WO1999020331A1 - Method and apparatus for delivering aerosolized medication - Google Patents

Method and apparatus for delivering aerosolized medication Download PDF

Info

Publication number
WO1999020331A1
WO1999020331A1 PCT/US1998/021667 US9821667W WO9920331A1 WO 1999020331 A1 WO1999020331 A1 WO 1999020331A1 US 9821667 W US9821667 W US 9821667W WO 9920331 A1 WO9920331 A1 WO 9920331A1
Authority
WO
WIPO (PCT)
Prior art keywords
die
conduit
air
canister
medication
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/021667
Other languages
English (en)
French (fr)
Inventor
Thomas Alex Armer
Bryce Burwick Evans
Nahed Mohsen Mohsen
Richard Matthew Pavkov
Atul M. Sudhalkar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SYSTEMIC PULMONARY DEVELOPMENT Ltd
Systemic Pulmonary Dev Ltd
Original Assignee
SYSTEMIC PULMONARY DEVELOPMENT Ltd
Systemic Pulmonary Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ504021A priority Critical patent/NZ504021A/xx
Application filed by SYSTEMIC PULMONARY DEVELOPMENT Ltd, Systemic Pulmonary Dev Ltd filed Critical SYSTEMIC PULMONARY DEVELOPMENT Ltd
Priority to KR1020007004125A priority patent/KR20010031187A/ko
Priority to JP2000516721A priority patent/JP2001520088A/ja
Priority to AU10847/99A priority patent/AU750459B2/en
Priority to CN98811903A priority patent/CN1285759A/zh
Priority to MXPA00003766A priority patent/MXPA00003766A/es
Publication of WO1999020331A1 publication Critical patent/WO1999020331A1/en
Anticipated expiration legal-status Critical
Priority to AU44363/02A priority patent/AU777488B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A61M15/0088—Inhalation chambers with variable volume
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0095—Preventing manual activation in absence of inhalation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Definitions

