TWI800139B - 人類化抗人類cd19抗體及使用方法 - Google Patents

人類化抗人類cd19抗體及使用方法 Download PDF

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Publication number
TWI800139B
TWI800139B TW110145448A TW110145448A TWI800139B TW I800139 B TWI800139 B TW I800139B TW 110145448 A TW110145448 A TW 110145448A TW 110145448 A TW110145448 A TW 110145448A TW I800139 B TWI800139 B TW I800139B
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Taiwan
Prior art keywords
antibodies
human
methods
humanized anti
humanized
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TW110145448A
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English (en)
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TW202210522A (zh
Inventor
蓋 喬治絲
亞歷山大 哈斯
胡伯特 凱騰伯格
克勞蒂亞 費拉拉 寇樂
羅倫 拉瑞維爾
艾克哈得 摩斯納
麥可 莫賀傑
提爾曼 薛洛紹爾
Original Assignee
瑞士商赫孚孟拉羅股份公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TW110145448A 2015-10-01 2016-09-30 人類化抗人類cd19抗體及使用方法 TWI800139B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15187820.4 2015-10-01
EP15187820 2015-10-01

Publications (2)

Publication Number Publication Date
TW202210522A TW202210522A (zh) 2022-03-16
TWI800139B true TWI800139B (zh) 2023-04-21

Family

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Family Applications (2)

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TW105131517A TWI747842B (zh) 2015-10-01 2016-09-30 人類化抗人類cd19抗體及使用方法
TW110145448A TWI800139B (zh) 2015-10-01 2016-09-30 人類化抗人類cd19抗體及使用方法

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Country Status (32)

Country Link
US (2) US11286300B2 (zh)
EP (2) EP3356408B1 (zh)
JP (2) JP6629437B2 (zh)
KR (1) KR20180056768A (zh)
CN (2) CN108137696B (zh)
AR (1) AR106188A1 (zh)
AU (2) AU2016333511B2 (zh)
BR (1) BR112018006579A2 (zh)
CA (1) CA3000562A1 (zh)
CL (1) CL2018000728A1 (zh)
CO (1) CO2018002265A2 (zh)
CR (1) CR20180141A (zh)
DK (1) DK3356408T3 (zh)
ES (1) ES2791989T3 (zh)
HK (1) HK1251585A1 (zh)
HR (1) HRP20200767T1 (zh)
HU (1) HUE049083T2 (zh)
IL (2) IL257679B (zh)
LT (1) LT3356408T (zh)
MA (2) MA43024B1 (zh)
MX (2) MX2018003410A (zh)
MY (1) MY185171A (zh)
PE (1) PE20181054A1 (zh)
PH (1) PH12018500708A1 (zh)
PL (1) PL3356408T3 (zh)
PT (1) PT3356408T (zh)
RS (1) RS60250B1 (zh)
RU (2) RU2020124153A (zh)
SI (1) SI3356408T1 (zh)
TW (2) TWI747842B (zh)
UA (1) UA125285C2 (zh)
WO (1) WO2017055541A1 (zh)

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MX2017006250A (es) 2014-11-14 2017-11-17 Hoffmann La Roche Moleculas de union a antigeno que comprenden un trimero de ligando de la familia de tnf.
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AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
CN108026177B (zh) * 2015-10-02 2021-11-26 豪夫迈·罗氏有限公司 双特异性抗cd19xcd3 t细胞活化性抗原结合分子
UA123323C2 (uk) 2016-05-02 2021-03-17 Ф. Хоффманн-Ля Рош Аг Димерний злитий поліпептид
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CR20190309A (es) 2017-01-03 2019-08-21 Hoffmann La Roche Moleculas de unión de3 antígeno biespecíficas que comprenden el clon 20h4.9 anti-4-1bb
CN110573528B (zh) 2017-03-29 2023-06-09 豪夫迈·罗氏有限公司 针对共刺激性tnf受体的双特异性抗原结合分子
EP3703746A1 (en) 2017-11-01 2020-09-09 F. Hoffmann-La Roche AG Novel tnf family ligand trimer-containing antigen binding molecules
CA3113548A1 (en) 2018-10-01 2020-04-09 F. Hoffmann-La Roche Ag Bispecific antigen binding molecules comprising anti-fap clone 212
UA128001C2 (uk) 2018-12-21 2024-03-06 Ф. Хоффманн-Ля Рош Аг Націлені на пухлину агоністичні cd28-антигензв'язувальні молекули
AR121706A1 (es) 2020-04-01 2022-06-29 Hoffmann La Roche Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap
JP2023538716A (ja) 2020-06-19 2023-09-11 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｃｄ３及びｃｄ１９に結合する抗体
RU2020122142A (ru) * 2020-07-03 2022-01-04 Петр Иванович Никитин Композиция и способ для улучшения эффективности и снижения побочных эффектов терапевтического агента, доставляемого к мишени с помощью магнитного поля
JP2023548529A (ja) * 2020-11-06 2023-11-17 ノバルティス アーゲー Ｃｄ１９結合分子及びその使用

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CA3000562A1 (en) 2017-04-06
AU2016333511B2 (en) 2022-11-24
BR112018006579A2 (pt) 2018-10-09
TW201731875A (zh) 2017-09-16
EP3825331A1 (en) 2021-05-26
TWI747842B (zh) 2021-12-01
DK3356408T3 (da) 2020-05-18
ES2791989T3 (es) 2020-11-06
PE20181054A1 (es) 2018-07-03
MA43024B1 (fr) 2020-05-29
PL3356408T3 (pl) 2020-08-10
PH12018500708A1 (en) 2018-10-15
IL288457A (en) 2022-01-01
EP3356408B1 (en) 2020-03-18
LT3356408T (lt) 2020-06-10
AU2022262918A1 (en) 2022-12-08
CN108137696A (zh) 2018-06-08
CL2018000728A1 (es) 2019-04-26
US11286300B2 (en) 2022-03-29
RS60250B1 (sr) 2020-06-30
RU2731156C1 (ru) 2020-08-31
KR20180056768A (ko) 2018-05-29
EP3356408A1 (en) 2018-08-08
WO2017055541A1 (en) 2017-04-06
JP2018529733A (ja) 2018-10-11
CN114349862A (zh) 2022-04-15
CO2018002265A2 (es) 2018-05-10
HK1251585A1 (zh) 2019-02-01
IL257679A (en) 2018-04-30
JP2020055842A (ja) 2020-04-09
TW202210522A (zh) 2022-03-16
US20220204616A1 (en) 2022-06-30
MA55063A (fr) 2022-01-05
AU2016333511A1 (en) 2018-03-15
SI3356408T1 (sl) 2020-07-31
CN108137696B (zh) 2022-01-11
HRP20200767T1 (hr) 2020-07-24
JP6629437B2 (ja) 2020-01-15
US20180282409A1 (en) 2018-10-04
CR20180141A (es) 2018-04-24
AR106188A1 (es) 2017-12-20
IL257679B (en) 2022-01-01
MX2021011167A (es) 2021-10-22
HUE049083T2 (hu) 2020-09-28
UA125285C2 (uk) 2022-02-16
MX2018003410A (es) 2018-06-06
MY185171A (en) 2021-04-30
RU2020124153A (ru) 2020-09-02

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