SG11201808306PA - Treatment of cancer with tg02 - Google Patents
Treatment of cancer with tg02Info
- Publication number
- SG11201808306PA SG11201808306PA SG11201808306PA SG11201808306PA SG11201808306PA SG 11201808306P A SG11201808306P A SG 11201808306PA SG 11201808306P A SG11201808306P A SG 11201808306PA SG 11201808306P A SG11201808306P A SG 11201808306PA SG 11201808306P A SG11201808306P A SG 11201808306PA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- tgo2
- mab
- california
- pct
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 abstract 2
- 229940111134 coxibs Drugs 0.000 abstract 2
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 abstract 2
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 abstract 2
- 235000007328 Hericium erinaceus Nutrition 0.000 abstract 1
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 abstract 1
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MD 110111101110101011111 010111110111011110111001111100101 1111110111 III International Bureau .. .... ..Yejd ..... ...1 (10) International Publication Number (43) International Publication Date WO 2017/165732 Al 28 September 2017 (28.09.2017) WIP0 I PCT (51) (21) (22) (25) Filing Language: (26) Publication Language: (30) (71) (72) Inventors: ESTOK, Thomas M.; 121 Formby, Williams- International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 31/535 (2006.01) C07D 498/06 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/US2017/023965 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 24 March 2017 (24.03.2017) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, English ZA, ZM, ZW. Priority Data: (84) Designated States (unless otherwise indicated, for every 62/312,712 24 March 2016 (24.03.2016) US kind of regional protection available): ARIPO (BW, GH, 62/423,468 17 November 2016 (17.11.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Applicant: TRAGARA PHARMACEUTICALS, INC. TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, [US/US]; 3152 Lionshead Avenue, Carlsbad, California DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 92010 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, burg, Virginia 23188 (US). WEBER, Eckard; 4040 Miller GW, KM, ML, MR, NE, SN, TD, TG). Street, San Diego, California 92103 (US). PARROTT, Published: Tracy; 212 Via Tavira, Encinitas, California 92024 (US). — with international search report (Art. 21(3)) Agents: ESMOND, Robert W. et al.; Sterne, Kessler, before the expiration of the time limit for amending the Goldstein & Fox P.L.L.C, 1100 New York Avenue, NW, claims and to be republished in the event of receipt of Washington, District of Columbia 20005 (US). amendments (Rule 48.2(h)) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (74) (81) Title: TREATMENT OF 100 ?:- :•9 80 ._ > 60 6- .._, 40 20 0) a. (54) CANCER WITH TGO2 -4- IgG Control + Vehicle -0- TG02, 20 mglkg -lir- TG02, 40 mglkg -6- PD-1 mAb (1 Al2) -8- TG02, 20 mg/kg + PD-1 mAb - -a-TG02, 40 mg/kg + PD-1 mAb = 1-1 ei cr) IN kin 1-1 IN 1-1 (57) N agent, C and : The present disclosure e.g., TGO2 and an immune a COX-2 inhibitor. 0 20 40 60 80 100 Days after implantation Fig. 27 provides therapeutic methods of treating a cancer patient with TGO2 and a second therapeutic checkpoint inhibitor, TGO2 and a COX-2 inhibitor, or TGO2 and an immune checkpoint inhibitor
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662312712P | 2016-03-24 | 2016-03-24 | |
US201662423468P | 2016-11-17 | 2016-11-17 | |
PCT/US2017/023965 WO2017165732A1 (en) | 2016-03-24 | 2017-03-24 | Treatment of cancer with tg02 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201808306PA true SG11201808306PA (en) | 2018-10-30 |
