ATE499940T1 - Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen - Google Patents

Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen

Info

Publication number
ATE499940T1
ATE499940T1 AT07799643T AT07799643T ATE499940T1 AT E499940 T1 ATE499940 T1 AT E499940T1 AT 07799643 T AT07799643 T AT 07799643T AT 07799643 T AT07799643 T AT 07799643T AT E499940 T1 ATE499940 T1 AT E499940T1
Authority
AT
Austria
Prior art keywords
prodrugs
thiazolo
carbonate
carbamat
pyrimidines
Prior art date
Application number
AT07799643T
Other languages
English (en)
Inventor
Gregory Haley
Joseph Lennox
Alan Xiang
Stephen Webber
Original Assignee
Anadys Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anadys Pharmaceuticals Inc filed Critical Anadys Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE499940T1 publication Critical patent/ATE499940T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
AT07799643T 2006-07-18 2007-07-17 Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen ATE499940T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83145506P 2006-07-18 2006-07-18
PCT/US2007/073681 WO2008011406A2 (en) 2006-07-18 2007-07-17 Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines

Publications (1)

Publication Number Publication Date
ATE499940T1 true ATE499940T1 (de) 2011-03-15

Family

ID=38957547

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07799643T ATE499940T1 (de) 2006-07-18 2007-07-17 Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen

Country Status (7)

Country Link
US (1) US7528115B2 (de)
EP (1) EP2040712B1 (de)
JP (1) JP5225991B2 (de)
AT (1) ATE499940T1 (de)
BR (1) BRPI0714831A2 (de)
DE (1) DE602007012881D1 (de)
WO (1) WO2008011406A2 (de)

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US7709448B2 (en) * 2006-06-22 2010-05-04 Anadys Pharmaceuticals, Inc. Prodrugs of 5-amino-3-(3′-deoxy-β-D-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
US20110166092A1 (en) * 2007-08-20 2011-07-07 Anadys Pharmaceuticals, Inc. Dosing methods for treating disease
CN107001386A (zh) 2014-10-11 2017-08-01 豪夫迈·罗氏有限公司 用于治疗感染性疾病的化合物
HUE053704T2 (hu) 2014-12-08 2021-07-28 Hoffmann La Roche 3-szubsztitutált 5-amino-6H-tiazolo[4,5-d]pirimidin-2,7-dion vegyületek vírusfertõzések kezelésére és megelõzésére
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CN107592864B (zh) 2015-05-12 2021-04-16 豪夫迈·罗氏有限公司 用于治疗和预防病毒感染的新的取代的氨基噻唑并嘧啶二酮
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CN110139868B (zh) 2017-01-06 2021-07-09 豪夫迈·罗氏有限公司 制备3-取代的5-氨基-6H-噻唑并[4,5-d]嘧啶-2,7-二酮化合物的方法
EP3636646A4 (de) 2017-05-18 2020-12-09 Jiangsu Hengrui Medicine Co., Ltd. Heteroaryl-pyrazol-derivat und herstellungsverfahren dafür sowie medizinische verwendung davon
CN111819178B (zh) 2018-05-25 2022-04-12 江苏恒瑞医药股份有限公司 一种吡唑并杂芳基类衍生物盐酸盐的晶型及制备方法
CA3104088A1 (en) 2018-06-21 2019-12-26 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
WO2020255979A1 (ja) * 2019-06-18 2020-12-24 大鵬薬品工業株式会社 ピロロピリミジン骨格を有する新規なカーボネート化合物又はその薬学的に許容可能な塩
WO2021154687A1 (en) 2020-01-27 2021-08-05 Gilead Sciences, Inc. Methods for treating sars cov-2 infections
EP4132651A1 (de) 2020-04-06 2023-02-15 Gilead Sciences, Inc. Inhalationsformulierungen von 1'-cyansubstituierten carbanukleosidanaloga
US20210393653A1 (en) 2020-05-29 2021-12-23 Gilead Sciences, Inc. Remdesivir treatment methods
BR112022026321A2 (pt) 2020-06-24 2023-01-17 Gilead Sciences Inc Análogos de 1'-ciano nucleosídeo e usos dos mesmos
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Also Published As

Publication number Publication date
EP2040712B1 (de) 2011-03-02
JP2009543884A (ja) 2009-12-10
JP5225991B2 (ja) 2013-07-03
WO2008011406A3 (en) 2008-12-31
BRPI0714831A2 (pt) 2013-04-02
WO2008011406A2 (en) 2008-01-24
EP2040712A2 (de) 2009-04-01
DE602007012881D1 (en) 2011-04-14
US20080020989A1 (en) 2008-01-24
US7528115B2 (en) 2009-05-05
EP2040712A4 (de) 2010-04-14

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