JP5352630B2 - エアロゾル流制御装置 - Google Patents
エアロゾル流制御装置 Download PDFInfo
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- JP5352630B2 JP5352630B2 JP2011146003A JP2011146003A JP5352630B2 JP 5352630 B2 JP5352630 B2 JP 5352630B2 JP 2011146003 A JP2011146003 A JP 2011146003A JP 2011146003 A JP2011146003 A JP 2011146003A JP 5352630 B2 JP5352630 B2 JP 5352630B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
- A61M15/0088—Inhalation chambers with variable volume
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
- A61M15/0095—Preventing manual activation in absence of inhalation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Nozzles (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Colloid Chemistry (AREA)
Description
Claims (6)
- 使用者の吸入の試みに応答して薬剤を自動排出するエアロゾル流制御装置であって、
キャニスタ本体と、薬剤の排出が防止される非動作位置と薬剤が排出軸を介して排出される動作位置との間でキャニスタ本体に対して移動可能な中空排出軸とを含む薬剤の加圧キャニスタと、
キャニスタを支持して、排出軸が非動作位置にある第1の位置と排出軸が動作位置にある第2の位置との間でのキャニスタの移動を可能にするようになっているとともに、使用者が吸入できる出口を含む第1の空気通路を規定しており、さらに、第1の空気通路と第1の空気通路の外側の周囲空気との間に延在し、スロートを有するベンチュリを含んだ第2の空気通路を規定しているハウジングと、
ハウジング内に支持され、ハウジングに対して移動可能な壁を含み、ハウジング内にベンチュリのスロートと流体連通する可変容積チャンバを規定する可変容積装置と、
可変容積装置の可動壁に固定され、キャニスタが第1の位置にありキャニスタ本体と排出軸との間の相対的な移動が防止される静止位置から、キャニスタが第2の位置に自由に移動できる排出位置まで、可動壁とともに移動可能なキャニスタ抑制手段と、
キャニスタ抑制手段が排出位置に移動すると、キャニスタを第2の位置に付勢する弾性部材とを備えており、
可変容積チャンバが第1の空気通路と流体連通しており、そのため、出口を介した使用者の吸入により、空気がベンチュリのスロートを通って吸気されて、可変容積チャンバと連通するスロート中に低圧が生起され、この低圧により、可変容積チャンバから空気が排気されて、可動壁がキャニスタ抑制手段を排出位置に移動させる、前記エアロゾル流制御装置。 - ベンチュリのスロートが、ハウジング内で第3の空気通路により可変容積チャンバと接続されており、エアロゾル流制御装置がさらに、第1の空気通路を通る所定の流量に応じて第3の空気通路を通る流量を選択的に変化させて、使用者の吸入周期に対する薬剤排出のタイミングを変化させるように、選択的に位置決めされる調節装置を備えている請求項1に記載のエアロゾル流制御装置。
- 可変容積装置が、可撓ダイヤフラムによってハウジングの壁に密封して接続されるピストンを備え、キャニスタ抑制手段が、ピストンに取り付けられ、キャニスタが第2の位置に移動するのを防ぐように、静止位置では第1と第2の位置の間でキャニスタによって移動させる経路内に導入される部材を含み、可変容積装置のチャンバの内部から空気を排気することにより、ピストンはハウジングの壁に向かって移動し、それにより部材をキャニスタが第2の位置に移動できる排出位置内に引き込ませる請求項1に記載のエアロゾル流制御装置。
- ハウジングが、キャニスタを受け取る主要本体部と、排出軸を持つ端部とは反対のキャニスタの端部を覆い、主要本体部と係合して不注意に外れるのを防止されるエンドキャップとを備え、弾性部材が、エンドキャップが主要本体部と係合するとき、エンドキャップの内面とキャニスタとの間に、キャニスタに支持されるような圧力ばねを備える請求項1に記載のエアロゾル流制御装置。
- 主要本体部が、縦軸を有し、キャニスタが存在する略円筒形の凹部を規定する略円筒形のレセプタクルを含み、装置は、
レセプタクル内でキャニスタを囲む内側スリーブであって、内側スリーブとキャニスタが、ユニットとして縦軸に沿ってレセプタクル内を摺動可能であり、レセプタクル内のスロットを介して外面から外側に延出する少なくとも1つのピンをさらに備える内側スリーブと、
レセプタクルを囲み、少なくとも1つのピンに係合する表面を持つコッキングリングであって、内側スリーブとキャニスタを上方に引っ張り、それによってキャニスタを、キャニスタ抑制手段が静止位置内に移動できるコック位置内に移動するように、エンドキャップに向かう縦軸によって規定される方向にピンを移動させ、これによって装置が使用者の吸入の試みに応答して作動する準備をするように、レセプタクルに対して移動可能なコッキングリングと、を備えるコッキング装置をさらに備える請求項3に記載のエアロゾル流制御装置。 - 可変容積装置は、弾性的に圧縮可能なベローを備え、ベローが、キャニスタネックとキャニスタネックに対面するハウジングの壁との間に配設され、可動壁がベローの端壁であり、キャニスタ抑制手段が端壁に固定されキャニスタネックと接触し、ベローが、キャニスタが第1の位置から第2の位置へ移動する方向と実質的に平行な方向にハウジングの壁に向かって圧縮可能であり、ベローが、キャニスタを第1の位置に対して付勢しようとするキャニスタにばね力を印加するようになっており、使用者がハウジングの出口を介して吸入するとき、ベローの外側の大気圧とベローの内側の低圧との差によってベローの端壁に印加される圧力が、所定量を超えるように選択される所定量だけ、ばね力が弾性部材によってキャニスタに印加される力を超え、これにより、端壁がベローをハウジング壁に向かって圧縮し、キャニスタが弾性部材によって第2の位置に移動するように、排出位置内にキャニスタ抑制手段を移動する請求項1に記載のエアロゾル流制御装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/954,352 US5954047A (en) | 1997-10-17 | 1997-10-17 | Methods and apparatus for delivering aerosolized medication |
US08/954,352 | 1997-10-17 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009092696A Division JP2009183734A (ja) | 1997-10-17 | 2009-04-07 | エアロゾル化薬剤の送出方法と装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011189194A JP2011189194A (ja) | 2011-09-29 |
JP5352630B2 true JP5352630B2 (ja) | 2013-11-27 |
Family
ID=25495309
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000516721A Pending JP2001520088A (ja) | 1997-10-17 | 1998-10-15 | エアロゾル化薬剤の送出方法と装置 |
JP2009092696A Withdrawn JP2009183734A (ja) | 1997-10-17 | 2009-04-07 | エアロゾル化薬剤の送出方法と装置 |
JP2010043745A Expired - Lifetime JP5114515B2 (ja) | 1997-10-17 | 2010-03-01 | エアロゾル化薬剤の送出方法と装置 |
JP2011031934A Expired - Lifetime JP5395100B2 (ja) | 1997-10-17 | 2011-02-17 | エアロゾル化薬剤の送出方法と装置 |
JP2011146003A Expired - Lifetime JP5352630B2 (ja) | 1997-10-17 | 2011-06-30 | エアロゾル流制御装置 |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000516721A Pending JP2001520088A (ja) | 1997-10-17 | 1998-10-15 | エアロゾル化薬剤の送出方法と装置 |
JP2009092696A Withdrawn JP2009183734A (ja) | 1997-10-17 | 2009-04-07 | エアロゾル化薬剤の送出方法と装置 |
JP2010043745A Expired - Lifetime JP5114515B2 (ja) | 1997-10-17 | 2010-03-01 | エアロゾル化薬剤の送出方法と装置 |
JP2011031934A Expired - Lifetime JP5395100B2 (ja) | 1997-10-17 | 2011-02-17 | エアロゾル化薬剤の送出方法と装置 |
Country Status (16)
Country | Link |
---|---|
US (3) | US5954047A (ja) |
EP (3) | EP1591137B1 (ja) |
JP (5) | JP2001520088A (ja) |
KR (1) | KR20010031187A (ja) |
CN (1) | CN1285759A (ja) |
AT (2) | ATE463271T1 (ja) |
AU (1) | AU750459B2 (ja) |
CA (3) | CA2565088C (ja) |
DE (2) | DE69841603D1 (ja) |
DK (2) | DK0911048T3 (ja) |
ES (2) | ES2348495T3 (ja) |
MX (1) | MXPA00003766A (ja) |
NO (1) | NO983631L (ja) |
NZ (1) | NZ504021A (ja) |
TR (1) | TR200001033T2 (ja) |
WO (1) | WO1999020331A1 (ja) |
Families Citing this family (240)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010031244A1 (en) * | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
US6703050B1 (en) * | 1998-09-04 | 2004-03-09 | The Regents Of The University Of Michigan | Methods and compositions for the prevention or treatment of cancer |
DZ2947A1 (fr) * | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
US6257231B1 (en) * | 1998-12-03 | 2001-07-10 | Ferraris Medical, Inc. | Aerosol enhancement |
ZA9811257B (en) * | 1998-12-09 | 2001-01-31 | App Sub Cipla Ltd 8 8 2000 | Inhalation device. |
DE60027714T3 (de) * | 1999-05-20 | 2008-01-24 | Kos Life Sciences, Inc., Weston | Zerstäubungssystem mit niedriger spraykraft und retention |
US6315985B1 (en) * | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
IT1313553B1 (it) | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione. |
MXPA02002714A (es) * | 1999-09-13 | 2003-10-14 | Sheffield Pharmaceuticals Inc | Sistema y metodo de control de flujo de aire en aerosol. |
US6367471B1 (en) * | 1999-11-01 | 2002-04-09 | Sheffield Pharmaceuticals, Inc. | Internal vortex mechanism for inhaler device |
IT1317720B1 (it) * | 2000-01-07 | 2003-07-15 | Chiesi Farma Spa | Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani. |
GB0002798D0 (en) * | 2000-02-09 | 2000-03-29 | Glaxo Group Ltd | Actuator nozzle for metered dose inhaler |
IT1317846B1 (it) | 2000-02-22 | 2003-07-15 | Chiesi Farma Spa | Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva. |
CA2401288A1 (en) | 2000-02-28 | 2001-09-07 | Vectura Limited | Improvements in or relating to the delivery of oral drugs |
US6443151B1 (en) | 2000-03-08 | 2002-09-03 | Aradigm Corporation | Fluid velocity-sensitive trigger mechanism |
GB2360216A (en) * | 2000-03-18 | 2001-09-19 | Astrazeneca Uk Ltd | Inhaler |
ES2257996T3 (es) * | 2000-04-07 | 2006-08-16 | Andi-Ventis Limited | Boquilla para inhalador de particulas. |
EP1272243B1 (en) | 2000-04-11 | 2005-10-26 | Trudell Medical International | Aerosol delivery apparatus with positive expiratory pressure capacity |
US6328035B1 (en) * | 2000-05-09 | 2001-12-11 | Iep Pharmaceutical Devices Inc. | Pneumatic breath actuated inhaler |
IT1318514B1 (it) * | 2000-05-12 | 2003-08-27 | Chiesi Farma Spa | Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari. |
AU2000250701B2 (en) | 2000-05-22 | 2004-07-01 | Chiesi Farmaceutici S.P.A. | Stable pharmaceutical solution formulations for pressurised metered dose inhalers |
TWI224511B (en) * | 2000-06-23 | 2004-12-01 | Norton Healthcare Ltd | De-agglomerator for breath-actuated dry powder inhaler |
US6339107B1 (en) | 2000-08-02 | 2002-01-15 | Syntex (U.S.A.) Llc | Methods for treatment of Emphysema using 13-cis retinoic acid |
SE517226C2 (sv) * | 2000-09-25 | 2002-05-14 | Microdrug Ag | Inhalator med luftbroms för torrt pulver |
EP1320397B1 (en) * | 2000-09-29 | 2010-01-20 | Pfizer Limited | Medical Inhalation-Device |
GB0023845D0 (en) * | 2000-09-29 | 2000-11-15 | Pa Knowledge Ltd | Dosing device |
EP1935869A1 (en) | 2000-10-02 | 2008-06-25 | F. Hoffmann-La Roche Ag | Retinoids for the treatment of emphysema |
US6964647B1 (en) * | 2000-10-06 | 2005-11-15 | Ellaz Babaev | Nozzle for ultrasound wound treatment |
US6601581B1 (en) | 2000-11-01 | 2003-08-05 | Advanced Medical Applications, Inc. | Method and device for ultrasound drug delivery |
US6761729B2 (en) | 2000-12-22 | 2004-07-13 | Advanced Medicalapplications, Inc. | Wound treatment method and device with combination of ultrasound and laser energy |
US6533803B2 (en) | 2000-12-22 | 2003-03-18 | Advanced Medical Applications, Inc. | Wound treatment method and device with combination of ultrasound and laser energy |
US8235919B2 (en) | 2001-01-12 | 2012-08-07 | Celleration, Inc. | Ultrasonic method and device for wound treatment |
US7914470B2 (en) | 2001-01-12 | 2011-03-29 | Celleration, Inc. | Ultrasonic method and device for wound treatment |
US6960173B2 (en) * | 2001-01-30 | 2005-11-01 | Eilaz Babaev | Ultrasound wound treatment method and device using standing waves |
US6623444B2 (en) | 2001-03-21 | 2003-09-23 | Advanced Medical Applications, Inc. | Ultrasonic catheter drug delivery method and device |
SE0101233L (sv) * | 2001-04-05 | 2002-10-01 | Microdrug Ag | Förfarande och anordning för frigörande av pulver och inhalatoranordning för administrering av medicinskt pulver |
US6478754B1 (en) | 2001-04-23 | 2002-11-12 | Advanced Medical Applications, Inc. | Ultrasonic method and device for wound treatment |
EP1382995B1 (en) | 2001-04-25 | 2014-05-07 | Panasonic Corporation | Projection display device |
EG24184A (en) * | 2001-06-15 | 2008-10-08 | Otsuka Pharma Co Ltd | Dry powder inhalation system for transpulmonary |
US6681768B2 (en) * | 2001-06-22 | 2004-01-27 | Sofotec Gmbh & Co. Kg | Powder formulation disintegrating system and method for dry powder inhalers |
SI1273292T1 (en) * | 2001-07-02 | 2004-12-31 | Chiesi Farmaceutici S.P.A. | Optimised formulation of tobramycin for aerosolization |
CN100374171C (zh) * | 2001-09-06 | 2008-03-12 | 微计量技术有限公司 | 用于提高吸入器性能的转接器 |
AU2002340083A1 (en) * | 2001-09-28 | 2003-04-07 | Kurve Technology, Inc | Nasal nebulizer |
US6701922B2 (en) * | 2001-12-20 | 2004-03-09 | Chrysalis Technologies Incorporated | Mouthpiece entrainment airflow control for aerosol generators |
DK3494995T3 (da) * | 2002-03-01 | 2020-03-23 | Chiesi Farm Spa | Superfin formoterolformulering |
DE60318938T2 (de) | 2002-03-20 | 2009-01-22 | Mannkind Corp., Valencia | Inhalationsgerät |
GB0209494D0 (en) * | 2002-04-25 | 2002-06-05 | Optinose As | Nasal devices |
US20030205226A1 (en) | 2002-05-02 | 2003-11-06 | Pre Holding, Inc. | Aerosol medication inhalation system |
AU2003225071A1 (en) * | 2002-05-03 | 2003-11-17 | Trudell Medical International | Aerosol medication delivery apparatus with narrow orifice |
AU2003249623A1 (en) * | 2002-05-09 | 2003-12-12 | Kurve Technology, Inc. | Particle dispersion chamber for nasal nebulizer |
US6889690B2 (en) * | 2002-05-10 | 2005-05-10 | Oriel Therapeutics, Inc. | Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages |
US7677411B2 (en) | 2002-05-10 | 2010-03-16 | Oriel Therapeutics, Inc. | Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders |
US6904908B2 (en) | 2002-05-21 | 2005-06-14 | Trudell Medical International | Visual indicator for an aerosol medication delivery apparatus and system |
JP4243499B2 (ja) * | 2002-06-11 | 2009-03-25 | 富士通株式会社 | 貼合せ基板製造装置及び貼合せ基板製造方法 |
EP1534366B1 (en) * | 2002-06-27 | 2014-01-08 | Oriel Therapeutics, Inc. | Dry powder dose filling systems and related methods |
GEP20074270B (en) | 2002-07-23 | 2007-12-25 | Univ Michigan | Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies |
US7189865B2 (en) * | 2002-07-23 | 2007-03-13 | Attenuon, Llc | Thiomolybdate analogues and uses thereof |
AU2003270321B2 (en) * | 2002-09-06 | 2008-04-03 | Philip Morris Products S.A. | Aerosol generating devices and methods for generating aerosols having controlled particle sizes |
EP1551386A4 (en) * | 2002-09-27 | 2009-03-25 | Bioenvision Inc | METHOD AND COMPOSITIONS FOR TREATING LUPUS WITH CLOFARABIN |
AU2003276988B2 (en) * | 2002-09-27 | 2009-11-05 | Bioenvision, Inc. | Methods and compositions for the treatment of autoimmune disorders using clofarabine |
US6834717B2 (en) | 2002-10-04 | 2004-12-28 | R&M Energy Systems, Inc. | Tubing rotator |
MXPA05003718A (es) * | 2002-10-07 | 2005-09-30 | Radiorx Inc | Compuestos x-nitro, sus composiciones farmaceuticas y sus usos. |
AU2003285109A1 (en) * | 2002-10-30 | 2004-06-07 | Glaxo Group Limited | Tubular nozzles for use in systems for delivering medicaments |
WO2004047771A2 (en) * | 2002-11-25 | 2004-06-10 | Attenuon, Llc. | Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof |
AU2003293361A1 (en) * | 2002-12-18 | 2004-07-29 | Glaxo Group Limited | Drug delivery system with vented mouthpiece |
US20040187869A1 (en) * | 2003-01-17 | 2004-09-30 | Schering Corporation | Training device for medicament inhalers |
ZA200504940B (en) * | 2003-01-28 | 2006-09-27 | Xenoport Inc | Amino acid derived prodrugs of propofol, compositions and uses thereof |
JP4713465B2 (ja) | 2003-03-12 | 2011-06-29 | セルジーン コーポレイション | 7−アミド−イソインドリル化合物およびその薬学的使用 |
SI3889142T1 (sl) | 2003-04-11 | 2022-10-28 | Ptc Therapeutics, Inc. | Spojine 1,2,4-oksadiazol benzojske kisline in njihova uporaba za zatiranje nesmiselne ter zdravljenje bolezni |
US7360537B2 (en) * | 2003-04-16 | 2008-04-22 | Trudell Medical International | Antistatic medication delivery apparatus |
ZA200509719B (en) * | 2003-05-27 | 2007-03-28 | Attenuon Llc | Thiotungstate analogues and uses thereof |
WO2005004882A1 (en) * | 2003-07-09 | 2005-01-20 | Monash University | Antiviral charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and methods of use thereof |
US8001963B2 (en) * | 2003-09-05 | 2011-08-23 | Kurve Technology, Inc. | Integrated nebulizer and particle dispersion chamber for nasal delivery of medicament to deep nasal cavity and paranasal sinuses |
WO2005023334A2 (en) * | 2003-09-05 | 2005-03-17 | Kurve Technology, Inc. | Nasal adapter for the base of the nose |
US7230003B2 (en) * | 2003-09-09 | 2007-06-12 | Xenoport, Inc. | Aromatic prodrugs of propofol, compositions and uses thereof |
CA2538237A1 (en) * | 2003-09-10 | 2005-03-24 | Map Pharmaceuticals, Inc. | Aerosol formulations for delivery of dihydroergotamine to the systemic circulation via pulmonary inhalation |
GB2405799A (en) * | 2003-09-15 | 2005-03-16 | Vectura Ltd | Dry powder inhaler incorporating a valve which is opened and closed by pressurized gas |
US7305984B2 (en) | 2003-09-25 | 2007-12-11 | Deka Products Limited Partnership | Metering system and method for aerosol delivery |
US7342660B2 (en) * | 2003-09-25 | 2008-03-11 | Deka Products Limited Partnership | Detection system and method for aerosol delivery |
CA2546493A1 (en) | 2003-11-19 | 2005-06-09 | Signal Pharmaceuticals, Llc | Indazole compounds and methods of use thereof as protein kinase inhibitors |
WO2005082382A1 (en) * | 2004-02-23 | 2005-09-09 | Attenuon Llc | Formulations of thiomolybdate or thiotungstate compounds and uses thereof |
EP1595531A1 (en) | 2004-05-13 | 2005-11-16 | CHIESI FARMACEUTICI S.p.A. | Stable pharmaceutical solution formulations for pressurized metered dose inhalers |
WO2005088655A1 (en) * | 2004-03-12 | 2005-09-22 | The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | A magnetoresistive medium |
US7448385B2 (en) * | 2004-06-07 | 2008-11-11 | Purepharm Inc. | Nasal adaptation of an oral inhaler device |
WO2006017351A1 (en) * | 2004-07-12 | 2006-02-16 | Xenoport, Inc. | Prodrugs of propofol, compositions and uses thereof |
WO2006017352A1 (en) * | 2004-07-12 | 2006-02-16 | Xenoport, Inc. | Amino acid derived prodrugs of propofol, compositions and uses thereof |
US20060128676A1 (en) * | 2004-07-13 | 2006-06-15 | Pharmacofore, Inc. | Compositions of nicotinic agonists and therapeutic agents and methods for treating or preventing diseases or pain |
ES2385934T3 (es) | 2004-08-20 | 2012-08-03 | Mannkind Corporation | Catálisis de la síntesis de dicetopiperazina. |
EP2314298B1 (en) | 2004-08-23 | 2015-05-27 | MannKind Corporation | Microparticles comprising diketopiperazine salts for drug delivery |
US8365725B2 (en) * | 2004-09-13 | 2013-02-05 | Oriel Therapeutics, Inc. | Dry powder inhalers that inhibit agglomeration, related devices and methods |
ZA200703291B (en) * | 2004-10-15 | 2008-09-25 | Cipla Ltd | An improved spacer |
EP1824847A2 (en) * | 2004-12-17 | 2007-08-29 | Anadys Pharmaceuticals, Inc. | Pyridazinone compounds |
WO2006066080A1 (en) | 2004-12-17 | 2006-06-22 | Anadys Pharmaceuticals, Inc. | 3, 5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO AND 3H-THIAZOLO [4,5-d]PYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF |
JP2008525501A (ja) * | 2004-12-23 | 2008-07-17 | ゼノポート,インコーポレイティド | セリンアミノ酸誘導のプロポフォールのプロドラッグ、その使用及び結晶体 |
FR2881118B1 (fr) * | 2005-01-25 | 2007-04-20 | Valois Sas | Dispositif de distribution de produit fluide. |
US7785277B2 (en) | 2005-06-23 | 2010-08-31 | Celleration, Inc. | Removable applicator nozzle for ultrasound wound therapy device |
US7713218B2 (en) | 2005-06-23 | 2010-05-11 | Celleration, Inc. | Removable applicator nozzle for ultrasound wound therapy device |
EP1907357A1 (en) | 2005-07-22 | 2008-04-09 | Amgen Inc. | Aniline sulfonamide derivatives and their uses |
US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
US20070135380A1 (en) | 2005-08-12 | 2007-06-14 | Radiorx, Inc. | O-nitro compounds, pharmaceutical compositions thereof and uses thereof |
EP1928881A2 (en) | 2005-08-19 | 2008-06-11 | Pharmacofore, Inc. | Prodrugs of active agents |
KR20160022404A (ko) | 2005-09-14 | 2016-02-29 | 맨카인드 코포레이션 | 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법 |
DE102005054383B4 (de) * | 2005-11-15 | 2013-10-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Nadel zum Lochen von Pulverkapseln für die Inhalation |
US20070197486A1 (en) * | 2005-12-20 | 2007-08-23 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids |
US20070178049A1 (en) * | 2005-12-20 | 2007-08-02 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
US20070249572A1 (en) * | 2005-12-20 | 2007-10-25 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
US20070185066A1 (en) * | 2005-12-20 | 2007-08-09 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
US20070160542A1 (en) * | 2005-12-20 | 2007-07-12 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
EP2335754B1 (en) | 2006-02-09 | 2013-12-18 | DEKA Products Limited Partnership | Patch-sized fluid delivery systems |
JP2009526860A (ja) * | 2006-02-15 | 2009-07-23 | ティカ レーケメデル アーベー | 安定したコルチコステロイド混合物 |
AU2013205495B2 (en) * | 2006-02-17 | 2015-11-26 | Sanofi Sa | Dispersing unit |
DE102006007495A1 (de) * | 2006-02-17 | 2007-08-23 | Siegfried Generics International Ag | Dispergiereinheit |
GB2433207B (en) | 2006-02-21 | 2009-01-07 | Jianhe Li | Active suction actuated inhalers with timing devices |
MX2008010721A (es) | 2006-02-22 | 2008-09-01 | Mannkind Corp | Un metodo para mejorar las propiedades farmaceuticas de microparticulas que contienen dicetopiperazina y un agente activo. |
AU2007231594A1 (en) * | 2006-03-23 | 2007-10-04 | Amgen Inc. | 1-phenylsulfonyl-diaza heterocyclic amide compounds and their uses as modulators of hydroxsteroid dehydrogenases |
US8217005B2 (en) | 2006-05-26 | 2012-07-10 | Signature Therapeutics, Inc. | Controlled release of phenolic opioids |
US8562547B2 (en) | 2006-06-07 | 2013-10-22 | Eliaz Babaev | Method for debriding wounds |
US7431704B2 (en) * | 2006-06-07 | 2008-10-07 | Bacoustics, Llc | Apparatus and method for the treatment of tissue with ultrasound energy by direct contact |
AU2007259143A1 (en) * | 2006-06-08 | 2007-12-21 | Amgen Inc. | Benzamide derivatives and uses related thereto |
TW200808695A (en) * | 2006-06-08 | 2008-02-16 | Amgen Inc | Benzamide derivatives and uses related thereto |
JP5306194B2 (ja) | 2006-06-22 | 2013-10-02 | アナディス ファーマシューティカルズ インク | ピロ[1,2−b]ピリダジノン化合物 |
CA2655904C (en) | 2006-06-22 | 2014-11-18 | Anadys Pharmaceuticals, Inc. | Prodrugs of 5-amino-3-(3'-deoxy-.beta.-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione |
US20080090814A1 (en) * | 2006-06-22 | 2008-04-17 | Anadys Pharmaceuticals, Inc. | Pyridazinone compounds |
WO2008008281A2 (en) | 2006-07-07 | 2008-01-17 | Proteus Biomedical, Inc. | Smart parenteral administration system |
ATE499940T1 (de) | 2006-07-18 | 2011-03-15 | Anadys Pharmaceuticals Inc | Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen |
AU2007275301A1 (en) * | 2006-07-20 | 2008-01-24 | Amgen Inc. | Substituted azole aromatic heterocycles as inhibitors of 11-beta-HSD-1 |
US7905229B2 (en) | 2006-08-30 | 2011-03-15 | Kurve Technology, Inc. | Aerosol generating and delivery device |
BRPI0603695A (pt) * | 2006-09-13 | 2008-04-29 | Cesar Eduardo Marques Da Silva | aerocámara para aplicação de medicamentos aerossol com válvula geométrica |
US20080087279A1 (en) * | 2006-10-11 | 2008-04-17 | Tieck Catharine Laureen Johnso | Metered dose inhaler |
US20080177221A1 (en) * | 2006-12-22 | 2008-07-24 | Celleration, Inc. | Apparatus to prevent applicator re-use |
AU2007343726A1 (en) * | 2006-12-26 | 2008-07-24 | Amgen Inc. | N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases |
WO2008082725A1 (en) * | 2006-12-29 | 2008-07-10 | Anadys Pharmaceuticals, Inc. | Pyridazinone compounds |
US20080214965A1 (en) * | 2007-01-04 | 2008-09-04 | Celleration, Inc. | Removable multi-channel applicator nozzle |
US8491521B2 (en) * | 2007-01-04 | 2013-07-23 | Celleration, Inc. | Removable multi-channel applicator nozzle |
AU2008214205B2 (en) | 2007-02-11 | 2014-04-24 | Map Pharmaceuticals, Inc. | Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile |
PL2129422T3 (pl) * | 2007-02-27 | 2013-09-30 | Ivax Pharmaceuticals Ireland | Inhalator z odmierzaną dawką |
JP4916954B2 (ja) * | 2007-05-30 | 2012-04-18 | 株式会社吉野工業所 | 吸引式投薬器 |
US7928111B2 (en) | 2007-06-08 | 2011-04-19 | Senomyx, Inc. | Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors |
US8633186B2 (en) | 2007-06-08 | 2014-01-21 | Senomyx Inc. | Modulation of chemosensory receptors and ligands associated therewith |
US9603848B2 (en) * | 2007-06-08 | 2017-03-28 | Senomyx, Inc. | Modulation of chemosensory receptors and ligands associated therewith |
US20080306076A1 (en) * | 2007-06-08 | 2008-12-11 | Senomyx, Inc. | Modulation of chemosensory receptors and ligands associated therewith |
US9125979B2 (en) | 2007-10-25 | 2015-09-08 | Proteus Digital Health, Inc. | Fluid transfer port information system |
GB2454742B (en) * | 2007-11-17 | 2011-02-02 | David Ohayon | Inhaler adapter |
US8419638B2 (en) | 2007-11-19 | 2013-04-16 | Proteus Digital Health, Inc. | Body-associated fluid transport structure evaluation devices |
DE102007056263A1 (de) | 2007-11-22 | 2009-05-28 | Siegfried Generics International Ag | Dosiervorrichtung zur Inhalierung einer pulverförmigen Substanz |
CA2709071C (en) | 2007-12-14 | 2016-11-15 | Labogroup S.A.S. | Delivering aerosolizable food products |
EP2231279A1 (en) * | 2007-12-28 | 2010-09-29 | Celleration, Inc. | Methods for treating inflammatory skin disorders |
US20090177123A1 (en) * | 2007-12-28 | 2009-07-09 | Celleration, Inc. | Methods for treating inflammatory disorders |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
EP3281663B8 (en) | 2008-06-13 | 2022-09-21 | MannKind Corporation | Breath powered dry powder inhaler for drug delivery |
MX2010014240A (es) | 2008-06-20 | 2011-03-25 | Mankind Corp | Un metodo y aparato interactivo para perfilar en tiempo real esfuerzos de inhalacion. |
WO2010008523A1 (en) * | 2008-07-13 | 2010-01-21 | Map Pharmaceuticals, Inc. | Methods and apparatus for delivering aerosolized medication |
US20100022919A1 (en) * | 2008-07-22 | 2010-01-28 | Celleration, Inc. | Methods of Skin Grafting Using Ultrasound |
US8609173B2 (en) | 2008-07-31 | 2013-12-17 | Senomyx Inc. | Compositions comprising sweetness enhancers and methods of making them |
MY153622A (en) | 2008-07-31 | 2015-02-27 | Senomyx Inc | Processes and intermediates for making sweet taste enhancers |
TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
TWI480272B (zh) | 2008-10-09 | 2015-04-11 | Anadys Pharmaceuticals Inc | 藉由5,6-二氫-1h-吡啶-2-酮與一或多種其他抗病毒化合物的組合物抑制c型肝炎病毒的方法 |
US20100196286A1 (en) * | 2008-12-01 | 2010-08-05 | Armer Thomas A | Inhalation delivery methods and devices |
WO2010074753A1 (en) * | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
CA2754595C (en) | 2009-03-11 | 2017-06-27 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
US8551528B2 (en) | 2009-06-12 | 2013-10-08 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
US8495998B2 (en) * | 2009-06-17 | 2013-07-30 | British American Tobacco (Investments) Limited | Inhaler |
WO2010151804A1 (en) * | 2009-06-26 | 2010-12-29 | Map Pharmaceuticals, Inc. | Administration of dihydroergotamine mesylate particles using a metered dose inhaler |
EP2496295A1 (en) | 2009-11-03 | 2012-09-12 | MannKind Corporation | An apparatus and method for simulating inhalation efforts |
NZ600208A (en) * | 2009-11-17 | 2014-06-27 | Cipla Ltd | Inhalation solutions |
WO2011079310A1 (en) * | 2009-12-23 | 2011-06-30 | Map Pharmaceuticals,Inc. | Enhanced eductor design |
US9014779B2 (en) | 2010-02-01 | 2015-04-21 | Proteus Digital Health, Inc. | Data gathering system |
SG182824A1 (en) | 2010-02-01 | 2012-09-27 | Proteus Biomedical Inc | Two-wrist data gathering system |
US8471041B2 (en) * | 2010-02-09 | 2013-06-25 | Alliant Techsystems Inc. | Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same |
NZ603226A (en) | 2010-04-30 | 2015-02-27 | Alexion Pharma Inc | Anti-c5a antibodies and methods for using the antibodies |
DE102010024912B4 (de) * | 2010-06-15 | 2013-02-28 | Aptar Radolfzell Gmbh | Inhalationsvorrichtung |
BR112012033060A2 (pt) | 2010-06-21 | 2018-02-27 | Mannkind Corp | métodos de sistema de liberação de fármaco em pó seco |
KR20130036276A (ko) | 2010-06-22 | 2013-04-11 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 보체 결합 3의 C3d 조각에 대한 항체들 |
RU2576451C2 (ru) | 2010-08-12 | 2016-03-10 | Синомикс, Инк. | Способ улучшения стабильности усилителей сладкого вкуса и композиция, содержащая стабилизированный усилитель сладкого вкуса |
KR101940832B1 (ko) | 2011-04-01 | 2019-01-21 | 맨카인드 코포레이션 | 의약 카트리지용 블리스터 패키지 |
WO2012158271A1 (en) | 2011-04-06 | 2012-11-22 | Anadys Pharmaceuticals, Inc. | Bridged polycyclic compounds as antiviral agents |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
US8664247B2 (en) | 2011-08-26 | 2014-03-04 | Radiorx, Inc. | Acyclic organonitro compounds for use in treating cancer |
US9139519B2 (en) | 2011-10-07 | 2015-09-22 | Epicentrx, Inc. | Organonitro thioether compounds and medical uses thereof |
WO2013052803A2 (en) | 2011-10-07 | 2013-04-11 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
EP2776053A1 (en) | 2011-10-24 | 2014-09-17 | MannKind Corporation | Methods and compositions for treating pain |
WO2013114374A1 (en) | 2012-02-01 | 2013-08-08 | Protalix Ltd. | Dnase i polypeptides, polynucleotides encoding same, methods of producing dnase i and uses thereof in therapy |
SG11201500218VA (en) | 2012-07-12 | 2015-03-30 | Mannkind Corp | Dry powder drug delivery systems and methods |
AU2013299859B2 (en) | 2012-08-06 | 2017-06-15 | Firmenich Incorporated | Sweet flavor modifier |
US9713687B2 (en) * | 2012-08-21 | 2017-07-25 | Philip Morris Usa Inc. | Ventilator aerosol delivery system with transition adapter for introducing carrier gas |
GB201215282D0 (en) | 2012-08-28 | 2012-10-10 | Kind Consumer Ltd | An inhaler |
EP2911690A1 (en) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalable influenza vaccine compositions and methods |
JO3155B1 (ar) | 2013-02-19 | 2017-09-20 | Senomyx Inc | معدِّل نكهة حلوة |
EP3587404B1 (en) | 2013-03-15 | 2022-07-13 | MannKind Corporation | Microcrystalline diketopiperazine compositions, methods for preparation and use thereof |
BR122019026637B1 (pt) | 2013-07-18 | 2023-09-26 | Mannkind Corporation | Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco |
CA2920488C (en) | 2013-08-05 | 2022-04-26 | Mannkind Corporation | Insufflation apparatus and methods |
EP3074089A4 (en) | 2013-11-26 | 2017-07-26 | Alliqua Biomedical, Inc. | Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing |
GB2524469A (en) * | 2014-02-14 | 2015-09-30 | Kind Consumer Ltd | A cannabinoid inhaler and composition therefor |
NZ711451A (en) | 2014-03-07 | 2016-05-27 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
WO2015187025A1 (en) * | 2014-06-06 | 2015-12-10 | Rijksuniversiteit Groningen | A breath actuated dry powder inhaler |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
WO2016057693A1 (en) | 2014-10-10 | 2016-04-14 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for inhalation delivery of conjugated oligonucleotide |
CA2991138A1 (en) * | 2015-07-20 | 2017-01-26 | Daniel Deaton | Aerosol delivery systems and related methods |
CN105092786A (zh) * | 2015-07-23 | 2015-11-25 | 上海化工研究院 | 一种对冲式定量雾化给药装置 |
US10335406B2 (en) | 2015-10-01 | 2019-07-02 | Elysium Therapeutics, Inc. | Opioid compositions resistant to overdose and abuse |
CA2998708C (en) | 2015-10-01 | 2019-09-03 | Elysium Therapeutics, Inc. | Polysubunit opioid prodrugs resistant to overdose and abuse |
US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
WO2017112451A1 (en) | 2015-12-21 | 2017-06-29 | 3M Innovative Properties Company | Auto-reset dose release firing systems, medicinal inhalers comprising same, and methods of using same |
WO2017112476A2 (en) * | 2015-12-21 | 2017-06-29 | 3M Innovative Properties Company | Dose release firing systems and medicinal inhalers comprising same |
KR20190040931A (ko) | 2016-01-11 | 2019-04-19 | 에피센트알엑스, 인코포레이티드 | 2-브로모-1-(3,3-디니트로아제티딘-1-일)에타논의 정맥내 투여를 위한 조성물 및 방법 |
FR3050116B1 (fr) * | 2016-04-15 | 2020-05-15 | Aptar France Sas | Dispositif de distribution de produit fluide synchronise avec l'inhalation |
FR3050115B1 (fr) * | 2016-04-15 | 2023-05-12 | Aptar France Sas | Dispositif de distribution de produit fluide synchronise avec l'inhalation. |
WO2018064825A1 (zh) * | 2016-10-09 | 2018-04-12 | 益得生物科技股份有限公司 | 药物传递装置及其系统 |
MX2019004280A (es) | 2016-10-14 | 2019-09-18 | Epicentrx Inc | Organonitro-sulfoalquilo y compuestos relacionados y composiciones farmacéuticas para uso en medicina. |
JP7234130B2 (ja) | 2017-03-17 | 2023-03-07 | エリージウム セラピューティクス, インコーポレイテッド | 過剰摂取および乱用に対して抵抗性のポリサブユニットオピオイドプロドラッグ |
WO2019010447A1 (en) | 2017-07-07 | 2019-01-10 | Epicentrx, Inc. | COMPOSITIONS FOR PARENTERAL ADMINISTRATION OF THERAPEUTIC AGENTS |
JP7079844B2 (ja) | 2017-07-27 | 2022-06-02 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 高濃度抗c5抗体製剤 |
CN109481802A (zh) * | 2017-09-12 | 2019-03-19 | 张海飞 | 全自动定量气雾吸入装置 |
IL255520A0 (en) * | 2017-11-08 | 2017-12-31 | Omrix Biopharmaceuticals Ltd | Powder release device |
WO2019164593A2 (en) | 2018-01-08 | 2019-08-29 | Epicentrx, Inc. | Methods and compositions utilizing rrx-001 combination therapy for radioprotection |
JP7101787B2 (ja) * | 2018-01-23 | 2022-07-15 | エスエイチエル・メディカル・アーゲー | エアロゾル発生器 |
EP3773614A1 (en) | 2018-04-12 | 2021-02-17 | Matrx Therapeutics Corporation | Compositions and methods for treating elastic fiber breakdown |
JP7313439B2 (ja) * | 2018-06-04 | 2023-07-24 | トゥルーデル メディカル インターナショナル | 陽気圧治療装置、そのキット、並びに使用法及び組み立て法 |
CN109078234A (zh) * | 2018-07-03 | 2018-12-25 | 李骏达 | 用于慢性伤口清创的局部组织闭合涡流冲洗器 |
BR112021002261A2 (pt) | 2018-08-07 | 2021-05-04 | Firmenich Incorporated | 2,2-dióxidos de 4-amino-1h-benzo[c][1,2,6]tiadiazina 5-substituídos e formulações e usos dos mesmos |
JP7250317B2 (ja) * | 2019-03-18 | 2023-04-03 | 学校法人日本大学 | 薬剤吸入器 |
NL2023033B1 (en) * | 2019-04-30 | 2020-11-23 | Medspray B V | Spray inhaler device |
CA3139468A1 (en) * | 2019-05-24 | 2020-12-03 | Blue Ocean Group, LLC | Compact spacer for metered dose inhaler |
KR102200764B1 (ko) * | 2020-02-18 | 2021-01-08 | 가톨릭대학교 산학협력단 | 마취용 기화기의 마취액용기 가압유지장치 |
CN111359060A (zh) * | 2020-02-20 | 2020-07-03 | 深圳麦克韦尔科技有限公司 | 雾化吸嘴及雾化装置 |
CN111214737B (zh) * | 2020-03-06 | 2020-10-20 | 张洁 | 一种儿童用雾化器 |
CN111544715B (zh) * | 2020-04-02 | 2022-08-19 | 佛山市澳斯卡医疗器械有限公司 | 一种瓶装雾化器 |
CN111536555A (zh) * | 2020-05-08 | 2020-08-14 | 中国航发湖南动力机械研究所 | 发动机及其发动机燃烧室 |
US11925749B2 (en) * | 2021-03-18 | 2024-03-12 | Funai Electric Co., Ltd. | Venting of pharmaceutical drug delivery device for air flow and humidity control |
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WO2023178283A1 (en) | 2022-03-18 | 2023-09-21 | Epicentrx, Inc. | Co-crystals of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone and methods |
WO2023215227A1 (en) | 2022-05-02 | 2023-11-09 | Epicentrx, Inc. | Systems and methods to improve exercise tolerance |
WO2023215229A1 (en) | 2022-05-02 | 2023-11-09 | Epicentrx, Inc. | Compositions and methods for treatment of pulmonary hypertension |
WO2023244973A1 (en) | 2022-06-13 | 2023-12-21 | Epicentrx, Inc. | Compositions and methods for reducing adverse side effects in cancer treatment |
WO2024098009A1 (en) | 2022-11-04 | 2024-05-10 | Epicentrx, Inc. | Rrx-001 for minimizing post-infarct adverse ventricular remodeling and complications |
WO2024124152A1 (en) | 2022-12-08 | 2024-06-13 | Epicentrx, Inc. | Rrx-001 for the treatment of a hemoglobinopathy |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2305210A (en) * | 1940-10-28 | 1942-12-15 | Spraying Systems Co | Spray shaper |
US2751252A (en) * | 1953-12-14 | 1956-06-19 | Spraying Systems Co | Whirl spray nozzle |
US2984420A (en) * | 1959-11-20 | 1961-05-16 | Jr John W Hession | Aerosol devices |
US3072346A (en) * | 1961-09-29 | 1963-01-08 | Spraying Systems Co | Spray nozzle |
FR1322998A (fr) * | 1962-02-23 | 1963-04-05 | Perfectionnements aux dispositifs de production d'aérosols | |
US3240431A (en) * | 1964-05-27 | 1966-03-15 | Clayton Corp Of Delaware | Combination valve spout and spray head assembly |
US3385295A (en) * | 1966-02-07 | 1968-05-28 | Puritan Compressed Gas Corp | Apparatus for use in administering intermittent positive pressure breathing therapy |
US3406913A (en) * | 1966-09-01 | 1968-10-22 | Revlon | Mechanical break-up actuator for fluid dispensers |
US3456644A (en) * | 1967-01-19 | 1969-07-22 | Dart Ind Inc | Inhalation-actuated aerosol dispensing device |
GB1253221A (ja) * | 1968-04-23 | 1971-11-10 | ||
US3522806A (en) * | 1968-08-07 | 1970-08-04 | G S Intern Lab Corp | Aerosol apparatus for inhalation therapy |
DE1813993C3 (de) * | 1968-12-11 | 1974-01-24 | Paul Ritzau Pari-Werk Kg, 8135 Soecking | Vorrichtung zum Zerstäuben und Vernebeln von flüssigen oder pulverförmigen Stoffen |
US3565070A (en) * | 1969-02-28 | 1971-02-23 | Riker Laboratories Inc | Inhalation actuable aerosol dispenser |
US3636949A (en) * | 1969-08-08 | 1972-01-25 | Armstrong Kropp Dev Corp | Inhalation-initiated aerosol dispenser |
US3838686A (en) * | 1971-10-14 | 1974-10-01 | G Szekely | Aerosol apparatus for inhalation therapy |
US4049200A (en) * | 1976-04-05 | 1977-09-20 | Sobol Jacob M | Nebulizer |
DE3166709D1 (en) * | 1980-08-04 | 1984-11-22 | Fisons Plc | Inhalation device for administering medicaments |
DE3043377A1 (de) * | 1980-11-17 | 1982-07-01 | Brugger, Inge, 8130 Starnberg | Zerstaeuber |
FI69962C (fi) * | 1983-12-28 | 1986-09-12 | Huhtamaeki Oy | Inhalationsanordning |
US4534343A (en) * | 1984-01-27 | 1985-08-13 | Trutek Research, Inc. | Metered dose inhaler |
DE8621135U1 (de) * | 1985-09-02 | 1987-01-29 | Callahan, George Edgar, Prof., 40479 Düsseldorf | Sprühvorrichtung zum Aufsetzen auf einen zusammenpressbaren Behälter |
SE453566B (sv) * | 1986-03-07 | 1988-02-15 | Draco Ab | Anordning vid pulverinhalatorer |
US4739754A (en) * | 1986-05-06 | 1988-04-26 | Shaner William T | Suction resistant inhalator |
GB8614805D0 (en) * | 1986-06-18 | 1986-07-23 | British American Tobacco Co | Aerosol device |
EP0261649B2 (en) * | 1986-09-22 | 1995-04-26 | Omron Tateisi Electronics Co. | Nebulizer |
JP2587817B2 (ja) * | 1986-09-22 | 1997-03-05 | オムロン株式会社 | 霧化器 |
US4768717A (en) * | 1987-02-12 | 1988-09-06 | Specialty Packaging Licensing Company | Nozzle |
JPH0199570A (ja) * | 1987-09-30 | 1989-04-18 | Bootran Medical Technol Inc | 吸入装置と吸入方法 |
WO1989005195A1 (en) * | 1987-12-11 | 1989-06-15 | Deutsche Forschungsanstalt Für Luft- Und Raumfahrt | Whirl nozzle for atomizing a liquid |
EP0363060B1 (en) * | 1988-10-04 | 1994-04-27 | The Johns Hopkins University | Aerosol inhaler |
SE466684B (sv) * | 1989-03-07 | 1992-03-23 | Draco Ab | Anordning vid en inhalator samt foerfarande foer att med anordningen registrera medicinering med inhalator |
GB8919131D0 (en) * | 1989-08-23 | 1989-10-04 | Riker Laboratories Inc | Inhaler |
DE8912098U1 (de) * | 1989-10-11 | 1990-11-08 | Magasi, Josef, 6902 Sandhausen | Inhalator |
FR2658081B1 (fr) * | 1990-02-09 | 1995-06-30 | Pesenti Yvan | Dispositif d'automatisation et synchronisation des appareils aerosols a pompe doseuse. |
GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
US5615670A (en) * | 1990-03-07 | 1997-04-01 | Fisons Plc | Powder inhaler with centrifugal force used to meter powder |
GB9015077D0 (en) * | 1990-07-09 | 1990-08-29 | Riker Laboratories Inc | Inhaler |
US5060643A (en) * | 1990-08-07 | 1991-10-29 | Tenax Corporation | Breath-activated inhalation device |
DE4027391A1 (de) * | 1990-08-30 | 1992-03-12 | Boehringer Ingelheim Kg | Treibgasfreies inhalationsgeraet |
US5178138A (en) * | 1990-09-11 | 1993-01-12 | Walstrom Dennis R | Drug delivery device |
GB9020555D0 (en) * | 1990-09-20 | 1990-10-31 | Bespak Plc | Dispensing apparatus |
US5027808A (en) * | 1990-10-31 | 1991-07-02 | Tenax Corporation | Breath-activated inhalation device |
US5217004A (en) * | 1990-12-13 | 1993-06-08 | Tenax Corporation | Inhalation actuated dispensing apparatus |
US5040527A (en) * | 1990-12-18 | 1991-08-20 | Healthscan Products Inc. | Metered dose inhalation unit with slide means |
JP3532204B2 (ja) * | 1991-03-05 | 2004-05-31 | アラダイム コーポレーション | 流量計の圧力センサのドリフトオフセットを補正する方法および装置 |
EP0504459B1 (de) * | 1991-03-21 | 1996-06-05 | PAUL RITZAU PARI-WERK GmbH | Vernebler insbesondere zur Anwendung in Geräten für die Inhalationstherapie |
AU662919B2 (en) * | 1991-07-02 | 1995-09-21 | Inhale, Inc. | Method and device for delivering aerosolized medicaments |
BR9206422A (pt) * | 1991-08-29 | 1995-10-17 | Christoph Klein | Aparelho médico para a inalação de aerossóis dosados |
DE4211475A1 (de) * | 1991-12-14 | 1993-06-17 | Asta Medica Ag | Pulverinhalator |
US5228624A (en) * | 1992-03-02 | 1993-07-20 | Mensink Daniel L | Swirling structure for mixing two concentric fluid flows at nozzle outlet |
DE4208880A1 (de) * | 1992-03-19 | 1993-09-23 | Boehringer Ingelheim Kg | Separator fuer pulverinhalatoren |
SE9201411D0 (sv) * | 1992-05-05 | 1992-05-05 | Astra Ab | Dosage inhalator with indicating/interupting means |
KR0177265B1 (ko) * | 1992-10-19 | 1999-04-01 | 미첼 알. 우드베리 | 건분말 흡입기 |
GB2279879B (en) * | 1993-07-14 | 1997-10-08 | Bespak Plc | Medicament inhalers |
US5415162A (en) * | 1994-01-18 | 1995-05-16 | Glaxo Inc. | Multi-dose dry powder inhalation device |
GB2299512A (en) * | 1995-04-06 | 1996-10-09 | Ian James Sharp | Inhaler |
US5474059A (en) * | 1995-04-08 | 1995-12-12 | Cooper; Guy F. | Aerosol dispensing apparatus for dispensing a medicated vapor into the lungs of a patient |
US5598836A (en) * | 1995-05-26 | 1997-02-04 | Healthscan Products, Inc. | Metered dose inhalation unit with slide means |
US5724986A (en) * | 1995-11-06 | 1998-03-10 | Jones Medical Instrument Co. | Casing and spirometer for metered dose inhaler |
TR199801265T2 (xx) * | 1996-01-03 | 1998-10-21 | Glaxo Group Limited | ��e soluma cihaz�. |
US5875774A (en) * | 1996-01-05 | 1999-03-02 | Sunrise Medical Hhg Inc. | Nebulizer |
GB2312379B (en) * | 1996-04-25 | 1999-11-17 | Bespak Plc | Improved inhalers |
GB2312848B (en) * | 1996-04-26 | 1999-11-17 | Bespak Plc | Controlled flow inhalers |
GB2318737B (en) * | 1996-10-30 | 2000-06-14 | Bespak Plc | Improved inhalers |
GB9626263D0 (en) * | 1996-12-18 | 1997-02-05 | Innovata Biomed Ltd | Powder inhaler |
US5894995A (en) * | 1997-07-08 | 1999-04-20 | Mazzei; Angelo L. | Infusion nozzle imparting axial and rotational flow elements |
GB2334686B (en) * | 1998-02-26 | 2002-06-19 | Medic Aid Ltd | Nebuliser |
-
1997
- 1997-10-17 NZ NZ504021A patent/NZ504021A/xx not_active Application Discontinuation
- 1997-10-17 US US08/954,352 patent/US5954047A/en not_active Expired - Lifetime
-
1998
- 1998-07-14 CA CA002565088A patent/CA2565088C/en not_active Expired - Lifetime
- 1998-07-14 CA CA002565964A patent/CA2565964C/en not_active Expired - Lifetime
- 1998-07-14 CA CA002243175A patent/CA2243175C/en not_active Expired - Lifetime
- 1998-07-31 EP EP05076801A patent/EP1591137B1/en not_active Expired - Lifetime
- 1998-07-31 AT AT05076801T patent/ATE463271T1/de active
- 1998-07-31 DK DK98306113T patent/DK0911048T3/da active
- 1998-07-31 EP EP98306113A patent/EP0911048B1/en not_active Expired - Lifetime
- 1998-07-31 ES ES05076801T patent/ES2348495T3/es not_active Expired - Lifetime
- 1998-07-31 DK DK05076801.9T patent/DK1591137T3/da active
- 1998-07-31 ES ES98306113T patent/ES2255134T3/es not_active Expired - Lifetime
- 1998-07-31 DE DE69841603T patent/DE69841603D1/de not_active Expired - Lifetime
- 1998-07-31 EP EP05076802.7A patent/EP1627655B1/en not_active Expired - Lifetime
- 1998-07-31 AT AT98306113T patent/ATE311913T1/de active
- 1998-07-31 DE DE69832679T patent/DE69832679T2/de not_active Expired - Lifetime
- 1998-08-07 NO NO983631A patent/NO983631L/no not_active Application Discontinuation
- 1998-10-15 AU AU10847/99A patent/AU750459B2/en not_active Expired
- 1998-10-15 CN CN98811903A patent/CN1285759A/zh active Pending
- 1998-10-15 KR KR1020007004125A patent/KR20010031187A/ko not_active Application Discontinuation
- 1998-10-15 WO PCT/US1998/021667 patent/WO1999020331A1/en not_active Application Discontinuation
- 1998-10-15 MX MXPA00003766A patent/MXPA00003766A/es active IP Right Grant
- 1998-10-15 TR TR2000/01033T patent/TR200001033T2/xx unknown
- 1998-10-15 JP JP2000516721A patent/JP2001520088A/ja active Pending
-
1999
- 1999-06-07 US US09/326,531 patent/US6095141A/en not_active Expired - Lifetime
- 1999-06-07 US US09/326,538 patent/US6026808A/en not_active Expired - Lifetime
-
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- 2009-04-07 JP JP2009092696A patent/JP2009183734A/ja not_active Withdrawn
-
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- 2010-03-01 JP JP2010043745A patent/JP5114515B2/ja not_active Expired - Lifetime
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- 2011-02-17 JP JP2011031934A patent/JP5395100B2/ja not_active Expired - Lifetime
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