SG11201903312VA - Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine - Google Patents

Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine

Info

Publication number
SG11201903312VA
SG11201903312VA SG11201903312VA SG11201903312VA SG11201903312VA SG 11201903312V A SG11201903312V A SG 11201903312VA SG 11201903312V A SG11201903312V A SG 11201903312VA SG 11201903312V A SG11201903312V A SG 11201903312VA SG 11201903312V A SG11201903312V A SG 11201903312VA
Authority
SG
Singapore
Prior art keywords
international
co7c
co7d
compounds
pct
Prior art date
Application number
SG11201903312VA
Inventor
Bryan Oronsky
Jan Scicinski
Original Assignee
Epicentrix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epicentrix Inc filed Critical Epicentrix Inc
Publication of SG11201903312VA publication Critical patent/SG11201903312VA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111111H11 01011011111 0111111101111 0111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/071741 Al 19 April 2018 (19.04.2018) WIP0 1 PCT (51) International Patent Classification: TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, CO7C 317/48 (2006.01) A61K 31/10 (2006.01) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, CO7C 317/50 (2006.01) A61K 31/397 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, CO7C 317/04 (2006.01) A61K 31/4025 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, CO7C 317/06 (2006.01) A61K 31/44 (2006.01) KM, ML, MR, NE, SN, TD, TG). CO7D 205/04 (2006.01) A61K 38/05 (2006.01) CO7D 207/10 (2006.01) A61K 45/06 (2006.01) Published: CO7D 211/38 (2006.01) A61P 25/16 (2006.01) — with international search report (Art. 21(3)) CO7D 295/06 (2006.01) A61P 35/00 (2006.01) — before the expiration of the time limit for amending the A61N 5/10 (2006.01) A61P 25/28 (2006.01) claims and to be republished in the event of receipt of A61K 31/04 (2006.01) A61P 29/00 (2006.01) amendments (Rule 48.2(h)) A61K 31/19 (2006.01) A61P 31/00 (2006.01) A61K 31/198 (2006.01) A61P 33/00 (2006.01) A61K 31/215 (2006.01) (21) International Application Number: PCT/US2017/056454 (22) International Filing Date: 13 October 2017 (13.10.2017) (25) Filing Language: English Publication Language: English (26) Priority Data: (30) 62/408,182 14 October 2016 (14.10.2016) US Applicant: EPICENTRIX, INC. [US/US]; 4445 Eastgate (71) Mall, Suite 200, San Diego, CA 92121 (US). Inventors: ORONSKY, Bryan, T.; 28540 Matadero Creek (72) = Lane, Los Altos Hillas, CA 94022 (US). SCICINSKI, Jan; 19546 Vineyark Lane, Saratoga, CA 95070 (US). Agent: DAVIS, Chad, E. et al.; Goodwin Procter LLP, 100 (74) Northern Avenue, Boston, MA 02210 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = (81) Designated States (unless otherwise indicated, for every (84) - kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 1-1 71' IN 1-1 N (54) Title: SULFOXYALKYL ORGANONITRO AND RELATED COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS 0 FOR USE IN MEDICINE --.... ,_ 1 (57) : The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, 0 and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoimmune N disease, infection, or cancer in a patient. Exemplary sulfoxyalkyl organonitro compounds described herein include ((2-(3,3-dinitroaze- 0 tidin-l-y1)-2-oxoethyl)sulfmy1)-D-alanine and variants thereof.
SG11201903312VA 2016-10-14 2017-10-13 Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine SG11201903312VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662408182P 2016-10-14 2016-10-14
PCT/US2017/056454 WO2018071741A1 (en) 2016-10-14 2017-10-13 Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine

Publications (1)

Publication Number Publication Date
SG11201903312VA true SG11201903312VA (en) 2019-05-30

Family

ID=61906413

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201903312VA SG11201903312VA (en) 2016-10-14 2017-10-13 Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine

Country Status (13)

Country Link
US (1) US11008287B2 (en)
EP (1) EP3526195A4 (en)
JP (1) JP7332469B2 (en)
KR (1) KR20190128619A (en)
CN (1) CN110352190A (en)
AU (2) AU2017342436C1 (en)
BR (1) BR112019007453A2 (en)
CA (1) CA3040479A1 (en)
EA (1) EA201990949A1 (en)
IL (1) IL265970B (en)
MX (1) MX2019004280A (en)
SG (1) SG11201903312VA (en)
WO (1) WO2018071741A1 (en)

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AU2017342436A1 (en) 2019-05-02
WO2018071741A8 (en) 2019-05-31
WO2018071741A1 (en) 2018-04-19
EP3526195A1 (en) 2019-08-21
EA201990949A1 (en) 2019-10-31
KR20190128619A (en) 2019-11-18
CN110352190A (en) 2019-10-18
AU2022203169A1 (en) 2022-06-02
JP2019532067A (en) 2019-11-07
US11008287B2 (en) 2021-05-18
AU2017342436C1 (en) 2022-11-03
IL265970A (en) 2019-06-30
AU2022203169B2 (en) 2024-04-18
CA3040479A1 (en) 2018-04-19
BR112019007453A2 (en) 2019-07-16
EP3526195A4 (en) 2020-05-20
AU2017342436B2 (en) 2022-05-19
US20200157047A1 (en) 2020-05-21
JP7332469B2 (en) 2023-08-23
IL265970B (en) 2022-03-01
MX2019004280A (en) 2019-09-18

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