PL1824482T3 - 3,5-Dipodstawione oraz 3,5,7-tripodstawione związki 3H-oksazolo- oraz 3H-tiazolo[4,5-d]pirymidyn-2-onowe i ich proleki - Google Patents
3,5-Dipodstawione oraz 3,5,7-tripodstawione związki 3H-oksazolo- oraz 3H-tiazolo[4,5-d]pirymidyn-2-onowe i ich prolekiInfo
- Publication number
- PL1824482T3 PL1824482T3 PL05854334T PL05854334T PL1824482T3 PL 1824482 T3 PL1824482 T3 PL 1824482T3 PL 05854334 T PL05854334 T PL 05854334T PL 05854334 T PL05854334 T PL 05854334T PL 1824482 T3 PL1824482 T3 PL 1824482T3
- Authority
- PL
- Poland
- Prior art keywords
- oxazolo
- thiazolo
- trisubstituted
- pyrimidin
- disubstituted
- Prior art date
Links
- DCSLKYLPOSSKFY-UHFFFAOYSA-N 3h-[1,3]thiazolo[4,5-d]pyrimidin-2-one Chemical class C1=NC=C2SC(=O)NC2=N1 DCSLKYLPOSSKFY-UHFFFAOYSA-N 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63663304P | 2004-12-17 | 2004-12-17 | |
US63663404P | 2004-12-17 | 2004-12-17 | |
EP05854334.9A EP1824482B1 (en) | 2004-12-17 | 2005-12-16 | 3, 5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO AND 3H-THIAZOLO [4,5-d]PYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF |
PCT/US2005/045589 WO2006066080A1 (en) | 2004-12-17 | 2005-12-16 | 3, 5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO AND 3H-THIAZOLO [4,5-d]PYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
PL1824482T3 true PL1824482T3 (pl) | 2014-07-31 |
Family
ID=36588217
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL05854334T PL1824482T3 (pl) | 2004-12-17 | 2005-12-16 | 3,5-Dipodstawione oraz 3,5,7-tripodstawione związki 3H-oksazolo- oraz 3H-tiazolo[4,5-d]pirymidyn-2-onowe i ich proleki |
PL12193759T PL2561872T3 (pl) | 2004-12-17 | 2005-12-16 | 3,5-Dipodstawione oraz 3,5,7-tripodstawione związki 3H-oksazolo[4,5-d]pirymidyn-2-onowe i ich proleki |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL12193759T PL2561872T3 (pl) | 2004-12-17 | 2005-12-16 | 3,5-Dipodstawione oraz 3,5,7-tripodstawione związki 3H-oksazolo[4,5-d]pirymidyn-2-onowe i ich proleki |
Country Status (29)
Country | Link |
---|---|
US (4) | US7560544B2 (pl) |
EP (2) | EP2561872B1 (pl) |
JP (1) | JP5303149B2 (pl) |
KR (1) | KR101320008B1 (pl) |
CN (1) | CN102504001B (pl) |
AR (1) | AR052995A1 (pl) |
AU (1) | AU2005316397B2 (pl) |
BR (1) | BRPI0518861B8 (pl) |
CA (1) | CA2589529C (pl) |
DK (2) | DK2561872T3 (pl) |
EA (1) | EA013594B1 (pl) |
EG (1) | EG25920A (pl) |
ES (2) | ES2459368T3 (pl) |
GT (1) | GT200500374A (pl) |
HK (2) | HK1108377A1 (pl) |
IL (2) | IL183512A (pl) |
MX (1) | MX2007007263A (pl) |
MY (1) | MY176938A (pl) |
NO (1) | NO20073615L (pl) |
NZ (1) | NZ555723A (pl) |
PA (1) | PA8657201A1 (pl) |
PE (1) | PE20060837A1 (pl) |
PL (2) | PL1824482T3 (pl) |
PT (2) | PT1824482E (pl) |
SI (2) | SI1824482T1 (pl) |
TN (1) | TNSN07208A1 (pl) |
TW (1) | TWI407956B (pl) |
UY (1) | UY29265A1 (pl) |
WO (1) | WO2006066080A1 (pl) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7321033B2 (en) * | 2001-11-27 | 2008-01-22 | Anadys Pharmaceuticals, Inc. | 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof |
ES2345904T3 (es) * | 2005-11-21 | 2010-10-05 | Anadys Pharmaceuticals, Inc. | Proceso para preparar 5-amino-3h-tiazolo(4,5-d)pirimidin-2-ona. |
KR101461604B1 (ko) * | 2006-06-22 | 2014-11-18 | 애나디스 파마슈티칼스, 인코포레이티드 | 5-아미노-3-(3''-데옥시-β-D-리보퓨라노실)-티아졸로[4,5-d]파이리미딘-2,7-다이온의 프로드럭 |
JP5225991B2 (ja) | 2006-07-18 | 2013-07-03 | アナディス ファーマシューティカルズ インク | チアゾロ[4,5−d]ピリミジンのカーボネート及びカルバメートプロドラッグ |
BRPI0717741A2 (pt) * | 2006-10-17 | 2014-04-08 | Anadys Pharmaceuticals Inc | Compostos e respectivos método de preparação, método de redução de composto de sulfonil substituído, composição farmacêutica método de tratamento ou prevenção de doença |