  • the present invention relates to methods and apparatus for delivering a
  • Aerosols are increasingly being used for delivering medication for therapeutic treatment of the lungs.
  • inhalers for example, in the treatment of asthma, inhalers
  • MDIs metered dose inhalers
  • DPIs dry powder inhalers
  • the medication is provided by the pharmaceutical manufacturer in a pressurized aerosol canister, with the medication being suspended or dissolved in a liquid propellant such as a chlorofluorocarbon (CFC) or
  • the canister includes a metering valve having a hollow
  • a typical MDI for use with such a canister includes a
  • the housing having an actuator and nozzle.
  • the canister is inserted into the housing with the hollow discharge stem of the canister being received in a bore in the actuator.
  • the housing further defines a flowpath in fluid communication with the nozzle, the flowpath having an outlet at a mouthpiece portion of the housing, such that the aerosolized medication may be inhaled after it exits the mouthpiece portion.
  • the patient either inserts the mouthpiece into the mouth with the lips closed around the mouthpiece, or holds the mouthpiece at a slight distance away from an open mouth. The patient then depresses the canister to discharge the medication, and simultaneously inhales.
  • Existing MDIs suffer from a number of significant disadvantages.
  • One problem with existing MDIs is poor delivery efficiency of the medication. It has been estimated that on average, with existing MDIs, only about 10 percent of the medication dose which is dispensed from the canister actually reaches the lungs where
  • metered dose being delivered in a form which cannot be inhaled into the lungs.
  • micron one-thousandth of a millimeter
  • mouthpiece results in a substantial fraction of the metered dose being delivered in the form of relatively large liquid droplets instead of fine dry particles and/or vapor. Such droplets cannot be inspired, but rather tend to impact the inside of the mouth
  • velocity of the aerosol substantially exceeds the velocity of the patient's breath.
  • spacers improve delivery efficiency, most of the drug which is discharged from the nozzle impacts and sticks on inner surfaces of the spacer, and is therefore unavailable for inhalation by the user. Thus, MDIs with spacers still suffer from unacceptably
  • DPIs still suffer from the problem of impaction and sticking of medication on the inner surfaces of the devices, particularly under certain environmental conditions such as high
  • fraction of the metered dose i.e., the fraction in the form of dry particles of the optimum size
  • the fraction in the form of dry particles of the optimum size is maximized at the exit of the apparatus.
  • velocity of the aerosol at the exit of the apparatus approximately matches the velocity of the patient's inspired breath. It has been another object of the invention to maximize dispersion and mixing of the drug particles in the bolus of an aerosol within an inhaler apparatus. It has been a still further object of the present invention to provide a
  • the bolus of aerosolized medication which exits the apparatus is as short as possible.
  • a further object of the invention has been to provide a method
  • Still another object of the invention has been to provide a method
  • the invention also provides an apparatus and method for synchronizing the actuation of the canister with the patient's inspiratory effort exerted on the mouthpiece of the apparatus. More specifically, the invention provides a metered dose inhaler
  • apparatus including a housing adapted to support a pressurized canister, the housing
  • the housing further including a. generally tubular conduit
  • a nozzle discharge orifice of the actuator and nozzle assembly being positioned
  • the conduit the air tube being oriented so that air flowing out of the air tube outlet is directed so as to impinge on a plume of aerosolized medication discharged from the canister through the nozzle discharge orifice.
  • the mouthpiece causes air to flow into the air tube inlet and out the air tube outlet to
  • the air jet from the air tube also causes the plume to slow down so mat the velocity of the aerosol exiting the device approximately matches the
  • the apparatus is configured so that
  • the nozzle discharge orifice directs a plume toward the open end of the mouthpiece.
  • the air mbe is arranged to direct an air jet away from the open end of the mouthpiece
  • the air tube is supported .within the conduit by one or
  • each spoke being connected at one end to a corresponding passage through the
  • conduit wall to ambient air outside the conduit and at the other end to the inlet of the air tube.
  • the canister is acmated to discharge a plume of aerosol toward the air jet.
  • the nozzle is positioned to direct a plume away from the open end of the mouthpiece toward the far end of the conduit, which end is substantially closed by an end wall.
  • the air mbe is mounted on
  • the apparatus provides an aerosol flow control apparatus, useful for
  • either MDI or DPI devices including a housing defining a conduit, the conduit
  • the medication is arranged within the housing to direct medication into the conduit.
  • dispenser may be a pressurized canister with actuator and nozzle, or alternatively may
  • the end wall includes a plurality of auxiliary air inlets in fluid communication with ambient air outside the conduit, the
  • auxiliary air inlets opening into the conduit adjacent the inner wall of the conduit, in a
  • the conduit furthermore
  • auxiliary air inlets includes a plurality of vortex generators mounted on the inner wall thereof downstream of the auxiliary air inlets, the auxiliary air inlets and vortex generators
  • the vortex generators preferably comprise inwardly directed vanes which are oriented at an angle to the axial direction so as to impart swirl and vorticity to the air flowing over them.
  • the invention further provides an aerosol flow control apparatus for
  • a housing adapted to support the canister between a first position in which the discharge stem of the canister is in an inoperative position to a second position in
  • the housing further including an outlet through which a user can
  • a canister restraint is arranged in
  • the housing is movable from a rest position in which relative movement between the canister body and discharge stem is prevented to a discharge position in which
  • the canister restraint forms a part of, or alternatively is
  • a device such as a bellows or a movable diaphragm piston assembly
  • variable-volume chamber which defines a variable-volume chamber.
  • the inhaler includes a resilient member which urges the canister into the second position upon movement of the canister restraint into its discharge position.
  • a secondary air passage extends through the housing between the primary air passage and ambient air outside the housing, the secondary air passage including a venmri.
  • the variable-volume chamber is in fluid communication with a throat of the venmri, whereby inhalation of a user through the outlet causes a low pressure in the venmri throat so as to evacuate air from the
  • the device can be designed to cause acmation of
  • the canister near the peak of a patient's inspiratory effort.
  • the device preferably further includes means for selectively varying the timing of acmation.
  • the device may include an adjustment screw
  • the screw one direction increases the amount of flow restriction, such that for a given
  • FIG.l is a perspective view of an inhaler in accordance with the
  • FIG. 2 is an exploded view of the inhaler of FIG. 1.
  • FIG. 3 is a cross-sectional view of the inhaler taken along lines 3-3 of
  • FIG. 3A is a partial cross-sectional view showing an alternative
  • FIG. 4 is a cross-sectional view similar to FIG. 3, showing an alternative embodiment of the inhaler.
  • FIG. 5 is a cross-sectional view similar to FIG. 3, showing yet another
  • FIG. 6 is cross-sectional view of the inhaler of FIG. 5 taken on a plane
  • FIG. 7 is a cross-sectional view of still another alternative embodiment
  • FIG. 8 is a perspective view of the trigger which engages and
  • FIG. 9 is side elevational view, partly in cross-section, of yet another embodiment of the invention, showing an alternative arrangement for achieving automatic acmation of a canister responsive to a patient's breath.
  • FIGS. 1-3 depict a first embodiment of an inhaler 10 in accordance
  • the inhaler 10 includes a housing 12 which has
  • a receptacle portion 14 connected to a conduit 16.
  • the receptacle portion 14 is in the
  • the canister 18 forms no part of the present invention.
  • the inhaler apparatus of the present invention is usable with any standard pressurized canister
  • the conduit 16 includes an open end 20 spaced from the receptacle
  • the end wall 24 preferably is generally conical or hemispherical in shape, with an apex of the end wall 24 forming the portion of the
  • the housing 12 further includes an actuator and nozzle assembly 26 supported by the end wall 24.
  • the actuator and nozzle assembly 26 includes a bore 28 which is adapted to receive the hollow discharge stem (not shown in FIGS. 1-3) of the canister 18, and a nozzle discharge orifice 30 in fluid communication with the bore 28.
  • the nozzle discharge orifice 30 is advantageously
  • the inhaler 10 includes an air mbe 34 supported within the conduit 16.
  • the air mbe 34 has an outlet 36 which is spaced downstream of and in opposing relationship with the nozzle
  • the air mbe 34 is a bent mbe which has a generally axial portion 40 which is generally aligned along the conduit's longitudinal axis 32, and a generally radial portion 42 which is attached to the inner wall 44 of the conduit 16.
  • a user exerts an inspiratory effort on the open end 20 of the conduit 16
  • air is drawn from outside the conduit 16 into the air mbe inlet 38, exiting the air mbe outlet 36 in a direction toward the nozzle discharge orifice 30.
  • the portion 40 of air mbe 34 is located and oriented within the conduit 16
  • metering valve of the canister 18 is acmated to discharge a plume of aerosolized
  • plume causes the plume to slow down and be dispersed so as to occupy a larger
  • particles of the optimum size of about one to five microns moving at a relatively low velocity that substantially matches the inspiratory breath velocity, as opposed to relatively large liquid droplets moving at a relatively high velocity. Impaction and sticking of medication within the mouth and tirroat are thereby reduced.
  • the air mbe 34 and conduit 16 can be integrally formed of one piece, with the internal passage of the air mbe 34 extending through the conduit 16 to establish fluid communication with air outside the conduit 16.
  • the air mbe 34 can be formed of a metal mbe bent into the appropriate configuration and attached to the conduit 16 at the inlet end 38.
  • portion 40 may be
  • an obmse angle i.e., between about 90 degrees and 180 degrees, 180
  • attaches to the conduit wall need not be radial, but can be oriented at an acute or
  • the invention further includes feamres which reduce the likelihood of
  • the inhaler 10 includes a plurality of
  • auxiliary air inlets 46 through the end wall 24 and circumferentially spaced therearound at at least two different radii from the nozzle orifice 30.
  • a first circumferential ring of auxiliary air inlets 46 are located adjacent the juncture 48 between the end wall 24 and the inner wall 44 of the conduit 16.
  • a second circumferential ring of auxiliary air inlets 47 are located radially between the juncture 48 and the nozzle orifice 30.
  • the inhaler 10 also includes a
  • vanes 54 are
  • each vane 54 advantageously
  • the vanes 54 are oriented at an angle to the axial direction defined by longitudinal axis 32, so that vorticity and swirl are imparted to air flowing over them.
  • the boundary layer air flow created by auxiliary air inlets 46 encounters the vanes 54, which impart vorticity and swirl to the boundary layer air flow. This vorticity and
  • the inhaler 10 includes a separate mouthpiece 56 which connects to the open end 20 of the conduit 16.
  • the mouthpiece 56 has a reduced diameter portion 58 adapted to be inserted into the mouth of a user of the inhaler 10. After completely exhaling, the user inserts the portion 58 into the mouth with the lips closed around the portion 58, and then begins to inhale, which establishes air flow from the air mbe 34 and through the auxiliary air inlets 46. Once these air flows are established and while continuing to inhale, the user depresses the
  • canister 18 to discharge a metered volume of medication and propellant mixture from
  • the housing 12 is formed in four sections
  • the housing 12 may alternatively be formed in fewer than four
  • the housing 12 may be formed in two sections, a first section
  • the housing 14 may be formed in two sections split on a longitudinal plane through the conduit, the two sections being generally mirror images of each other which are joined together along the plane of symmetry. Nevertheless, for illustration purposes, an embodiment
  • a first section 60 includes the receptacle portion 14, the end wall 24 and actuator and nozzle assembly 26, and a generally cylindrical portion 62 which forms a part of the conduit 16 and is connected to the end wall 24 at the juncture 48.
  • the first section 60 advantageously is integrally formed of one piece, although it may alternatively be formed in multiple pieces which are subsequently joined together.
  • a second section 64 includes a second generally cylindrical portion 66 whose inner and outer diameters are equal to those of the first generally cylindrical
  • the portion 68 has an inner
  • 64 preferably is integrally formed of one piece, although it may alternatively be formed in multiple pieces which are subsequently joined.
  • a third section 72 of the housing 12 includes a third generally cylindrical portion 74 whose inner and outer diameters are equal to those of the
  • second generally cylindrical portion 66 and a reduced diameter cylindrical portion 76 which is telescopingly received within the open downstream end of second generally cylindrical portion 66.
  • the outer diameter of portion 76 is approximately equal to the
  • portion 66 has a diameter which is approximately equal to the
  • the air mbe 34 is mounted on me inner surface of the third section 72 at the juncture between the inner surface 78 and the inner surface 80 of third cylindrical portion 74.
  • a hole 82 through the portion 74 mates with the internal passage of air mbe 34 to provide fluid communication between the inlet 38 of air mbe 34 and ambient air outside the conduit 16.
  • Third section 72 may be integrally formed of one
  • the fourth section of the housing 12 is the mouthpiece 56, which has a
  • the portion 84 is attached to an annular flange 86,
  • portion 84 is approximately equal to the outer diameter of portion 84
  • the housing 12 advantageously is formed of a plastic such as
  • the housing 12 may be manufactured by any suitable technique such as
  • FIG. 3 A shows an alterative embodiment of an actuator and nozzle
  • the actuator and nozzle assembly 26a includes two spaced-
  • impingement of the two plumes aids in creating smaller droplets, which
  • the bore 28a is shown as being elongated in die horizontal direction and
  • orifices 30a are shown as being spaced apart in the horizontal plane.
  • the bore 28a may simply be extended in the vertical
  • FIG. 4 depicts an alternative embodiment of an inhaler 10a in which
  • the hub 40a is analogous to the axial portion 40 of the air mbe 34, and the spokes 42a are analogous to the radial po ⁇ ion 42 of air mbe 34.
  • the hub 40a includes a central cavity 88 of a first diameter, and an outlet passage 36a of a second smaller diameter.
  • the outlet passage 36a is generally coaxial with the conduit 16 and oriented so that air flowing outward therefrom is directed toward the nozzle orifice 30.
  • the internal passages of spokes 42a are connected to outside air by a pair of holes 82a through the cylindrical portion 74a. In the embodiment of the inhaler 10a shown in FIG. 4, there is no section of the housing
  • FIGS. 5 and 6 illustrate yet another embodiment of an inhaler in
  • FIG. 5 schematically depicts
  • FIG. 3 a horizontal cross section analogous to FIG. 3, showing an inhaler 10b in which the aerosol plume is directed away from the user so that the aerosol must reverse
  • FIG. 6 schematically depicts a vertical cross section
  • the inhaler 10b includes a housing 12b defining a conduit 16b which has a first closed end defined by an end wall 90 and a second open end defined by a mouthpiece portion 58b adapted to be
  • the conduit 16b has a first larger internal cross
  • the housing further includes a receptacle portion 14b which penetrates into the conduit 16b at a location between the end wall 90 and the mouthpiece portion 58b.
  • the receptacle portion 14b receives a standard pressurized canister (not shown).
  • the housing 12b further includes an actuator and nozzle assembly 26 arranged at the bottom end of receptacle portion 14b such that the hollow outlet stem of the canister may be inserted into a bore 28 of the
  • actuator and nozzle assembly 26 The details of the actuator and nozzle assembly 26
  • the inhaler 10b includes an internal conduit 92 which is coaxially
  • the internal conduit 92 has an open end 94 spaced
  • the inhaler further includes an air mbe 34b attached to the end wall 90 and coaxially
  • the air mbe 34b intrudes part way into the inner conduit 92 toward the nozzle discharge orifice 30.
  • the inlet 38b of air mbe 34b is connected to ambient air outside the conduit 16b by a hole 98 through end wall 90.
  • mouthpiece will be substantially equal to the velocity of the user's inspired breath
  • FIG. 7 depicts yet another embodiment of the invention providing
  • An inhaler 10c includes a housing 12c having a conduit 16c within which an aerosol plume is created for
  • the conduit 16c is shown to include the air mbe 34 and the
  • auxiliary air inlets 46 may also include the vanes 54 of inhaler 10. Alternatively,
  • the conduit 16c may be a simple straight duct with an open end for the exit of aerosolized medication.
  • the conduit 16c must adapted
  • breath-synchronization feamres of the invention breath-synchronization feamres of the invention.
  • the housing 12c further includes a receptacle portion 14c which is connected to the conduit 16c.
  • the receptacle portion 14c comprises a generally cylindrical sleeve having a longimdinal axis 108 which is oriented at an oblique angle to the longimdinal axis of the conduit 16c.
  • a canister 18 resides within the receptacle portion 14c with its longimdinal axis aligned with the longimdinal axis of the
  • the 18 is an inner sleeve 100.
  • the inner sleeve 100 has an open top end 102 through
  • the sleeve 100 adjacent bottom end 104 has inwardly extending ledges 105 which abut the cap portion 106 of the canister.
  • the canister 18 is slidable within inner sleeve along the direction defined by the
  • the inner sleeve 100 is also slidable within the receptacle portion 14c
  • the receptacle portion 14c has four longimdinal slots 110 circumferentially spaced apart about 90 degrees, two of which receive a pair of diametrically opposite lugs or cam followers 112 extending outwardly from the outer surface of inner sleeve 100.
  • the receptacle portion 14c may have only two slots 110 spaced 180 degrees apart and receiving the lugs 112.
  • the inhaler includes a generally cylindrical cam ring 114 which fits
  • the cam ring 114 has an annular flange
  • Each cam track 120 presents a generally helical surface 124 in facing relationship with one of the lugs 112 protruding
  • cam tracks 120 causes the lugs 112 to ride along the helical surfaces 124 and thereby upwardly advance the inner sleeve 100 in the longimdinal direction
  • a compression spring 126 Resisting this upward movement of the canister 18 is a compression spring 126.
  • the spring 126 is attached to the inner surface of a removable end cap 128 which surrounds the top end 130 of the receptacle portion 14c and the top end 122 of the cam ring 114 to completely enclose the canister 18 in the housing.
  • the end cap 128 When the end cap 128 is thus installed, the spring 126 bears against the end of the canister 18, biasing the canister downward toward the actuator and nozzle
  • the inhaler 10c includes a mechanism which engages the
  • the inhaler 10c includes a piston assembly 132 which is
  • the piston assembly 132 includes a circular disc 136 having a
  • shaft 138 extending centrally therethrough coaxial with axis 134 and protruding outward from both sides of the disc 136.
  • a forked trigger 154 is attached to the head end 150.
  • the trigger 154 is attached to the head end 150.
  • axis 134 to approximately the longimdinal axis 108 of the receptacle portion 14c.
  • the prongs 156 are spaced apart by a distance D which is slightly smaller than the
  • the canister neck 158 contacts inner edge portions
  • canister neck 158 clears the prongs 156 so that movement of the canister 18 toward
  • the prongs 156 include portions 157 which slope gently away from the canister neck 158 in the direction along axis 134 toward the canister.
  • the portions 157 reduce the amount of force required for disengagement of the trigger 154 from the canister neck 158. Movement of the piston assembly 132 in the direction away from the canister is responsive to air pressure within a variable-volume chamber 162 within the
  • the chamber 162 is defined by the disc 136, the housing wall 144, and a flexible diaphragm 164 which connects the disc 136 to d e wall 144 in a substantially air-tight manner.
  • the diaphragm 164 includes a circular portion 166 which lies against the side of disc 136 facing the canister 18, and a skirt 168 which depends from the outer edge of the circular portion 166 and attaches to the housing wall 144.
  • the housing wall 144 comprises a removable
  • circular portion 166 of diaphragm 164 includes a central hole through which the shaft
  • the removable cover 170 includes a recess 172 facing the disc 136
  • conduit 16c is
  • the passage 174 terminates at the end of first section 62c which connects to second section 74c.
  • a passage 178 through a sidewall 180 of the second section 74c is fluidly connected with and forms an extension of passage 174.
  • the passage 178 extends into the internal passage 182 of the air mbe 34.
  • a venmri 184 is inserted into the air mbe passage 182.
  • the venmri 184 includes a restricted portion or throat 186.
  • Air passages 188 extend through the venmri wall in the vicinity of the throat 186.
  • the venmri 184 is disposed in passage 182 such that these air passages 188 align with the passage 178.
  • fluid communication is provided between the venmri throat 186 and the variable-volume chamber 162 by air passages 188, passage 178 in second
  • the trigger 154 begins to move so as to disengage the prongs 156 from the canister neck 158.
  • the decrease in volume is sufficient to move the trigger 154 far enough to totally disengage the prongs 156 from the neck 158, movement of the canister 18 toward the actuator 26 is no longer impeded, and the force of spring 126 moves the canister downward so as to cause
  • the user grasps the ring 114 and rotates it with respect to the housing 12c
  • the spring 152 urges the trigger 154 toward the canister 18 so that the trigger 154
  • inhaler 10c is then ready to be used again.
  • breath-synchronization feamres described above provide an inhaler in which discharge of medication is automatically responsive to the user's inspiratory effort, so that the user does not have to carefully coordinate manual depression of a canister with the inhalation. Furthermore, discharge of medication does not occur immediately upon the user beginning to inhale on the open end of the device, but rather is somewhat delayed until the volume of chamber 162 has decreased enough to cause acmation. It will also be appreciated that the degree of
  • time delay between initiation of a breath and acmation is dependent on a number of
  • the primary factors being the cross-sectional area of the chamber 162 and the
  • inhaler 10c may be designed with appropriate selection of these factors so as to
  • the inhaler 10c provides breath-responsive acmation of the
  • canister 18 which automatically adjusts to the user's rate of inhalation to discharge the medication near the peak of the inhalation, i.e., near the point at which 50 percent of the volume which the user will eventually inspire with a full inhalation has been
  • the inhaler 10c further includes an adjustment screw 190 which extends through the housing 12c into the passage 174 to form a restriction within passage 174. By turning the screw 190 one direction, the screw 190 extends farther into passage 174 to increase the restriction, and by turning the screw 190 the opposite
  • canister 18 in relation to a particular patient's inhalation may be varied by adjusting
  • variable- volume chamber 162 the variable- volume chamber 162
  • FIG. 9 depicts a subassembly of yet another embodiment of an inhaler having feamres for automatic breath acmation of discharge.
  • the forked trigger 154 is eliminated and the diaphragm piston assembly 132 is replaced
  • a resiliently compressible bellows 200 which is disposed between a fixed wall 202 of the housing (not shown) and the canister neck 158.
  • the bellows 200 itself acts as
  • the bellows 200 is advantageously made of stainless steel and has a blind end wall 204 at die end adjacent die canister neck 158, the end wall 204 being integrally formed with me accordion-folded side wall 206.
  • the bellows 200 has a second end wall 208 at d e end adjacent the housing wall 202, the end wall 208 also
  • the second end wall 208 is pierced
  • a tube or needle 210 which establishes an air passage into the interior of the
  • the needle 210 advantageously is a stainless steel mbe similar to a
  • hypodermic needle and is integrally affixed at one end to the end wall 208 by welding
  • the free end 212 of the needle 210 extends is attached
  • the venmri 216 is
  • the mbe 218 and venmri 216 may also be formed of stainless steel.
  • a support/release platform 224 is attached to die blind end wall 204 of
  • the support/release platform 224 contacts the canister neck 158
  • the canister 18 contains an internal spring (not shown) which acts between the canister body and the hollow outlet stem 19 in a direction tending to move the canister 18 away from the actuator 26.
  • the spring constant of the bellows 200 is selected such that the sum of die spring force exerted by the bellows 200 and die force exerted by die internal spring is slightly
  • the inhaler 10c which creates a low pressure within the throat 214 of venmri 216.
  • This low pressure is communicated via me extension mbe 213 and needle 210 to the
  • the pressure within the bellows 200 is less than the atmospheric pressure which surrounds the outside of the bellows 200, and therefore there is an air pressure force exerted on the blind end wall 204 in the
  • the bellows 200 preferably has a spring constant of about 1 pound per
  • the venmri 216 must be sized to create a gage pressure within the throat 214 of about one pound per square inch.
  • die venmri inlet in communication with ambient air via a passage through the conduit wall
  • die venmri inlet may alternatively draw air through one of the auxiliary air inlets 46 in the end wall 24, or through any arrangement having the venmri inlet outside the primary air passage
  • bellows 200 being attached to die forked trigger 154, and die spring 152 being

