不是必需的或不可缺少的。
附图说明
为了说明的目的，在附图中描绘了各种实施方式，并且绝不应该将其解释为限制实施方式的范围。此外，不同公开的实施方式的各种特征可以被组合以形成作为本公开内容的一部分的另外的实施方式。
图1示意性地示出沿着具有散光的眼睛的水平子午线的未矫正和矫正的聚焦效果，其中眼睛的最低焦度(power)子午线与水平子午线对准。
图2示意性地示出沿着具有散光的眼睛的垂直子午线的未矫正和矫正的聚焦效果，其中眼睛的最高焦度子午线与垂直子午线对准。
图3示出了被配置成矫正图1和图2中所示的旋转非对称屈光不正的人工晶状体(IOL)的屈光元件的焦度分布。
图4A至图4D示出了具有屈光元件和与屈光元件耦接的掩模的IOL的实施方式。
图5A示出了掩模的实施方式。
图5B示出了掩模的另一实施方式。
图6示意性地示出了图5A和图5B的掩模的焦深延伸效果。
图7示出了与另外包含小孔口光学器件的相同IOL相比具有角膜像差矫正的单焦点IOL的模拟散焦性能。
图8示出了与另外包含小孔口光学器件的相同IOL相比具有角膜像差矫正的单焦点IOL的模拟柱面性能。
图9示出了与另外包含小孔口光学器件的相同IOL相比具有柱面角膜的眼睛系统中的单焦点复曲面IOL的模拟散焦性能。
图10示出了与另外包含小孔口光学器件的相同IOL相比在角膜处具有柱面并且在IOL平面处具有另外的柱面的眼睛系统中的单焦点复曲面IOL的模拟柱面性能。
图11示出了与另外包含小孔口光学器件的相同IOL相比在角膜处具有柱面的眼睛系统中的单焦点复曲面IOL的模拟旋转未对准性能。
图12是如本文中某些实施方式提供的示出对错位的容忍度增加的眼睛的示意图。
具体实施方式
患有散光的患者在眼睛的不同旋转位置处具有不同的光焦度。眼睛的焦度在眼睛的一些子午线中比在其他子午线中大。经历IOL植入手术的患者可能患有散光。这可能是因为：即使IOL具有完全对称的光学器件，放置有IOL的眼睛的角膜也可能以提供不均匀的旋转非对称的焦度的方式形成。
图1和图2示出了散光眼10如何使穿过晶状体的光聚集的简单示例。图1示出了眼睛10的水平子午线H。入射在水平子午线上的光穿过晶状体18并且在视网膜14后方聚集。实线示出沿着水平子午线H通过的光聚焦在视网膜14后方第一量的位置处。图2示出了眼睛10的垂直子午线V。在图2中，实线示出沿垂直子午线V通过的光聚焦在视网膜14后方第二量(大于第一量)的位置处，这是散光的光学效果。
图3示出了可以对眼睛中的引起散光的屈光力(refractive power)的旋转非对称进行矫正的屈光元件100。屈光元件100包括具有屈光力的表面104。亦即，表面104被配置成使得在散光眼中被折射并且穿过元件100的光线在共同的焦点处聚集。表面104可以具有引起这样的聚集的折射率，可以被弯曲以引起这样的聚集，或者可以将折射率和曲率组合在一起或与其他光学效应组合以引起这样的聚集。在一个实施方式中，表面104具有第一曲率108和第二曲率112。第一曲率108小于第二曲率112。因此，第一曲率108具有比第二曲率112更小的光焦度。与第一曲率108相比，第二曲率112引起沿着第二曲率112的线入射在表面104上的光线的更多的聚集。
如果屈光元件100被适当地放置在图1和图2所示的散光眼10中，则屈光元件100可以矫正散光。屈光元件100可以被放置在眼睛10中使得第一曲率108与图1中所示的水平子午线H对准。当如此放置时，第一曲率108将眼睛10的水平子午线H上的相对较小的远视误差矫正了第一量。屈光元件100可以被放置在眼睛10中使得第二曲率112与图2中所示的垂直子午线V对准。当放置成使得第二曲率112与垂直子午线对准时，相对较大的远视误差被矫正了比在水平子午线H中矫正的量更大的量。因此，两条子午线上的光线都聚焦在相同位置处。在需要的情况下可以提供另外的焦度以将焦平面移动至视网膜，如图1和图2中的实聚集线所示。
图3示出了由虚线包围的屈光元件100。如下面进一步讨论的，包含屈光元件100的IOL的其他部件可以在植入之前或者在包含屈光元件100的IOL的使用寿命的过程期间与屈光元件100耦接。
人工晶状体
如图4A至图4D所示，人工晶状体1000包括光学器件1004和掩模1012。光学器件1004可以由透光材料形成，而掩模1012可以由不透明材料形成。光学器件1004可以包括屈光元件100以矫正屈光不正例如旋转非对称焦度，例如散光。除了屈光元件100之外，光学器件1004还可以包括其他结构以改善IOL 1000的整体视力性能。
光学器件1004可以是单焦点或多焦点的，并且其可以具有正光焦度或负光焦度。光学器件1004可以是非球面的或如上下文可以指示的任何其他配置。在各种实施方式中，光学器件1004具有柱面焦度或其他旋转非对称焦度，使得光学器件1004可以如以上所讨论的矫正眼睛的散光。在一些实现方式中，光学器件1004的最大厚度是光学器件1004的中心处。在其他实现方式中，光学器件1004在其中心处可以具有减小的厚度，这在2010年8月13日提交的美国公开第2011/0040376号中进一步描述，其全部内容由此通过引用并入本文中。光学器件1004可以是基本圆形的，其中外径在大约5.0mm与大约8.0mm之间，例如大约6.0mm。光学器件1004的中心厚度可以小于或等于大约1.0mm，例如在大约0.75mm与大约1.0mm之间。
人工晶状体1000可以包括一个或更多个触觉件(haptic)1008(例如，一个、两个、三个、四个或更多)以防止人工晶状体1000在眼睛内移动或旋转。如本文中所使用的，术语“触觉件”旨在是包括支柱(strut)和其他机械结构的广义术语，所述支柱和其他机械结构可以抵靠眼睛的内表面对置(appose)并且被安装至光学器件以将人工晶状体牢固地定位在眼睛的光路中。取决于人工晶状体1000被植入眼睛中的位置，触觉件1008可以是各种形状和尺寸。触觉件1008可以是C形、J形、板式设计或任何其他设计。触觉件1008可以被制造为相对于光学器件呈基本上平坦或拱形。在2010年8月13日提交的美国公开第2011/0040376号中可以找到关于光学器件和触觉件的形状的变型，其全部内容由此通过引用并入本文中。
掩模1012可以形成在光学器件1004的前表面1016上(参见图4A至图4D)，形成在光学器件1004的后表面1020上或者被嵌入在光学器件1004内。当掩模1012被嵌入在光学器件1004内时，掩模1012可以基本形成在光学器件1004的后部1020与前表面1016之间的中线处。但是掩模1012也可以形成在光学器件1004内的其他位置处。关于制造这样的人工晶状体的另外的信息可以在2016年10月3日提交的PCT/US2016/055207中找到，其全部内容由此通过引用并入本文中。
掩模
图5A示出了具有环形区域2036a的掩模2034a，该环形区域2036a包围基本位于掩模2034a中心上的孔口2038a。环形区域2036a的前表面可以具有从环形区域2036a的外周至内周的曲率，并且环形区域2036a的后表面可以具有类似的曲率。图5B示出了在一些实施方式中掩模2034b可以是平坦的。掩模2034b可以包括环形区域2034b，该环形区域2034b包围基本上以掩模2034b的光轴2039b为中心的孔口2038b。虽然下面描述的特征是相对于掩模2034a描述的，但是所述特征中的一个或更多个可以被应用于掩模2034b。
在一些实施方式中，掩模2034a的外周通常为具有至少大约3mm并且小于大约6mm的外径的圆形。在一些实施方式中，掩模2034a的外周的直径为至少大约3mm并且小于或等于大约4mm。
掩模2034a的厚度可以是恒定的，或者可以在内周(靠近孔口)和外周之间变化。例如，厚度可以从掩模2034a的外周和/或内周起并且朝向环形区域2036a的径向中线增加。通常，掩模2034a的任何位置处的厚度可以小于或等于大约200微米，或者小于或等于大约100微米，但是优选地在大约1微米和大约20微米之间。例如，掩模2034a的厚度可以在如下范围内：从大约1微米至大约40微米、从大约5微米至大约20微米、从大约5微米至大约15微米。在一些实现方式中，掩模2034a的厚度可以在如下的大约2微米内：大约15微米、大约10微米、大约8微米或大约5微米。
孔口2038a可以透射基本上全部的沿着光轴2039a的入射可见光。例如，孔口2038a可以是环形区域2036a中的通孔或其基本上透光(例如对可见光透明的)部分。孔口2038a可以是基本上圆形的和/或基本上以掩模2034a的光轴2039a为中心。孔口2038a的尺寸可以是有效增加患有远视眼的患者的眼睛的焦深的任何尺寸。具体地，孔口2038a的尺寸可以取决于眼睛内的掩模2034a的位置(例如，距离视网膜的距离)。在一些实现方式中，孔口2038a可以具有如下大小的直径：至少大约0.85mm并且小于或等于大约2.8mm、至少大约1.1mm并且小于或等于大约1.6mm，或者至少大约1.3mm并且小于或等于大约1.4mm。
环形区域2036a可以防止如下光谱的透射：入射可见光的光谱(例如，对人眼可见的电磁光谱中的辐射能量)的基本上全部或至少一部分和/或非可见光的光谱(例如，对人类可见的范围之外的辐射能量)。防止可见光透射通过环形区域2036a可以阻挡不会聚集在视网膜和中央凹(fovea)处的光以形成清晰的图像。图6示出了这样的效果。具体地，IOL1000被放置在眼睛10的囊袋中。掩模1012以眼睛10的光轴为中心。由虚线示出不会聚集在视网膜14上的光线。这些光线被掩模1012的环形区域2036a或环形区域2036b阻挡，并且因此防止通过引起视网膜上的模糊而视力下降。聚集在视网膜14上的光线穿过掩模1012的孔口。如下面进一步讨论的，通过这种聚焦光提供在一定距离范围内的清晰图像。
在一些实现方式中，环形区域2036a可以防止透射至少大约：90％的入射可见光、92％的入射可见光、95％的入射可见光、98％的全部入射可见光或99％的全部入射可见光。环形区域2036a可以透射不超过大约：10％的入射可见光、8％的入射可见光、5％的入射可见光、3％的入射可见光、2％的入射可见光或1％的入射可见光。
在一些实施方式中，实现了环形区域2036a的不透明性，因为用于制造掩模2034a的材料是天然不透明的。在其他实施方式中，用于制造掩模2034a的材料可以是天然基本透明的，但是用染料或其他染色剂(例如炭黑)处理。在一些实施方式中，掩模由与晶状体本体相同的材料制成，其中添加了染料或其他染色剂。在其他实施方式中，掩模由与晶状体本体不同的材料制成。
掩模的进一步变型可以在以下项中找到：2015年10月5日提交的美国申请第62/237429号(律师案卷ACUFO.169PR)、2004年5月26日提交的美国专利第7,628,810号、2012年2月19日提交的美国公开第2012/0143325号、2010年8月13日提交的美国公开第2011/0040376号；2012年11月30日提交的美国公开第2013/0268071号；美国公开第2014/0264981号；2014年8月7日提交的美国公开第2015/0073549号；1996年6月14日提交的美国专利第5,662,706号；1996年6月14日提交的美国专利第5,905,561号；以及1996年12月6日提交的美国专利第5,965,330号，以上所有的全部内容由此通过引用并入本文中。
模拟测试的讨论
图7的上行是对21屈光度(diopter)单焦点IOL的光学性能的Zemax光学模拟。在模拟中，矫正了角膜像差并且模拟假设具有3mm瞳孔的真实多色模型眼睛。最左侧的框示出了针对0屈光度散焦的视敏度(visual acuity)。所示出的敏度在20/20或更高处是可接受的。从左侧起的第二个框示出了使用与最左侧框中使用的晶状体和模型相同的晶状体和模型针对﹣0.5屈光度散焦的视敏度。可以看到，性能已经下降，但是阈值敏度水平仍然在大约20/20处。从左侧起第三个框示出了使用与在生成最左侧框中使用的晶状体和模拟模型相同的晶状体和模拟模型针对﹣1.0屈光度散焦的视敏度。可以看到，该框没有记录任何水平的视敏度，并且因此IOL在该散焦量和更大的散焦量处完全无效。
图7的下行是对其中设置有用于延伸焦深的小孔口掩模的IOL的光学性能的Zemax光学模拟。小孔口光学器件可以具有1.36mm的有效孔径。IOL具有最佳的焦点。模拟使用了具有3mm瞳孔的真实多色模型眼睛。最左侧的框示出针对0屈光度散焦的视敏度，该视敏度在20/20或更高处是可接受的。与上行相比，下行中的来自﹣0.5屈光度、﹣1.0屈光度、﹣1.5屈光度和﹣2.0屈光度散焦的从最左侧框起朝向右侧的散焦位置中的每一个示出了20/20视敏度或更好的视敏度。该模拟证实了图6中所示的小孔口光学器件的有效性。
图8的上行是对使用具有3mm瞳孔的真实多色模型眼睛来矫正角膜像差的21屈光度单焦点IOL的光学性能的Zemax光学模拟。最左侧的框示出了针对0屈光度添加的柱面焦度的视敏度。所示出的敏度在20/20或更高处是可接受的。从左侧起的第三个框示出了使用与最左侧框中使用的晶状体和模型相同的晶状体和模型针对﹣0.5屈光度添加的柱面焦度的视敏度。可以看到，性能已经下降，但是阈值敏度水平仍然在大约20/20处。从左侧起的第五个框示出了使用与在最左侧框中使用的晶状体和模型相同的晶状体和模型针对﹣1.0屈光度添加的柱面焦度的视敏度。可以看到，该框没有记录任何有用的视敏度水平并且因此IOL在该量和更大量的柱面处完全无效。
图8的下行是对具有提供延伸的焦深的小孔口掩模的IOL的Zemax光学模拟。掩模设置有1.36有效孔径并且IOL具有最佳焦点。再次使用具有3nm瞳孔的真实多色模型眼睛构建该模型。最左侧的框示出针对0添加的柱面焦度的视敏度，并且在该框中所示的敏度在20/20或更高处是可接受的。从左侧起第三个框和第五个框示出了使用与在下行的最左侧框中使用的晶状体和模型相同的晶状体和模型针对﹣0.5和﹣1.0屈光度添加的柱面焦度的视敏度。可以看到，性能已经下降，但是阈值敏度水平仍然在大约20/20处。事实上，小孔口IOL的性能仍然是可接受的，即使是示出了具有﹣1.5屈光度的柱面的性能的最右侧的框。因此，图8示出小孔口IOL可以为即使达到﹣1.5屈光度的添加柱面的小量散光提供视力矫正。
图9示出了复曲面IOL的性能。具体地，图9的上行是对使用具有3mm瞳孔和复曲面角膜的真实多色模型眼睛的3屈光度复曲面单焦点IOL的光学性能的Zemax光学模拟。复曲面IOL的性能与图7所示的单焦点IOL的性能类似。亦即，它可以容忍大约﹣0.5屈光度的散焦。但是更大量的散焦使视敏度过度劣化，而使复曲面IOL不能提供功能性视敏度。相比之下，图9的下行示出了可以通过具有小孔口光学器件的3屈光度复曲面IOL(例如具有1.36mm有效孔径，其中IOL具有最佳焦点)来更加鲁棒地矫正眼睛中的散光。下行示出具有小孔口光学器件的复曲面IOL在高达﹣2.0屈光度的散焦处仍然可以表现良好。
图10示出了对21屈光度单焦点复曲面IOL与具有小孔口光学器件(例如具有1.36mm有效孔径的光学器件)的相同IOL的性能的进一步比较。图10示出了这两种IOL在与逐渐增多的另外的柱面焦度一起工作时维持视敏度的能力。上行示出复曲面IOL可以维持高达添加的﹣0.5屈光度的柱面的可接受的视敏度。下行示出即使当经受高达﹣1.5屈光度的柱面时具有小孔口光学器件的复曲面IOL也可以表现良好。这意味着，即使在患有逐渐恶化的散光的患者中，具有小孔口光学器件的复曲面IOL也可以在比标准复曲面IOL长得多时间内继续提供良好的视力，而无需另外的晶状体或过程。
图11示出了对21屈光度单焦点复曲面IOL与具有小孔口光学器件(例如具有1.36mm有效孔径的光学器件)的相同IOL的性能的进一步比较。图11示出了这两个IOL维持旋转错位的能力。上行示出了复曲面IOL可以维持5度旋转错位或未对准。超过该数量，由标准复曲面IOL提供的视敏度不足。下行示出了具有小孔口光学器件的复曲面IOL在高达15度的旋转错位或未对准下可以表现良好。这意味着，即使IOL植入过程未按照手术前计划进行，IOL也将表现良好。这是因为IOL具有宽得多的可接受旋转放置的窗口。图11的下行表明可以提供30度窗口，患者在该窗口内将具有可接受的视敏度。这比标准IOL可以容忍的更多限制的放置范围大三倍。这表示对复曲面IOL设计的显著改进，提高了IOL的鲁棒性，使得即使在放置为次优的情况下，结果不佳的可能性也被大大降低。
模拟性能可以总结如下：
图12示意性地示出了某些实施方式的方面。具体地，在矫正之前眼睛10中存在柱面焦度，从而引起散光。在该情况下，垂直子午线V中的焦度显著小于水平子午线H中的焦度。包括屈光元件100的IOL 1000被提供并且被放置在眼睛10中。如以上所讨论的，屈光元件100在不同部分具有不同的焦度。例如，屈光元件100的子午线可以具有第一曲率108，并且元件100的另一子午线可以具有大于第一曲率的第二曲率112。曲率108、112沿着垂直的子午线，但是可以根据眼睛的焦度分布彼此处于其他角度。如以上所讨论的，较陡的第二曲率112引起更多的聚集。因此，第二曲率112应该与眼睛10的垂直子午线V最佳地对准，使得眼睛10的局部较低的焦度通过第二曲率112来补偿，以使得垂直子午线V和水平子午线H能够在相同位置聚集。然而，如图所示，屈光元件100从最佳对准位置旋转偏移。有利的是，通过屈光元件100的复曲面配置和掩模1012的组合使得IOL 1000能够具有比从最佳位置的常规可接受的旋转偏移大得多的旋转偏移。图12在阴影饼状区域中示出了在较大IOL放置范围内存在可接受的敏度。在该实施方式中，该范围在最佳(垂直)位置的两侧例如对称地延伸。同样地，IOL 1000提供了对旋转错位的容忍度的增加。范围延伸超过IOL 1000的错位角度。在常规IOL中，范围将小得多，例如在第二曲率112的位置与垂直子午线V之间，阻止常规IOL在如图12所示放置时提供功能性视敏度。
术语
除非在所使用的上下文中另有特别说明或以其他方式解释，否则条件性语言诸如“能够”、“可”、“可能”或“可以”通常旨在表达某些实施方式包括而其他实施方式不包括某些特征、元件和/或步骤。因此，这样的条件语言通常并不旨在暗示特征、元件和/或步骤无论如何都是一个或更多个实施方式所需的，或者一个或更多个实施方式必然包括用于在有或者没有用户输入或提示的情况下决定在任何特定实施方式中是否包括或要执行这些特征、元件和/或步骤的逻辑。
术语“包括”、“包含”、“具有”等是同义词，并且以开放式的方式包含性地被使用，并且不排除另外的元件、特征、动作、操作等。此外，术语“或”以其包含性含义(而不是其排他性含义)被使用，使得例如当用于连接一系列元件时，术语“或”意指列表中的元件中的一个、一些或全部。
如本文所使用的术语“近似地”、“大约”和“基本上”表示接近所述量的量，其仍然执行期望的功能或实现期望的结果。例如，术语“近似地”、“大约”和“基本上”可以指在小于所述量的10％内的量，如上下文可以指示的。
本文中公开的范围还涵盖任何和全部交叠、子范围及其组合。诸如“高达”、“至少”、“大于”、“小于”、“之间”等语言包括所列举的数字。以诸如“大约”或“近似地”的术语在前的数字包括所列举的数字。例如，“大约3mm”包括“3mm”。
虽然本文中已经描述了某些实施方式和示例，但是本领域技术人员将会理解，本公开内容中示出和描述的方法和IOL的许多方面可以被不同地组合和/或修改以形成另外的实施方式或可接受的示例。所有这样的修改和变型在本文中旨在被包括在本公开内容的范围内。各种各样的设计和方法都是可能的。本文中公开的任何特征、结构或步骤并不是必须的或不可或缺的。
为了本公开内容的目的，在本文中描述了某些方面、优点和新颖特征。应当理解的是，根据任何特定实施方式不一定可以实现全部这样的优点。因此，例如，本领域技术人员将认识到，本公开内容可以以实现如本文中所教导的一个优点或一组优点的方式来实施或执行，而不必实现如本文中可能教导或建议的其他优点。
此外，虽然本文已描述了说明性的实施方式，但是本领域技术人员将基于本公开内容理解具有等同元件、修改、省略、(例如跨越各种实施方式的方面的)组合、适应和/或改变的任何和所有实施方式的范围。权利要求中的限制将基于权利要求中使用的语言来广义地解释，而不限于本说明书中或在本申请的实践期间描述的示例，这些示例将被解释为非排他性的。此外，可以以任何方式修改所公开的过程和方法的动作，包括通过对动作重新排序和/或插入附加动作和/或删除动作。因此，旨在将说明书和示例仅视为说明性的，其中，真正的范围和精神由权利要求及其等同物的全部范围指示。

