TWI290464B - Treatment of burns - Google Patents
Treatment of burns Download PDFInfo
- Publication number
- TWI290464B TWI290464B TW090117812A TW90117812A TWI290464B TW I290464 B TWI290464 B TW I290464B TW 090117812 A TW090117812 A TW 090117812A TW 90117812 A TW90117812 A TW 90117812A TW I290464 B TWI290464 B TW I290464B
- Authority
- TW
- Taiwan
- Prior art keywords
- treatment
- gel
- sodium
- pharmaceutical composition
- topical
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 claims abstract description 9
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims abstract 2
- 229960001259 diclofenac Drugs 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims description 13
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 12
- 229910052708 sodium Inorganic materials 0.000 claims description 12
- 239000011734 sodium Substances 0.000 claims description 12
- HPNMFZURTQLUMO-UHFFFAOYSA-O diethylammonium Chemical compound CC[NH2+]CC HPNMFZURTQLUMO-UHFFFAOYSA-O 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- XBRDBODLCHKXHI-UHFFFAOYSA-N epolamine Chemical compound OCCN1CCCC1 XBRDBODLCHKXHI-UHFFFAOYSA-N 0.000 claims description 2
- 229950008932 epolamine Drugs 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims 1
- 229910052602 gypsum Inorganic materials 0.000 claims 1
- 239000010440 gypsum Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 abstract description 12
- 239000003814 drug Substances 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000000499 gel Substances 0.000 description 12
- 208000010201 Exanthema Diseases 0.000 description 11
- 201000005884 exanthem Diseases 0.000 description 11
- 206010037844 rash Diseases 0.000 description 11
- 239000000902 placebo Substances 0.000 description 10
- 229940068196 placebo Drugs 0.000 description 10
- 206010042496 Sunburn Diseases 0.000 description 9
- 238000009472 formulation Methods 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 231100000673 dose–response relationship Toxicity 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 239000012049 topical pharmaceutical composition Substances 0.000 description 4
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 229960001985 dextromethorphan Drugs 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 208000008035 Back Pain Diseases 0.000 description 2
- 241000700198 Cavia Species 0.000 description 2
- 230000002079 cooperative effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- KPHWPUGNDIVLNH-UHFFFAOYSA-M diclofenac sodium Chemical compound [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KPHWPUGNDIVLNH-UHFFFAOYSA-M 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- WDKXLLJDNUBYCY-UHFFFAOYSA-N ibopamine Chemical compound CNCCC1=CC=C(OC(=O)C(C)C)C(OC(=O)C(C)C)=C1 WDKXLLJDNUBYCY-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 229940063674 voltaren Drugs 0.000 description 2
- 208000034656 Contusions Diseases 0.000 description 1
- 201000011275 Epicondylitis Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000009519 contusion Effects 0.000 description 1
- DCERVXIINVUMKU-UHFFFAOYSA-N diclofenac epolamine Chemical compound OCC[NH+]1CCCC1.[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCERVXIINVUMKU-UHFFFAOYSA-N 0.000 description 1
- 229960000942 diclofenac epolamine Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229960004370 ibopamine Drugs 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000013465 muscle pain Diseases 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 229960003424 phenylacetic acid Drugs 0.000 description 1
- 239000003279 phenylacetic acid Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 231100000075 skin burn Toxicity 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- -1 tinctures Substances 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polarising Elements (AREA)
