UY37926A - Formulaciones de 6-(2-hidroxi-2-metilpropoxi)-4-(6-(6-((6-metoxipiridin-3-il)metil)-3,6-diazabiciclo[3.1.1]heptan-3-il)piridin-3-il)pirazolo[1,5-a]piridina-3-carbonitrilo - Google Patents

Formulaciones de 6-(2-hidroxi-2-metilpropoxi)-4-(6-(6-((6-metoxipiridin-3-il)metil)-3,6-diazabiciclo[3.1.1]heptan-3-il)piridin-3-il)pirazolo[1,5-a]piridina-3-carbonitrilo

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Publication number
UY37926A
UY37926A UY0001037926A UY37926A UY37926A UY 37926 A UY37926 A UY 37926A UY 0001037926 A UY0001037926 A UY 0001037926A UY 37926 A UY37926 A UY 37926A UY 37926 A UY37926 A UY 37926A
Authority
UY
Uruguay
Prior art keywords
formulations
heptan
carbonitrile
methyl
disorders
Prior art date
Application number
UY0001037926A
Other languages
English (en)
Inventor
Mark Reynolds
Charles Todd Eary
Original Assignee
Loxo Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Loxo Oncology Inc filed Critical Loxo Oncology Inc
Publication of UY37926A publication Critical patent/UY37926A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se divulgan 6-(2-hidroxi-2-metilpropoxi)-4-(6-(6-((6-metoxipiridin-3-il)metil)-3,6- diazabiciclo[3.1.1]heptan-3-il)piridin-3-il)pirazolo[1,5-a]piridina-3-carbonitrilo, o una sal farmacéuticamente aceptable, forma amorfa, forma polimorfa, o composición farmacéutica (incluyendo formulaciones sólidas o formulaciones líquidas) del mismo, y el uso de los mismos para tratar enfermedades y trastornos que pueden tratarse con un inhibidor de RET quinasa, tal como enfermedades y trastornos asociados con RET, por ejemplo, trastornos proliferativos tales como cáncer, incluyendo cáncer hematológico y tumores sólidos, y trastornos gastrointestinales tales como IBS
UY0001037926A 2017-10-10 2018-10-10 Formulaciones de 6-(2-hidroxi-2-metilpropoxi)-4-(6-(6-((6-metoxipiridin-3-il)metil)-3,6-diazabiciclo[3.1.1]heptan-3-il)piridin-3-il)pirazolo[1,5-a]piridina-3-carbonitrilo UY37926A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762570601P 2017-10-10 2017-10-10

Publications (1)

Publication Number Publication Date
UY37926A true UY37926A (es) 2019-04-30

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UY0001037926A UY37926A (es) 2017-10-10 2018-10-10 Formulaciones de 6-(2-hidroxi-2-metilpropoxi)-4-(6-(6-((6-metoxipiridin-3-il)metil)-3,6-diazabiciclo[3.1.1]heptan-3-il)piridin-3-il)pirazolo[1,5-a]piridina-3-carbonitrilo

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Country Link
US (4) US10786489B2 (es)
EP (1) EP3694556A1 (es)
JP (2) JP7153719B2 (es)
KR (2) KR102561569B1 (es)
CN (1) CN111465413A (es)
AR (1) AR113759A1 (es)
AU (1) AU2018347375B2 (es)
BR (1) BR112020005368A2 (es)
CA (1) CA3079010C (es)
EA (1) EA202090659A1 (es)
IL (1) IL273729B1 (es)
MX (1) MX2020003585A (es)
TW (2) TW202410896A (es)
UY (1) UY37926A (es)
WO (1) WO2019075114A1 (es)

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TW202410896A (zh) * 2017-10-10 2024-03-16 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
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TW202237086A (zh) 2020-12-18 2022-10-01 美商絡速藥業公司 以ret抑制劑及鉑劑治療癌症之方法
CN112679494B (zh) * 2020-12-24 2023-05-16 贵州民族大学 一种吡唑并[1,5-a]吡啶衍生物的制备方法
WO2022168122A1 (en) * 2021-02-06 2022-08-11 Msn Laboratories Private Limited, R&D Center Processes for the preparation of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
CN115594678A (zh) * 2021-07-09 2023-01-13 北京志健金瑞生物医药科技有限公司（Cn） 含氮多环稠环类化合物的制备方法及其中间体和用途
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