Claims (16)

1.一种人工晶状体，包括：
屈光元件，其包括第一子午线中的第一焦度和第二子午线中的大于所述第一焦度的第二焦度，所述第一焦度和所述第二焦度的大小以及所述第一子午线和所述第二子午线的位置被配置成矫正人的眼睛中的散光；以及
掩模，其被配置成阻挡大部分光穿过所述掩模的环形区域并且允许大部分光穿过所述掩模的中心孔口，以增大散光矫正旋转错位范围。
2.根据权利要求1所述的人工晶状体，其中，所述散光矫正旋转错位范围包括﹢/﹣15度。
3.根据权利要求1所述的人工晶状体，其中，所述掩模与包含所述掩模的光学器件的前表面耦接。
4.根据权利要求3所述的人工晶状体，其中，所述掩模形成在背驮式IOL上，所述背驮式IOL被配置成与所述眼睛耦接以将所述掩模放置在所述光学器件的前表面上。
5.根据权利要求1所述的人工晶状体，其中，所述掩模被嵌入在包括所述屈光元件的光学器件中。
6.根据权利要求1所述的人工晶状体，其中，所述掩模包括小于大约1.4mm的孔口。
7.根据权利要求1所述的人工晶状体，其中，所述掩模被配置成在通过小孔IOL插入器放置在所述眼睛中时以可预测的方式破裂。
8.根据权利要求1所述的人工晶状体，其中，所述掩模包括多个小孔，所述多个小孔被布置成通过所述环形区域，以将所述掩模固定至包括所述屈光元件的光学器件。
9.一种人工晶状体，包括：
屈光元件，其适于对抗人的眼睛中的散光；以及
掩模，其被配置成防止光穿过所述掩模的环形区域并且允许光穿过所述掩模的中心孔口，以增加焦深并且将对所述眼睛内的旋转错位的容忍度增加多达15度。
10.根据权利要求9所述的人工晶状体，其中，所述屈光元件包括复曲面配置。
11.根据权利要求9所述的人工晶状体，其中，所述掩模被配置成将焦深增加相当于高达2屈光度的添加焦度的量。
12.一种矫正散光的方法，包括：
将人工晶状体放入到患者的眼睛中，所述人工晶状体包括：柱面焦度部件，其与所述人工晶状体的子午线对准；以及掩模，其包括由不透明构件包围的小孔口；以及
确认所述人工晶状体的子午线在超过所述眼睛的局部最小焦度的5度的范围内被对准以减少所述眼睛中的散光，使得所述眼睛达到功能性敏度。
13.根据权利要求12所述的方法，其中，所述范围从5度以内延伸至15度以内。
14.根据权利要求12所述的方法，其中，确认所述人工晶状体的子午线在所述范围内包括：执行对所述眼睛和所述人工晶状体的术中像差测量，以确认所述眼睛的术前柱面焦度被减小。
15.根据权利要求12所述的方法，其中，确认所述人工晶状体的子午线在所述范围内包括：观察所述晶状体的旋转对准功件与术前限定的旋转位置相比的位置。
16.根据权利要求15所述的方法，还包括：确认视敏度为至少20/20。
CN201680075406.3A 2015-11-24 2016-11-21 具有延伸的焦深的复曲面小孔口人工晶状体 Active CN108431676B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562259524P 2015-11-24 2015-11-24
US62/259,524 2015-11-24
PCT/US2016/063181 WO2017091520A1 (en) 2015-11-24 2016-11-21 Toric small aperture intraocular lens with extended depth of focus

Publications (2)

Publication Number Publication Date
CN108431676A true CN108431676A (zh) 2018-08-21
CN108431676B CN108431676B (zh) 2022-01-04

Family

ID=58763587

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680075406.3A Active CN108431676B (zh) 2015-11-24 2016-11-21 具有延伸的焦深的复曲面小孔口人工晶状体

Country Status (7)

Country Link
US (2) US11464625B2 (zh)
EP (1) EP3384342B1 (zh)
JP (1) JP7055747B2 (zh)
KR (1) KR102407311B1 (zh)
CN (1) CN108431676B (zh)
CA (1) CA3005891C (zh)
WO (1) WO2017091520A1 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7628810B2 (en) 2003-05-28 2009-12-08 Acufocus, Inc. Mask configured to maintain nutrient transport without producing visible diffraction patterns
KR101796801B1 (ko) 2009-08-13 2017-11-10 아큐포커스, 인크. 마스크형 안구 내 임플란트 및 렌즈
US10004593B2 (en) 2009-08-13 2018-06-26 Acufocus, Inc. Intraocular lens with elastic mask
WO2013082545A1 (en) 2011-12-02 2013-06-06 Acufocus, Inc. Ocular mask having selective spectral transmission
US9427922B2 (en) 2013-03-14 2016-08-30 Acufocus, Inc. Process for manufacturing an intraocular lens with an embedded mask
EP3220859B8 (en) 2014-11-19 2020-06-10 AcuFocus, Inc. Fracturable mask for treating presbyopia
US11696823B2 (en) 2015-04-14 2023-07-11 Z Optics, Inc. High definition and extended depth of field intraocular lens
US11547554B2 (en) 2015-04-14 2023-01-10 Z Optics, Inc. High definition and extended depth of field intraocular lens
EP3359987B1 (en) 2015-10-05 2024-02-28 AcuFocus, Inc. Methods of molding intraocular lenses
KR102407311B1 (ko) 2015-11-24 2022-06-10 아큐포커스, 인크. 연장된 초점 깊이를 가진 원환형 작은 구멍의 안내 렌즈
WO2019217471A1 (en) 2018-05-09 2019-11-14 Acufocus, Inc. Intraocular implant with removable optic
US20230058505A1 (en) * 2021-08-18 2023-02-23 Michael Snyder Ophthalmic pinhole prosthetic with surface modifications and method of fabrication
US20230054347A1 (en) * 2021-08-18 2023-02-23 Michael Snyder Ophthalmic prosthetic to treat negative and positive dysphotopsia

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795462A (en) * 1987-08-24 1989-01-03 Grendahl Dennis T Cylindrically segmented zone of focus artificial lens
US20110166652A1 (en) * 2007-08-27 2011-07-07 Amo Groningen B.V. Toric lens with decreased sensitivity to cylinder power and rotation and method of using the same
CN102448404A (zh) * 2009-08-13 2012-05-09 阿库福库斯公司 掩盖型眼内植入物和透镜
CN202490048U (zh) * 2012-02-29 2012-10-17 张斌 复曲面人工晶状体