- Magnetic Heads (AREA)
- Semiconductor Lasers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00118968 | 2000-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TWI290464B true TWI290464B (en) | 2007-12-01 |
Family
ID=8169725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW090117812A TWI290464B (en) | 2000-09-01 | 2001-07-20 | Treatment of burns |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20030187069A1 (enExample) |
| JP (1) | JP2004507497A (enExample) |
| KR (1) | KR100880056B1 (enExample) |
| CN (1) | CN100350905C (enExample) |
| AR (1) | AR030522A1 (enExample) |
| AT (1) | AT504040B1 (enExample) |
| AU (2) | AU2001287706B2 (enExample) |
| BE (1) | BE1014352A5 (enExample) |
| CA (1) | CA2414921C (enExample) |
| CH (1) | CH695416A5 (enExample) |
| CZ (1) | CZ303849B6 (enExample) |
| DE (2) | DE10196483T1 (enExample) |
| DK (1) | DK200300274A (enExample) |
| ES (1) | ES2201941B1 (enExample) |
| FI (1) | FI119840B (enExample) |
| FR (1) | FR2813530B1 (enExample) |
| GB (1) | GB2381455B (enExample) |
| GR (1) | GR1004434B (enExample) |
| HU (1) | HU230783B1 (enExample) |
| IL (2) | IL153816A0 (enExample) |
| IT (1) | ITMI20011820A1 (enExample) |
| LU (1) | LU91009B1 (enExample) |
| MX (1) | MXPA03001830A (enExample) |
| NL (1) | NL1018862C2 (enExample) |
| NO (1) | NO330590B1 (enExample) |
| PL (1) | PL359807A1 (enExample) |
| RU (1) | RU2314802C2 (enExample) |
| SE (1) | SE527137C2 (enExample) |
| TW (1) | TWI290464B (enExample) |
| WO (1) | WO2002017905A2 (enExample) |
| ZA (1) | ZA200300284B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20040321A1 (es) * | 2002-08-22 | 2004-07-15 | Novartis Consumer Health Sa | Composicion topica que comprende diclofenaco |
| EP2055298A1 (en) * | 2007-10-30 | 2009-05-06 | Novartis AG | Topical composition |
| CN105395544A (zh) * | 2014-08-23 | 2016-03-16 | 南京海纳医药科技有限公司 | 双氯芬酸依泊胺凝胶制备方法及药物用途 |
| WO2016038553A1 (en) | 2014-09-10 | 2016-03-17 | Novartis Consumer Health S.A. | Topical diclofenac sodium compositions |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT370721B (de) | 1981-02-24 | 1983-04-25 | Ciba Geigy Ag | Verfahren zur herstellung von neuen salzen der 2- (2,6-dichloranilino)-phenylessigsaeure, der |
| DE8210781U1 (de) * | 1982-04-16 | 1982-06-24 | Unilever N.V., 3000 Rotterdam | Staubdichte Faltschachtel |
| CH655656B (enExample) * | 1982-10-07 | 1986-05-15 | ||
| JPS59170011A (ja) * | 1983-03-16 | 1984-09-26 | Pola Chem Ind Inc | 日焼け防止化粧料 |
| DE3707532C2 (de) | 1987-03-09 | 1998-05-28 | Bauer Johann | Verwendung einer Kombination von Extr. Gingko biloba oder mindestens einem Gingkolid und Acetylsalicylsäure oder DL-Lysin-mono-acetylsalicylat oder Diflunisal zur Behandlung von Verbrennungen, Verbrühungen, Strahlenschäden und Erfrierungen |
| US4847071A (en) | 1987-10-22 | 1989-07-11 | The Procter & Gamble Company | Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent |
| IT1229489B (it) | 1988-12-09 | 1991-09-03 | Altergon Sa | Composizioni farmaceutiche lipidiche per uso topico atte a veicolare un principio attivo antiinfiammatorio idrosolubile |
| RU2008002C1 (ru) * | 1989-03-23 | 1994-02-28 | Центр по химии лекарственных средств | Противовоспалительный состав и способ его получения |
| US5674912A (en) * | 1991-03-01 | 1997-10-07 | Warner-Lambert Company | Sunscreen-wound healing compositions and methods for preparing and using same |
| JP3526887B2 (ja) | 1993-04-23 | 2004-05-17 | 帝國製薬株式会社 | 消炎鎮痛外用貼付剤 |
| JP2000500449A (ja) * | 1995-11-13 | 2000-01-18 | ピットミー・インターナショナル・ナムローゼ・フェンノートシャップ | 一酸化二窒素を含む鎮痛剤、抗炎症剤、および抗発熱剤のための投与媒体とそれらの医薬組成物 |
| JP4181232B2 (ja) * | 1997-07-18 | 2008-11-12 | 帝國製薬株式会社 | ジクロフェナクナトリウム含有油性外用貼付製剤 |
| KR19990026792A (ko) * | 1997-09-26 | 1999-04-15 | 김윤 | 디클로페낙 디에틸암모늄염을 함유한 매트릭스형 패취제제 |
| EP0923937B1 (en) * | 1997-12-08 | 2004-03-10 | Council of Scientific and Industrial Research | A herbal formulation useful as a therapeutic and cosmetic application for the treatment of general skin disorders |
| DE19844116A1 (de) | 1998-08-06 | 2000-02-24 | Vascular Biotech Gmbh | Wirkstoffkombination insbesondere zur Prophylaxe und Therapie von ischämischen Organschäden und Reperfusionssyndromen |
| RU2140258C1 (ru) * | 1999-03-17 | 1999-10-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" | Гидрофильная фармацевтическая композиция, обладающая противовоспалительным действием |
| WO2000072883A2 (en) * | 1999-06-02 | 2000-12-07 | Aviana Biopharm | Pharmaceutical transdermal compositions |
| US6368618B1 (en) * | 1999-07-01 | 2002-04-09 | The University Of Georgia Research Foundation, Inc. | Composition and method for enhanced transdermal absorption of nonsteroidal anti-inflammatory drugs |
| DE10025328A1 (de) * | 2000-05-23 | 2001-12-06 | Lohmann Therapie Syst Lts | Acetylsalicylsäure enthaltendes superfizielles therapeutisches System zur Behandlung von Hautschmerzen |
-
2001
- 2001-07-20 TW TW090117812A patent/TWI290464B/zh not_active IP Right Cessation
- 2001-08-07 GR GR20010100390A patent/GR1004434B/el unknown
- 2001-08-27 BE BE2001/0561A patent/BE1014352A5/fr not_active IP Right Cessation
- 2001-08-27 FR FR0111126A patent/FR2813530B1/fr not_active Expired - Fee Related
- 2001-08-28 IT IT2001MI001820A patent/ITMI20011820A1/it unknown
- 2001-08-30 JP JP2002522879A patent/JP2004507497A/ja active Pending
- 2001-08-30 KR KR1020037003022A patent/KR100880056B1/ko not_active Expired - Fee Related
- 2001-08-30 IL IL15381601A patent/IL153816A0/xx unknown
- 2001-08-30 CZ CZ20030574A patent/CZ303849B6/cs not_active IP Right Cessation
- 2001-08-30 MX MXPA03001830A patent/MXPA03001830A/es active IP Right Grant
- 2001-08-30 PL PL35980701A patent/PL359807A1/xx not_active Application Discontinuation
- 2001-08-30 DE DE10196483T patent/DE10196483T1/de active Granted
- 2001-08-30 AR ARP010104137A patent/AR030522A1/es unknown
- 2001-08-30 AU AU2001287706A patent/AU2001287706B2/en not_active Ceased
- 2001-08-30 GB GB0304150A patent/GB2381455B/en not_active Expired - Fee Related
- 2001-08-30 US US10/363,497 patent/US20030187069A1/en not_active Abandoned
- 2001-08-30 LU LU91009A patent/LU91009B1/de active
- 2001-08-30 RU RU2003108858/15A patent/RU2314802C2/ru active
- 2001-08-30 AT AT0918401A patent/AT504040B1/de not_active IP Right Cessation
- 2001-08-30 HU HU0300876A patent/HU230783B1/hu unknown
- 2001-08-30 CH CH00305/03A patent/CH695416A5/de not_active IP Right Cessation
- 2001-08-30 WO PCT/EP2001/010041 patent/WO2002017905A2/en not_active Ceased
- 2001-08-30 CA CA2414921A patent/CA2414921C/en not_active Expired - Fee Related
- 2001-08-30 ES ES200350010A patent/ES2201941B1/es not_active Expired - Fee Related
- 2001-08-30 AU AU8770601A patent/AU8770601A/xx active Pending
- 2001-08-30 DE DE10196483.8A patent/DE10196483B4/de not_active Expired - Lifetime
- 2001-08-30 CN CNB018149340A patent/CN100350905C/zh not_active Expired - Fee Related
- 2001-08-31 NL NL1018862A patent/NL1018862C2/nl not_active IP Right Cessation
-
2003
- 2003-01-06 IL IL153816A patent/IL153816A/en active IP Right Grant
- 2003-01-10 ZA ZA200300284A patent/ZA200300284B/en unknown
- 2003-02-18 NO NO20030767A patent/NO330590B1/no not_active IP Right Cessation
- 2003-02-24 DK DK200300274A patent/DK200300274A/da not_active Application Discontinuation
- 2003-02-25 FI FI20030276A patent/FI119840B/fi not_active IP Right Cessation
- 2003-02-28 SE SE0300535A patent/SE527137C2/sv unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |