DE602007012881D1 - Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen - Google Patents
Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinenInfo
- Publication number
- DE602007012881D1 DE602007012881D1 DE602007012881T DE602007012881T DE602007012881D1 DE 602007012881 D1 DE602007012881 D1 DE 602007012881D1 DE 602007012881 T DE602007012881 T DE 602007012881T DE 602007012881 T DE602007012881 T DE 602007012881T DE 602007012881 D1 DE602007012881 D1 DE 602007012881D1
- Authority
- DE
- Germany
- Prior art keywords
- prodrugs
- thiazolo
- pyrimidinen
- carbamat
- carbonat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83145506P | 2006-07-18 | 2006-07-18 | |
PCT/US2007/073681 WO2008011406A2 (en) | 2006-07-18 | 2007-07-17 | Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602007012881D1 true DE602007012881D1 (en) | 2011-04-14 |
Family
ID=38957547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602007012881T Active DE602007012881D1 (en) | 2006-07-18 | 2007-07-17 | Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen |
Country Status (7)
Country | Link |
---|---|
US (1) | US7528115B2 (de) |
EP (1) | EP2040712B1 (de) |
JP (1) | JP5225991B2 (de) |
AT (1) | ATE499940T1 (de) |
BR (1) | BRPI0714831A2 (de) |
DE (1) | DE602007012881D1 (de) |
WO (1) | WO2008011406A2 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7321033B2 (en) * | 2001-11-27 | 2008-01-22 | Anadys Pharmaceuticals, Inc. | 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof |
CN101365705A (zh) | 2005-11-21 | 2009-02-11 | 安那迪斯药品股份有限公司 | 制备5-氨基-3H-噻唑并[4,5-d]嘧啶-2-酮的方法 |
TWI418561B (zh) * | 2006-06-22 | 2013-12-11 | Anadys Pharmaceuticals Inc | 5-胺基-3-(3’-去氧-β-D-核糖呋喃糖基(ribofuranosyl))-噻唑并〔4,5-d〕嘧啶-2,7-二酮之前藥 |
WO2009026292A1 (en) * | 2007-08-20 | 2009-02-26 | Anadys Pharmaceuticals, Inc. | Dosing methods for treating disease |
WO2016055553A1 (en) | 2014-10-11 | 2016-04-14 | F. Hoffmann-La Roche Ag | Compounds for use in the treatment of infectious diseases |
PL3230298T3 (pl) | 2014-12-08 | 2021-06-14 | F.Hoffmann-La Roche Ag | 3-podstawione związki 5-amino-6h-tiazolo[4,5-d]pirymidyno-2,7-dionowe do leczenia i profilaktyki zakażenia wirusowego |
CA2979490C (en) | 2015-03-16 | 2023-07-18 | F. Hoffmann-La Roche Ag | Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor |
EP3294745B1 (de) | 2015-05-08 | 2020-01-01 | H. Hoffnabb-La Roche Ag | Neuartige oxathiolan-carbonsäuren und derivate zur behandlung und prophylaxe von virusinfektionen |
WO2016180743A1 (en) | 2015-05-12 | 2016-11-17 | F. Hoffmann-La Roche Ag | Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection |
CN107820498B (zh) | 2015-06-30 | 2020-06-19 | 豪夫迈·罗氏有限公司 | 用于治疗和预防病毒感染的取代的氨基噻唑并嘧啶二酮 |
CN110234656B (zh) | 2016-09-09 | 2023-02-28 | 卡利泰拉生物科技公司 | 外核苷酸酶抑制剂及其使用方法 |
KR20190084991A (ko) | 2016-11-28 | 2019-07-17 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 피라졸로-헤테로아릴 유도체, 이의 제조 방법 및 의학적 용도 |
AU2017382888B2 (en) | 2016-12-22 | 2021-12-23 | Antengene Therapeutics Limited | Ectonucleotidase inhibitors and methods of use thereof |
KR102602328B1 (ko) | 2017-01-06 | 2023-11-16 | 에프. 호프만-라 로슈 아게 | 3-치환된 5-아미노-6H-티아졸로[4,5-d]피리미딘-2,7-다이온 화합물의 제조 방법 |
US11111249B2 (en) | 2017-05-18 | 2021-09-07 | Jiangsu Hengrui Medicine Co., Ltd. | Heteroaryl-pyrazole derivative, and preparation method therefor and medical application thereof |
EP3651734A1 (de) | 2017-07-11 | 2020-05-20 | Gilead Sciences, Inc. | Zusammensetzungen mit einem rna-polymerasehemmer und cyclodextrin zur behandlung von virusinfektionen |
BR112020023875A2 (pt) | 2018-05-25 | 2021-02-09 | Jiangsu Hengrui Medicine Co., Ltd. | sal de cloridrato, formas cristalinas, métodos de preparação, composição farmacêutica, e usos do sal e das formas cristalinas |