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
  • Nozzles (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Colloid Chemistry (AREA)
PCT/US1998/021667 1997-10-17 1998-10-15 Method and apparatus for delivering aerosolized medication Ceased WO1999020331A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
NZ504021A NZ504021A (en) 1997-10-17 1997-10-17 Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication
KR1020007004125A KR20010031187A (ko) 1997-10-17 1998-10-15 에어로졸 화된 약품의 전달방법 및 그 장치
JP2000516721A JP2001520088A (ja) 1997-10-17 1998-10-15 エアロゾル化薬剤の送出方法と装置
AU10847/99A AU750459B2 (en) 1997-10-17 1998-10-15 Method and apparatus for delivering aerosolized medication
CN98811903A CN1285759A (zh) 1997-10-17 1998-10-15 输送气雾化药品的方法及装置
MXPA00003766A MXPA00003766A (es) 1997-10-17 1998-10-15 Metodo y aparato para surtir medicamento en aerosol.
AU44363/02A AU777488B2 (en) 1997-10-17 2002-05-23 Method and apparatus for delivering aerosolized medication

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/954,352 1997-10-17
US08/954,352 US5954047A (en) 1997-10-17 1997-10-17 Methods and apparatus for delivering aerosolized medication

Publications (1)

Publication Number Publication Date
WO1999020331A1 true WO1999020331A1 (en) 1999-04-29

Family

ID=25495309

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/021667 Ceased WO1999020331A1 (en) 1997-10-17 1998-10-15 Method and apparatus for delivering aerosolized medication

Country Status (16)