Family Cites Families (451)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2350421A (en) 1941-01-22 1944-06-06 William P Schoder Method of producing inlaid jewels
US2470927A (en) 1947-01-10 1949-05-24 South Chester Corp Fastening means
US3034403A (en) 1959-04-03 1962-05-15 Neefe Hamilton Res Company Contact lens of apparent variable light absorption
US3458870A (en) 1964-05-25 1969-08-05 William Stone Jr Artificial corneal implants having a removable lens member
US3270099A (en) 1964-12-07 1966-08-30 Richard N Camp A method for making multi-focal length contact lenses
GB1276003A (en) 1969-03-10 1972-06-01 Frank Auld Corneal contact device
US3578850A (en) 1970-02-11 1971-05-18 Alan H Grant Anti-flare contact lens
US3794414A (en) 1972-05-12 1974-02-26 Jessen Inc Wesley Multiple focal contact lens
US3776230A (en) 1973-04-18 1973-12-04 C Neefe Method of rapidly reshaping the cornea to eliminate refractive errors
US3877502A (en) 1973-08-29 1975-04-15 Hunckler Products Inc Nut locking means and method for muffler clamps
US3996627A (en) 1975-09-22 1976-12-14 American Optical Corporation Artificial intraocular lens
US4010496A (en) 1975-10-01 1977-03-08 Neefe Charles W Bifocal lens which positions within the anterior chamber
US4104338A (en) 1976-04-30 1978-08-01 Guerrieri Salvatore A Bubble cap tray
US4116439A (en) 1976-09-30 1978-09-26 C.F.F. Inc. Pool ball
DE2727410C3 (de) 1977-06-18 1980-03-06 Friedrichsfeld Gmbh Steinzeug- Und Kunststoffwerke, 6800 Mannheim Keratopro these
US4210391A (en) 1977-09-14 1980-07-01 Cohen Allen L Multifocal zone plate
US4340283A (en) 1978-12-18 1982-07-20 Cohen Allen L Phase shift multifocal zone plate
US4767647A (en) 1979-12-17 1988-08-30 The D. L. Auld Company Decorative emblem
US4435050A (en) 1980-02-26 1984-03-06 Stanley Poler Contact lens assembly with haptic and method for making the same
US4298996A (en) 1980-07-23 1981-11-10 Barnet Ronald W Magnetic retention system for intraocular lens
DE3169818D1 (en) 1980-08-05 1985-05-15 Choyce David P Intraocular lens
US4402579A (en) 1981-07-29 1983-09-06 Lynell Medical Technology Inc. Contact-lens construction
US4450593A (en) 1981-11-09 1984-05-29 Lynell Medical Technology Inc. Intraocular and contact lens construction
SU1380743A1 (ru) 1982-02-15 1988-03-15 Московский научно-исследовательский институт микрохирургии глаза Искусственный хрусталик глаза
US4402396A (en) 1982-02-16 1983-09-06 Cooper Laboratories, Inc. Intraocular lens case
US4423728A (en) 1982-02-26 1984-01-03 Lieberman David M Cam-guided trephine
US4470159A (en) 1982-03-03 1984-09-11 Peyman Gholam A Keratoprosthesis
US4639105A (en) 1982-09-13 1987-01-27 Neefe Charles W Spin cast ocular cosmetic device with color separation
JPS5954527A (ja) 1982-09-22 1984-03-29 Hashimoto Forming Co Ltd 車両用モ−ルデイングの製造方法
US4505855A (en) 1982-09-30 1985-03-19 Massachusetts General Hospital Transparent non-fibrilized collagen material by ultracentrifugation
US4701038A (en) 1983-01-31 1987-10-20 Bausch & Lomb Incorporated Cosmetic contact lens
US4563565A (en) 1983-03-02 1986-01-07 Minnesota Mining And Manufacturing Company Method for forming a peripheral edge on contact lenses
US4512039A (en) 1983-05-24 1985-04-23 Lieberman David M Method of offsetting postoperative astigmatism with an intraocular lens
DE3332313A1 (de) 1983-09-07 1985-04-04 Titmus Eurocon Kontaktlinsen GmbH, 8750 Aschaffenburg Multifokale, insbesondere bifokale intraokulare kuenstliche augenlinse
US4665913A (en) 1983-11-17 1987-05-19 Lri L.P. Method for ophthalmological surgery
US4596578A (en) 1984-01-30 1986-06-24 Kelman Charles D Intraocular lens with miniature optic
US5041133A (en) 1984-04-11 1991-08-20 Pharmacia Ab Intraocular implant
US4605409A (en) 1984-05-21 1986-08-12 Kelman Charles D Intraocular lens with miniature optic having expandable and contractible glare-reducing means
US4976732A (en) 1984-09-12 1990-12-11 International Financial Associates Holdings, Inc. Optical lens for the human eye
US4624669A (en) 1984-09-26 1986-11-25 Surgidev Corporation Corneal inlay with holes
US4575373A (en) 1984-11-02 1986-03-11 Johnson Don R Laser adjustable intraocular lens and method of altering lens power
US4744647A (en) 1984-12-04 1988-05-17 Lens Plus Co. Semi-opaque corneal contact lens or intraoccular lens and method of formation
US4669466A (en) 1985-01-16 1987-06-02 Lri L.P. Method and apparatus for analysis and correction of abnormal refractive errors of the eye
US4646720A (en) 1985-03-12 1987-03-03 Peyman Gholam A Optical assembly permanently attached to the cornea
US4669834A (en) 1985-04-30 1987-06-02 Richter Judy C Light reflective contact lens
US6264648B1 (en) 1985-07-29 2001-07-24 Bausch & Lomb Incorporated Corneal curvature modification via internal ablation
US4676791A (en) 1985-08-01 1987-06-30 Surgidev Corporation Intraocular lens and method for making same
US4676790A (en) 1985-09-25 1987-06-30 Kern Seymour P Method of manufacture and implantation of corneal inlays
US4678422A (en) 1985-11-12 1987-07-07 York Kenneth K Systems and methods for precise, accurate formation of products by photoablation
GB2185124B (en) 1986-01-03 1989-10-25 Choyce David P Intra-corneal implant
JPS62167343A (ja) 1986-01-20 1987-07-23 Toagosei Chem Ind Co Ltd ポリ弗化ビニリデン組成物
DE3610833A1 (de) 1986-04-01 1987-10-08 Inprohold Ets Intraokulare implantationslinse
DE3613207A1 (de) * 1986-04-18 1987-10-22 Akzo Gmbh Mit wasser quellbare zusammensetzung, ihre herstellung und verwendung
US4799931A (en) 1986-05-14 1989-01-24 Lindstrom Richard L Intracorneal lens
US5269812A (en) 1986-05-16 1993-12-14 White Thomas C Methods and devices employed in replacement of the corneal endothelium
US5030230A (en) 1986-05-16 1991-07-09 Great Plains Eye Clinic, Ltd. Corneal implant
US4807623A (en) 1986-05-30 1989-02-28 David M. Lieberman Device for simultaneously forming two incisions along a path on an eye
US4799784A (en) 1986-06-23 1989-01-24 Aran Safir Visual vertex finder
US4715858A (en) 1986-07-25 1987-12-29 Lindstrom Richard L Epicorneal lens
US4842782A (en) 1986-10-14 1989-06-27 Allergan, Inc. Manufacture of ophthalmic lenses by excimer laser
US4842599A (en) 1986-10-28 1989-06-27 Ann M. Bronstein Prosthetic cornea and method of implantation therefor
JPS63199908A (ja) 1987-02-10 1988-08-18 金沢　秀樹 固定構造
US6387379B1 (en) 1987-04-10 2002-05-14 University Of Florida Biofunctional surface modified ocular implants, surgical instruments, medical devices, prostheses, contact lenses and the like
AU594233B2 (en) 1987-04-10 1990-03-01 University Of Florida Improved ocular implants and methods for their manufacture
US4798608A (en) 1987-08-24 1989-01-17 Grendahl Dennis T Laminated zone of focus artificial lens
US4817789A (en) 1987-09-23 1989-04-04 Allergan, Inc. Lens container assembly
US5171318A (en) 1987-11-09 1992-12-15 Chiron Ophthalmics, Inc. Treated corneal prosthetic device
US4830855A (en) 1987-11-13 1989-05-16 Landec Labs, Inc. Temperature-controlled active agent dispenser
US4851003A (en) 1988-01-05 1989-07-25 Lindstrom Richard L Corneal implant lens with fixation holes
US5112328A (en) 1988-01-25 1992-05-12 Refractive Laser Research & Development Program, Ltd. Method and apparatus for laser surgery
JPH01195852A (ja) 1988-01-29 1989-08-07 Canon Inc 眼内レンズ
US4815690A (en) 1988-02-09 1989-03-28 Shepherd Thomas H Apparatus for the production of monolithic intraocular implants
US5192316A (en) 1988-02-16 1993-03-09 Allergan, Inc. Ocular device
US4969912A (en) 1988-02-18 1990-11-13 Kelman Charles D Human collagen processing and autoimplant use
US5067961A (en) 1988-02-18 1991-11-26 Autogenesis Technologies, Inc. Non-biodegradable two phase corneal implant and method for preparing same
JPH027954A (ja) 1988-03-04 1990-01-11 Alcon Surgical Inc 着色周辺部付きレンズの製造方法
US4907586A (en) 1988-03-31 1990-03-13 Intelligent Surgical Lasers Method for reshaping the eye
US4994080A (en) 1988-07-15 1991-02-19 Shepard Dennis D Optical lens having at least one stenopaeic opening located in the central area thereof
US5034166A (en) 1988-07-21 1991-07-23 Allergan, Inc. Method of molding a colored contact lens
US5120121A (en) 1988-07-21 1992-06-09 Allergan, Inc. Colored lens
US5092880A (en) 1988-10-21 1992-03-03 Genjiro Ohmi Method of determining the astigmatic power and the power for an intraocular lens, for a toric intraocular lens
US5185107A (en) 1988-10-26 1993-02-09 Iovision, Inc. Fabrication of an intraocular lens
US4903695C1 (en) 1988-11-30 2001-09-11 Lri L P Method and apparatus for performing a keratomileusis or the like operation
GB8900616D0 (en) 1989-01-12 1989-03-08 Galley Geoffrey H Methods of manufacturing contact lenses
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US5358520A (en) 1989-04-28 1994-10-25 Nestle S.A. Supplementary intraocular lens system
US5055602A (en) 1989-05-02 1991-10-08 Bausch & Lomb Incorporated Polymerizable dye
US5013319A (en) 1989-06-05 1991-05-07 Mount Sinai School Of Medicine Of The City University Of New York Apparatus and method for cornea marking
FR2649605B1 (fr) 1989-07-13 1995-07-21 France Chirurgie Instr Implant corneen
US4955904A (en) 1989-08-21 1990-09-11 The Beth Israel Hospital Association Masked intraocular lens and method for treating a patient with cataracts
FR2660859B1 (fr) 1990-04-12 1992-07-10 Hanna Khalil Keratotome destine a la realisation d'incisions arciformes.
US5547468A (en) 1990-07-12 1996-08-20 University Of Miami Instruments for use in performing gel injection adjustable keratoplasty
US5607437A (en) 1990-07-12 1997-03-04 University Of Miami Instruments for use in performing gel injection adjustable keratoplasty
US5372580A (en) 1990-07-12 1994-12-13 University Of Miami Gel injection adjustable keratoplasty
US5090955A (en) 1990-07-12 1992-02-25 University Of Miami Gel injection adjustable keratoplasty
US5120120A (en) 1990-07-27 1992-06-09 Cohen Allen L Multifocal optical device with spurious order suppression and method for manufacture of same