CN101605457B (zh) * | 2006-10-17 | 2013-10-30 | 安那迪斯药品股份有限公司 | 5-氨基-3-(2'-0-乙酰基-3'-脱氧-β-D-呋喃核糖基)-3H-噻唑[4,5-d]嘧啶-2-酮的对甲苯磺酸盐及制备方法 |
WO2009026292A1 (en) | 2007-08-20 | 2009-02-26 | Anadys Pharmaceuticals, Inc. | Dosing methods for treating disease |
US8227431B2 (en) * | 2008-03-17 | 2012-07-24 | Hetero Drugs Limited | Nucleoside derivatives |
WO2010082050A1 (en) | 2009-01-16 | 2010-07-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections |
JP2012521359A (ja) * | 2009-03-20 | 2012-09-13 | アリオス バイオファーマ インク. | 置換されたヌクレオシドアナログおよびヌクレオチドアナログ |
NZ599963A (en) | 2009-12-18 | 2014-02-28 | Boehringer Ingelheim Int | Hcv combination therapy |
WO2012040127A1 (en) | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
CA2860234A1 (en) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
NZ631601A (en) | 2012-03-21 | 2016-06-24 | Alios Biopharma Inc | Solid forms of a thiophosphoramidate nucleotide prodrug |
NZ630805A (en) | 2012-03-22 | 2016-01-29 | Alios Biopharma Inc | Pharmaceutical combinations comprising a thionucleotide analog |
WO2014121417A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
WO2014121416A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
WO2014121418A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
US9227718B2 (en) * | 2013-06-07 | 2016-01-05 | The Boeing Company | Lower joints between outboard wing boxes and center wing sections of aircraft wing assemblies |
CA2954056C (en) | 2014-07-11 | 2020-04-28 | Gilead Sciences, Inc. | Modulators of toll-like receptors for the treatment of hiv |
JP2017531655A (ja) * | 2014-10-11 | 2017-10-26 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 感染性疾患の処置に使用するための化合物 |
DK3230298T3 (da) * | 2014-12-08 | 2021-03-22 | Hoffmann La Roche | 3-substituerede 5-amino-6H-thiazolo[4,5-d]pyrimidin-2,7-dion forbindelser til behandling og forebyggelse af virusinfektion |
CA2979490C (en) | 2015-03-16 | 2023-07-18 | F. Hoffmann-La Roche Ag | Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor |
JP6779232B2 (ja) | 2015-05-08 | 2020-11-04 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ウイルス感染の治療又は予防のための新規オキサチオランカルボン酸と誘導体 |
EP3294746B1 (en) * | 2015-05-12 | 2021-10-06 | F. Hoffmann-La Roche AG | Substituted aminothiazolopyrimidinedione derivatives for the treatment and prophylaxis of virus infection |
WO2017001307A1 (en) | 2015-06-30 | 2017-01-05 | F. Hoffmann-La Roche Ag | Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection |
WO2017211791A1 (en) | 2016-06-07 | 2017-12-14 | F. Hoffmann-La Roche Ag | Combination therapy of an hbsag inhibitor and a tlr7 agonist |
EP3568400A1 (en) * | 2017-01-06 | 2019-11-20 | H. Hoffnabb-La Roche Ag | PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-d]PYRIMIDINE-2-7-DIONE COMPOUNDS |
CR20200649A (es) * | 2018-05-25 | 2021-05-11 | Primmune Therapeutics Inc | Agosnistas de tlr7 |
IL293293A (en) * | 2019-11-26 | 2022-07-01 | Primmune Therapeutics Inc | tlr7 agonists |
JP2023509870A (ja) | 2019-12-24 | 2023-03-10 | エフ. ホフマン-ラ ロシュ アーゲー | Hbvの処置のためのhbvを標的とする治療用オリゴヌクレオチドとtlr7アゴニストとの医薬組合せ |
EP4081217A1 (en) | 2019-12-24 | 2022-11-02 | F. Hoffmann-La Roche AG | Pharmaceutical combination of antiviral agents targeting hbv and/or an immune modulator for treatment of hbv |
WO2022197927A1 (en) * | 2021-03-18 | 2022-09-22 | Lankenau Institute For Medical Research | Methods and compositions for the treatment of drug resistant topical infections |