Country Link
US (3) US5954047A (https=)
EP (3) EP1627655B1 (https=)
JP (5) JP2001520088A (https=)
KR (1) KR20010031187A (https=)
CN (1) CN1285759A (https=)
AT (2) ATE463271T1 (https=)
AU (1) AU750459B2 (https=)
CA (3) CA2243175C (https=)
DE (2) DE69832679T2 (https=)
DK (2) DK0911048T3 (https=)
ES (2) ES2348495T3 (https=)
MX (1) MXPA00003766A (https=)
NO (1) NO983631L (https=)
NZ (1) NZ504021A (https=)
TR (1) TR200001033T2 (https=)
WO (1) WO1999020331A1 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001097889A3 (en) * 2000-06-23 2002-05-02 Ivax Corp De-agglomerator for breath-actuated dry powder inhaler
JP2003513763A (ja) * 1999-11-01 2003-04-15 システミツク・パルマナリイ・デリバリー・リミテツド 吸入装置のための内部渦機構
US8508385B2 (en) 2007-11-22 2013-08-13 Sanofi-Aventis Deutschland Gmbh Metering device for the inhalation of a pulverulent substance
US8517009B2 (en) 2008-07-13 2013-08-27 Map Pharmaceuticals, Inc. Methods and apparatus for delivering aerosolized medication
US10441734B2 (en) 2012-08-28 2019-10-15 Kind Consumer Limited Inhaler
NL2023033B1 (en) * 2019-04-30 2020-11-23 Medspray B V Spray inhaler device
EP4059551A1 (en) * 2021-03-18 2022-09-21 Funai Electric Co., Ltd. Pharmaceutical drug delivery device, and method of air flow and humidity control thereof

