NI201900060A - Inhibidores de moléculas pequeñas de la familia de quinasa jak - Google Patents

Inhibidores de moléculas pequeñas de la familia de quinasa jak

Info

Publication number
NI201900060A
NI201900060A NI201900060A NI201900060A NI201900060A NI 201900060 A NI201900060 A NI 201900060A NI 201900060 A NI201900060 A NI 201900060A NI 201900060 A NI201900060 A NI 201900060A NI 201900060 A NI201900060 A NI 201900060A
Authority
NI
Nicaragua
Prior art keywords
kinasa
small molecule
molecule inhibitors
jak family
methods
Prior art date
Application number
NI201900060A
Other languages
English (en)
Inventor
Koudriakova Tatiana
D Kreutter Kevin
Leonard Kristi
C Rizzolio Michele
C Smith Russell
S Tichenor Mark
Wang Ailhua
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NI201900060A publication Critical patent/NI201900060A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos de 2-((1r,4r)-4-(imidazo[4,5-d]pirrolo[2,3-b]piridina-1(6H)-il)ciclohexil)acetonitrilo, composiciones farmacéuticas que los contienen, métodos de elaboración, y métodos para utilizarlos que incluyen métodos para tratar enfermedades, desórdenes y condiciones mediadas por JAK, tales como la enfermedad inflamatoria del intestino.
NI201900060A 2016-12-16 2019-06-14 Inhibidores de moléculas pequeñas de la familia de quinasa jak NI201900060A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662435609P 2016-12-16 2016-12-16
US201762592680P 2017-11-30 2017-11-30
US201762596607P 2017-12-08 2017-12-08

Publications (1)

Publication Number Publication Date
NI201900060A true NI201900060A (es) 2020-03-16

Family

ID=61692222

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201900060A NI201900060A (es) 2016-12-16 2019-06-14 Inhibidores de moléculas pequeñas de la familia de quinasa jak

Country Status (34)

Country Link
US (5) US10294226B2 (es)
EP (2) EP3555097B1 (es)
JP (2) JP7291077B2 (es)
KR (1) KR102352462B1 (es)
CN (1) CN110088105B (es)
AU (3) AU2017377069B2 (es)
BR (1) BR112019011968A2 (es)
CA (1) CA3046965A1 (es)
CL (1) CL2019001626A1 (es)
CO (1) CO2019006200A2 (es)
CR (1) CR20190282A (es)
DK (1) DK3555097T3 (es)
EC (1) ECSP19042688A (es)
ES (1) ES2922379T3 (es)
HR (1) HRP20220885T1 (es)
HU (1) HUE059274T2 (es)
IL (1) IL267275B (es)
JO (1) JOP20190143B1 (es)
LT (1) LT3555097T (es)
MD (1) MD3555097T2 (es)
MX (2) MX2019007073A (es)
MY (1) MY196260A (es)
NI (1) NI201900060A (es)
PE (1) PE20191105A1 (es)
PH (1) PH12019501254A1 (es)
PL (1) PL3555097T3 (es)
PT (1) PT3555097T (es)
RS (1) RS63500B1 (es)
SA (1) SA519402216B1 (es)
SI (1) SI3555097T1 (es)
TW (1) TWI777997B (es)
UA (1) UA125042C2 (es)
WO (1) WO2018112379A1 (es)
ZA (1) ZA201904615B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3040040A1 (en) 2016-10-24 2018-05-03 Astrazeneca Ab 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer
CN110088105B (zh) 2016-12-16 2022-03-18 詹森药业有限公司 Jak家族激酶的小分子抑制剂
JOP20190144A1 (ar) * 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物
PT3494116T (pt) 2017-01-30 2020-01-28 Astrazeneca Ab Moduladores de recetores de estrogénio
TW202016110A (zh) * 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
MX2020013692A (es) 2018-06-15 2021-02-26 Reata Pharmaceuticals Inc Compuestos de pirazol e imidazol para la inhibicion de il-17 y rorgamma.
WO2020216936A1 (en) 2019-04-24 2020-10-29 Janssen Pharmaceutica Nv Non-clinical liquid formulations of pan-jak inhibitor
CN113906035B (zh) * 2019-06-06 2023-11-10 杭州高光制药有限公司 呋喃并咪唑并吡啶类化合物的合成方法、呋喃并咪唑并吡啶类化合物的晶型及其盐的晶型
CN110483514B (zh) * 2019-09-16 2022-06-14 启元生物(杭州)有限公司 一种氰基取代的环肼衍生物及其应用
KR20220157398A (ko) * 2020-02-21 2022-11-29 주하이 유나이티드 라보라토리즈 컴퍼니 리미티드 Jak 억제제의 결정형 및 그의 적용
CN114149428B (zh) * 2020-09-08 2023-06-13 中国药科大学 吡啶并环类化合物及其制备方法、中间体、组合物和应用
US20220288041A1 (en) 2021-03-11 2022-09-15 Janssen Pharmaceutica Nv Small molecule inhibitor of the jak family of kinases
CN113292561A (zh) * 2021-05-22 2021-08-24 中国药科大学 一种二吡咯并吡啶结构的化合物、制备方法和医药用途
CN114432317A (zh) * 2021-05-31 2022-05-06 广州嘉越医药科技有限公司 吡咯并嘧啶类化合物的用途
CN113861194B (zh) * 2021-11-10 2022-07-05 英维沃化工科技(广州)有限公司 一种含吡咯并吡啶双酰胺咪唑类化合物及其制备方法和应用

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Publication number Priority date Publication date Assignee Title
US6080747A (en) 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
WO2007007919A2 (en) * 2005-07-14 2007-01-18 Astellas Pharma Inc. Heterocyclic janus kinase 3 inhibitors
EP2251341A1 (en) * 2005-07-14 2010-11-17 Astellas Pharma Inc. Heterocyclic Janus kinase 3 inhibitors
ME02340B (me) 2008-06-10 2017-02-20 Abbvie Inc Triciklična jedinjenja
JP2011066747A (ja) * 2009-09-18 2011-03-31 Panasonic Corp 弾性波フィルタ
KR20180101626A (ko) * 2009-12-01 2018-09-12 애브비 인코포레이티드 신규한 트리사이클릭 화합물
MX2012006381A (es) 2009-12-01 2012-06-19 Abbott Lab Nuevos compuestos triciclicos.
RU2012132278A (ru) * 2010-01-12 2014-02-20 Ф. Хоффманн-Ля Рош Аг Трициклические гетероциклические соединения, содержащие их композиции и способы их применения
AU2011214254B2 (en) 2010-02-10 2016-06-09 Genon Biotechnologies Oy Dual activity kinase domains and uses thereof
WO2013007765A1 (en) * 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Fused tricyclic compounds for use as inhibitors of janus kinases
EP2924026A1 (en) * 2014-03-28 2015-09-30 Novartis Tiergesundheit AG Aminosulfonylmethylcyclohexanes as JAK inhibitors
ES2753159T3 (es) 2015-05-28 2020-04-07 Theravance Biopharma R&D Ip Llc Compuestos de naftiridina como inhibidores de quinasa JAK
WO2017079639A1 (en) 2015-11-04 2017-05-11 Mayo Foundation For Medical Education And Research Methods and materials for treating autoimmune conditions
CA3040040A1 (en) 2016-10-24 2018-05-03 Astrazeneca Ab 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer
KR20190092539A (ko) 2016-12-16 2019-08-07 바스프 에스이 살충 화합물
UA123640C2 (uk) 2016-12-16 2021-05-05 Елі Ліллі Енд Компані Сполука 7-фенілетиламіно-4н-піримідо[4,5-d][1,3]оксазин-2-ону (варіанти) як інгібітор мутантів idh1 та idh2
JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
CN110088105B (zh) 2016-12-16 2022-03-18 詹森药业有限公司 Jak家族激酶的小分子抑制剂
CN109982582A (zh) 2016-12-16 2019-07-05 雀巢产品技术援助有限公司 用于产生风味物的低聚糖
BR112019012211A2 (pt) 2016-12-16 2019-11-12 Pfizer agonistas de receptor de glp-1 e usos dos mesmos
PT3494116T (pt) 2017-01-30 2020-01-28 Astrazeneca Ab Moduladores de recetores de estrogénio
TWI778050B (zh) 2017-04-21 2022-09-21 美商醫肯納腫瘤學公司 吲哚ahr抑制劑及其用途
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
WO2020216936A1 (en) 2019-04-24 2020-10-29 Janssen Pharmaceutica Nv Non-clinical liquid formulations of pan-jak inhibitor

Also Published As

Publication number Publication date
WO2018112379A1 (en) 2018-06-21
EP3555097B1 (en) 2022-06-15
US10487083B2 (en) 2019-11-26
PT3555097T (pt) 2022-09-22
TW201831180A (zh) 2018-09-01
UA125042C2 (uk) 2021-12-29
CN110088105A (zh) 2019-08-02
AU2017377069B2 (en) 2020-07-23
US10364246B2 (en) 2019-07-30
SI3555097T1 (sl) 2022-09-30
JP7291077B2 (ja) 2023-06-14
US20190185474A1 (en) 2019-06-20
US10294226B2 (en) 2019-05-21
LT3555097T (lt) 2022-08-25
KR102352462B1 (ko) 2022-01-17
SA519402216B1 (ar) 2022-10-02
JOP20190143A1 (ar) 2019-06-13
US20190177322A1 (en) 2019-06-13
AU2022204240B2 (en) 2023-10-05
AU2022204240A1 (en) 2022-07-07
HRP20220885T1 (hr) 2022-12-09
US11059823B2 (en) 2021-07-13
IL267275A (en) 2019-08-29
EP4086256A1 (en) 2022-11-09
MD3555097T2 (ro) 2022-12-31
CR20190282A (es) 2019-08-21
TWI777997B (zh) 2022-09-21
CO2019006200A2 (es) 2019-06-28
CA3046965A1 (en) 2018-06-21
US20210340143A1 (en) 2021-11-04
CN110088105B (zh) 2022-03-18
DK3555097T3 (da) 2022-07-25
ZA201904615B (en) 2021-05-26
EP3555097A1 (en) 2019-10-23
JP2020502113A (ja) 2020-01-23
JP7493068B2 (ja) 2024-05-30
JP2023071709A (ja) 2023-05-23
IL267275B (en) 2021-07-29
BR112019011968A2 (pt) 2019-11-05
AU2017377069A1 (en) 2019-06-20
KR20190086779A (ko) 2019-07-23
US20190177321A1 (en) 2019-06-13
US20180170931A1 (en) 2018-06-21
MX2022004474A (es) 2023-08-15
RS63500B1 (sr) 2022-09-30
AU2020257068A1 (en) 2020-11-19
PL3555097T3 (pl) 2022-10-17
MY196260A (en) 2023-03-24
PH12019501254A1 (en) 2020-01-20
ES2922379T3 (es) 2022-09-14
PE20191105A1 (es) 2019-08-23
ECSP19042688A (es) 2019-06-30
JOP20190143B1 (ar) 2023-09-17
HUE059274T2 (hu) 2022-11-28
CL2019001626A1 (es) 2019-10-04
MX2019007073A (es) 2019-10-15

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