DK163435C - Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf - Google Patents

Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf

Info

Publication number
DK163435C
DK163435C DK452188A DK452188A DK163435C DK 163435 C DK163435 C DK 163435C DK 452188 A DK452188 A DK 452188A DK 452188 A DK452188 A DK 452188A DK 163435 C DK163435 C DK 163435C
Authority
DK
Denmark
Prior art keywords
amino
aralkyl
aryl
alkyl
acid residue
Prior art date
Application number
DK452188A
Other languages
English (en)
Other versions
DK452188A (da
DK452188D0 (da
DK163435B (da
Inventor
Stig Aasmul-Olsen
Pia Thorbek
Fred Widmer
Soeren Hansen
Original Assignee
Carlsberg Biotechnology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlsberg Biotechnology Ltd filed Critical Carlsberg Biotechnology Ltd
Publication of DK452188D0 publication Critical patent/DK452188D0/da
Priority to DK452188A priority Critical patent/DK163435C/da
Priority to DE68913880T priority patent/DE68913880T2/de
Priority to AT89308232T priority patent/ATE103003T1/de
Priority to JP1508952A priority patent/JPH04501056A/ja
Priority to AU40792/89A priority patent/AU4079289A/en
Priority to EP89308232A priority patent/EP0359399B1/en
Priority to PCT/DK1989/000193 priority patent/WO1990001555A1/en
Publication of DK452188A publication Critical patent/DK452188A/da
Publication of DK163435B publication Critical patent/DK163435B/da
Application granted granted Critical
Publication of DK163435C publication Critical patent/DK163435C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK452188A 1988-08-12 1988-08-12 Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf DK163435C (da)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DK452188A DK163435C (da) 1988-08-12 1988-08-12 Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf
DE68913880T DE68913880T2 (de) 1988-08-12 1989-08-14 Verfahren zur enzymatischen Herstellung von Dipeptiden.
AT89308232T ATE103003T1 (de) 1988-08-12 1989-08-14 Verfahren zur enzymatischen herstellung von dipeptiden.
JP1508952A JPH04501056A (ja) 1988-08-12 1989-08-14 ジペプチドまたは構造関連化合物の酵素的製造方法
AU40792/89A AU4079289A (en) 1988-08-12 1989-08-14 A process for enzymatic production of dipeptides or structurally related compounds
EP89308232A EP0359399B1 (en) 1988-08-12 1989-08-14 Process for the enzymatic production of dipeptides
PCT/DK1989/000193 WO1990001555A1 (en) 1988-08-12 1989-08-14 A process for enzymatic production of dipeptides or structurally related compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK452188 1988-08-12
DK452188A DK163435C (da) 1988-08-12 1988-08-12 Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf

Publications (4)

Publication Number Publication Date
DK452188D0 DK452188D0 (da) 1988-08-12
DK452188A DK452188A (da) 1990-02-13
DK163435B DK163435B (da) 1992-03-02
DK163435C true DK163435C (da) 1992-07-20

Family

ID=8134301

Family Applications (1)

Application Number Title Priority Date Filing Date
DK452188A DK163435C (da) 1988-08-12 1988-08-12 Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf

Country Status (7)

Country Link
EP (1) EP0359399B1 (da)
JP (1) JPH04501056A (da)
AT (1) ATE103003T1 (da)
AU (1) AU4079289A (da)
DE (1) DE68913880T2 (da)
DK (1) DK163435C (da)
WO (1) WO1990001555A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR930002966B1 (ko) * 1990-11-24 1993-04-16 주식회사 미 원 디펩티드의 제조방법
US5508182A (en) * 1991-02-13 1996-04-16 Schneider; Manfred P. Esterification of hydrophilic polyols by adsorption onto a solid support and employing a substrate-immiscible solvent
DK53191D0 (da) * 1991-03-25 1991-03-25 Carlbiotech Ltd As Organosvovlforbindelse og farmaceutisk praeparat indeholdende en saadan forbindelse
WO1995003321A1 (en) * 1993-07-20 1995-02-02 Bionebraska, Inc. Method for endomodification of proteins
FR2708938B1 (fr) * 1993-08-09 1995-11-03 Bioeurope Procédé enzymatique perfectionné de préparation d'oligomères de L-lysine.
DE19834308C2 (de) * 1998-07-30 2002-11-07 Univ Leipzig Verfahren zur Herstellung von Säureamiden
RU2279440C2 (ru) * 2001-07-26 2006-07-10 Адзиномото Ко., Инк. Способ получения l-аланил-l-глутамина
KR20030080439A (ko) * 2002-04-08 2003-10-17 새롬시엠에스 주식회사 인쇄매체를 이용한 홀로그램 부분 정착, 박리방법 및 그에의해 형성된 플라스틱 필름
ATE458056T1 (de) 2002-07-26 2010-03-15 Ajinomoto Kk Verfahren zur herstellung eines tripeptids oder höheren peptids
JP4501689B2 (ja) * 2002-07-26 2010-07-14 味の素株式会社 ペプチドを生成する新規酵素およびこれを生産する微生物およびこれらを用いるジペプチドの製造方法
PL374830A1 (en) * 2002-07-26 2005-10-31 Ajinomoto Co, Inc. Novel peptide synthase gene
JP2005040037A (ja) 2003-07-25 2005-02-17 Ajinomoto Co Inc ジペプチドの製造方法、それに用いるペプチド生成酵素、およびペプチド生成酵素の製造方法
JP2005168405A (ja) 2003-12-11 2005-06-30 Ajinomoto Co Inc ジペプチドの製造方法
JP5754682B2 (ja) * 2010-01-27 2015-07-29 国立大学法人鳥取大学 Ｄ−，ｌ−ペプチドの立体選択的合成法
EP2765190B1 (en) 2011-10-07 2018-05-23 Ajinomoto Co., Inc. Mutant y-glutamyltransferase, and method for producing y-glutamylvalylglycine or salt thereof
CN107936089B (zh) * 2017-11-07 2021-01-29 重庆大学 一种合成苯丙氨酰-赖氨酸二肽的方法
WO2019208700A1 (ja) * 2018-04-26 2019-10-31 ゼリア新薬工業株式会社 ジペプチド及びこれを含有する医薬組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI70597C (fi) * 1979-04-06 1986-09-24 Carlsberg Biotechnology Ltd Foerfarande foer enzymatisk framstaellning av peptider
US4506011A (en) * 1981-09-05 1985-03-19 Toyo Soda Manufacturing Co., Ltd. Process for preparation of aspartylphenylalanine alkyl esters
DE3573614D1 (en) * 1984-03-07 1989-11-16 Ajinomoto Kk Process for the production of l-aspartyl-l-phenylalanine ester
NZ217813A (en) * 1985-10-21 1991-01-29 Grace W R & Co Dipeptides and process for their preparation using an enzyme coupling agent
EP0269390B1 (en) * 1986-11-21 1993-08-25 Genencor International, Inc. Enzymatic l-aspartyl-l-phenylalanine alkyl ester production
DK72587D0 (da) * 1987-02-13 1987-02-13 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk fremstilling af dipeptider

Also Published As

Publication number Publication date
JPH04501056A (ja) 1992-02-27
DE68913880D1 (de) 1994-04-21
DK452188A (da) 1990-02-13
AU4079289A (en) 1990-03-05
WO1990001555A1 (en) 1990-02-22
DE68913880T2 (de) 1994-09-22
DK452188D0 (da) 1988-08-12
ATE103003T1 (de) 1994-04-15
EP0359399A1 (en) 1990-03-21
DK163435B (da) 1992-03-02
EP0359399B1 (en) 1994-03-16

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