Families Citing this family (248)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031244A1 (en) * 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
US6703050B1 (en) * 1998-09-04 2004-03-09 The Regents Of The University Of Michigan Methods and compositions for the prevention or treatment of cancer
DZ2947A1 (fr) * 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
US6257231B1 (en) * 1998-12-03 2001-07-10 Ferraris Medical, Inc. Aerosol enhancement
ZA9811257B (en) * 1998-12-09 2001-01-31 App Sub Cipla Ltd 8 8 2000 Inhalation device.
CA2377566C (en) * 1999-05-20 2007-08-07 Iep Pharmaceutical Devices, Inc. Low spray force, low retention atomization system
US6315985B1 (en) * 1999-06-18 2001-11-13 3M Innovative Properties Company C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
IT1313553B1 (it) 1999-07-23 2002-09-09 Chiesi Farma Spa Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
CA2383058A1 (en) * 1999-09-13 2001-05-31 Nahed Mohsen Aerosol airflow control system and method
IT1317720B1 (it) * 2000-01-07 2003-07-15 Chiesi Farma Spa Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani.
GB0002798D0 (en) * 2000-02-09 2000-03-29 Glaxo Group Ltd Actuator nozzle for metered dose inhaler
IT1317846B1 (it) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
US7089934B2 (en) 2000-02-28 2006-08-15 Vectura Limited Delivery of oral drugs
US6443151B1 (en) 2000-03-08 2002-09-03 Aradigm Corporation Fluid velocity-sensitive trigger mechanism
GB2360216A (en) * 2000-03-18 2001-09-19 Astrazeneca Uk Ltd Inhaler
DE60025889T2 (de) * 2000-04-07 2006-08-03 Andi-Ventis Ltd. Mundstück für eine Vorrichtung zum Inhalieren von Partikeln
CA2733850C (en) 2000-04-11 2013-10-22 Trudell Medical International Aerosol delivery apparatus with positive expiratory pressure capacity
US6328035B1 (en) * 2000-05-09 2001-12-11 Iep Pharmaceutical Devices Inc. Pneumatic breath actuated inhaler
IT1318514B1 (it) * 2000-05-12 2003-08-27 Chiesi Farma Spa Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari.
JP5392880B2 (ja) * 2000-05-22 2014-01-22 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 加圧式定量吸入器のための安定な製薬学的溶液製剤
US6339107B1 (en) 2000-08-02 2002-01-15 Syntex (U.S.A.) Llc Methods for treatment of Emphysema using 13-cis retinoic acid
SE517226C2 (sv) * 2000-09-25 2002-05-14 Microdrug Ag Inhalator med luftbroms för torrt pulver
GB0023845D0 (en) * 2000-09-29 2000-11-15 Pa Knowledge Ltd Dosing device
DE60119139T2 (de) * 2000-09-29 2007-06-14 Pfizer Ltd., Sandwich Druckempfindliche vorrichtung und herstellungsverfahren
EP1935869A1 (en) 2000-10-02 2008-06-25 F. Hoffmann-La Roche Ag Retinoids for the treatment of emphysema
US6964647B1 (en) * 2000-10-06 2005-11-15 Ellaz Babaev Nozzle for ultrasound wound treatment
US6601581B1 (en) 2000-11-01 2003-08-05 Advanced Medical Applications, Inc. Method and device for ultrasound drug delivery
US6761729B2 (en) 2000-12-22 2004-07-13 Advanced Medicalapplications, Inc. Wound treatment method and device with combination of ultrasound and laser energy
US6533803B2 (en) 2000-12-22 2003-03-18 Advanced Medical Applications, Inc. Wound treatment method and device with combination of ultrasound and laser energy
US8235919B2 (en) 2001-01-12 2012-08-07 Celleration, Inc. Ultrasonic method and device for wound treatment
US7914470B2 (en) * 2001-01-12 2011-03-29 Celleration, Inc. Ultrasonic method and device for wound treatment
US6960173B2 (en) * 2001-01-30 2005-11-01 Eilaz Babaev Ultrasound wound treatment method and device using standing waves
US6623444B2 (en) 2001-03-21 2003-09-23 Advanced Medical Applications, Inc. Ultrasonic catheter drug delivery method and device
SE518397C2 (sv) * 2001-04-05 2002-10-01 Microdrug Ag Förfarande och anordning för frigörande av pulver och inhalatoranordning för administrering av medicinskt pulver
US6478754B1 (en) 2001-04-23 2002-11-12 Advanced Medical Applications, Inc. Ultrasonic method and device for wound treatment
JP3484435B2 (ja) 2001-04-25 2004-01-06 松下電器産業株式会社 投写型表示装置
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
US6681768B2 (en) * 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
ES2222294T3 (es) * 2001-07-02 2005-02-01 Chiesi Farmaceutici S.P.A. Formulacion optimizada de tobramicina para administracion en forma de aerosol.
DK1446172T3 (da) * 2001-09-06 2010-08-02 Microdose Therapeutx Inc Tilpasningsstykker til inhalationsapparater og som tjener til at forbedre sidstnævntes ydelse
JP4795637B2 (ja) * 2001-09-28 2011-10-19 カーブ テクノロジー，インコーポレイティド 鼻ネブライザー
US6701922B2 (en) * 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
EP3384931B1 (en) * 2002-03-01 2019-07-24 Chiesi Farmaceutici S.p.A. Formoterol superfine formulation
US6923175B2 (en) 2002-03-20 2005-08-02 Mannkind Corporation Inhalation apparatus
GB0209494D0 (en) * 2002-04-25 2002-06-05 Optinose As Nasal devices
US20030205226A1 (en) 2002-05-02 2003-11-06 Pre Holding, Inc. Aerosol medication inhalation system
WO2003092777A1 (en) * 2002-05-03 2003-11-13 Trudell Medical International Aerosol medication delivery apparatus with narrow orifice
US8122881B2 (en) 2002-05-09 2012-02-28 Kurve Technology, Inc. Particle dispersion device for nasal delivery
US7677411B2 (en) 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
US6985798B2 (en) 2002-05-10 2006-01-10 Oriel Therapeutics, Inc. Dry powder dose filling systems and related methods
US7118010B2 (en) 2002-05-10 2006-10-10 Oriel Therapeutics, Inc. Apparatus, systems and related methods for dispensing and /or evaluating dry powders
US6889690B2 (en) 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
US6904908B2 (en) 2002-05-21 2005-06-14 Trudell Medical International Visual indicator for an aerosol medication delivery apparatus and system
JP4243499B2 (ja) * 2002-06-11 2009-03-25 富士通株式会社 貼合せ基板製造装置及び貼合せ基板製造方法
EP1534366B1 (en) * 2002-06-27 2014-01-08 Oriel Therapeutics, Inc. Dry powder dose filling systems and related methods
US7189865B2 (en) * 2002-07-23 2007-03-13 Attenuon, Llc Thiomolybdate analogues and uses thereof
WO2004009072A2 (en) 2002-07-23 2004-01-29 The Regents Of The University Of Michigan Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies
EP1556171B1 (en) * 2002-09-06 2010-12-15 Philip Morris USA Inc. Aerosol generating devices and methods for generating aerosols having controlled particle sizes
EP1551386A4 (en) * 2002-09-27 2009-03-25 Bioenvision Inc METHOD AND COMPOSITIONS FOR TREATING LUPUS WITH CLOFARABIN
EP1549141A4 (en) * 2002-09-27 2008-06-25 Bioenvision Inc METHOD AND COMPOSITIONS FOR THE TREATMENT OF AUTOIMMUNE DISEASES USING CLOFARABIN
US6834717B2 (en) 2002-10-04 2004-12-28 R&M Energy Systems, Inc. Tubing rotator
US20040167212A1 (en) * 2002-10-07 2004-08-26 Bednarski Mark D. X-nitro compounds, pharmaceutical compositions thereof and uses thereof
WO2004041326A2 (en) * 2002-10-30 2004-05-21 Glaxo Group Limited Tubular nozzles for use in systems for delivering medicaments
HRP20050585A2 (en) * 2002-11-25 2006-02-28 Attenuon Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof
WO2004060260A2 (en) * 2002-12-18 2004-07-22 Glaxo Group Limited Drug delivery system with vented mouthpiece
WO2004064705A2 (en) * 2003-01-17 2004-08-05 Schering Corporation Training device for medicament inhalers
ZA200504940B (en) * 2003-01-28 2006-09-27 Xenoport Inc Amino acid derived prodrugs of propofol, compositions and uses thereof
US7034052B2 (en) 2003-03-12 2006-04-25 Celgene Corporation 7-Amido-isoindolyl compounds and their pharmaceutical uses
EP4101846B1 (en) 2003-04-11 2023-08-02 PTC Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
US7360537B2 (en) * 2003-04-16 2008-04-22 Trudell Medical International Antistatic medication delivery apparatus
MXPA05012722A (es) * 2003-05-27 2006-05-25 Attenuon Llc Analogos de tiotungstato y sus usos.
US20050009782A1 (en) * 2003-07-09 2005-01-13 Comper Wayne D. Antiviral charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and methods of use thereof
WO2005023335A2 (en) * 2003-09-05 2005-03-17 Kurve Technology, Inc. Integrated nebulizer and particle dispersing chamber for delivery of medicament
US20070131230A1 (en) * 2003-09-05 2007-06-14 Kurve Technology, Inc. Nasal adapter for the base of the nose
US7230003B2 (en) * 2003-09-09 2007-06-12 Xenoport, Inc. Aromatic prodrugs of propofol, compositions and uses thereof
CA2538237A1 (en) * 2003-09-10 2005-03-24 Map Pharmaceuticals, Inc. Aerosol formulations for delivery of dihydroergotamine to the systemic circulation via pulmonary inhalation
GB2405799A (en) * 2003-09-15 2005-03-16 Vectura Ltd Dry powder inhaler incorporating a valve which is opened and closed by pressurized gas
US7342660B2 (en) * 2003-09-25 2008-03-11 Deka Products Limited Partnership Detection system and method for aerosol delivery
US7066029B2 (en) * 2003-09-25 2006-06-27 Deka Products Limited Partnership System and method for improved volume measurement
US7377277B2 (en) 2003-10-27 2008-05-27 Oriel Therapeutics, Inc. Blister packages with frames and associated methods of fabricating dry powder drug containment systems
US7451761B2 (en) 2003-10-27 2008-11-18 Oriel Therapeutics, Inc. Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
AU2004293443A1 (en) 2003-11-19 2005-06-09 Signal Pharmaceuticals, Llc. Indazole Compounds and methods of use thereof as protein kinase inhibitors
WO2005082382A1 (en) * 2004-02-23 2005-09-09 Attenuon Llc Formulations of thiomolybdate or thiotungstate compounds and uses thereof
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
ATE446581T1 (de) * 2004-03-12 2009-11-15 Trinity College Dublin Magnetoresistives medium
US7448385B2 (en) * 2004-06-07 2008-11-11 Purepharm Inc. Nasal adaptation of an oral inhaler device
WO2006017351A1 (en) * 2004-07-12 2006-02-16 Xenoport, Inc. Prodrugs of propofol, compositions and uses thereof
CA2571407A1 (en) * 2004-07-12 2006-02-16 Xenoport, Inc. Amino acid derived prodrugs of propofol, compositions and uses thereof
US20060128676A1 (en) * 2004-07-13 2006-06-15 Pharmacofore, Inc. Compositions of nicotinic agonists and therapeutic agents and methods for treating or preventing diseases or pain
ATE486064T1 (de) 2004-08-20 2010-11-15 Mannkind Corp Katalyse der diketopiperazinsynthese
KR20130066695A (ko) 2004-08-23 2013-06-20 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
CA2616997C (en) * 2004-09-13 2014-12-23 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
SI1804871T1 (sl) * 2004-10-15 2012-11-30 Cipla Ltd Izboljšan distančni kos
CN102504001B (zh) 2004-12-17 2015-02-25 安那迪斯药品股份有限公司 3,5-二取代的和3,5,7-三取代的-3H-噁唑并以及3H-噻唑并[4,5-d]嘧啶-2-酮化合物及其前药
TW200635596A (en) * 2004-12-17 2006-10-16 Anadys Pharmaceuticals Inc Pyridazinone compounds
EP1844000B1 (en) * 2004-12-23 2010-01-27 Xenoport, Inc. Serine amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof
FR2881118B1 (fr) * 2005-01-25 2007-04-20 Valois Sas Dispositif de distribution de produit fluide.
US7785277B2 (en) * 2005-06-23 2010-08-31 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
US7713218B2 (en) 2005-06-23 2010-05-11 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
AU2006272922A1 (en) 2005-07-22 2007-02-01 Amgen Inc. Aniline sulfonamide derivatives and their uses
US20070135380A1 (en) 2005-08-12 2007-06-14 Radiorx, Inc. O-nitro compounds, pharmaceutical compositions thereof and uses thereof
US7507842B2 (en) * 2005-08-12 2009-03-24 Radiorx, Inc. Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
EP1928881A2 (en) 2005-08-19 2008-06-11 Pharmacofore, Inc. Prodrugs of active agents
MX373000B (es) 2005-09-14 2020-05-21 Mannkind Corp Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas.
DE102005054383B4 (de) * 2005-11-15 2013-10-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Nadel zum Lochen von Pulverkapseln für die Inhalation
US20070178049A1 (en) * 2005-12-20 2007-08-02 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile
US20070197486A1 (en) * 2005-12-20 2007-08-23 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids
US20070160542A1 (en) * 2005-12-20 2007-07-12 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
US20070249572A1 (en) * 2005-12-20 2007-10-25 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070185066A1 (en) * 2005-12-20 2007-08-09 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
CN103736165B (zh) 2006-02-09 2017-05-10 德卡产品有限公司 流体分配器件、流体流的测量方法和系统及流体输送系统
JP2009526858A (ja) * 2006-02-15 2009-07-23 ティカ レーケメデル アーベー コルチコステロイド溶液を製造する方法
AU2013205495B2 (en) * 2006-02-17 2015-11-26 Sanofi Sa Dispersing unit
DE102006007495A1 (de) * 2006-02-17 2007-08-23 Siegfried Generics International Ag Dispergiereinheit
GB2433207B (en) * 2006-02-21 2009-01-07 Jianhe Li Active suction actuated inhalers with timing devices
EP1986679B1 (en) 2006-02-22 2017-10-25 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
JP2009530390A (ja) * 2006-03-23 2009-08-27 アムゲン インコーポレイティッド １−フェニルスルホニル−ジアザ複素環アミド化合物およびヒドロキシステロイドデヒドロゲナーゼ調節因子としてのその使用
CA2653741C (en) 2006-05-26 2015-07-07 Thomas E. Jenkins Controlled release of phenolic opioids