WO2023288047A2 (en) * | 2021-07-15 | 2023-01-19 | Alnylam Pharmaceuticals, Inc. | Multiplexing targeting ligands through click chemistry at the anomeric site of sugars |
CA3234478A1 (en) | 2021-11-11 | 2023-05-19 | Souphalone LUANGSAY | Pharmaceutical combinations for treatment of hbv |
Family Cites Families (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
AU531759B2 (en) | 1978-04-17 | 1983-09-08 | Ici Ltd. | Electrostatic spraying |
US4539205A (en) * | 1982-11-09 | 1985-09-03 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
US4643992A (en) * | 1982-11-09 | 1987-02-17 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
US5166141A (en) * | 1983-11-01 | 1992-11-24 | Scripps Clinic And Research Foundation | Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals |
US4746651A (en) * | 1983-11-01 | 1988-05-24 | Scripps Clinic And Research Foundation | Antimicrobial chemotherapeutic potentiation using substituted nucleoside derivatives |
IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
GB8504253D0 (en) | 1985-02-19 | 1985-03-20 | Ici Plc | Electrostatic spraying apparatus |
US5011828A (en) * | 1985-11-15 | 1991-04-30 | Michael Goodman | Immunostimulating guanine derivatives, compositions and methods |
GB8712745D0 (en) * | 1987-05-30 | 1987-07-01 | Wellcome Found | Antiviral compounds |
US5041426A (en) * | 1987-12-21 | 1991-08-20 | Brigham Young University | Immune system enhancing 3-β-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides |
US4880784A (en) | 1987-12-21 | 1989-11-14 | Brigham Young University | Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives |
DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
US5041542A (en) | 1988-06-03 | 1991-08-20 | Nucleic Acid Research Institute | Substituted pyrimido[5,4-d]pyrimidine nucleosides |
US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
GB9015914D0 (en) * | 1990-07-19 | 1990-09-05 | Wellcome Found | Heterocyclic compounds |
US5248672A (en) * | 1990-11-01 | 1993-09-28 | The Regents Of The University Of Michigan | Polysubstituted benzimidazole nucleosides as antiviral agents |
GB9105899D0 (en) | 1991-03-20 | 1991-05-08 | Wellcome Found | Therapeutic nucleosides |
US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
AU5165793A (en) | 1992-10-01 | 1994-04-26 | Mcneilab, Inc. | Derivatives of 7,8-disubstituted guanosines |
GB9225098D0 (en) | 1992-12-01 | 1993-01-20 | Coffee Ronald A | Charged droplet spray mixer |
GB9226717D0 (en) | 1992-12-22 | 1993-02-17 | Coffee Ronald A | Induction-operated electro-hydrodynamic spray device with means of modifying droplet trajectories |
GB9301000D0 (en) | 1993-01-20 | 1993-03-10 | Glaxo Group Ltd | Chemical compounds |
US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
US5395937A (en) * | 1993-01-29 | 1995-03-07 | Minnesota Mining And Manufacturing Company | Process for preparing quinoline amines |
US5994321A (en) | 1993-12-20 | 1999-11-30 | Aronex Pharmaceuticals, Inc. | Antiviral guanine analogs |
US5446045A (en) * | 1993-12-20 | 1995-08-29 | Revankar; Ganapathi R. | Antiviral guanine analogs |
GB9406255D0 (en) | 1994-03-29 | 1994-05-18 | Electrosols Ltd | Dispensing device |
GB9406171D0 (en) | 1994-03-29 | 1994-05-18 | Electrosols Ltd | Dispensing device |
GB9410658D0 (en) | 1994-05-27 | 1994-07-13 | Electrosols Ltd | Dispensing device |
IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
WO1996028205A1 (en) | 1995-03-14 | 1996-09-19 | Siemens Aktiengesellschaft | Ultrasonic atomizer device with removable precision dosing unit |
ZA962077B (en) | 1995-03-14 | 1997-03-26 | Siemens Ag | Ultrasonic atomizer device with removable precision dosating unit |