Family
ID=59899752
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201808306PA SG11201808306PA (en) | 2016-03-24 | 2017-03-24 | Treatment of cancer with tg02 |
SG10202005621WA SG10202005621WA (en) | 2016-03-24 | 2017-03-24 | Treatment of cancer with tg02 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202005621WA SG10202005621WA (en) | 2016-03-24 | 2017-03-24 | Treatment of cancer with tg02 |
Country Status (13)
Country | Link |
---|---|
US (2) | US11865116B2 (en) |
EP (1) | EP3432888B1 (en) |
JP (2) | JP7026299B2 (en) |
KR (2) | KR20230020549A (en) |
CN (2) | CN109195603B (en) |
AU (1) | AU2017238647B2 (en) |
CA (1) | CA3018875A1 (en) |
ES (1) | ES2941687T3 (en) |
IL (1) | IL261959B2 (en) |
MX (2) | MX2021012977A (en) |
RU (1) | RU2749025C2 (en) |
SG (2) | SG11201808306PA (en) |
WO (1) | WO2017165732A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230133934A (en) | 2016-10-11 | 2023-09-19 | 아게누스 인코포레이티드 | Anti-lag-3 antibodies and methods of use thereof |
EP3664830A4 (en) | 2017-08-07 | 2020-07-01 | The Regents of the University of California | Platform for generating safe cell therapeutics |
JP7250764B2 (en) | 2017-08-18 | 2023-04-03 | コセラ バイオサイエンス, インコーポレイテッド | Polymorphic forms of TG02 |
MX2021011301A (en) * | 2019-03-18 | 2022-01-19 | Univ Texas | Tumor-selective combination therapy. |
EP3958854A4 (en) | 2019-04-22 | 2023-02-01 | University of Pittsburgh - of The Commonwealth System of Higher Education | Use of tg02 for treating gliomas in pediatric subjects |
US20230287510A1 (en) * | 2020-08-10 | 2023-09-14 | The Broad Institute, Inc. | Compositions, panels, and methods for characterizing chronic lymphocytic leukemia |
WO2023092076A1 (en) * | 2021-11-18 | 2023-05-25 | Lantern Pharma Inc. | Method for treating cancer with acylfulvene and radiation |
CN114113051B (en) * | 2021-12-16 | 2023-06-16 | 南京信息工程大学 | Preparation method and application of PSMA electrochemiluminescence sensor |
EP4197525A1 (en) | 2021-12-20 | 2023-06-21 | Scandion Oncology A/S | Combination of drugs for the treatment of cancer |
CN114480639B (en) * | 2021-12-24 | 2022-09-30 | 中国医学科学院北京协和医院 | Novel targets for diagnosis and treatment of pituitary adenomas |
CN116510024A (en) * | 2022-01-30 | 2023-08-01 | 上海复东生物医药有限责任公司 | Composition, preparation method and application thereof |
WO2023242235A1 (en) | 2022-06-14 | 2023-12-21 | Scandion Oncology A/S | Abcg2 inhibitor and nae inhibitor for the treatment of cancer |
CN115429793A (en) * | 2022-08-15 | 2022-12-06 | 复旦大学附属中山医院 | Application of compound in preparation of medicine for treating hepatocellular carcinoma |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR8108820A (en) | 1980-09-24 | 1982-08-24 | Cetus Corp | DIAGNOSTIC PROCESS AND PROBE |
US4582788A (en) | 1982-01-22 | 1986-04-15 | Cetus Corporation | HLA typing method and cDNA probes used therein |
EP0084796B1 (en) | 1982-01-22 | 1990-05-02 | Cetus Corporation | Hla typing method and cdna probes used therein |
US4683194A (en) | 1984-05-29 | 1987-07-28 | Cetus Corporation | Method for detection of polymorphic restriction sites and nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
CA1284931C (en) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
CA1338457C (en) | 1986-08-22 | 1996-07-16 | Henry A. Erlich | Purified thermostable enzyme |
US6605712B1 (en) | 1990-12-20 | 2003-08-12 | Arch Development Corporation | Gene transcription and ionizing radiation: methods and compositions |