IL95381A0 (en) 1990-08-06 1991-06-30 Wolman Michael Rimless molded eyeglasses
JPH06502782A (ja) 1990-10-05 1994-03-31 ユニヴァーシティ　オブ　フロリダ 改良された眼科用インプラントとその製造方法
US5314961A (en) 1990-10-11 1994-05-24 Permeable Technologies, Inc. Silicone-containing polymers, compositions and improved oxygen permeable hydrophilic contact lenses
DE4134320C2 (de) 1990-10-22 1993-10-28 Gerhard M Krahmer Künstliches Haar
US5260727A (en) 1990-10-22 1993-11-09 Oksman Henry C Wide depth of focus intraocular and contact lenses
JPH04158859A (ja) 1990-10-23 1992-06-01 Seiko Epson Corp 人工角膜
US5137441A (en) 1990-10-30 1992-08-11 Minnesota Mining And Manufacturing Company Mold assembly for making an ocular lens blank
US5288436A (en) 1990-11-06 1994-02-22 Colloptics, Inc. Methods of fabricating a collagen lenticule precursor for modifying the cornea
US5290892A (en) 1990-11-07 1994-03-01 Nestle S.A. Flexible intraocular lenses made from high refractive index polymers
US5094521A (en) 1990-11-07 1992-03-10 Vision Research Laboratories Apparatus for evaluating eye alignment
US5108427A (en) 1991-01-07 1992-04-28 Majercik Stephen M Active pupillary prosthesis
US5269795A (en) 1991-07-03 1993-12-14 Arnott Eric J Trephine device for removing anterior epithelial cells from corneal surfaces
US5147395A (en) 1991-07-16 1992-09-15 Allergan Inc. Small incision endocapsulator IOL
US5213749A (en) 1991-07-31 1993-05-25 Westinghouse Air Brake Company Method of forming a rubber seal having a metallic insert
SG81873A1 (en) 1991-08-16 2001-07-24 Miles A Galin Medicament coated refractive anterior chamber ocular implant
JP3092233B2 (ja) 1991-09-04 2000-09-25 三菱化学株式会社 液晶性ポリエステルアミド
US5196026A (en) 1991-09-16 1993-03-23 Chiron Ophthalmics, Inc. Method of implanting corneal inlay lenses smaller than the optic zone
US5864128A (en) 1991-10-15 1999-01-26 Geo Labs, Inc. Lens with variable focal length
US5647865A (en) 1991-11-01 1997-07-15 Swinger; Casimir A. Corneal surgery using laser, donor corneal tissue and synthetic material
JPH0539527U (ja) 1991-11-05 1993-05-28 株式会社メニコン 角膜ホストマーカー
DE69232640T2 (de) 1991-11-06 2003-02-06 Shui T Lai Vorrichtung für hornhautchirurgie
US5578080A (en) 1991-11-12 1996-11-26 Henry H. McDonald Plastic optical lens with reduced thickness light blocking segments, and anchoring means
US5786883A (en) 1991-11-12 1998-07-28 Pilkington Barnes Hind, Inc. Annular mask contact lenses
EP0619724B1 (en) 1992-01-02 2000-02-09 BAUSCH & LOMB SURGICAL, INC. Corneal ring inlay
US5266241A (en) 1992-02-12 1993-11-30 Iolab Corporation Haptic attachment for soft intraocular lens
US5188494A (en) 1992-04-21 1993-02-23 Itt Corporation Torque indicator device and method for use with a threaded fastener
US5312330A (en) 1992-05-20 1994-05-17 Summit Technology, Inc. Medical treatment of the eye involving removal of the epithelium
US5292514A (en) 1992-06-24 1994-03-08 Minnesota Mining And Manufacturing Company Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof
US5354331A (en) 1992-07-15 1994-10-11 Schachar Ronald A Treatment of presbyopia and other eye disorders
AU650156B2 (en) 1992-08-05 1994-06-09 Lions Eye Institute Limited Keratoprosthesis and method of producing the same
US5288293A (en) 1992-09-24 1994-02-22 Donnell Jr Francis E O In vivo modification of refractive power of an intraocular lens implant
US6090141A (en) 1993-03-05 2000-07-18 Lindstrom; Richard L. Small intracorneal lens
US5507740A (en) 1993-05-03 1996-04-16 O'donnell, Jr.; Francis E. Corneal topography enhancement device
US5870167A (en) 1993-07-14 1999-02-09 Knopp; Carl F. Apparatus and method for imaging anterior structures of the eye
US5474548A (en) 1993-07-14 1995-12-12 Knopp; Carl F. Method of establishing a unique machine independent reference frame for the eye
ATE172665T1 (de) 1993-07-28 1998-11-15 Iolab Corp Intraokularlinse mit bruchfesten haltebügeln
PT712297E (pt) 1993-08-02 2004-08-31 Addition Technology Inc Inserto de cornea intraestroma maleavel e segmentado
EP0712301A4 (en) 1993-08-02 1996-12-11 Keravision Inc SEGMENTED PREFORM INSERT FOR CORNEAN STROMA
CA2169771C (en) 1993-08-18 2000-02-15 Gyorgy Abraham Method and optical means for improving or modifying color vision and method for making said optical means
JP2812860B2 (ja) 1993-08-31 1998-10-22 株式会社メニコン 眼内レンズ
US5603774A (en) 1993-09-27 1997-02-18 Alcon Laboratories, Inc. Method for reducing tackiness of soft acrylic polymers
TW257671B (zh) 1993-11-19 1995-09-21 Ciba Geigy
JP3439809B2 (ja) 1993-12-24 2003-08-25 京セラ株式会社 人工角膜
AU705648B2 (en) 1994-01-07 1999-05-27 Keravision, Inc. System for inserting material into corneal stroma
JP3406677B2 (ja) 1994-03-31 2003-05-12 京セラ株式会社 人工角膜
US20030060880A1 (en) 1994-04-08 2003-03-27 Vladimir Feingold Toric intraocular lens
US5837156A (en) 1994-04-21 1998-11-17 Cumming; J. Stuart Methods of fabricating intraocular lenses and lens molds
US6197019B1 (en) 1994-04-25 2001-03-06 Gholam A. Peyman Universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith
US5507806A (en) 1994-05-13 1996-04-16 Pharmacia Iovision, Inc. Multi-faceted intraocular lens
US6302877B1 (en) 1994-06-29 2001-10-16 Luis Antonio Ruiz Apparatus and method for performing presbyopia corrective surgery
US5910537A (en) 1994-07-22 1999-06-08 Staar Surgical Company Inc. Biocompatible, optically transparent, ultraviolet light absorbing, polymeric material based upon collagen and method of making
JP3640690B2 (ja) 1994-10-03 2005-04-20 株式会社ニデック 眼内レンズ
AU3735195A (en) 1994-10-06 1996-05-02 Vladimir Feingold Intraocular contact lens and method of implantation
JPH08164155A (ja) 1994-12-14 1996-06-25 Nikon Corp 眼科用照明装置
JP3625097B2 (ja) 1995-02-07 2005-03-02 セイコーエプソン株式会社 着色コンタクトレンズおよびその製造法
US5653752A (en) 1995-02-28 1997-08-05 Keravision, Inc. Adjustable devices for corneal curvature adjustment
US5628795A (en) 1995-03-15 1997-05-13 Langerman David W Spare parts for use in ophthalmic surgical procedures
US6110166A (en) 1995-03-20 2000-08-29 Escalon Medical Corporation Method for corneal laser surgery
US5697923A (en) 1995-03-29 1997-12-16 Poler; Stanley Corneal drape for use in performing a photorefractory keratectomy procedure
US5652638A (en) 1995-05-04 1997-07-29 Johnson & Johnson Vision Products, Inc. Concentric annular ring lens designs for astigmatism
US5693094A (en) 1995-05-09 1997-12-02 Allergan IOL for reducing secondary opacification
US5752967A (en) 1995-07-27 1998-05-19 Kritzinger; Michiel S. Corneal surface marker and marking method for improving laser centration
USD375245S (en) 1995-08-18 1996-11-05 Irving Thomas W E Pistol lock
US5919185A (en) 1997-04-25 1999-07-06 Peyman; Gholam A. Universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith
US20050143717A1 (en) 2001-04-27 2005-06-30 Peyman Gholam A. Method of treatment of refractive errors using subepithelial or intrastromal corneal inlay with bonding coating
US5722971A (en) 1995-10-20 1998-03-03 Peyman; Gholam A. Intrastromal corneal modification
US6280470B1 (en) 1995-10-20 2001-08-28 Gholam A. Peyman Intrastromal corneal modification
US6551307B2 (en) 2001-03-23 2003-04-22 Gholam A. Peyman Vision correction using intrastromal pocket and flap
US5964748A (en) 1995-10-20 1999-10-12 Peyman; Gholam A. Intrastromal corneal modification
US6221067B1 (en) 1995-10-20 2001-04-24 Gholam A. Peyman Corneal modification via implantation
US6989008B2 (en) 2001-03-23 2006-01-24 Minu Llc Adjustable ablatable inlay
US20090069817A1 (en) 1995-10-20 2009-03-12 Acufocus, Inc. Intrastromal corneal modification
US20010027314A1 (en) 1995-10-20 2001-10-04 Peyman Gholam A. Intrastromal corneal modification via laser
US6203538B1 (en) 1995-11-03 2001-03-20 Gholam A. Peyman Intrastromal corneal modification
FR2743154B1 (fr) 1995-12-29 1998-03-06 Essilor Int Lentille oculaire artificielle multifocale a transparence variable avec l'eclairement
US5702440A (en) 1996-01-26 1997-12-30 Allergan Multifocal ophthalmic lens for dim-lighting conditions
US5624456A (en) 1996-02-07 1997-04-29 Hellenkamp; Johann F. Automatic surgical device for cutting a cornea
EP0822790A1 (en) 1996-02-09 1998-02-11 Keravision, Inc. Segmented intrastromal corneal insert for altering corneal refractive properties and methods thereof
US5628794A (en) 1996-03-08 1997-05-13 Lindstrom; Richard L. Multifocal corneal implant lens having a hydrogelo coating
US20020128710A1 (en) 1996-03-18 2002-09-12 Eggleston Harry C. Modular intraocular implant
US6171336B1 (en) 1996-03-26 2001-01-09 Mark R. Sawusch Method, implant, and apparatus for refractive keratoplasty
US5693268A (en) 1996-04-01 1997-12-02 Johnson & Johnson Vision Products, Inc. Wedge demolding of cast lens mold assemblies
US5925294A (en) 1996-04-24 1999-07-20 Hoya Corporation Process for the production of an intraocular lens
US5662706A (en) 1996-06-14 1997-09-02 Pbh, Inc. Variable transmissivity annular mask lens for the treatment of optical aberrations
US5905561A (en) * 1996-06-14 1999-05-18 Pbh, Inc. Annular mask lens having diffraction reducing edges
US5746558A (en) 1996-07-24 1998-05-05 Lockheed Martin Corporation Locking apparatus for fastening system
US5728156A (en) 1996-08-06 1998-03-17 Prism Opthalmics, L.L.C. Prismatic intraocular lenses and related methods of in situ alteration of their optical characteristics
US5769889A (en) 1996-09-05 1998-06-23 Kelman; Charles D. High myopia anterior chamber lens with anti-glare mask
CA2688799C (en) 1996-11-15 2014-09-30 Marsupial Holdings, Inc. In-line holographic mask for micromachining
US20010041884A1 (en) 1996-11-25 2001-11-15 Frey Rudolph W. Method for determining and correcting vision
US5965330A (en) 1996-12-06 1999-10-12 Pbh, Inc. Methods for fabricating annular mask lens having diffraction-reducing edges
CA2229093A1 (en) 1997-02-13 1998-08-13 Joseph J. Berto Handlebar device
US6228114B1 (en) 1997-04-01 2001-05-08 Joseph Y. Lee Adjustable corneal ring
US6063073A (en) 1997-04-25 2000-05-16 Peyman; Gholam A. Universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith
US20010034516A1 (en) 1997-04-25 2001-10-25 Peyman Gholam A. Universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith
US5980040A (en) 1997-06-30 1999-11-09 Wesley Jessen Corporation Pinhole lens and contact lens
JPH1184125A (ja) 1997-09-12 1999-03-26 Tokyo Ohka Kogyo Co Ltd 色フィルタ用光重合性組成物、および色フィルタの製造方法
US5964776A (en) 1997-09-24 1999-10-12 Peyman; Gholam A. Internal keratome apparatus and method for using the same to form a pocket/flap between layers of a live cornea
MC2461A1 (fr) 1997-09-26 1998-12-18 Exsymol Sa Dispositifs ophtalmiques et implantables recouverts d'un revêtement et procédés pour la production de ces derniers
RU2138837C1 (ru) 1997-10-31 1999-09-27 Институт автоматики и электрометрии СО РАН Растровая дифракционно-апертурная маска для коррекции недостатков зрения
US5876442A (en) 1998-01-15 1999-03-02 Visioncare Ltd. Intraocular lens implant with telescope support
US6007579A (en) 1998-01-15 1999-12-28 Visioncare Ltd. Intraocular carrying member with attachment for telescope
US6201036B1 (en) 1998-07-21 2001-03-13 Mezhoiraslevoi Nauchno-Tekhnichesky Komplex “Mikrokhirurgia Glaza” Light-curable polymer material, method for making an elastic intraocular lens, and an elastic intraocular lens
CN1110711C (zh) 1998-07-24 2003-06-04 长春科利尔光学制品有限公司 降低凹面反射的色觉矫正树脂眼镜
BR9914455A (pt) 1998-10-02 2001-05-22 Scient Optics Inc Método e aparelho para diagnosticar e melhorar a visão
US6178593B1 (en) 1998-10-23 2001-01-30 Robert J. Carlson Vertical pin automobile door hinge wear compensator
US20020010510A1 (en) 1998-11-04 2002-01-24 Thomas A. Silvestrini Variable modulus corneal implant and fabrication methods
US6228115B1 (en) 1998-11-05 2001-05-08 Bausch & Lomb Surgical, Inc. Intraocular lenses with improved axial stability
US6164777A (en) 1998-12-16 2000-12-26 Bausch & Lomb Incorporated Color-imparting contact lenses with interference coating and method for making the same
US6102946A (en) 1998-12-23 2000-08-15 Anamed, Inc. Corneal implant and method of manufacture
US6361560B1 (en) 1998-12-23 2002-03-26 Anamed, Inc. Corneal implant and method of manufacture
US6554424B1 (en) 1999-03-01 2003-04-29 Boston Innovative Optices, Inc. System and method for increasing the depth of focus of the human eye
JP2000249890A (ja) 1999-03-02 2000-09-14 Olympus Optical Co Ltd 絞り装置
US6997428B1 (en) 1999-03-31 2006-02-14 Novartis Ag Contact lens mold
US6138307A (en) 1999-05-06 2000-10-31 Surgical Concepts, Inc. Corneal intra-stromel prostheses
ATE246222T1 (de) 1999-05-12 2003-08-15 Menicon Co Ltd Material für okularlinse und verfahren zu deren herstellung
US6152959A (en) 1999-05-14 2000-11-28 Portney; Valdemar Iris fixated intraocular lens
US6469844B1 (en) 1999-06-02 2002-10-22 Fuji Photo Film Co., Ltd. Lens holding method and lens holder
US6461384B1 (en) 1999-06-17 2002-10-08 Bausch & Lomb Incorporated Intraocular lenses
US6423093B1 (en) 1999-09-14 2002-07-23 The Lions Eye Institute Of Western Australia Incorporated Method of insertion of keratoprostheses
US6352764B1 (en) 1999-08-09 2002-03-05 3M Innovative Properties Company Multi-layer articles including UV-absorbing polymeric compositions
US6217596B1 (en) 1999-09-01 2001-04-17 Samir G. Farah Corneal surface and pupillary cardinal axes marker
US7008396B1 (en) 1999-09-03 2006-03-07 Restorvision, Inc. Ophthalmic device and method of manufacture and use
US6280471B1 (en) 1999-09-16 2001-08-28 Gholam A. Peyman Glare-free intraocular lens and method for using the same
US6277146B1 (en) 1999-09-16 2001-08-21 Gholam A. Peyman Glare-free intraocular lens and method for using the same
EP1214065A4 (en) 1999-09-16 2009-01-07 Ocularis Pharma Inc METHOD USING THE ALPHA AGONIST TO OPTIMIZE THE SIZE OF THE PUPIL
US20020082288A1 (en) 1999-09-16 2002-06-27 Gerald Horn Ophthalmic formulations comprising an imidazoline
US6649722B2 (en) 1999-12-10 2003-11-18 Novartis Ag Contact lens
CA2295431A1 (en) 2000-01-06 2001-07-06 Scott Howard Phillips Ophthalmic apparatus
US6228113B1 (en) 2000-01-10 2001-05-08 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Intracorneal astigmatic onlay
US6391230B1 (en) 2000-02-18 2002-05-21 Bausch & Lomb Incorporated Intraocular lens manufacturing process
DE10010683A1 (de) 2000-03-04 2001-09-06 Morcher Gmbh Intraoculare Linse
US6458141B1 (en) 2000-03-10 2002-10-01 Gholam A. Peyman Method and apparatus for creating a flap in the cornea and incisions or shrinkage under the flap to correct vision disorders
US6436092B1 (en) 2000-03-21 2002-08-20 Gholam A. Peyman Adjustable universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith
US6949093B1 (en) 2000-03-21 2005-09-27 Minu, L.L.C. Adjustable universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith
US7044602B2 (en) 2002-05-30 2006-05-16 Visx, Incorporated Methods and systems for tracking a torsional orientation and position of an eye
US6755858B1 (en) 2000-04-07 2004-06-29 Thomas C. White Prosthetic corneal graft and method
US7635388B1 (en) 2000-05-04 2009-12-22 Tyler Thomas D Device and method for incremental correction of sight disorders and occular diseases
JP3073059U (ja) 2000-05-09 2000-11-14 船井電機株式会社 レンズホルダ
US6554860B2 (en) 2000-05-15 2003-04-29 Bausch & Lomb Incorporated Foldable iris fixated intraocular lenses
KR100335722B1 (ko) 2000-05-17 2002-05-09 김쌍기 미용을 위한 채색 콘택트렌즈 및 그의 제조방법
US20010050750A1 (en) 2000-06-08 2001-12-13 Breger Joseph L. Pinhole presbyopic contact lenses
US6544286B1 (en) 2000-07-18 2003-04-08 Tissue Engineering Refraction, Inc. Pre-fabricated corneal tissue lens method of corneal overlay to correct vision
AR030341A1 (es) 2000-08-14 2003-08-20 Novartis Ag Articulos biomedicos moldeados
US6543610B1 (en) 2000-09-12 2003-04-08 Alok Nigam System for packaging and handling an implant and method of use
AU2002220570A1 (en) 2000-09-28 2002-04-08 Novartis Pharma Gmbh Fenestrated lens for increased tear flow and method for making the same
JP3709335B2 (ja) 2000-09-28 2005-10-26 株式会社ニデック 眼科装置
US6607527B1 (en) 2000-10-17 2003-08-19 Luis Antonio Ruiz Method and apparatus for precision laser surgery
US6335190B1 (en) 2000-10-20 2002-01-01 New England Biolabs, Inc. Method for cloning and producing the BsmI restriction endonuclease in E. coli
US6515006B2 (en) 2000-11-08 2003-02-04 Hmt Pharma, Inc. Ophthalmic formulation which modulates dilation
US6811256B1 (en) 2000-12-08 2004-11-02 Paul Douglas Becherer Post-ophthalmologic procedure lenses and methods
US20020167640A1 (en) 2000-12-22 2002-11-14 Francis Charles Auxilium Contact lens with opaque iris pattern
US20020120329A1 (en) 2001-02-28 2002-08-29 Allergan Sales, Inc. Moveable intraocular lenses and combinations of intraocular lenses
US20050182488A1 (en) 2001-04-27 2005-08-18 Peyman Gholam A. Implant and method for altering the refractive properties of the eye
US20050182489A1 (en) 2001-04-27 2005-08-18 Peyman Gholam A. Intraocular lens adapted for adjustment via laser after implantation
US20050222679A1 (en) 2001-04-27 2005-10-06 Peyman Gholam A Bifocal implant and method for altering the refractive properties of the eye
US7645299B2 (en) 2001-05-11 2010-01-12 Koziol Jeffrey E Intracorneal lens system having connected lenses
US6589280B1 (en) 2001-05-11 2003-07-08 Jeffrey E. Koziol Method for producing a multifocal corneal surface using intracorneal microscopic lenses
MXPA03011631A (es) 2001-06-15 2007-01-30 Univ Houston System Detectores opticos de pelicula delgada para implante retiniano y metodos para elaborarlos y usarlos.
WO2003000500A1 (en) 2001-06-22 2003-01-03 Bausch & Lomb Incorporated Lens with colored portion
US6497700B1 (en) 2001-06-28 2002-12-24 Lahaye Leon C. Multi-function surgical instrument for facilitating ophthalmic laser surgery
US6655804B2 (en) 2001-06-29 2003-12-02 Daniel G. Streibig Colored contact lens and method of making same
US20030014042A1 (en) 2001-07-13 2003-01-16 Tibor Juhasz Method of creating stromal pockets for corneal implants
US6638304B2 (en) 2001-07-20 2003-10-28 Massachusetts Eye & Ear Infirmary Vision prosthesis
US6533416B1 (en) 2001-07-20 2003-03-18 Ocular Sciences, Inc. Contact or intraocular lens and method for its preparation
US20030045930A1 (en) 2001-08-30 2003-03-06 Allergan Sales, Inc. Apparatus and methods for packaging intrcorneal implants and facilitating placement thereof
US6702807B2 (en) 2001-09-10 2004-03-09 Minu, L.L.C. Ablatable intracorneal inlay with predetermined refractive properties
US6575573B2 (en) 2001-10-17 2003-06-10 Carl Zeiss Ophthalmic Systems, Inc. Method and apparatus for measuring a corneal profile of an eye
US6786926B2 (en) 2001-11-09 2004-09-07 Minu, L.L.C. Method and apparatus for alignment of intracorneal inlay
US7037338B2 (en) 2001-12-14 2006-05-02 Toshiyuki Nagamoto Intraocular ring assembly and artificial lens kit
WO2003059208A2 (en) 2002-01-14 2003-07-24 Advanced Medical Optics, Inc. Accommodating intraocular lens with integral capsular bag ring
MXPA04006954A (es) 2002-01-17 2005-03-23 Perez Edward Metodos para producir colgajos epiteliales sobre la cornea y para la colocacion de dispositivos oculares y lentes debajo de un colgajo o membrana epitelial, dispositivo de deslaminacion epitelial, y estructuras de epitelio y dispositivos y lentes ocu
US8048155B2 (en) 2002-02-02 2011-11-01 Powervision, Inc. Intraocular implant devices
WO2003079272A1 (en) 2002-03-15 2003-09-25 University Of Washington Materials and methods for simulating focal shifts in viewers using large depth of focus displays
US20030204258A1 (en) 2002-04-24 2003-10-30 Graham William M. Posterior chamber phakic lens
US20030216763A1 (en) 2002-05-14 2003-11-20 Patel Anilbhai S. Method of determining the visual axis of an eye
US6951556B2 (en) 2002-07-01 2005-10-04 Epstein Robert L Method and apparatus for correcting off-center laser ablations in refractive surgery
US6855163B2 (en) 2002-07-19 2005-02-15 Minu, Llc Gradual correction of corneal refractive error using multiple inlays
US7364674B1 (en) 2002-07-23 2008-04-29 Advanced Optical Technologies, Inc. Corneal implants produced by irradiation of polymer films