TW552261B (en) * | 1996-07-03 | 2003-09-11 | Japan Energy Corp | Novel purine derivative |
SK48199A3 (en) * | 1996-10-16 | 2000-01-18 | Icn Pharmaceuticals | Purine l-nucleosides, analogs and uses thereof |
US6509320B1 (en) * | 1996-10-16 | 2003-01-21 | Icn Pharmaceuticals, Inc. | Purine L-nucleosides, analogs and uses thereof |
KR100518903B1 (ko) | 1996-10-25 | 2005-10-06 | 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 | Th2 매개 질병 및 관련 질병의 치료용 면역 반응 조절 화합물 |
NZ504021A (en) | 1997-10-17 | 2003-04-29 | Systemic Pulmonary Delivery Lt | Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication |
NZ504800A (en) * | 1997-11-28 | 2001-10-26 | Sumitomo Pharma | 6-Amino-9-benzyl-8-hydroxy-purine derivatives and interferon inducers, antiviral agents, anticancer agents and therapeutic agents for immunologic diseases thereof |
TW572758B (en) * | 1997-12-22 | 2004-01-21 | Sumitomo Pharma | Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives |
JP2002510695A (ja) * | 1998-04-03 | 2002-04-09 | デュポン ファーマシューティカルズ カンパニー | 副腎皮質刺激ホルモン放出因子(CRF)拮抗剤としてのチアゾロ[4,5−d]ピリミジンおよびピリジン |
US6444652B1 (en) * | 1998-08-10 | 2002-09-03 | Novirio Pharmaceuticals Limited | β-L-2'-deoxy-nucleosides for the treatment of hepatitis B |
GB9915437D0 (en) * | 1999-07-01 | 1999-09-01 | Cerebrus Ltd | Chemical compounds III |
US6667312B2 (en) * | 2000-12-08 | 2003-12-23 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
US6664260B2 (en) * | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Heterocyclic ether substituted imidazoquinolines |
US6545017B1 (en) * | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Urea substituted imidazopyridines |
US6545016B1 (en) * | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Amide substituted imidazopyridines |
US6664264B2 (en) * | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
KR100892614B1 (ko) | 2001-04-17 | 2009-04-09 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 신규 아데닌 유도체 |
US6914068B2 (en) * | 2001-07-12 | 2005-07-05 | Basf Aktiengesellschaft | Thiazolo[4,5-b]pyridines as fungicides |
US7321033B2 (en) | 2001-11-27 | 2008-01-22 | Anadys Pharmaceuticals, Inc. | 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof |
CN1300165C (zh) * | 2001-11-27 | 2007-02-14 | 安那迪斯药品股份有限公司 | 3-β-呋喃核糖基噻唑并[4,5-d]嘧啶核苷及其应用 |
NZ536123A (en) * | 2002-05-06 | 2006-09-29 | Genelabs Tech Inc | Nucleoside derivatives for treating hepatitis C virus infection |
WO2005016235A2 (en) * | 2003-04-14 | 2005-02-24 | The Regents Of The University Of California | Combined use of impdh inhibitors with toll-like receptor agonists |
WO2004096233A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Nucleoside phosphonate conjugates |
BRPI0418887A (pt) * | 2004-06-07 | 2007-10-30 | Anadys Pharmaceuticals Inc | nucleosìdeos de 3-beta-d-ribofuranossiltiazol[4,5-d] pirimidina e usos dos mesmos |
-
2005
- 2005-12-16 JP JP2007546931A patent/JP5303149B2/ja active Active
- 2005-12-16 SI SI200531850T patent/SI1824482T1/sl unknown
- 2005-12-16 MX MX2007007263A patent/MX2007007263A/es active IP Right Grant
- 2005-12-16 AR ARP050105306A patent/AR052995A1/es not_active Application Discontinuation
- 2005-12-16 ES ES05854334.9T patent/ES2459368T3/es active Active
- 2005-12-16 BR BRPI0518861A patent/BRPI0518861B8/pt active IP Right Grant
- 2005-12-16 ES ES12193759.3T patent/ES2525567T3/es active Active
- 2005-12-16 DK DK12193759.3T patent/DK2561872T3/en active
- 2005-12-16 AU AU2005316397A patent/AU2005316397B2/en active Active
- 2005-12-16 EP EP12193759.3A patent/EP2561872B1/en active Active
- 2005-12-16 PT PT58543349T patent/PT1824482E/pt unknown
