UA73166C2 - Dipeptidilpeptidasa iv inhibitor, pharmaceutical composition on its base - Google Patents
Dipeptidilpeptidasa iv inhibitor, pharmaceutical composition on its base Download PDFInfo
- Publication number
- UA73166C2 UA73166C2 UA2002108484A UA2002108484A UA73166C2 UA 73166 C2 UA73166 C2 UA 73166C2 UA 2002108484 A UA2002108484 A UA 2002108484A UA 2002108484 A UA2002108484 A UA 2002108484A UA 73166 C2 UA73166 C2 UA 73166C2
- Authority
- UA
- Ukraine
- Prior art keywords
- carbonyl
- carbonitrile
- pyrrolidine
- thiazolidine
- lysinyl
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 7
- 239000003112 inhibitor Substances 0.000 title abstract description 18
- 150000001875 compounds Chemical class 0.000 claims abstract description 49
- 150000003839 salts Chemical class 0.000 claims abstract description 9
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract description 9
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 6
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 56
- OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical compound C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 claims description 33
- ALSCEGDXFJIYES-UHFFFAOYSA-N pyrrolidine-2-carbonitrile Chemical compound N#CC1CCCN1 ALSCEGDXFJIYES-UHFFFAOYSA-N 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 24
- 201000010099 disease Diseases 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
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- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 8
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- 125000000217 alkyl group Chemical group 0.000 claims description 6
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- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 4
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- 125000001424 substituent group Chemical group 0.000 claims description 4
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- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
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- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/82—Amides; Imides in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0010188.1A GB0010188D0 (en) | 2000-04-26 | 2000-04-26 | Inhibitors of dipeptidyl peptidase IV |
| PCT/GB2001/001875 WO2001081337A1 (fr) | 2000-04-26 | 2001-04-26 | Inhibiteurs de dipeptidyl peptidase iv |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA73166C2 true UA73166C2 (en) | 2005-06-15 |
Family
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Family Applications (1)
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| UA2002108484A UA73166C2 (en) | 2000-04-26 | 2001-04-26 | Dipeptidilpeptidasa iv inhibitor, pharmaceutical composition on its base |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7125863B2 (fr) |
| EP (1) | EP1280797B1 (fr) |
| JP (1) | JP2003531204A (fr) |
| KR (1) | KR20020093942A (fr) |
| CN (1) | CN1249056C (fr) |
| AT (1) | ATE279408T1 (fr) |
| AU (1) | AU784007B2 (fr) |
| BR (1) | BR0110021A (fr) |
| CA (1) | CA2407662A1 (fr) |
| CZ (1) | CZ20023512A3 (fr) |
| DE (1) | DE60106422T2 (fr) |
| DK (1) | DK1280797T3 (fr) |
| EE (1) | EE200200603A (fr) |
| ES (1) | ES2231474T3 (fr) |
| GB (1) | GB0010188D0 (fr) |
| HK (1) | HK1051043A1 (fr) |
| HR (1) | HRP20020813B1 (fr) |
| HU (1) | HUP0300563A3 (fr) |
| IL (1) | IL151917A0 (fr) |
| MX (1) | MXPA02010490A (fr) |
| NO (1) | NO323750B1 (fr) |
| NZ (1) | NZ522436A (fr) |
| PL (1) | PL357724A1 (fr) |
| PT (1) | PT1280797E (fr) |
| RU (1) | RU2280035C2 (fr) |
| SI (1) | SI1280797T1 (fr) |
| SK (1) | SK15292002A3 (fr) |
| UA (1) | UA73166C2 (fr) |
| WO (1) | WO2001081337A1 (fr) |
| ZA (1) | ZA200208523B (fr) |
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| EP2574336A1 (fr) | 1998-02-02 | 2013-04-03 | Trustees Of Tufts College | Utilisation dýinhibiteurs de dipeptidylpeptidase pour réguler le métabolisme du glucose |
| GB0109146D0 (en) * | 2001-04-11 | 2001-05-30 | Ferring Bv | Treatment of type 2 diabetes |
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| KR20040033048A (ko) | 2001-09-14 | 2004-04-17 | 미츠비시 웰파마 가부시키가이샤 | 티아졸리딘 유도체 및 이의 약학적 용도 |
| GB0125445D0 (en) * | 2001-10-23 | 2001-12-12 | Ferring Bv | Protease Inhibitors |
| GB0125446D0 (en) * | 2001-10-23 | 2001-12-12 | Ferring Bv | Novel anti-diabetic agents |
| EP2769715A3 (fr) | 2001-11-26 | 2014-09-17 | Trustees Of Tufts College | Procédés pour le traitement de troubles auto-immuns et réactifs associés |
| CA2837936A1 (fr) | 2001-11-26 | 2003-06-05 | Trustees Of Tufts College | Inhibiteurs peptidomimetiques d'enzymes de clivage post-proline |
| CN1308311C (zh) * | 2002-02-13 | 2007-04-04 | 霍夫曼-拉罗奇有限公司 | 新型吡啶－和喹啉－衍生物 |
| ES2301879T3 (es) * | 2002-10-18 | 2008-07-01 | MERCK & CO., INC. | Inhibidores de dipeptidilpeptidasa heterociclica beta-amino para el tratamiento o prevencion de diabetes. |
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| KR20110059664A (ko) | 2003-05-05 | 2011-06-02 | 프로비오드룩 아게 | 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도 |
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| BRPI0614732A2 (pt) * | 2005-08-11 | 2011-04-12 | Hoffmann La Roche | composição farmacêutica que compreende um inibidor de dpp-iv, uso de um inibidor de dpp-iv e método para o tratamento de enfermidades associadas com nìveis de glicose sanguìnea elevados |
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| BRPI0616077B8 (pt) * | 2005-09-14 | 2021-05-25 | Takeda Pharmaceuticals Co | composição farmacêutica formulada em uma dose única, kit, artigo de manufatura, uso da composição farmacêutica e uso de um ou mais compostos antidiabéticos |
| CN102675221A (zh) * | 2005-09-16 | 2012-09-19 | 武田药品工业株式会社 | 用于制备嘧啶二酮衍生物的方法中的中间体 |
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| KR101281962B1 (ko) | 2006-04-11 | 2013-07-08 | 아레나 파마슈티칼스, 인크. | 특정 개체에게서 골 질량을 증가시키는 데에 유용한 화합물을 확인하기 위해 ｇｐｒ119 수용체를 사용하는 방법 |
| PE20071221A1 (es) | 2006-04-11 | 2007-12-14 | Arena Pharm Inc | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas |
| BRPI0709984A2 (pt) | 2006-04-12 | 2011-08-02 | Probiodrug Ag | inibidores de enzima |
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| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
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| JP5523107B2 (ja) | 2006-11-30 | 2014-06-18 | プロビオドルグ エージー | グルタミニルシクラーゼの新規阻害剤 |
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| DK2475428T3 (en) | 2009-09-11 | 2015-09-28 | Probiodrug Ag | Heterocyclic derivatives as glutaminylcyklaseinhibitorer |
| US9181233B2 (en) | 2010-03-03 | 2015-11-10 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| BR112012022478B1 (pt) | 2010-03-10 | 2021-09-21 | Probiodrug Ag | Inibidores heterocíclicos de glutaminil ciclase (qc, ec 2.3.2.5), seu processo de preparação, e composição farmacêutica |
| EP2556056A1 (fr) | 2010-04-06 | 2013-02-13 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur de gpr119 et traitement de troubles associés |
| EP2560953B1 (fr) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibiteurs de glutaminyl cyclase |
| BR112013008100A2 (pt) | 2010-09-22 | 2016-08-09 | Arena Pharm Inc | "moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles." |
| DK2686313T3 (en) | 2011-03-16 | 2016-05-02 | Probiodrug Ag | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| WO2012135570A1 (fr) | 2011-04-01 | 2012-10-04 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur gpr119 et traitement de troubles qui lui sont associés |
| WO2012145361A1 (fr) | 2011-04-19 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur gpr119 et traitement de troubles liés à celui-ci |
| US20140038889A1 (en) | 2011-04-22 | 2014-02-06 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
| WO2012145604A1 (fr) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur gpr119 et traitement de troubles liés à celui-ci |
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| US5462928A (en) | 1990-04-14 | 1995-10-31 | New England Medical Center Hospitals, Inc. | Inhibitors of dipeptidyl-aminopeptidase type IV |
| US6011155A (en) * | 1996-11-07 | 2000-01-04 | Novartis Ag | N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV |
| TW492957B (en) | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| ES2296962T3 (es) * | 2001-06-27 | 2008-05-01 | Smithkline Beecham Corporation | Pirrolidinas como inhibidores de dipeptidil peptidasa. |
| ES2296979T3 (es) * | 2001-06-27 | 2008-05-01 | Smithkline Beecham Corporation | Fluoropirrolidinas como inhibidores de dipeptidil peptidasa. |
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2000
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2001
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- 2001-04-26 DE DE60106422T patent/DE60106422T2/de not_active Expired - Fee Related
- 2001-04-26 MX MXPA02010490A patent/MXPA02010490A/es active IP Right Grant
- 2001-04-26 IL IL15191701A patent/IL151917A0/xx unknown
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- 2001-04-26 BR BR0110021-1A patent/BR0110021A/pt not_active IP Right Cessation
- 2001-04-26 WO PCT/GB2001/001875 patent/WO2001081337A1/fr active IP Right Grant
- 2001-04-26 CN CNB018086748A patent/CN1249056C/zh not_active Expired - Fee Related
- 2001-04-26 AU AU50537/01A patent/AU784007B2/en not_active Ceased
- 2001-04-26 SI SI200130259T patent/SI1280797T1/xx unknown
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- 2001-04-26 RU RU2002131639/04A patent/RU2280035C2/ru not_active IP Right Cessation
- 2001-04-26 ES ES01923854T patent/ES2231474T3/es not_active Expired - Lifetime
- 2001-04-26 CA CA002407662A patent/CA2407662A1/fr not_active Abandoned
- 2001-04-26 UA UA2002108484A patent/UA73166C2/uk unknown
- 2001-04-26 PT PT01923854T patent/PT1280797E/pt unknown
- 2001-04-26 PL PL01357724A patent/PL357724A1/xx not_active Application Discontinuation
- 2001-04-26 US US10/258,804 patent/US7125863B2/en not_active Expired - Fee Related
- 2001-04-26 KR KR1020027014230A patent/KR20020093942A/ko active IP Right Grant
- 2001-04-26 JP JP2001578427A patent/JP2003531204A/ja active Pending
- 2001-04-26 EE EEP200200603A patent/EE200200603A/xx unknown
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- 2001-04-26 NZ NZ522436A patent/NZ522436A/en unknown
- 2001-04-26 EP EP01923854A patent/EP1280797B1/fr not_active Expired - Lifetime
- 2001-04-26 AT AT01923854T patent/ATE279408T1/de not_active IP Right Cessation
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- 2002-10-10 HR HR20020813A patent/HRP20020813B1/xx not_active IP Right Cessation
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