US7431704B2 (en) 2006-06-07 2008-10-07 Bacoustics, Llc Apparatus and method for the treatment of tissue with ultrasound energy by direct contact
US8562547B2 (en) 2006-06-07 2013-10-22 Eliaz Babaev Method for debriding wounds
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
US7659287B2 (en) * 2006-06-08 2010-02-09 Amgen Inc. Benzamide derivatives and uses related thereto
MX2008016518A (es) 2006-06-22 2009-01-19 Anadys Pharmaceuticals Inc Profarmacos de 5-amino-3-(3'-desoxi-beta-d-ribofuranosil)-tiazolo[ 4,5-d]pirimidin-2,7-dion.
JP5306194B2 (ja) 2006-06-22 2013-10-02 アナディス ファーマシューティカルズ インク ピロ［１，２−ｂ］ピリダジノン化合物
US20080090814A1 (en) * 2006-06-22 2008-04-17 Anadys Pharmaceuticals, Inc. Pyridazinone compounds
EP2037999B1 (en) 2006-07-07 2016-12-28 Proteus Digital Health, Inc. Smart parenteral administration system
WO2008011406A2 (en) 2006-07-18 2008-01-24 Anadys Pharmaceuticals, Inc. Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines
US7666888B2 (en) * 2006-07-20 2010-02-23 Amgen Inc. Substituted azole aromatic heterocycles as inhibitors of 11β-HSD-1
CA2698137A1 (en) * 2006-08-30 2008-03-06 Kurve Technology, Inc. Aerosol generating and delivery device
BRPI0603695A (pt) * 2006-09-13 2008-04-29 Cesar Eduardo Marques Da Silva aerocámara para aplicação de medicamentos aerossol com válvula geométrica
US20080087279A1 (en) * 2006-10-11 2008-04-17 Tieck Catharine Laureen Johnso Metered dose inhaler
US20080177221A1 (en) * 2006-12-22 2008-07-24 Celleration, Inc. Apparatus to prevent applicator re-use
WO2008088540A2 (en) * 2006-12-26 2008-07-24 Amgen Inc. N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases
US20080275032A1 (en) * 2006-12-29 2008-11-06 Yuefen Zhou Pyridazinone compounds
US8491521B2 (en) * 2007-01-04 2013-07-23 Celleration, Inc. Removable multi-channel applicator nozzle
US20080214965A1 (en) * 2007-01-04 2008-09-04 Celleration, Inc. Removable multi-channel applicator nozzle
DK2425820T3 (en) 2007-02-11 2015-07-13 Map Pharmaceuticals Inc A method for the therapeutic administration of DHE in order to enable quick relief of migraine, while minimizing the adverse event profile
JP5385793B2 (ja) * 2007-02-27 2014-01-08 アイバックス ファーマシューティカルズ アイルランド 計量式吸入器のキット
JP4916954B2 (ja) * 2007-05-30 2012-04-18 株式会社吉野工業所 吸引式投薬器
US7928111B2 (en) * 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US20080306076A1 (en) * 2007-06-08 2008-12-11 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US9603848B2 (en) * 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US8633186B2 (en) 2007-06-08 2014-01-21 Senomyx Inc. Modulation of chemosensory receptors and ligands associated therewith
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system
GB2454742B (en) * 2007-11-17 2011-02-02 David Ohayon Inhaler adapter
WO2009067463A1 (en) 2007-11-19 2009-05-28 Proteus Biomedical, Inc. Body-associated fluid transport structure evaluation devices
JP5570996B2 (ja) 2007-12-14 2014-08-13 エアロデザインズ インコーポレイテッド エアロゾル化可能な食料品の送達
US20090177123A1 (en) * 2007-12-28 2009-07-09 Celleration, Inc. Methods for treating inflammatory disorders
US20090177122A1 (en) * 2007-12-28 2009-07-09 Celleration, Inc. Methods for treating inflammatory skin disorders
CN101827626B (zh) 2008-06-13 2015-03-18 曼金德公司 干粉吸入器和用于药物输送的系统
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2421385T3 (es) 2008-06-20 2013-09-02 Mannkind Corp Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación
US20100022919A1 (en) * 2008-07-22 2010-01-28 Celleration, Inc. Methods of Skin Grafting Using Ultrasound
ES2525551T3 (es) 2008-07-31 2014-12-26 Senomyx, Inc. Composiciones que comprenden potenciadores de dulzor y métodos de producirlas
KR101577159B1 (ko) 2008-07-31 2015-12-11 세노믹스, 인코포레이티드 단맛 향상제의 제조 방법 및 중간체
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
WO2010042834A1 (en) 2008-10-09 2010-04-15 Anadys Pharmaceuticals, Inc. A method of inhibiting hepatitis c virus by combination of a 5,6-dihydro-1h-pyridin-2-one and one or more additional antiviral compounds
US20100196286A1 (en) * 2008-12-01 2010-08-05 Armer Thomas A Inhalation delivery methods and devices
WO2010074753A1 (en) 2008-12-23 2010-07-01 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
DK2405963T3 (da) 2009-03-11 2013-12-16 Mannkind Corp Apparat, system og fremgangsmåde til at måle modstand i en inhalator
KR102584844B1 (ko) 2009-06-12 2023-10-04 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
US8495998B2 (en) * 2009-06-17 2013-07-30 British American Tobacco (Investments) Limited Inhaler
US20110171141A1 (en) * 2009-06-26 2011-07-14 Kellerman Donald J Administration of dihydroergotamine mesylate particles using a metered dose inhaler
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
KR20120109504A (ko) * 2009-11-17 2012-10-08 시플라 리미티드 흡입 용액
IN2012DN04857A (https=) * 2009-12-23 2015-09-25 Map Pharmaceuticals Inc
KR20120114368A (ko) 2010-02-01 2012-10-16 프로테우스 디지털 헬스, 인코포레이티드 양 손목을 이용한 데이터 수집 시스템
KR101798128B1 (ko) 2010-02-01 2017-11-16 프로테우스 디지털 헬스, 인코포레이티드 데이터 수집 시스템
US8471041B2 (en) * 2010-02-09 2013-06-25 Alliant Techsystems Inc. Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same
EP2824111B1 (en) 2010-04-30 2017-03-22 Alexion Pharmaceuticals, Inc. Anti-C5A Antibodies and Methods for Using the Antibodies
DE102010024912B4 (de) * 2010-06-15 2013-02-28 Aptar Radolfzell Gmbh Inhalationsvorrichtung
CN102985125A (zh) 2010-06-21 2013-03-20 曼金德公司 干粉药物输送系统和方法
US9815890B2 (en) 2010-06-22 2017-11-14 The Regents Of The University Of Colorado, A Body Corporate Antibodies to the C3d fragment of complement component 3
WO2012021837A2 (en) 2010-08-12 2012-02-16 Senomyx, Inc. Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer
SG194034A1 (en) 2011-04-01 2013-11-29 Mannkind Corp Blister package for pharmaceutical cartridges
US20120321590A1 (en) 2011-04-06 2012-12-20 Anadys Pharmaceuticals, Inc. Bridged polycyclic compounds
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
US8664247B2 (en) 2011-08-26 2014-03-04 Radiorx, Inc. Acyclic organonitro compounds for use in treating cancer
US20140308260A1 (en) 2011-10-07 2014-10-16 Radiorx, Inc. Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
CA2850723C (en) 2011-10-07 2019-07-09 Radiorx, Inc. Organonitro thioether compounds and medical uses thereof
MX2014004983A (es) 2011-10-24 2014-09-22 Mannkid Corp Metodos y composiciones para tratar dolor.
US9603907B2 (en) 2012-02-01 2017-03-28 Protalix Ltd. Dry powder formulations of dNase I
US20150174158A1 (en) 2012-03-07 2015-06-25 Advanced Inhalation Therapies (Ait) Ltd. Inhalation of nitric oxide for treating respiratory diseases
KR102264177B1 (ko) 2012-07-12 2021-06-11 맨카인드 코포레이션 건조 분말 약물 전달 시스템 및 방법
PE20191204A1 (es) 2012-08-06 2019-09-10 Firmenich Incorporated Modificador del sabor dulce
US9713687B2 (en) * 2012-08-21 2017-07-25 Philip Morris Usa Inc. Ventilator aerosol delivery system with transition adapter for introducing carrier gas
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
JO3155B1 (ar) 2013-02-19 2017-09-20 Senomyx Inc معدِّل نكهة حلوة
EP3587404B1 (en) 2013-03-15 2022-07-13 MannKind Corporation Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
MX375448B (es) 2013-07-18 2025-03-06 Mannkind Corp Composiciones farmacéuticas en polvo seco estables al calor y métodos.
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
CA2931612C (en) 2013-11-26 2023-03-21 Alliqua Biomedical, Inc. Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing
GB2524469A (en) * 2014-02-14 2015-09-30 Kind Consumer Ltd A cannabinoid inhaler and composition therefor
NZ631007A (en) 2014-03-07 2015-10-30 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
CN106470723B (zh) * 2014-06-06 2019-12-13 格罗宁根大学 呼吸启动的干粉吸入器
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US20170304459A1 (en) 2014-10-10 2017-10-26 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhalation delivery of conjugated oligonucleotide
JP6818008B2 (ja) * 2015-07-20 2021-01-20 パール セラピューティクス，インコーポレイテッド エアロゾル送達システムおよび関連する方法
CN105092786A (zh) * 2015-07-23 2015-11-25 上海化工研究院 一种对冲式定量雾化给药装置
JP2018534269A (ja) 2015-10-01 2018-11-22 エリージウム セラピューティクス， インコーポレイテッド 過剰摂取および乱用に抵抗性のポリサブユニットオピオイドプロドラッグ
US10335406B2 (en) 2015-10-01 2019-07-02 Elysium Therapeutics, Inc. Opioid compositions resistant to overdose and abuse
US10342778B1 (en) 2015-10-20 2019-07-09 Epicentrx, Inc. Treatment of brain metastases using organonitro compound combination therapy
US9987270B1 (en) 2015-10-29 2018-06-05 Epicentrix, Inc. Treatment of gliomas using organonitro compound combination therapy
CN113616885B (zh) 2015-12-21 2024-06-21 3M创新有限公司 药用吸入器
US11071837B2 (en) 2015-12-21 2021-07-27 Kindeva Drug Delivery L.P. Dose release firing systems and medicinal inhalers comprising same
US11083855B2 (en) 2015-12-21 2021-08-10 Kindeva Drug Delivery L.P. Auto-reset dose release firing systems, medicinal inhalers comprising same, and methods of using same
CN109069420A (zh) 2016-01-11 2018-12-21 埃皮辛特瑞柯斯公司 2-溴-1-(3，3-二硝基氮杂环丁烷-1-基)乙酮静脉施用的组合物和方法
FR3050115B1 (fr) * 2016-04-15 2023-05-12 Aptar France Sas Dispositif de distribution de produit fluide synchronise avec l'inhalation.
FR3050116B1 (fr) * 2016-04-15 2020-05-15 Aptar France Sas Dispositif de distribution de produit fluide synchronise avec l'inhalation
JP2019517473A (ja) 2016-05-27 2019-06-24 アレクシオン ファーマシューティカルズ インコーポレイテッドＡｌｅｘｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 難治性全身型重症筋無力症の処置のための方法
WO2018064825A1 (zh) * 2016-10-09 2018-04-12 益得生物科技股份有限公司 药物传递装置及其系统
SG11201903312VA (en) 2016-10-14 2019-05-30 Epicentrix Inc Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine
EP3595663A4 (en) 2017-03-17 2021-01-13 Elysium Therapeutics, Inc. MULTIPLE SUBUNITY OPIOID PRODRUGS WITH RESISTANCE TO OVERDOSE AND ABUSE
EP3648740A1 (en) 2017-07-07 2020-05-13 EpicentRx, Inc. Compositions for parenteral administration of therapeutic agents
SI3658184T1 (sl) 2017-07-27 2024-01-31 Alexion Pharmaceuticals, Inc., Formulacije z visoko koncentracijo protiteles proti-C5
CN109481802B (zh) * 2017-09-12 2024-09-24 张海飞 全自动定量气雾吸入装置
CA3080187A1 (en) 2017-10-26 2019-05-02 Alexion Pharmaceuticals, Inc. Dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) and atypical hemolytic uremic syndrome (ahus)
IL255520A0 (en) * 2017-11-08 2017-12-31 Omrix Biopharmaceuticals Ltd Powder release device
WO2019164593A2 (en) 2018-01-08 2019-08-29 Epicentrx, Inc. Methods and compositions utilizing rrx-001 combination therapy for radioprotection
JP7101787B2 (ja) * 2018-01-23 2022-07-15 エスエイチエル・メディカル・アーゲー エアロゾル発生器
US10933084B2 (en) 2018-04-12 2021-03-02 MatRx Therapeutics Corporation Compositions and methods for treating elastic fiber breakdown
US12404320B2 (en) 2018-05-31 2025-09-02 Alexion Pharmaceuticals, Inc. Dosage and administration of anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (PNH) in pediatric patients
WO2019234584A1 (en) * 2018-06-04 2019-12-12 Trudell Medical International Positive air pressure therapy device, kit and methods for the use and assembly thereof
JP7577542B2 (ja) 2018-06-04 2024-11-05 アレクシオン ファーマシューティカルズ， インコーポレイテッド 小児患者における非典型溶血性尿毒症症候群（ａＨＵＳ）の治療のための抗Ｃ５抗体の用量および投与
WO2020006266A1 (en) 2018-06-28 2020-01-02 Alexion Pharmaceuticals, Inc. Methods of producing anti-c5 antibodies
CN109078234A (zh) * 2018-07-03 2018-12-25 李骏达 用于慢性伤口清创的局部组织闭合涡流冲洗器
JP7453210B2 (ja) 2018-08-07 2024-03-19 フィルメニッヒ インコーポレイテッド ５－置換４－アミノ－１Ｈ－ベンゾ［ｃ］［１，２，６］チアジアジン２，２－ジオキシド並びにその配合物及び使用
CN112996561A (zh) 2018-10-30 2021-06-18 亚力兄制药公司 用于治疗阵发性睡眠性血红蛋白尿症(pnh)的抗c5抗体的皮下剂量和施用
JP7250317B2 (ja) * 2019-03-18 2023-04-03 学校法人日本大学 薬剤吸入器
JP2022534133A (ja) * 2019-05-24 2022-07-27 ブルー オーシャン グループ，エルエルシー 定量噴霧式吸入器のコンパクトスペーサ
KR102200764B1 (ko) * 2020-02-18 2021-01-08 가톨릭대학교 산학협력단 마취용 기화기의 마취액용기 가압유지장치
CN111359060A (zh) * 2020-02-20 2020-07-03 深圳麦克韦尔科技有限公司 雾化吸嘴及雾化装置
CN111214737B (zh) * 2020-03-06 2020-10-20 张洁 一种儿童用雾化器
CN111544715B (zh) * 2020-04-02 2022-08-19 佛山市澳斯卡医疗器械有限公司 一种瓶装雾化器
CN111536555A (zh) * 2020-05-08 2020-08-14 中国航发湖南动力机械研究所 发动机及其发动机燃烧室
CN115120819B (zh) * 2021-03-24 2024-02-09 心诚镁行动医电股份有限公司 雾化装置以及喷嘴模块
KR102682149B1 (ko) * 2022-03-15 2024-07-05 주식회사 이엠텍 액상의 점성 변화에 의해 분무되는 에어로졸 발생 장치
WO2023178283A1 (en) 2022-03-18 2023-09-21 Epicentrx, Inc. Co-crystals of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone and methods
WO2023215227A1 (en) 2022-05-02 2023-11-09 Epicentrx, Inc. Systems and methods to improve exercise tolerance
WO2023215229A1 (en) 2022-05-02 2023-11-09 Epicentrx, Inc. Compositions and methods for treatment of pulmonary hypertension
EP4536222A1 (en) 2022-06-13 2025-04-16 EpicentRx, Inc. Compositions and methods for reducing adverse side effects in cancer treatment
WO2024098009A1 (en) 2022-11-04 2024-05-10 Epicentrx, Inc. Rrx-001 for minimizing post-infarct adverse ventricular remodeling and complications
WO2024124152A1 (en) 2022-12-08 2024-06-13 Epicentrx, Inc. Rrx-001 for the treatment of a hemoglobinopathy
CN116510139B (zh) * 2023-04-04 2025-12-12 深圳雾芯科技有限公司 用于吸入器的测速装置及具有其的吸入器套装
US20260007841A1 (en) * 2024-07-03 2026-01-08 Kaer Biotherapeutics Corporation Ergonomic and utilitarian aerosol delivery system