- 2005-12-16 CA CA2589529A patent/CA2589529C/en active Active
- 2005-12-16 PL PL05854334T patent/PL1824482T3/pl unknown
- 2005-12-16 GT GT200500374A patent/GT200500374A/es unknown
- 2005-12-16 SI SI200531920T patent/SI2561872T1/sl unknown
- 2005-12-16 WO PCT/US2005/045589 patent/WO2006066080A1/en active Application Filing
- 2005-12-16 PL PL12193759T patent/PL2561872T3/pl unknown
- 2005-12-16 PT PT121937593T patent/PT2561872E/pt unknown
- 2005-12-16 DK DK05854334.9T patent/DK1824482T3/en active
- 2005-12-16 NZ NZ555723A patent/NZ555723A/en unknown
- 2005-12-16 EP EP05854334.9A patent/EP1824482B1/en active Active
- 2005-12-16 CN CN201110291130.1A patent/CN102504001B/zh active Active
- 2005-12-16 US US11/304,691 patent/US7560544B2/en active Active
- 2005-12-16 MY MYPI20055966A patent/MY176938A/en unknown
- 2005-12-16 KR KR1020077016338A patent/KR101320008B1/ko active IP Right Grant
- 2005-12-16 TW TW094144743A patent/TWI407956B/zh active
- 2005-12-16 EA EA200701296A patent/EA013594B1/ru not_active IP Right Cessation
- 2005-12-19 PA PA20058657201A patent/PA8657201A1/es unknown
- 2005-12-20 UY UY29265A patent/UY29265A1/es not_active Application Discontinuation
-
2006
- 2006-01-03 PE PE2006000034A patent/PE20060837A1/es not_active Application Discontinuation
-
2007
- 2007-05-28 TN TNP2007000208A patent/TNSN07208A1/fr unknown
- 2007-05-29 IL IL183512A patent/IL183512A/en active IP Right Grant
- 2007-06-13 EG EGNA2007000583 patent/EG25920A/xx active
- 2007-07-13 NO NO20073615A patent/NO20073615L/no not_active Application Discontinuation
-
2008
- 2008-02-25 HK HK08102093.4A patent/HK1108377A1/xx unknown
-
2009
- 2009-07-01 US US12/496,448 patent/US8097718B2/en active Active
-
2012
- 2012-01-13 US US13/350,003 patent/US20120121541A1/en not_active Abandoned
- 2012-07-04 IL IL220759A patent/IL220759A/en active IP Right Grant
-
2013
- 2013-03-11 HK HK13102952.7A patent/HK1175990A1/xx unknown
- 2013-05-22 US US13/900,199 patent/US8883758B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL183512A0 (en) | 3,5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO AND 3H-THIAZOLO [4,5-d] PYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF | |
IL182099A0 (en) | Piperidinylamino-thieno[2,3-d] pyrimidine compounds | |
ZA200606974B (en) | Substituted 1,2,3,4-tetrahydrolsoquinoline derivatives | |
HK1118556A1 (en) | 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives | |
IL183706A0 (en) | 2,4(4,6) pyrimidine derivatives | |
IL178899A0 (en) | [3.2.0] heterocyclic compounds and methods of using the same | |
ZA200705791B (en) | 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d)pyrimidin-2-one compounds and prodrugs thereof | |
GB2414454B (en) | Adjustable steering lock | |
GB0328530D0 (en) | Agrochemical composition | |
GB0425572D0 (en) | 1,7-Naphthyridines | |
EP1711189A4 (en) | AZALIDE DERIVATIVES 8A 6,11-3C-BICYCLIC | |
GB0425739D0 (en) | Humanised baculovirus 2 | |
ZA200609778B (en) | [3.2.0.] Heterocyclic compounds and methods of using the same | |
AU2003905340A0 (en) | Ultimate sports challenge | |
PL114818U1 (en) | V .03 | |
AU3018P (en) | SIR 5 Lomandra confertifolia | |
IL177362A0 (en) | Fungicidal mixtures based on triazolopyrimidine derivatives | |
AU2003100096A4 (en) | Competitive Boxercise | |
GB0403746D0 (en) | 2031 Oxidoreductase | |
GB0424080D0 (en) | 2031 Oxidoreductase | |
IL165461A0 (en) | 2,5-disubstituted 3-mercaptopentanoic acid | |
GB0312137D0 (en) | Slinky`s | |
GB0420894D0 (en) | Compounds and uses 2 | |
GB0417637D0 (en) | Final set 2 | |
GB0417638D0 (en) | Final set 1 |