US20040019379A1 (en) 2002-07-25 2004-01-29 Advanced Medical Optics, Inc. Intracorneal lens with flow enhancement area for increased nutrient transport
JP2006516038A (ja) 2002-08-09 2006-06-15 オタワ ヘルス リサーチ インスティテュート 生合成基質およびその用法
US20040106929A1 (en) 2002-08-20 2004-06-03 Samuel Masket Method and apparatus for performing an accurately sized and placed anterior capsulorhexis
WO2004024035A1 (en) 2002-09-13 2004-03-25 Ocular Sciences, Inc. Devices and methods for improving vision
US20040056371A1 (en) 2002-09-25 2004-03-25 Medennium, Inc. Method of manufacturing ophthalmic lenses made from hydrophobic acrylic polymers
US20040068317A1 (en) 2002-10-07 2004-04-08 Knight Patricia M. Anterior chamber intraocular lens with size and position indicators
US7387759B2 (en) 2002-12-17 2008-06-17 Novartis Ag System and method for curing polymeric moldings having a masking collar
US20040153150A1 (en) 2003-01-30 2004-08-05 Advanced Medical Optics, Inc. Composite anterior chamber intraocular lens and method of manufacture thereof
US7628810B2 (en) 2003-05-28 2009-12-08 Acufocus, Inc. Mask configured to maintain nutrient transport without producing visible diffraction patterns
US20050288784A1 (en) 2004-06-23 2005-12-29 Peyman Gholam A Bifocal intraocular telescope for low vision correction
US6951391B2 (en) 2003-06-16 2005-10-04 Apollo Optical Systems Llc Bifocal multiorder diffractive lenses for vision correction
US20050046794A1 (en) 2003-06-17 2005-03-03 Silvestrini Thomas A. Method and apparatus for aligning a mask with the visual axis of an eye
ATE527570T1 (de) 2003-06-30 2011-10-15 Werner Fiala Intraokularlinse oder kontaktlinsen mit grosser tiefenschärfe
JP4038454B2 (ja) 2003-07-31 2008-01-23 株式会社ニデック 眼内レンズ
US7422604B2 (en) 2003-08-28 2008-09-09 Bausch & Lomb Incorporated Preloaded IOL injector
US20050056954A1 (en) 2003-09-12 2005-03-17 Devlin Brian Gerrard Method for making contact lenses
US20050137703A1 (en) 2003-12-05 2005-06-23 Vanderbilt University Accommodative intraocular lens
US7025455B2 (en) 2003-12-19 2006-04-11 J&J Vision Care, Inc. Multifocal contact lenses having a pinhole
EP1699385B1 (en) 2003-12-29 2012-10-24 Abbott Medical Optics Inc. Intraocular lenses having a visible light-selective-transmissive-region
US7281699B2 (en) 2003-12-29 2007-10-16 Bausch & Lomb Incorporated Universal accommodating IOL holder for lens processing and packaging
BRPI0418248A (pt) 2003-12-30 2007-04-17 Advanced Medical Optics Inc materiais de lente intra-ocular adequada para inserção através de um cartucho de furo pequeno
US20050187621A1 (en) 2004-02-24 2005-08-25 Brady Daniel G. Foldable unitary intraocular lens
TW201440760A (zh) 2004-07-16 2014-11-01 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
US10426600B2 (en) 2004-07-22 2019-10-01 University Of Houston Accommodating intraocular lens and methods of use
US20060064077A1 (en) 2004-08-13 2006-03-23 Peyman Gholam A Method for correcting hyperopia and presbyopia using a laser and an inlay outside the visual axis of eye
CN100368846C (zh) 2004-08-13 2008-02-13 亚洲光学股份有限公司 具有调整机构的照相镜头
US7061693B2 (en) 2004-08-16 2006-06-13 Xceed Imaging Ltd. Optical method and system for extended depth of focus
WO2006023871A2 (en) 2004-08-24 2006-03-02 Vision Membrane Technologies, Inc. Foldable intraocular lens with adaptable haptics
JP4555030B2 (ja) 2004-09-02 2010-09-29 富士フイルム株式会社 マイクロレンズアレイおよび光学部材並びにマイクロレンズアレイの作製方法
US9427313B2 (en) * 2004-09-17 2016-08-30 Gene Currie Intraocular lens (IOL)
CA2614519A1 (en) 2004-10-22 2006-05-04 Omer Yilmaz System and method for aligning an optic with an axis of an eye
AU2005299605C1 (en) 2004-10-25 2012-02-16 Johnson & Johnson Surgical Vision, Inc. Ophthalmic lens with multiple phase plates
US7922326B2 (en) 2005-10-25 2011-04-12 Abbott Medical Optics Inc. Ophthalmic lens with multiple phase plates
DE102004055683B4 (de) 2004-10-26 2006-09-07 Carl Zeiss Surgical Gmbh Augenchirurgie-Mikroskopiesystem und Verfahren hierzu
US7455691B2 (en) 2004-11-03 2008-11-25 Biovision, Ag Intraocular and intracorneal refractive lenses
US20060113054A1 (en) 2004-12-01 2006-06-01 Silvestrini Thomas A Method of making an ocular implant
US7491350B2 (en) 2004-12-01 2009-02-17 Acufocus, Inc. Method of making an ocular implant
US7446157B2 (en) 2004-12-07 2008-11-04 Key Medical Technologies, Inc. Nanohybrid polymers for ophthalmic applications
SE0403091D0 (sv) 2004-12-20 2004-12-20 Amo Groningen Bv New composition for injectable ophtalmic lenses
DE102004061943A1 (de) 2004-12-22 2006-07-06 *Acri.Tec Gesellschaft für ophthalmologische Produkte mbH Künstlicher in ein Auge implantierbarer Irisersatz
US7976577B2 (en) 2005-04-14 2011-07-12 Acufocus, Inc. Corneal optic formed of degradation resistant polymer
US20060235428A1 (en) 2005-04-14 2006-10-19 Silvestrini Thomas A Ocular inlay with locator
US7842367B2 (en) 2005-05-05 2010-11-30 Key Medical Technologies, Inc. Ultra violet, violet, and blue light filtering polymers for ophthalmic applications
DE102005032041A1 (de) 2005-07-08 2007-01-18 Carl Zeiss Meditec Ag Vorrichtung und Verfahren zum Ändern einer optischen und/oder mechanischen Eigenschaft einer in ein Auge implantierten Linse
JP2009503622A (ja) 2005-08-05 2009-01-29 ヴィジオジェン・インコーポレーテッド 調整された回折眼球内レンズ
DE102005045197B4 (de) 2005-09-21 2010-12-09 Schott Ag Verfahren zur Herstellung einer optischen Hybridlinse
CN101384704B (zh) 2005-10-12 2012-02-08 细胞生物工程公司 可再吸收的角膜扣状体
JP4851342B2 (ja) 2005-10-20 2012-01-11 三菱レイヨン株式会社 光制御フィルム、積層光制御フィルム、光制御フィルムの製造方法、および積層光制御フィルムの製造方法
CN1951843B (zh) 2005-10-21 2011-09-28 鸿富锦精密工业（深圳）有限公司 光学元件成型装置
ITBO20050647A1 (it) 2005-10-26 2007-04-27 Marinella Bergamaschi Lenti a contatto fotocromatiche a foro
US20070129797A1 (en) 2005-12-01 2007-06-07 Revision Optics, Inc. Intracorneal inlays
GB0603734D0 (en) 2006-02-24 2006-04-05 Applied Multilayers Ltd Method and apparatus for forming a coated optical lens
US8113651B2 (en) 2006-03-20 2012-02-14 High Performance Optics, Inc. High performance corneal inlay
CN100484498C (zh) 2006-04-19 2009-05-06 华中科技大学 一种柔性视网膜芯片及其制备方法
US20070258143A1 (en) 2006-05-08 2007-11-08 Valdemar Portney Aspheric multifocal diffractive ophthalmic lens
EP2074472A2 (en) 2006-05-31 2009-07-01 Junzhong Liang Methods and apparatus for improving vision
US20080077238A1 (en) 2006-09-21 2008-03-27 Advanced Medical Optics, Inc. Intraocular lenses for managing glare, adhesion, and cell migration
JP4812592B2 (ja) 2006-10-27 2011-11-09 パナソニック株式会社 複合光学部品の製造方法
US20080151190A1 (en) 2006-12-21 2008-06-26 Bentley Joseph R Corneal measurment apparatus and a method of using the same
US7641337B2 (en) 2006-12-22 2010-01-05 Bausch & Lomb Incorporated Ophthalmic lens including photochromic material
US8048156B2 (en) 2006-12-29 2011-11-01 Abbott Medical Optics Inc. Multifocal accommodating intraocular lens
AR064985A1 (es) * 2007-01-22 2009-05-06 E Vision Llc Lente electroactivo flexible
US20080306587A1 (en) 2007-02-21 2008-12-11 Jingjong Your Lens Material and Methods of Curing with UV Light
US20080255663A1 (en) 2007-04-13 2008-10-16 Akpek Esen K Artificial Cornea and Method of Making Same
US20080269884A1 (en) 2007-04-30 2008-10-30 Alcon, Inc. Graduated blue filtering intraocular lens
CN101322663A (zh) 2007-06-14 2008-12-17 苏州六六视觉科技股份有限公司 带虹膜隔人工晶状体
US8414123B2 (en) 2007-08-13 2013-04-09 Novartis Ag Toric lenses alignment using pre-operative images
US8747466B2 (en) 2007-08-27 2014-06-10 Amo Groningen, B.V. Intraocular lens having extended depth of focus
US8740978B2 (en) 2007-08-27 2014-06-03 Amo Regional Holdings Intraocular lens having extended depth of focus
WO2009050511A1 (en) 2007-10-16 2009-04-23 Donald Tan Ophthalmic surgical device for endothelial keratoplasty for descemet's stripping automated endothelial keratoplasty (dsaek) surgery
PL2211747T3 (pl) 2007-10-29 2019-12-31 Junzhong Liang Urządzenia do refrakcyjnej terapii prezbiopii
US20090164008A1 (en) 2007-12-21 2009-06-25 Xin Hong Lens surface with combined diffractive, toric, and aspheric components
US8480734B2 (en) 2007-12-27 2013-07-09 Anew Optics, Inc. Intraocular lens with accommodation
AU2009214036B2 (en) 2008-02-15 2014-04-17 Amo Regional Holdings System, ophthalmic lens, and method for extending depth of focus
JP5128308B2 (ja) 2008-02-20 2013-01-23 Ｈｏｙａ株式会社 眼内レンズ製造方法
US8439498B2 (en) * 2008-02-21 2013-05-14 Abbott Medical Optics Inc. Toric intraocular lens with modified power characteristics
US7780290B2 (en) 2008-02-21 2010-08-24 Abbott Medical Optics Inc. Toric intraocular lens with spatially-variant astigmatism
KR20100114133A (ko) 2008-03-18 2010-10-22 픽셀옵틱스, 인크. 진보한 전기-활성 광학 장치
IL190577A0 (en) 2008-04-02 2008-12-29 Nulens Ltd Cartridge for storing an iol and forceps for use therewith
NL2001503C2 (nl) 2008-04-21 2009-10-22 Oculentis B V Intra-oculaire lens.
US8167940B2 (en) 2008-05-06 2012-05-01 Novartis Ag Aspheric toric intraocular lens
US9060847B2 (en) 2008-05-19 2015-06-23 University Of Rochester Optical hydrogel material with photosensitizer and method for modifying the refractive index
US20090306773A1 (en) 2008-06-04 2009-12-10 Acufocus, Inc. Opaque corneal insert for refractive correction
KR20100004777A (ko) 2008-07-04 2010-01-13 김현호 인공수정체 및 인공수정체의 수술후 굴절오차 보정 방법
MX2011000419A (es) 2008-07-15 2011-02-24 Alcon Inc Iol acomodativo con profundidad de foco extendida y optica torica.
US8241354B2 (en) 2008-07-15 2012-08-14 Novartis Ag Extended depth of focus (EDOF) lens to increase pseudo-accommodation by utilizing pupil dynamics
US8441731B2 (en) 2008-09-04 2013-05-14 Innovega, Inc. System and apparatus for pixel matrix see-through display panels
US20100082017A1 (en) 2008-09-26 2010-04-01 Advanced Medical Optics, Inc. Laser modification of intraocular lens
US7878655B2 (en) * 2008-09-29 2011-02-01 Sifi Diagnostic Spa Systems and methods for implanting and examining intraocular lens
JP2010104772A (ja) 2008-09-30 2010-05-13 Yoichi Mikawa 眼内レンズ