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5040527A (en) * 1990-12-18 1991-08-20 Healthscan Products Inc. Metered dose inhalation unit with slide means
US5060643A (en) * 1990-08-07 1991-10-29 Tenax Corporation Breath-activated inhalation device
US5178138A (en) * 1990-09-11 1993-01-12 Walstrom Dennis R Drug delivery device
US5301666A (en) * 1991-12-14 1994-04-12 Asta Medica Aktiengesellschaft Powder inhaler
US5309900A (en) * 1991-03-21 1994-05-10 Paul Ritzau Pari-Werk Gmbh Atomizer particularly for use in devices for inhalation therapy
GB2279879A (en) * 1993-07-14 1995-01-18 Bespak Plc Medicament inhalers
US5435297A (en) * 1991-08-29 1995-07-25 Christoph Klein Medical device for inhaling metered aerosols
US5590645A (en) * 1990-03-02 1997-01-07 Glaxo Group Limited Inhalation device
EP0839544A2 (en) * 1996-10-30 1998-05-06 Bespak plc Inhalers

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2305210A (en) * 1940-10-28 1942-12-15 Spraying Systems Co Spray shaper
US2751252A (en) * 1953-12-14 1956-06-19 Spraying Systems Co Whirl spray nozzle
US2984420A (en) * 1959-11-20 1961-05-16 Jr John W Hession Aerosol devices
US3072346A (en) * 1961-09-29 1963-01-08 Spraying Systems Co Spray nozzle
FR1322998A (fr) * 1962-02-23 1963-04-05 Perfectionnements aux dispositifs de production d'aérosols
US3240431A (en) * 1964-05-27 1966-03-15 Clayton Corp Of Delaware Combination valve spout and spray head assembly
US3385295A (en) * 1966-02-07 1968-05-28 Puritan Compressed Gas Corp Apparatus for use in administering intermittent positive pressure breathing therapy
US3406913A (en) * 1966-09-01 1968-10-22 Revlon Mechanical break-up actuator for fluid dispensers
US3456644A (en) * 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
GB1253221A (https=) * 1968-04-23 1971-11-10
US3522806A (en) * 1968-08-07 1970-08-04 G S Intern Lab Corp Aerosol apparatus for inhalation therapy
DE1813993C3 (de) * 1968-12-11 1974-01-24 Paul Ritzau Pari-Werk Kg, 8135 Soecking Vorrichtung zum Zerstäuben und Vernebeln von flüssigen oder pulverförmigen Stoffen
US3565070A (en) * 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
US3636949A (en) * 1969-08-08 1972-01-25 Armstrong Kropp Dev Corp Inhalation-initiated aerosol dispenser
US3838686A (en) * 1971-10-14 1974-10-01 G Szekely Aerosol apparatus for inhalation therapy
US4049200A (en) * 1976-04-05 1977-09-20 Sobol Jacob M Nebulizer
EP0045419B1 (en) * 1980-08-04 1984-10-17 FISONS plc Inhalation device for administering medicaments
DE3043377A1 (de) * 1980-11-17 1982-07-01 Brugger, Inge, 8130 Starnberg Zerstaeuber
FI69962C (fi) * 1983-12-28 1986-09-12 Huhtamaeki Oy Inhalationsanordning
US4534343A (en) * 1984-01-27 1985-08-13 Trutek Research, Inc. Metered dose inhaler
DE8621135U1 (de) * 1985-09-02 1987-01-29 Callahan, George Edgar, Prof., 40479 Düsseldorf Sprühvorrichtung zum Aufsetzen auf einen zusammenpressbaren Behälter
SE453566B (sv) * 1986-03-07 1988-02-15 Draco Ab Anordning vid pulverinhalatorer
US4739754A (en) * 1986-05-06 1988-04-26 Shaner William T Suction resistant inhalator
GB8614805D0 (en) * 1986-06-18 1986-07-23 British American Tobacco Co Aerosol device
ES2029248T3 (es) * 1986-09-22 1992-08-01 Omron Tateisi Electronics Co. Pulverizador.
JP2587817B2 (ja) * 1986-09-22 1997-03-05 オムロン株式会社 霧化器
US4768717A (en) * 1987-02-12 1988-09-06 Specialty Packaging Licensing Company Nozzle
JPH0199570A (ja) * 1987-09-30 1989-04-18 Bootran Medical Technol Inc 吸入装置と吸入方法
DE3856185D1 (de) * 1987-12-11 1998-06-18 Deutsch Zentr Luft & Raumfahrt Dralldüse zum Zerstäuben einer Flüssigkeit
ATE104867T1 (de) * 1988-10-04 1994-05-15 Univ Johns Hopkins Inhalationsgeraet fuer aerosolen.
SE466684B (sv) * 1989-03-07 1992-03-23 Draco Ab Anordning vid en inhalator samt foerfarande foer att med anordningen registrera medicinering med inhalator
GB8919131D0 (en) * 1989-08-23 1989-10-04 Riker Laboratories Inc Inhaler
DE8912098U1 (de) * 1989-10-11 1990-11-08 Magasi, Josef, 6902 Sandhausen Inhalator
FR2658081B1 (fr) * 1990-02-09 1995-06-30 Pesenti Yvan Dispositif d'automatisation et synchronisation des appareils aerosols a pompe doseuse.
US5615670A (en) * 1990-03-07 1997-04-01 Fisons Plc Powder inhaler with centrifugal force used to meter powder
GB9015077D0 (en) * 1990-07-09 1990-08-29 Riker Laboratories Inc Inhaler
DE4027391A1 (de) * 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
GB9020555D0 (en) * 1990-09-20 1990-10-31 Bespak Plc Dispensing apparatus
US5027808A (en) * 1990-10-31 1991-07-02 Tenax Corporation Breath-activated inhalation device
US5217004A (en) * 1990-12-13 1993-06-08 Tenax Corporation Inhalation actuated dispensing apparatus
DE69430303T2 (de) * 1991-03-05 2002-11-28 Aradigm Corp Verfahren und vorrichtung zur korrektur eines nullsignals eines drucksensors fur einen durchflussmesser
WO1993000951A1 (en) * 1991-07-02 1993-01-21 Inhale, Inc. Method and device for delivering aerosolized medicaments
US5228624A (en) * 1992-03-02 1993-07-20 Mensink Daniel L Swirling structure for mixing two concentric fluid flows at nozzle outlet
DE4208880A1 (de) * 1992-03-19 1993-09-23 Boehringer Ingelheim Kg Separator fuer pulverinhalatoren
SE9201411D0 (sv) * 1992-05-05 1992-05-05 Astra Ab Dosage inhalator with indicating/interupting means
CA2147260C (en) * 1992-10-19 1999-04-13 Mark Bernard Mecikalski Dry powder inhaler
US5415162A (en) * 1994-01-18 1995-05-16 Glaxo Inc. Multi-dose dry powder inhalation device
GB2299512A (en) * 1995-04-06 1996-10-09 Ian James Sharp Inhaler
US5474059A (en) * 1995-04-08 1995-12-12 Cooper; Guy F. Aerosol dispensing apparatus for dispensing a medicated vapor into the lungs of a patient
US5598836A (en) * 1995-05-26 1997-02-04 Healthscan Products, Inc. Metered dose inhalation unit with slide means
US5724986A (en) * 1995-11-06 1998-03-10 Jones Medical Instrument Co. Casing and spirometer for metered dose inhaler
JP2000503565A (ja) * 1996-01-03 2000-03-28 グラクソ、グループ、リミテッド 吸入装置
US5875774A (en) * 1996-01-05 1999-03-02 Sunrise Medical Hhg Inc. Nebulizer
GB2312379B (en) * 1996-04-25 1999-11-17 Bespak Plc Improved inhalers
GB2312848B (en) * 1996-04-26 1999-11-17 Bespak Plc Controlled flow inhalers
GB9626263D0 (en) * 1996-12-18 1997-02-05 Innovata Biomed Ltd Powder inhaler
US5894995A (en) * 1997-07-08 1999-04-20 Mazzei; Angelo L. Infusion nozzle imparting axial and rotational flow elements
GB2334686B (en) * 1998-02-26 2002-06-19 Medic Aid Ltd Nebuliser

