DE69613305D1 - Verbesserte enzymatische Kupplungsreaktion von N-geschützte L-Asparaginsäure und Phenylalaninmethylester - Google Patents
Verbesserte enzymatische Kupplungsreaktion von N-geschützte L-Asparaginsäure und PhenylalaninmethylesterInfo
- Publication number
- DE69613305D1 DE69613305D1 DE69613305T DE69613305T DE69613305D1 DE 69613305 D1 DE69613305 D1 DE 69613305D1 DE 69613305 T DE69613305 T DE 69613305T DE 69613305 T DE69613305 T DE 69613305T DE 69613305 D1 DE69613305 D1 DE 69613305D1
- Authority
- DE
- Germany
- Prior art keywords
- protected
- methyl ester
- phenylalanine methyl
- coupling reaction
- aspartic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95202744 | 1995-10-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69613305D1 true DE69613305D1 (de) | 2001-07-19 |
DE69613305T2 DE69613305T2 (de) | 2002-05-02 |
Family
ID=8220708
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69613305T Expired - Fee Related DE69613305T2 (de) | 1995-10-11 | 1996-09-23 | Verbesserte enzymatische Kupplungsreaktion von N-geschützte L-Asparaginsäure und Phenylalaninmethylester |
Country Status (5)
Country | Link |
---|---|
US (1) | US5693485A (de) |
JP (1) | JPH09271389A (de) |
KR (1) | KR970021094A (de) |
AT (1) | ATE202146T1 (de) |
DE (1) | DE69613305T2 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6225493B1 (en) * | 2000-08-21 | 2001-05-01 | The Nutrasweet Company | Metal ion assisted N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester isomer resolution |
EP1264896A1 (de) * | 2001-06-07 | 2002-12-11 | Holland Sweetener Company V.o.F. | Enzymatische Kupplung von L-Phenylalaninemethylester und N-Benzyloxycarbonyl-Asparagensäure in einem kontinuierlichen oder fed-batch Verfahren |
JPWO2007000994A1 (ja) * | 2005-06-28 | 2009-01-22 | 中外製薬株式会社 | 抗hcv作用を有する化合物の製造方法 |
US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2801238C2 (de) * | 1977-01-27 | 1986-06-05 | (Zaidanhojin) Sagami Chemical Research Center, Tokio/Tokyo | Verfahren zur Herstellung von Salzen aus L,L-Dipeptiden und Phenylalaninestern |
JPS55135595A (en) * | 1979-04-03 | 1980-10-22 | Toyo Soda Mfg Co Ltd | Preparation of dipeptide |
EP0075160B1 (de) * | 1981-09-21 | 1987-01-07 | Toyo Soda Manufacturing Co., Ltd. | Verfahren zur Gewinnung eines Dipeptidderivates |
JPS5917997A (ja) * | 1982-07-23 | 1984-01-30 | Toyo Soda Mfg Co Ltd | ジペプチドエステルとアミノ酸エステルとの付加化合物の製造方法 |
US4873359A (en) * | 1985-10-21 | 1989-10-10 | W. R. Grace & Co. - Conn. | Process for preparing as partyl-phenylalanine dipeptides |
US5002872A (en) * | 1989-05-10 | 1991-03-26 | W. R. Grace & Co.-Conn. | Enzyme mediated coupling reactions |
KR930002966B1 (ko) * | 1990-11-24 | 1993-04-16 | 주식회사 미 원 | 디펩티드의 제조방법 |
US5279946A (en) * | 1991-07-10 | 1994-01-18 | Development Center For Biotechnology | Process for the preparation of N-benzyloxycarbonyl-alpha-L-aspartyl-L-phenylalanine methyl ester |
-
1996
- 1996-09-23 DE DE69613305T patent/DE69613305T2/de not_active Expired - Fee Related
- 1996-09-23 AT AT96202653T patent/ATE202146T1/de not_active IP Right Cessation
- 1996-10-10 KR KR1019960046010A patent/KR970021094A/ko not_active Application Discontinuation
- 1996-10-11 US US08/729,507 patent/US5693485A/en not_active Expired - Fee Related
- 1996-10-11 JP JP8269795A patent/JPH09271389A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US5693485A (en) | 1997-12-02 |
ATE202146T1 (de) | 2001-06-15 |
JPH09271389A (ja) | 1997-10-21 |
KR970021094A (ko) | 1997-05-28 |
DE69613305T2 (de) | 2002-05-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |