JP5606916B2 - システイン操作抗ｔｅｎｂ２抗体および抗体薬物結合体 - Google Patents

システイン操作抗ｔｅｎｂ２抗体および抗体薬物結合体 Download PDF

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Publication number
JP5606916B2
JP5606916B2 JP2010530101A JP2010530101A JP5606916B2 JP 5606916 B2 JP5606916 B2 JP 5606916B2 JP 2010530101 A JP2010530101 A JP 2010530101A JP 2010530101 A JP2010530101 A JP 2010530101A JP 5606916 B2 JP5606916 B2 JP 5606916B2
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antibody
tenb2
cysteine
cancer
drug conjugate
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Japanese (ja)
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JP2011504460A (ja
JP2011504460A5 (enExample
Inventor
ウェイグアン マオ，
ヤガス レディー ジュナトゥラ，
ポール ポラキス，
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ジェネンテック， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • G—PHYSICS
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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    • C07K—PEPTIDES
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    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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  • General Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
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  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
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  • Pregnancy & Childbirth (AREA)
JP2010530101A 2007-10-19 2008-10-16 システイン操作抗ｔｅｎｂ２抗体および抗体薬物結合体 Expired - Fee Related JP5606916B2 (ja)

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Application Number Priority Date Filing Date Title
US98141107P 2007-10-19 2007-10-19
US60/981,411 2007-10-19
PCT/US2008/080102 WO2009052249A1 (en) 2007-10-19 2008-10-16 Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates

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JP2013095417A Division JP2013173776A (ja) 2007-10-19 2013-04-30 システイン操作抗ｔｅｎｂ２抗体および抗体薬物結合体

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JP2011504460A JP2011504460A (ja) 2011-02-10
JP2011504460A5 JP2011504460A5 (enExample) 2011-10-13
JP5606916B2 true JP5606916B2 (ja) 2014-10-15

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JP2013095417A Withdrawn JP2013173776A (ja) 2007-10-19 2013-04-30 システイン操作抗ｔｅｎｂ２抗体および抗体薬物結合体

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US (3) US8937161B2 (enExample)
EP (1) EP2209808B1 (enExample)
JP (2) JP5606916B2 (enExample)
KR (1) KR101622412B1 (enExample)
CN (1) CN101835803B (enExample)
AR (1) AR068941A1 (enExample)
AU (2) AU2008312457B2 (enExample)
BR (1) BRPI0818780A2 (enExample)
CA (1) CA2698541C (enExample)
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