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5590645A (en) * 1990-03-02 1997-01-07 Glaxo Group Limited Inhalation device
US5060643A (en) * 1990-08-07 1991-10-29 Tenax Corporation Breath-activated inhalation device
US5178138A (en) * 1990-09-11 1993-01-12 Walstrom Dennis R Drug delivery device
US5040527A (en) * 1990-12-18 1991-08-20 Healthscan Products Inc. Metered dose inhalation unit with slide means
US5309900A (en) * 1991-03-21 1994-05-10 Paul Ritzau Pari-Werk Gmbh Atomizer particularly for use in devices for inhalation therapy
US5435297A (en) * 1991-08-29 1995-07-25 Christoph Klein Medical device for inhaling metered aerosols
US5301666A (en) * 1991-12-14 1994-04-12 Asta Medica Aktiengesellschaft Powder inhaler
GB2279879A (en) * 1993-07-14 1995-01-18 Bespak Plc Medicament inhalers
EP0839544A2 (en) * 1996-10-30 1998-05-06 Bespak plc Inhalers

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003513763A (ja) * 1999-11-01 2003-04-15 システミツク・パルマナリイ・デリバリー・リミテツド 吸入装置のための内部渦機構
WO2001097889A3 (en) * 2000-06-23 2002-05-02 Ivax Corp De-agglomerator for breath-actuated dry powder inhaler
US6871646B2 (en) 2000-06-23 2005-03-29 Norton Healthcare Ltd. De-agglomerator for breath-actuated dry powder inhaler
EP2189176A3 (en) * 2000-06-23 2014-07-16 Norton Healthcare Limited De-agglomerator for breath-actuated dry powder inhaler
US8508385B2 (en) 2007-11-22 2013-08-13 Sanofi-Aventis Deutschland Gmbh Metering device for the inhalation of a pulverulent substance
US8573204B2 (en) 2007-11-22 2013-11-05 Siegfried Generics International Metering device for the inhalation of a pulverulent substance
US9895501B2 (en) 2007-11-22 2018-02-20 Sanofi-Aventis Deutschland Gmbh Metering device for the inhalation of a pulverulent substance
US8517009B2 (en) 2008-07-13 2013-08-27 Map Pharmaceuticals, Inc. Methods and apparatus for delivering aerosolized medication
US9216259B2 (en) 2008-07-13 2015-12-22 Map Pharmaceuticals, Inc. Methods and apparatus for delivering aerosolized medication
US10441734B2 (en) 2012-08-28 2019-10-15 Kind Consumer Limited Inhaler
NL2023033B1 (en) * 2019-04-30 2020-11-23 Medspray B V Spray inhaler device
EP4059551A1 (en) * 2021-03-18 2022-09-21 Funai Electric Co., Ltd. Pharmaceutical drug delivery device, and method of air flow and humidity control thereof

Also Published As

Publication number Publication date
TR200001033T2 (tr) 2000-11-21
CA2565964A1 (en) 1999-04-17
JP2010115543A (ja) 2010-05-27
EP0911048A2 (en) 1999-04-28
ATE311913T1 (de) 2005-12-15
JP2011189194A (ja) 2011-09-29
JP5352630B2 (ja) 2013-11-27
CA2243175C (en) 2008-11-18
CA2565088A1 (en) 1999-04-17
ES2255134T3 (es) 2006-06-16
DK1591137T3 (da) 2010-07-05
CA2243175A1 (en) 1999-04-17
JP5395100B2 (ja) 2014-01-22
JP2011098224A (ja) 2011-05-19
JP2009183734A (ja) 2009-08-20
CN1285759A (zh) 2001-02-28
NO983631D0 (no) 1998-08-07
CA2565964C (en) 2008-06-10
NZ504021A (en) 2003-04-29
EP1591137A2 (en) 2005-11-02
DE69832679T2 (de) 2006-08-24
MXPA00003766A (es) 2002-04-09
US6026808A (en) 2000-02-22
EP1627655A2 (en) 2006-02-22
EP0911048B1 (en) 2005-12-07
AU750459B2 (en) 2002-07-18
ES2348495T3 (es) 2010-12-07
EP1627655A3 (en) 2010-01-13
EP1591137A3 (en) 2005-11-23
EP0911048A3 (en) 1999-06-02
AU1084799A (en) 1999-05-10
KR20010031187A (ko) 2001-04-16
JP2001520088A (ja) 2001-10-30
CA2565088C (en) 2008-11-18
DE69841603D1 (de) 2010-05-20
ATE463271T1 (de) 2010-04-15
DE69832679D1 (de) 2006-01-12
US5954047A (en) 1999-09-21
EP1591137B1 (en) 2010-04-07
DK0911048T3 (da) 2006-04-18
EP1627655B1 (en) 2016-11-23
NO983631L (no) 1999-04-19
US6095141A (en) 2000-08-01
JP5114515B2 (ja) 2013-01-09

Similar Documents

Publication Publication Date Title
US5954047A (en) Methods and apparatus for delivering aerosolized medication
CN102686261B (zh) 增强型的喷射器设计
EP1392382B1 (en) Inhaler
US6336455B1 (en) Relating to dispensing apparatus
CA2444729A1 (en) Inhalers
AU776816B2 (en) Method and apparatus for delivering aerosolized medication
AU2001253667A1 (en) Respiratory equipment spacer assembly
US6170482B1 (en) Inhalation apparatus
CN223555277U (zh) 一种喷雾装置
MXPA00002089A (en) Breath actuated nebulizer with valve assembly having a relief piston
HK1172857A (en) Enhanced eductor design
HK1172857B (en) Enhanced eductor design

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 98811903.X

Country of ref document: CN

AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10847/99

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 504021

Country of ref document: NZ

ENP Entry into the national phase

Ref document number: 2000 516721

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PA/a/2000/003766

Country of ref document: MX

Ref document number: 2000/01033

Country of ref document: TR

Ref document number: 1020007004125

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 1020007004125

Country of ref document: KR

WWG Wipo information: grant in national office

Ref document number: 10847/99

Country of ref document: AU

WWW Wipo information: withdrawn in national office

Ref document number: 1020007004125

Country of ref document: KR