BR112020025132B1 (pt) | 2018-06-21 | 2023-10-10 | Antengene Therapeutics Limited | Inibidores de ectonucleotidase e métodos de uso dos mesmos |
WO2020255978A1 (ja) * | 2019-06-18 | 2020-12-24 | 大鵬薬品工業株式会社 | ピロロピリミジン骨格を有する新規なリン酸エステル化合物又はその薬学的に許容可能な塩 |
TW202313067A (zh) | 2020-01-27 | 2023-04-01 | 美商基利科學股份有限公司 | 治療sars cov-2感染之方法 |
EP4118085A2 (de) | 2020-03-12 | 2023-01-18 | Gilead Sciences, Inc. | Verfahren zur herstellung von 1'-cyanonukleosiden |
KR20220164784A (ko) | 2020-04-06 | 2022-12-13 | 길리애드 사이언시즈, 인코포레이티드 | 1'-시아노 치환된 카르바뉴클레오시드 유사체의 흡입 제형 |
TW202203941A (zh) | 2020-05-29 | 2022-02-01 | 美商基利科學股份有限公司 | 瑞德西韋之治療方法 |
AU2021296841A1 (en) | 2020-06-24 | 2023-02-16 | Gilead Sciences, Inc. | 1'-cyano nucleoside analogs and uses thereof |
DK4204421T3 (da) | 2020-08-27 | 2024-05-27 | Gilead Sciences Inc | Forbindelser og fremgangsmåder til behandling af virale infektioner |
TW202400185A (zh) | 2022-03-02 | 2024-01-01 | 美商基利科學股份有限公司 | 用於治療病毒感染的化合物及方法 |
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US733566A (en) | 1903-03-16 | 1903-07-14 | August Sundh | Electric controller. |
US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
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US5166141A (en) | 1983-11-01 | 1992-11-24 | Scripps Clinic And Research Foundation | Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals |
US4746651A (en) | 1983-11-01 | 1988-05-24 | Scripps Clinic And Research Foundation | Antimicrobial chemotherapeutic potentiation using substituted nucleoside derivatives |
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US5011828A (en) | 1985-11-15 | 1991-04-30 | Michael Goodman | Immunostimulating guanine derivatives, compositions and methods |
GB8712745D0 (en) | 1987-05-30 | 1987-07-01 | Wellcome Found | Antiviral compounds |
US4880784A (en) | 1987-12-21 | 1989-11-14 | Brigham Young University | Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives |
US5041426A (en) * | 1987-12-21 | 1991-08-20 | Brigham Young University | Immune system enhancing 3-β-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides |
DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
US5041542A (en) | 1988-06-03 | 1991-08-20 | Nucleic Acid Research Institute | Substituted pyrimido[5,4-d]pyrimidine nucleosides |
US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
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PL1824482T3 (pl) | 2004-12-17 | 2014-07-31 | Anadys Pharmaceuticals Inc | 3,5-Dipodstawione oraz 3,5,7-tripodstawione związki 3H-oksazolo- oraz 3H-tiazolo[4,5-d]pirymidyn-2-onowe i ich proleki |
TWI418561B (zh) * | 2006-06-22 | 2013-12-11 | Anadys Pharmaceuticals Inc | 5-胺基-3-(3’-去氧-β-D-核糖呋喃糖基(ribofuranosyl))-噻唑并〔4,5-d〕嘧啶-2,7-二酮之前藥 |
-
2007
- 2007-07-17 AT AT07799643T patent/ATE499940T1/de not_active IP Right Cessation
- 2007-07-17 JP JP2009520953A patent/JP5225991B2/ja not_active Expired - Fee Related
- 2007-07-17 EP EP07799643A patent/EP2040712B1/de not_active Not-in-force
- 2007-07-17 WO PCT/US2007/073681 patent/WO2008011406A2/en active Application Filing
- 2007-07-17 DE DE602007012881T patent/DE602007012881D1/de active Active
- 2007-07-17 US US11/779,007 patent/US7528115B2/en not_active Expired - Fee Related
- 2007-07-17 BR BRPI0714831-3A patent/BRPI0714831A2/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP5225991B2 (ja) | 2013-07-03 |
JP2009543884A (ja) | 2009-12-10 |
US20080020989A1 (en) | 2008-01-24 |
ATE499940T1 (de) | 2011-03-15 |
BRPI0714831A2 (pt) | 2013-04-02 |
WO2008011406A2 (en) | 2008-01-24 |
EP2040712B1 (de) | 2011-03-02 |
EP2040712A4 (de) | 2010-04-14 |
WO2008011406A3 (en) | 2008-12-31 |
US7528115B2 (en) | 2009-05-05 |
EP2040712A2 (de) | 2009-04-01 |
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