DE69613305D1 - Verbesserte enzymatische Kupplungsreaktion von N-geschützte L-Asparaginsäure und Phenylalaninmethylester - Google Patents

Verbesserte enzymatische Kupplungsreaktion von N-geschützte L-Asparaginsäure und Phenylalaninmethylester

Info

Publication number
DE69613305D1
DE69613305D1 DE69613305T DE69613305T DE69613305D1 DE 69613305 D1 DE69613305 D1 DE 69613305D1 DE 69613305 T DE69613305 T DE 69613305T DE 69613305 T DE69613305 T DE 69613305T DE 69613305 D1 DE69613305 D1 DE 69613305D1
Authority
DE
Germany
Prior art keywords
protected
methyl ester
phenylalanine methyl
coupling reaction
aspartic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69613305T
Other languages
English (en)
Other versions
DE69613305T2 (de
Inventor
Tsuneo Harada
Shigeaki Irino
Yukio Kunisawa
Kiyotaka Oyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Holland Sweetener Co VOF
Original Assignee
Holland Sweetener Co VOF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Holland Sweetener Co VOF filed Critical Holland Sweetener Co VOF
Application granted granted Critical
Publication of DE69613305D1 publication Critical patent/DE69613305D1/de
Publication of DE69613305T2 publication Critical patent/DE69613305T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69613305T 1995-10-11 1996-09-23 Verbesserte enzymatische Kupplungsreaktion von N-geschützte L-Asparaginsäure und Phenylalaninmethylester Expired - Fee Related DE69613305T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95202744 1995-10-11

Publications (2)

Publication Number Publication Date
DE69613305D1 true DE69613305D1 (de) 2001-07-19
DE69613305T2 DE69613305T2 (de) 2002-05-02

Family

ID=8220708

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69613305T Expired - Fee Related DE69613305T2 (de) 1995-10-11 1996-09-23 Verbesserte enzymatische Kupplungsreaktion von N-geschützte L-Asparaginsäure und Phenylalaninmethylester

Country Status (5)

Country Link
US (1) US5693485A (de)
JP (1) JPH09271389A (de)
KR (1) KR970021094A (de)
AT (1) ATE202146T1 (de)
DE (1) DE69613305T2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225493B1 (en) * 2000-08-21 2001-05-01 The Nutrasweet Company Metal ion assisted N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester isomer resolution
EP1264896A1 (de) * 2001-06-07 2002-12-11 Holland Sweetener Company V.o.F. Enzymatische Kupplung von L-Phenylalaninemethylester und N-Benzyloxycarbonyl-Asparagensäure in einem kontinuierlichen oder fed-batch Verfahren
JPWO2007000994A1 (ja) * 2005-06-28 2009-01-22 中外製薬株式会社 抗ｈｃｖ作用を有する化合物の製造方法
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2801238C2 (de) * 1977-01-27 1986-06-05 (Zaidanhojin) Sagami Chemical Research Center, Tokio/Tokyo Verfahren zur Herstellung von Salzen aus L,L-Dipeptiden und Phenylalaninestern
JPS55135595A (en) * 1979-04-03 1980-10-22 Toyo Soda Mfg Co Ltd Preparation of dipeptide
DE3274985D1 (en) * 1981-09-21 1987-02-12 Toyo Soda Mfg Co Ltd Process for recovering a dipeptide derivative
JPS5917997A (ja) * 1982-07-23 1984-01-30 Toyo Soda Mfg Co Ltd ジペプチドエステルとアミノ酸エステルとの付加化合物の製造方法
US4873359A (en) * 1985-10-21 1989-10-10 W. R. Grace & Co. - Conn. Process for preparing as partyl-phenylalanine dipeptides
US5002872A (en) * 1989-05-10 1991-03-26 W. R. Grace & Co.-Conn. Enzyme mediated coupling reactions
KR930002966B1 (ko) * 1990-11-24 1993-04-16 주식회사 미 원 디펩티드의 제조방법
US5279946A (en) * 1991-07-10 1994-01-18 Development Center For Biotechnology Process for the preparation of N-benzyloxycarbonyl-alpha-L-aspartyl-L-phenylalanine methyl ester

Also Published As

Publication number Publication date
KR970021094A (ko) 1997-05-28
JPH09271389A (ja) 1997-10-21
DE69613305T2 (de) 2002-05-02
US5693485A (en) 1997-12-02
ATE202146T1 (de) 2001-06-15

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Legal Events

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8339 Ceased/non-payment of the annual fee