WO2003010307A1 - Peptide synthase gene, peptide synthase and process for producing dipeptide - Google Patents

Peptide synthase gene, peptide synthase and process for producing dipeptide Download PDF

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Publication number
WO2003010307A1
WO2003010307A1 PCT/JP2002/007635 JP0207635W WO03010307A1 WO 2003010307 A1 WO2003010307 A1 WO 2003010307A1 JP 0207635 W JP0207635 W JP 0207635W WO 03010307 A1 WO03010307 A1 WO 03010307A1
Authority
WO
WIPO (PCT)
Prior art keywords
peptide synthase
dipeptide
amino acid
culture
producing dipeptide
Prior art date
Application number
PCT/JP2002/007635
Other languages
English (en)
French (fr)
Inventor
Naoto Tonouchi
Sonoko Suzuki
Kenzo Yokozeki
Hiroyuki Nozaki
Masakazu Sugiyama
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Priority to KR1020047001175A priority Critical patent/KR100635803B1/ko
Priority to EP02751741A priority patent/EP1411116B1/en
Priority to DK02751741T priority patent/DK1411116T3/da
Priority to DE60226243T priority patent/DE60226243T2/de
Priority to JP2003515658A priority patent/JP4239819B2/ja
Publication of WO2003010307A1 publication Critical patent/WO2003010307A1/ja
Priority to US10/763,249 priority patent/US7288388B2/en
Priority to US11/589,842 priority patent/US7618796B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PCT/JP2002/007635 2001-07-26 2002-07-26 Peptide synthase gene, peptide synthase and process for producing dipeptide WO2003010307A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
KR1020047001175A KR100635803B1 (ko) 2001-07-26 2002-07-26 펩타이드 생성 효소 유전자, 펩타이드 생성 효소 및디펩타이드의 제조방법
EP02751741A EP1411116B1 (en) 2001-07-26 2002-07-26 Peptide synthase gene, peptide synthase and process for producing dipeptide
DK02751741T DK1411116T3 (da) 2001-07-26 2002-07-26 Peptidsyntasegen, peptidsyntase samt fremgangsmåde til fremstilling af dipeptid
DE60226243T DE60226243T2 (de) 2001-07-26 2002-07-26 Peptid-bildendes Enzymgen, Pepid-bildendes Enzym und Dipeptidherstellungsverfahren
JP2003515658A JP4239819B2 (ja) 2001-07-26 2002-07-26 ペプチド生成酵素遺伝子、ペプチド生成酵素およびジペプチドの製造方法
US10/763,249 US7288388B2 (en) 2001-07-26 2004-01-26 Peptide-forming enzyme gene, peptide-forming enzyme, and peptide producing method
US11/589,842 US7618796B2 (en) 2001-07-26 2006-10-31 Peptide-forming enzyme gene, peptide-forming enzyme, and peptide producing method

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001226568 2001-07-26
JP2001-226568 2001-07-26
JP2001-310547 2001-10-05
JP2001310547 2001-10-05

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/763,249 Continuation US7288388B2 (en) 2001-07-26 2004-01-26 Peptide-forming enzyme gene, peptide-forming enzyme, and peptide producing method

Publications (1)

Publication Number Publication Date
WO2003010307A1 true WO2003010307A1 (en) 2003-02-06

Family

ID=26619355

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/JP2002/007633 WO2003010187A1 (fr) 2001-07-26 2002-07-26 Procede de production de dipeptides, l-aminoacide amide hydrolase s'utilisant dans ce contexte et procede de production de l-aminoacide amide hydrolase
PCT/JP2002/007634 WO2003010189A1 (en) 2001-07-26 2002-07-26 Process for producing dipeptide, peptide synthase to be used therein and process for producing peptide synthase
PCT/JP2002/007635 WO2003010307A1 (en) 2001-07-26 2002-07-26 Peptide synthase gene, peptide synthase and process for producing dipeptide

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/JP2002/007633 WO2003010187A1 (fr) 2001-07-26 2002-07-26 Procede de production de dipeptides, l-aminoacide amide hydrolase s'utilisant dans ce contexte et procede de production de l-aminoacide amide hydrolase
PCT/JP2002/007634 WO2003010189A1 (en) 2001-07-26 2002-07-26 Process for producing dipeptide, peptide synthase to be used therein and process for producing peptide synthase

Country Status (9)

Country Link
US (5) US7037673B2 (ja)
EP (4) EP1411060A4 (ja)
JP (3) JP4289151B2 (ja)
KR (2) KR100602808B1 (ja)
CN (4) CN101982546A (ja)
DE (1) DE60226243T2 (ja)
DK (2) DK1911839T3 (ja)
RU (3) RU2280077C2 (ja)
WO (3) WO2003010187A1 (ja)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011653A1 (ja) * 2002-07-26 2004-02-05 Ajinomoto Co., Inc. 新規ペプチド生成酵素遺伝子
WO2005052153A1 (ja) * 2003-11-27 2005-06-09 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
EP1529837A3 (en) * 2003-11-05 2005-06-29 Kyowa Hakko Kogyo Co., Ltd. Microorganisms producing dipeptides and process for producing dipeptides using the microorganisms
JP2005218369A (ja) * 2004-02-05 2005-08-18 Ajinomoto Co Inc 変異型微生物およびこれを用いたペプチドの製造方法
WO2006001381A1 (ja) * 2004-06-25 2006-01-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドまたはジペプチド誘導体の製造法
EP1658375A1 (en) * 2003-07-25 2006-05-24 Ajinomoto Co., Inc. Method for producing dipeptides
JP2007319063A (ja) * 2006-05-31 2007-12-13 Okayama Prefecture ジペプチドの製造方法
WO2008001837A1 (en) 2006-06-28 2008-01-03 Kyowa Hakko Bio Co., Ltd. Method for purification of oligopeptide
WO2008126783A1 (ja) 2007-04-06 2008-10-23 Kyowa Hakko Bio Co., Ltd. ジペプチドの製造法
WO2011126054A1 (ja) 2010-04-07 2011-10-13 国立大学法人京都大学 生理活性ペプチド
JP5121462B2 (ja) * 2005-12-27 2013-01-16 協和発酵バイオ株式会社 ジペプチドの製造法
EP4094588A1 (en) 2015-03-02 2022-11-30 Kyoto University Peptide

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RU2280077C2 (ru) 2001-07-26 2006-07-20 Адзиномото Ко., Инк. Ген пептидообразующего фермента, пептидообразующий фермент и способ получения дипептида
ATE458056T1 (de) 2002-07-26 2010-03-15 Ajinomoto Kk Verfahren zur herstellung eines tripeptids oder höheren peptids
JP4447557B2 (ja) * 2003-11-28 2010-04-07 協和発酵バイオ株式会社 ジペプチドの製造法
JP2005168405A (ja) * 2003-12-11 2005-06-30 Ajinomoto Co Inc ジペプチドの製造方法
CN1320099C (zh) * 2005-02-04 2007-06-06 南京工业大学 利用北里孢菌PL6－3制备ε－聚赖氨酸及其盐的方法
CN101151369B (zh) * 2005-03-29 2017-02-15 协和发酵生化株式会社 二肽的结晶及其制备方法
CN101589155A (zh) * 2007-01-11 2009-11-25 丹尼斯科美国公司 在含粗甘油的培养基中生产酶
US8104191B2 (en) 2008-07-31 2012-01-31 Electrolux Home Products, Inc. Laundry dryer providing moisture application during tumbling and reduced airflow
KR101144987B1 (ko) * 2010-04-12 2012-05-11 목원대학교 산학협력단 크리세오박테리움 ｆｂｆ-7 균주 배양물 및 이를 함유하는 뿌리혹선충 방제용 조성물
RU2012129311A (ru) 2012-07-11 2014-01-20 Закрытое акционерное общество " Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Днк, кодирующая дипептид-синтезирующий фермер (варианты), бактерия рода escherichia и способ получения дипептидов с ее использованием
CN103114068B (zh) * 2013-03-15 2014-06-11 江苏南资环保科技有限公司 一株哌嗪降解无色杆菌菌mbpq-cg及其应用
RU2560980C2 (ru) * 2013-07-11 2015-08-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") ДНК, КОДИРУЮЩАЯ ДИПЕПТИД-СИНТЕЗИРУЮЩИЙ ФЕРМЕНТ (ВАРИАНТЫ), БАКТЕРИЯ РОДА Escherichia И СПОСОБ ПОЛУЧЕНИЯ ДИПЕПТИДОВ С ЕЕ ИСПОЛЬЗОВАНИЕМ
CN104480172A (zh) * 2014-11-19 2015-04-01 江南大学 一种利用重组大肠杆菌生产l-丙氨酰-l-谷氨酰胺的方法
CN106565822A (zh) * 2016-10-17 2017-04-19 湖北泓肽生物科技有限公司 手性l‑丙氨酰‑苯丙氨酸的制备方法
EP3564376B1 (en) * 2016-12-30 2021-12-15 Innobio Corporation Limited Gene encoding alanyl-glutamine dipeptide biosynthetic enzyme and application thereof
FR3076992B1 (fr) 2018-01-23 2022-10-14 Samirath Adeyendju Akanke Alli Dispositif de protection vulvaire, kit de protection vulvaire et anale et procede d'installation d'une telle protection
WO2020126484A1 (en) * 2018-12-18 2020-06-25 Patheon Austria Gmbh & Co Kg Single step biocatalytic amidation

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WO2001000842A2 (en) * 1999-06-25 2001-01-04 Basf Aktiengesellschaft Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation
EP1108790A2 (en) * 1999-12-16 2001-06-20 Kyowa Hakko Kogyo Co., Ltd. Novel polynucleotides

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Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8039232B2 (en) 2002-07-26 2011-10-18 Ajinomoto Co., Inc. Method for producing a dipeptide
US7531340B2 (en) 2002-07-26 2009-05-12 Ajinomoto Co., Inc. Peptide-forming enzyme gene
US7736876B2 (en) 2002-07-26 2010-06-15 Ajinomoto Co., Inc. Peptide-forming enzyme gene
US8389241B2 (en) 2002-07-26 2013-03-05 Ajinomoto Co., Inc. Enzyme that catalyzes a peptide-forming reaction from a carboxy component and an amine component, microbe producing the same, and a method of producing a dipeptide using the enzyme or microbe
US8753841B2 (en) 2002-07-26 2014-06-17 Ajinomoto Co., Inc. Enzyme that catalyzes a peptide-forming reaction from a carboxy component and an amine component, microbe producing the same, and a method of producing a dipeptide using the enzyme or microbe
US7736871B2 (en) 2002-07-26 2010-06-15 Ajinomoto Co., Inc. Peptide-forming enzyme gene
WO2004011653A1 (ja) * 2002-07-26 2004-02-05 Ajinomoto Co., Inc. 新規ペプチド生成酵素遺伝子
US8329428B2 (en) 2002-07-26 2012-12-11 Ajinomoto Co., Inc. Enzyme that catalyzes a peptide-forming reaction from a carboxy component and an amine component, microbe producing the same, and a method of producing a dipeptide using the enzyme or microbe
US7288389B2 (en) 2002-07-26 2007-10-30 Ajinomoto Co., Inc. Peptide-forming enzyme gene
US8084227B2 (en) 2003-07-25 2011-12-27 Ajinomoto Co., Inc. Method for producing dipeptides
EP1658375A1 (en) * 2003-07-25 2006-05-24 Ajinomoto Co., Inc. Method for producing dipeptides
EP1658375A4 (en) * 2003-07-25 2009-03-18 Ajinomoto Kk PROCESS FOR THE PREPARATION OF DIPEPTIDES
EP1865052A3 (en) * 2003-11-05 2010-09-22 Kyowa Hakko Bio Co., Ltd. Microorganisms producing dipeptides and process for producing dipeptides using the microorganisms
JPWO2005045006A1 (ja) * 2003-11-05 2007-05-17 協和醗酵工業株式会社 ジペプチドを生産する微生物および該微生物を用いたジペプチドの製造法
JP4593476B2 (ja) * 2003-11-05 2010-12-08 協和発酵バイオ株式会社 ジペプチドを生産する微生物および該微生物を用いたジペプチドの製造法
EP1529837A3 (en) * 2003-11-05 2005-06-29 Kyowa Hakko Kogyo Co., Ltd. Microorganisms producing dipeptides and process for producing dipeptides using the microorganisms
JPWO2005052153A1 (ja) * 2003-11-27 2007-06-21 協和醗酵工業株式会社 ジペプチドの製造法
JP4731327B2 (ja) * 2003-11-27 2011-07-20 協和発酵バイオ株式会社 ジペプチドの製造法
WO2005052153A1 (ja) * 2003-11-27 2005-06-09 Kyowa Hakko Kogyo Co., Ltd. ジペプチドの製造法
JP4507618B2 (ja) * 2004-02-05 2010-07-21 味の素株式会社 変異型微生物およびこれを用いたペプチドの製造方法
JP2005218369A (ja) * 2004-02-05 2005-08-18 Ajinomoto Co Inc 変異型微生物およびこれを用いたペプチドの製造方法
WO2006001381A1 (ja) * 2004-06-25 2006-01-05 Kyowa Hakko Kogyo Co., Ltd. ジペプチドまたはジペプチド誘導体の製造法
JP5121462B2 (ja) * 2005-12-27 2013-01-16 協和発酵バイオ株式会社 ジペプチドの製造法
JP2007319063A (ja) * 2006-05-31 2007-12-13 Okayama Prefecture ジペプチドの製造方法
WO2008001837A1 (en) 2006-06-28 2008-01-03 Kyowa Hakko Bio Co., Ltd. Method for purification of oligopeptide
WO2008126783A1 (ja) 2007-04-06 2008-10-23 Kyowa Hakko Bio Co., Ltd. ジペプチドの製造法
WO2011126054A1 (ja) 2010-04-07 2011-10-13 国立大学法人京都大学 生理活性ペプチド
EP4094588A1 (en) 2015-03-02 2022-11-30 Kyoto University Peptide