WO2007058628A1 (en) * | 2005-11-16 | 2007-05-24 | S*Bio Pte Ltd | Heteroalkyl linked pyrimidine derivatives |
ES2632548T3 (en) * | 2010-02-05 | 2017-09-14 | Tragara Pharmaceuticals, Inc. | Solid state forms of macrocyclic kinase inhibitors |
US9636328B2 (en) * | 2013-06-21 | 2017-05-02 | Zenith Epigenetics Ltd. | Substituted bicyclic compounds as bromodomain inhibitors |
ES2827679T3 (en) | 2013-08-20 | 2021-05-24 | Merck Sharp & Dohme | Cancer treatment with a combination of a PD-1 antagonist and dinaciclib |
WO2015095840A1 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Cancer treatments using combinations of cdk and erk inhibitors |
EP3126525B1 (en) | 2014-04-04 | 2020-02-19 | Memorial Sloan-Kettering Cancer Center | Method and kits for identifying of cdk9 inhibitors for the treatment of cancer |
US10233170B2 (en) | 2014-04-08 | 2019-03-19 | Rigel Pharmaceuticals, Inc. | 2,3-disubstituted pyridine compounds as TGF-beta inhibitors and methods of use |
EP3925622A1 (en) | 2014-09-13 | 2021-12-22 | Novartis AG | Combination therapies |
JP7250764B2 (en) | 2017-08-18 | 2023-04-03 | コセラ バイオサイエンス, インコーポレイテッド | Polymorphic forms of TG02 |
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2017
- 2017-03-24 SG SG11201808306PA patent/SG11201808306PA/en unknown
- 2017-03-24 WO PCT/US2017/023965 patent/WO2017165732A1/en active Application Filing
- 2017-03-24 SG SG10202005621WA patent/SG10202005621WA/en unknown
- 2017-03-24 AU AU2017238647A patent/AU2017238647B2/en active Active
- 2017-03-24 ES ES17771215T patent/ES2941687T3/en active Active
- 2017-03-24 EP EP17771215.5A patent/EP3432888B1/en active Active
- 2017-03-24 KR KR1020237001967A patent/KR20230020549A/en not_active Application Discontinuation
- 2017-03-24 KR KR1020187030053A patent/KR102491013B1/en active IP Right Grant
- 2017-03-24 MX MX2021012977A patent/MX2021012977A/en unknown
- 2017-03-24 CN CN201780032318.XA patent/CN109195603B/en active Active
- 2017-03-24 RU RU2018137217A patent/RU2749025C2/en active
- 2017-03-24 CA CA3018875A patent/CA3018875A1/en active Pending
- 2017-03-24 CN CN202211276427.5A patent/CN115969854A/en active Pending
- 2017-03-24 US US16/087,966 patent/US11865116B2/en active Active
- 2017-03-24 JP JP2019500752A patent/JP7026299B2/en active Active
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2018
- 2018-09-24 MX MX2022008868A patent/MX2022008868A/en unknown
- 2018-09-26 IL IL261959A patent/IL261959B2/en unknown
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2022
- 2022-01-17 JP JP2022004776A patent/JP7459149B2/en active Active
-
2023
- 2023-11-16 US US18/511,131 patent/US20240156824A1/en active Pending
Also Published As
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RU2018137217A (en) | 2020-04-24 |
EP3432888A4 (en) | 2019-11-13 |
AU2017238647B2 (en) | 2021-12-09 |
ES2941687T3 (en) | 2023-05-24 |
IL261959B1 (en) | 2023-04-01 |
SG10202005621WA (en) | 2020-07-29 |
CN109195603B (en) | 2022-11-08 |
AU2017238647A1 (en) | 2018-10-25 |
JP2022050631A (en) | 2022-03-30 |
RU2749025C2 (en) | 2021-06-03 |
WO2017165732A1 (en) | 2017-09-28 |
KR20190006948A (en) | 2019-01-21 |
JP2019509354A (en) | 2019-04-04 |
KR20230020549A (en) | 2023-02-10 |
JP7026299B2 (en) | 2022-02-28 |
CA3018875A1 (en) | 2017-09-28 |
CN109195603A (en) | 2019-01-11 |
IL261959A (en) | 2018-10-31 |
US11865116B2 (en) | 2024-01-09 |
MX2021012977A (en) | 2022-10-03 |
US20200323862A1 (en) | 2020-10-15 |
EP3432888A1 (en) | 2019-01-30 |
US20240156824A1 (en) | 2024-05-16 |
CN115969854A (en) | 2023-04-18 |
RU2018137217A3 (en) | 2020-05-29 |
EP3432888B1 (en) | 2022-10-05 |
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