TWI438004B - 半胱胺酸工程化之抗ｔｅｎｂ２抗體及抗體藥物共軛物 - Google Patents

半胱胺酸工程化之抗ｔｅｎｂ２抗體及抗體藥物共軛物 Download PDF

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Publication number
TWI438004B
TWI438004B TW097139977A TW97139977A TWI438004B TW I438004 B TWI438004 B TW I438004B TW 097139977 A TW097139977 A TW 097139977A TW 97139977 A TW97139977 A TW 97139977A TW I438004 B TWI438004 B TW I438004B
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Taiwan
Prior art keywords
antibody
cysteine
tenb2
engineered
cancer
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TW097139977A
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English (en)
Chinese (zh)
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TW200927172A (en
Inventor
Weiguang Mao
Jagath Reddy Junutula
Paul Polakis
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Genentech Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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TW097139977A 2007-10-19 2008-10-17 半胱胺酸工程化之抗ｔｅｎｂ２抗體及抗體藥物共軛物 TWI438004B (zh)

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US98141107P 2007-10-19 2007-10-19

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TW200927172A TW200927172A (en) 2009-07-01
TWI438004B true TWI438004B (zh) 2014-05-21

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US (3) US8937161B2 (enExample)
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KR (1) KR101622412B1 (enExample)
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US20100111856A1 (en) * 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
WO2009026274A1 (en) 2007-08-22 2009-02-26 Medarex, Inc. Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions
NZ584514A (en) 2007-10-19 2012-07-27 Genentech Inc Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates
AU2010271582B2 (en) 2009-07-15 2016-07-28 Aimm Therapeutics B.V. Gram-positive bacteria specific binding compounds
JP6184695B2 (ja) 2009-12-04 2017-08-23 ジェネンテック， インコーポレイテッド 多重特異性抗体、抗体アナログ、組成物、及び方法
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