Also Published As

Publication number Publication date
JPWO2003010189A1 (ja) 2004-11-18
EP1911839B1 (en) 2011-10-26
EP1411116A1 (en) 2004-04-21
CN100422207C (zh) 2008-10-01
CN1529712A (zh) 2004-09-15
CN1268742C (zh) 2006-08-09
US7618796B2 (en) 2009-11-17
JPWO2003010187A1 (ja) 2004-11-18
DK1411116T3 (da) 2008-08-25
DK1911839T3 (da) 2011-12-05
JP4289151B2 (ja) 2009-07-01
DE60226243D1 (de) 2008-06-05
WO2003010189A1 (en) 2003-02-06
EP1411060A1 (en) 2004-04-21
US20070048838A1 (en) 2007-03-01
US20070042459A1 (en) 2007-02-22
US20050054067A1 (en) 2005-03-10
EP1911839A1 (en) 2008-04-16
WO2003010187A1 (fr) 2003-02-06
US20040137558A1 (en) 2004-07-15
RU2279440C2 (ru) 2006-07-10
RU2316596C2 (ru) 2008-02-10
EP1411116A4 (en) 2005-08-24
EP1411060A4 (en) 2006-09-13
RU2003137001A (ru) 2005-05-27
RU2280077C2 (ru) 2006-07-20
CN1535279A (zh) 2004-10-06
DE60226243T2 (de) 2009-05-14
KR100635803B1 (ko) 2006-10-19
KR20040023686A (ko) 2004-03-18
KR20040026658A (ko) 2004-03-31
CN101982546A (zh) 2011-03-02
US7037673B2 (en) 2006-05-02
CN1558947A (zh) 2004-12-29
JP4239819B2 (ja) 2009-03-18
US7754466B2 (en) 2010-07-13
EP1411116B1 (en) 2008-04-23
US7288388B2 (en) 2007-10-30
EP1411062A1 (en) 2004-04-21
US20050037453A1 (en) 2005-02-17
JP4273967B2 (ja) 2009-06-03
KR100602808B1 (ko) 2006-07-20
JPWO2003010307A1 (ja) 2004-11-18
RU2004105652A (ru) 2005-04-27
RU2005138717A (ru) 2007-06-20
EP1411062A4 (en) 2006-09-13

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