US8292953B2 (en) 2008-10-20 2012-10-23 Amo Groningen B.V. Multifocal intraocular lens
WO2010059214A2 (en) 2008-11-20 2010-05-27 Insight Innovations, Llc Biocompatible biodegradable intraocular implant system
US20120232649A1 (en) 2008-11-20 2012-09-13 Insight Innovations, Llc Intraocular Lens Cell Migration Inhibition System
US7794633B2 (en) 2008-11-26 2010-09-14 Aptina Imaging Corporation Method and apparatus for fabricating lens masters
US9119565B2 (en) 2009-02-19 2015-09-01 Alcon Research, Ltd. Intraocular lens alignment
US8646916B2 (en) 2009-03-04 2014-02-11 Perfect Ip, Llc System for characterizing a cornea and obtaining an opthalmic lens
US8633292B2 (en) 2009-03-26 2014-01-21 Signet Armorlite Polyurethane-based photochromic optical materials
WO2010118469A1 (en) 2009-04-16 2010-10-21 Peter Leo Macken Surgical tool
US20100312336A1 (en) 2009-06-09 2010-12-09 Xin Hong Zonal diffractive multifocal intraocular lens with central monofocal diffractive region
TW201103518A (en) 2009-07-17 2011-02-01 Alcon Inc Accommodative IOL with toric optic and extended depth of focus
US20110029074A1 (en) 2009-08-03 2011-02-03 Abbott Medical Optics Inc. Fixation of ophthalmic implants
BR112012008079A2 (pt) 2009-08-13 2016-03-01 Acufocus Inc enxerto de córnea com estruturas de transporte de nutrientes
US10004593B2 (en) 2009-08-13 2018-06-26 Acufocus, Inc. Intraocular lens with elastic mask
WO2011030509A1 (ja) 2009-09-11 2011-03-17 株式会社トプコン 眼科手術用顕微鏡
US20120203239A1 (en) 2009-10-13 2012-08-09 Acufocus,Inc. Method and apparatus for centration of an ocular implant
EP2455799B1 (en) 2009-10-20 2017-05-31 Universal View Co., Ltd. Soft contact lens
US20120309761A1 (en) 2009-10-27 2012-12-06 Agency For Science, Technology And Research Fast-response photochromic nanostructured contact lenses
EP2319457A1 (en) 2009-11-10 2011-05-11 Lenspecial S.r.L. Vision aiding system comprising at least one intraocular dioptric lens
USD656526S1 (en) 2009-11-10 2012-03-27 Acufocus, Inc. Ocular mask
GB2475550B (en) 2009-11-23 2012-09-12 Rayner Intraocular Lenses Ltd Intraocular lens
US8287593B2 (en) 2009-11-24 2012-10-16 Valdemar Portney Adjustable multifocal intraocular lens system
US20120245683A1 (en) 2009-12-04 2012-09-27 Acufocus, Inc. Corneal implant for refractive correction
US8857803B2 (en) 2009-12-14 2014-10-14 Novartis Ag Devices and methods for holding an intraocular lens during the processing and packaging of the intraocular lens
WO2011088107A2 (en) 2010-01-12 2011-07-21 Acufocus, Inc. Ocular inlay delivery system and method of use
US8531783B2 (en) 2010-02-09 2013-09-10 Xceed Imaging Ltd. Imaging method and system for imaging with extended depth of focus
TW201138744A (en) 2010-03-31 2011-11-16 Alcon Inc Adjustable intraocular lens system
US8308800B2 (en) 2010-04-09 2012-11-13 Chu Milton W Intraocular lenses with high contrast haptics, materials, and methods
JP5511516B2 (ja) 2010-05-31 2014-06-04 株式会社ニデック 眼科装置
WO2012006370A2 (en) 2010-07-07 2012-01-12 California Institute Of Technology On-demand photoinitiated polymerization
RU2459598C2 (ru) 2010-12-01 2012-08-27 Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" Устройство для повышения ротационной стабильности торических интраокулярных линз
USD645337S1 (en) 2011-01-15 2011-09-20 Group-A Autosports, Inc. Small washer
RU2457812C1 (ru) 2011-03-23 2012-08-10 Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" Искусственный хрусталик глаза
RU110978U1 (ru) 2011-03-23 2011-12-10 Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" Торическая интраокулярная линза с разметкой для ее ориентации
RU2456968C1 (ru) 2011-03-23 2012-07-27 государственное бюджетное учреждение "Уфимский научно-исследовательский институт глазных болезней Академии наук Республики Башкортостан (ГБУ "Уф НИИ ГБ АН РБ") Способ имплантации торических интраокулярных линз у детей
CN103649789B (zh) 2011-06-06 2016-03-16 光学转变公司 偏振光致变色制品
SG11201402675RA (en) 2011-11-29 2014-10-30 Novartis Ag Method of treating a lens forming surface of at least one mold half for molding ophthalmic lenses
WO2013082545A1 (en) 2011-12-02 2013-06-06 Acufocus, Inc. Ocular mask having selective spectral transmission
US8950859B2 (en) 2011-12-25 2015-02-10 Global-Ok Vision, Inc. Multi-focal optical lenses
CA3177993A1 (en) 2012-01-24 2013-08-01 The Regents Of The University Of Colorado, A Body Corporate Modular intraocular lens designs and methods
RU2493801C1 (ru) 2012-01-31 2013-09-27 Владимир Николаевич Трубилин Разметчик капсулорексиса и астигматической оси торической интраокулярной линзы
WO2013123265A1 (en) 2012-02-16 2013-08-22 Acufocus, Inc. Masked ocular device for implantation adjacent to an intraocular lens
EP2838472B1 (en) 2012-04-20 2020-09-23 Hanita Lenses R.C.A. Ltd. Intraocular assembly
US20130289543A1 (en) 2012-04-23 2013-10-31 David Haydn Mordaunt System and method for in situ creation of a small aperture intraocular lens
RU2517488C2 (ru) 2012-04-26 2014-05-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СамГМУ Минздрава России) Способ коррекции пресбиопии
RU134784U1 (ru) 2012-07-04 2013-11-27 Общество с ограниченной ответственностью предприятие "Репер-НН" Интраокулярная линза
RU2511081C1 (ru) 2012-08-03 2014-04-10 Владимир Николаевич Трубилин Торический разметчик капсулорексиса
WO2014054946A1 (en) 2012-10-01 2014-04-10 Akkolens International B.V. Artificial asymmetrical pupil for extended depth of field
TWI600418B (zh) * 2012-10-17 2017-10-01 布萊恩荷登視覺協會 用於屈光不正之鏡片、裝置、方法及系統
WO2014070332A1 (en) 2012-10-31 2014-05-08 Novartis Ag Method and system for providing a toric intraocular lens
RU2500368C1 (ru) 2012-11-09 2013-12-10 федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Способ имплантации торических интраокулярных линз
US20140131905A1 (en) 2012-11-09 2014-05-15 Acufocus, Inc. Process for manufacturing an intraocular lens
US8998984B2 (en) 2013-01-14 2015-04-07 Andrew F. Phillips Adjustable toric intraocular lens
US9204962B2 (en) 2013-03-13 2015-12-08 Acufocus, Inc. In situ adjustable optical mask
US9427922B2 (en) 2013-03-14 2016-08-30 Acufocus, Inc. Process for manufacturing an intraocular lens with an embedded mask
RU134049U1 (ru) 2013-04-02 2013-11-10 Общество с ограниченной ответственностью "Приморский центр микрохирургии глаза" Торическая интраокулярная линза с маркировкой цилиндрического компонента
EP2986258B1 (en) 2013-04-17 2018-11-28 Optimedica Corporation Laser fiducials for axis alignment in cataract surgery
ES2407457B1 (es) 2013-05-07 2014-04-09 Francisco Javier FERNÁNDEZ CAMBRA Marcador corneal de eje tórico pre-operatorio
DE102013105738A1 (de) 2013-06-04 2014-12-04 Faramarz Madjlessi Laserbehandlungsvorrichtung für die Refraktivchirurgie
BR102013015451A2 (pt) 2013-06-19 2014-06-10 Claudio Lovaglio Cancado Trindade Implante intra-ocular de pequena abertura (pinhole) para ampliação da profundidade de foco
US9968295B2 (en) 2013-08-07 2018-05-15 Novartis Ag Surgical guidance and planning software for astigmatism treatment
WO2015021323A1 (en) 2013-08-08 2015-02-12 Acufocus, Inc. Intraocular lens with elastic mask
KR101504475B1 (ko) 2013-08-23 2015-03-20 주식회사 지앤아이솔루션 광학 렌즈, 광학 렌즈 제조 장치 및 제조 방법
WO2015069927A1 (en) 2013-11-06 2015-05-14 Nexisvision, Inc. Bimodular contact lenses
US9341864B2 (en) 2013-11-15 2016-05-17 Nexisvision, Inc. Contact lenses having a reinforcing scaffold
CN203647535U (zh) 2013-11-27 2014-06-18 爱博诺德（北京）医疗科技有限公司 散光矫正型人工晶体
CN104127262B (zh) 2013-11-27 2016-07-27 爱博诺德（北京）医疗科技有限公司 散光矫正型人工晶体及其设计和生产方法
DE102013020706A1 (de) 2013-12-10 2015-06-11 Carl Zeiss Meditec Ag Verfahren zur optimierten Auswahl der in ein Auge zu implantierenden IOL
HUE043202T2 (hu) 2013-12-20 2019-08-28 Novartis Ag Formák kontaktlencsék elõállítására
US9782942B2 (en) 2013-12-30 2017-10-10 Verily Life Sciences Llc Methods and apparatus for positioning a structure on a polymer layer
WO2015108156A1 (ja) 2014-01-16 2015-07-23 興和株式会社 トーリック眼用レンズ
AU2015242298B2 (en) 2014-03-10 2019-11-14 Amo Groningen B.V. Intraocular lens that improves overall vision where there is a local loss of retinal function
ES2529267B1 (es) * 2014-09-25 2015-12-18 Sergio Oscar Luque Lente intraocular multifocal con profundidad de campo extendida
EP3220859B8 (en) 2014-11-19 2020-06-10 AcuFocus, Inc. Fracturable mask for treating presbyopia
US9358103B1 (en) * 2015-02-10 2016-06-07 Omega Ophthalmics Llc Prosthetic capsular devices, systems, and methods
US20170049560A1 (en) 2015-08-21 2017-02-23 Scott A. Cherne Intraocular Lens Holder
EP3359987B1 (en) 2015-10-05 2024-02-28 AcuFocus, Inc. Methods of molding intraocular lenses
KR102407311B1 (ko) 2015-11-24 2022-06-10 아큐포커스, 인크. 연장된 초점 깊이를 가진 원환형 작은 구멍의 안내 렌즈
US11395732B2 (en) 2017-07-05 2022-07-26 Acufocus, Inc. Protective lens holder
EP3681438A1 (en) 2017-09-11 2020-07-22 AMO Groningen B.V. Methods and apparatuses to increase intraocular lenses positional stability
CN111629692A (zh) 2017-09-20 2020-09-04 明视有限责任公司 单件式人工晶状体及其制造方法
WO2019123128A1 (en) 2017-12-21 2019-06-27 Novartis Ag Method for manufacturing toric contact lenses
US10898316B2 (en) 2018-03-01 2021-01-26 Jellisee Ophthalmics Inc Intraocular lens
WO2019217471A1 (en) 2018-05-09 2019-11-14 Acufocus, Inc. Intraocular implant with removable optic
US10932902B2 (en) 2018-08-03 2021-03-02 Johnson & Johnson Vision Care, Inc. Dynamically tunable apodized multiple-focus opthalmic devices and methods
WO2020107126A1 (en) 2018-11-30 2020-06-04 Ma Joseph J K Electrochromatic optical devices, systems, and methods
US20210290373A1 (en) 2020-03-23 2021-09-23 Gholam Peyman Optical implant and methods of implantation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795462A (en) * 1987-08-24 1989-01-03 Grendahl Dennis T Cylindrically segmented zone of focus artificial lens
US20110166652A1 (en) * 2007-08-27 2011-07-07 Amo Groningen B.V. Toric lens with decreased sensitivity to cylinder power and rotation and method of using the same
CN102448404A (zh) * 2009-08-13 2012-05-09 阿库福库斯公司 掩盖型眼内植入物和透镜
CN202490048U (zh) * 2012-02-29 2012-10-17 张斌 复曲面人工晶状体

Also Published As

Publication number Publication date
WO2017091520A1 (en) 2017-06-01
CA3005891C (en) 2023-12-12
CA3005891A1 (en) 2017-06-01
KR20180087285A (ko) 2018-08-01
US20230078298A1 (en) 2023-03-16
EP3384342A1 (en) 2018-10-10
KR102407311B1 (ko) 2022-06-10
US11464625B2 (en) 2022-10-11
EP3384342B1 (en) 2021-08-25
EP3384342A4 (en) 2019-08-14
JP7055747B2 (ja) 2022-04-18
US20180338826A1 (en) 2018-11-29
CN108431676B (zh) 2022-01-04
JP2018535075A (ja) 2018-11-29

Similar Documents

Publication Publication Date Title
CN108431676A (zh) 具有延伸的焦深的复曲面小孔口人工晶状体
US20230014535A1 (en) Multizonal lens with enhanced performance
AU2017202382B2 (en) Asymmetric lens design and method for preventing and/or slowing myopia progression
JP6953115B2 (ja) 近視の進行を予防及び／又は鈍化するための、非共軸小型レンズを具備するコンタクトレンズ
CA2545184C (en) Multi-zonal monofocal intraocular lens for correcting optical aberrations
CN110068937A (zh) 具有用于近视控制的光学非同轴区的眼科镜片
KR102453441B1 (ko) 근시 진행을 예방하고/하거나 늦추기 위한 동공 크기-무관형 렌즈 설계 및 방법
CN104777628B (zh) 提供改进的视觉质量的多焦点矫正
CN107219640A (zh) 用于预防和/或减慢近视发展的多焦点镜片设计和方法
CN108205208A (zh) 高加中心治疗区镜片设计以及用于预防和/或减慢近视发展的方法
CN101460114B (zh) 矫正人眼屈光不正的角膜植入物
CN105388629A (zh) 高加治疗区镜片设计以及用于预防和/或减慢近视发展的方法
CA2469761A1 (en) Myopic corneal ring with central accommodating portion
US20050288784A1 (en) Bifocal intraocular telescope for low vision correction
CN106659565B (zh) 具有放大同轴光学部的二期眼内透镜
KR20170056675A (ko) 연장된 피사계 심도를 갖는 다초점 안구내 렌즈
JP2021092820A (ja) 非回転対称の眼の収差のための快適性が最適化されたコンタクトレンズシステム
CN108836571A (zh) 人工透镜
US11504226B2 (en) Intraocular lenses for reducing the risk of posterior capsule opacification
CN106388974A (zh) 中间视觉完全矫正型非球面人工晶状体
US20190307555A1 (en) Hybrid optical edge for an intraocular lens (iol)
RU2792078C2 (ru) Офтальмологические линзы, содержащие элементарные линзы, для предотвращения и/или замедления прогрессирования миопии
CN102262307A (zh) 一种新型软性角膜接触镜
US20210386539A1 (en) Intraocular lenses for reducing negative dysphotopsia
WO2023060017A8 (en) Ophthalmic implants for correcting vision with a tunable optic, and methods of manufacture and use

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant