TW303362B - - Google Patents

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Publication number
TW303362B
TW303362B TW084113098A TW84113098A TW303362B TW 303362 B TW303362 B TW 303362B TW 084113098 A TW084113098 A TW 084113098A TW 84113098 A TW84113098 A TW 84113098A TW 303362 B TW303362 B TW 303362B
Authority
TW
Taiwan
Prior art keywords
compound
tetrahydro
patent application
alkyl group
hydrogen
Prior art date
Application number
TW084113098A
Other languages
English (en)
Chinese (zh)
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Application granted granted Critical
Publication of TW303362B publication Critical patent/TW303362B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW084113098A 1994-12-14 1995-12-08 TW303362B (OSRAM)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9425211.1A GB9425211D0 (en) 1994-12-14 1994-12-14 Substituted 1H-imidazoles

Publications (1)

Publication Number Publication Date
TW303362B true TW303362B (OSRAM) 1997-04-21

Family

ID=10765918

Family Applications (1)

Application Number Title Priority Date Filing Date
TW084113098A TW303362B (OSRAM) 1994-12-14 1995-12-08

Country Status (26)

Country Link
US (1) US5658938A (OSRAM)
EP (1) EP0717037A1 (OSRAM)
JP (1) JPH08208622A (OSRAM)
KR (1) KR960022474A (OSRAM)
CN (1) CN1054376C (OSRAM)
AR (1) AR002257A1 (OSRAM)
AU (1) AU693614B2 (OSRAM)
BG (1) BG63043B1 (OSRAM)
BR (1) BR9505815A (OSRAM)
CA (1) CA2165133A1 (OSRAM)
CZ (1) CZ327195A3 (OSRAM)
EE (1) EE9500064A (OSRAM)
FI (1) FI955927L (OSRAM)
GB (1) GB9425211D0 (OSRAM)
HU (1) HUT73980A (OSRAM)
IL (1) IL116325A (OSRAM)
IS (1) IS4311A (OSRAM)
MX (1) MX9505063A (OSRAM)
NO (1) NO305316B1 (OSRAM)
NZ (1) NZ280646A (OSRAM)
PL (1) PL311736A1 (OSRAM)
RO (1) RO113346B1 (OSRAM)
RU (1) RU2156239C2 (OSRAM)
SK (1) SK155095A3 (OSRAM)
TW (1) TW303362B (OSRAM)
ZA (1) ZA9510554B (OSRAM)

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GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
GB9520150D0 (en) * 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
ZA981080B (en) 1997-02-11 1998-08-12 Warner Lambert Co Bicyclic inhibitors of protein farnesyl transferase
US20030073850A1 (en) * 1998-08-07 2003-04-17 Altenbach Robert J. 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use
US6503935B1 (en) 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
US6388090B2 (en) 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
AU5846901A (en) 2000-05-08 2001-11-20 Orion Corp New polycyclic indanylimidazoles with alpha2 adrenergic activity
TW200306783A (en) * 2002-04-29 2003-12-01 Fmc Corp Pesticidal heterocycles
US20040266776A1 (en) * 2003-06-25 2004-12-30 Gil Daniel W. Methods of preventing and reducing the severity of stress-associated conditions
FI20022007A0 (fi) * 2002-11-08 2002-11-08 Juvantia Pharma Ltd Oy Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi
FI20022159A0 (fi) * 2002-12-05 2002-12-05 Orion Corp Uusia farmaseuttisia yhdisteitä
KR20080090545A (ko) * 2006-01-27 2008-10-08 에프. 호프만-라 로슈 아게 Ｃｎｓ 장애 치료용 2-이미다졸의 용도
BRPI0717939A2 (pt) * 2006-10-19 2013-12-03 Hoffmann La Roche Aminometil-4-imidazóis
CN101528709B (zh) * 2006-10-19 2012-02-01 弗·哈夫曼-拉罗切有限公司 对痕量胺相关受体有亲和性的氨基甲基-2-咪唑类
ES2375578T3 (es) * 2006-11-02 2012-03-02 F. Hoffmann-La Roche Ag 2-imidazoles sustituidos como moduladores de receptores asociados a aminas trazas.
WO2008058867A2 (en) * 2006-11-16 2008-05-22 F. Hoffmann-La Roche Ag Substituted 4-imidazoles
MX2009005920A (es) * 2006-12-13 2009-06-16 Hoffmann La Roche Nuevos 2-imidazoles como ligandos para receptores asociados con trazas de amina.
US20080146523A1 (en) * 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
MX2009008255A (es) * 2007-02-02 2009-08-12 Hoffmann La Roche Nuevas 2-aminooxazolinas como ligandos taar1.
EP2125749A2 (en) * 2007-02-13 2009-12-02 Schering Corporation Functionally selective alpha2c adrenoreceptor agonists
CL2008000431A1 (es) * 2007-02-13 2008-08-18 Schering Corp Compuestos derivados de biciclos o heterociclos condensados; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar afecciones relacionadas con los a2c adrenegicos, tales como congestion relacionada con rinitis, polipos o re
JP2010518161A (ja) * 2007-02-13 2010-05-27 シェーリング コーポレイション 機能選択性α２Ｃアドレナリン受容体アゴニストとしてのクロマン誘導体および類似体
CA2676944C (en) * 2007-02-15 2016-01-19 F. Hoffmann-La Roche Ag 2-aminooxazolines as taar1 ligands
JP2010531837A (ja) 2007-07-02 2010-09-30 エフ．ホフマン−ラ ロシュ アーゲー 微量アミン関連レセプター（ｔａａｒ）に対して良好な親和性を有する２−イミダゾリン
EP2173719A1 (en) * 2007-07-03 2010-04-14 F. Hoffmann-Roche AG 4-imidazolines and their use as antidepressants
BRPI0813837A2 (pt) * 2007-07-27 2015-01-06 Hoffmann La Roche 2-azetidinametanoaminas e 2-pirrolidinametanoaminas como ligantes de taar
JP2010535172A (ja) * 2007-08-02 2010-11-18 エフ．ホフマン−ラ ロシュ アーゲー Ｃｎｓ障害の処置のためのベンズアミド誘導体の使用
CN101784515A (zh) * 2007-08-03 2010-07-21 弗·哈夫曼-拉罗切有限公司 作为taar1配体的吡啶甲酰胺和苯甲酰胺衍生物
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
EP2257546B1 (en) 2008-02-21 2012-08-15 Merck Sharp & Dohme Corp. Functionally selective alpha2c adrenoreceptor agonists
ES2556633T3 (es) * 2008-07-24 2016-01-19 F. Hoffmann-La Roche Ag Derivados de 4,5-dihidro-oxazol-2-ilo
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
WO2010017120A1 (en) * 2008-08-04 2010-02-11 Schering Corporation Cyclopropylchromene derivatives as modulators of the alpha-2c receptor
US8324213B2 (en) 2008-10-07 2012-12-04 Merck Sharp & Dohme Corp. Biaryl-spiroaminooxazoline analogues as alpha 2C adrenergic receptor modulators
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
US8673950B2 (en) 2010-11-02 2014-03-18 Hoffmann-Laroche Inc. Dihydrooxazol-2-amine derivatives
US8802673B2 (en) 2011-03-24 2014-08-12 Hoffmann-La Roche Inc Heterocyclic amine derivatives
US9073911B2 (en) 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
US9029370B2 (en) 2011-06-10 2015-05-12 Hoffmann-La Roche Inc. Substituted benzamide derivatives
MX354815B (es) 2012-01-12 2018-03-22 Hoffmann La Roche Derivados heterociclicos como receptores asociados con las aminas traza (taars).
PT2895477T (pt) 2012-09-14 2017-12-29 Hoffmann La Roche Derivados de pirazol carboxamida como moduladores taar para uso no tratamento de vários distúrbios, como depressão, diabetes e doença de parkinson.
CN104603129A (zh) * 2012-09-17 2015-05-06 霍夫曼-拉罗奇有限公司 三唑甲酰胺衍生物
WO2015165085A1 (en) 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Morpholin-pyridine derivatives
CA2954098A1 (en) 2014-08-27 2016-03-03 F. Hoffmann-La Roche Ag Substituted azetidine derivatives as taar ligands
CA2953040A1 (en) 2014-08-27 2016-03-03 F. Hoffmann-La Roche Ag Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders
EA036086B1 (ru) * 2016-03-17 2020-09-24 Фмк Корпорейшн Способ превращения s-энантиомера в его рацемическую форму
CN108713019B (zh) 2016-03-17 2021-06-15 豪夫迈·罗氏有限公司 具有作为taar的激动剂的活性的5-乙基-4-甲基-吡唑-3-甲酰胺衍生物
CN116496261B (zh) * 2023-03-09 2025-06-27 中国人民解放军军事科学院军事医学研究院 4-(1h)-咪唑类衍生物及其医药用途
CN118684628B (zh) * 2024-05-20 2025-06-17 中国人民解放军军事科学院军事医学研究院 取代二氢茚基咪唑类化合物及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6048972A (ja) * 1983-08-25 1985-03-16 Dai Ichi Seiyaku Co Ltd テトラヒドロナフタレン誘導体
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB8626287D0 (en) * 1986-11-04 1986-12-03 Ucb Sa Substituted 1h-imidazoles
GB2206880B (en) * 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
US5151526A (en) * 1990-10-11 1992-09-29 The United States Of America As Represented By The Secretary Of The Army 4-[1-(1-naphthalenyl)ethyl]-1H-imidazole, method of making and use as an anesthetic
JPH04210680A (ja) * 1990-12-01 1992-07-31 Nissan Chem Ind Ltd イミダゾール誘導体および植物生長調節剤
GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles

Also Published As

Publication number Publication date
SK155095A3 (en) 1997-02-05
NO955034L (no) 1996-06-17
IL116325A (en) 1999-10-28
AU4036895A (en) 1996-06-20
NO305316B1 (no) 1999-05-10
MX9505063A (es) 1997-01-31
AR002257A1 (es) 1998-03-11
NZ280646A (en) 1996-08-27
IL116325A0 (en) 1996-03-31
FI955927A7 (fi) 1996-06-15
AU693614B2 (en) 1998-07-02
PL311736A1 (en) 1996-06-24
ZA9510554B (en) 1996-06-13
JPH08208622A (ja) 1996-08-13
BG63043B1 (bg) 2001-02-28
GB9425211D0 (en) 1995-02-15
EE9500064A (et) 1996-06-17
FI955927A0 (fi) 1995-12-11
CN1054376C (zh) 2000-07-12
NO955034D0 (no) 1995-12-12
BR9505815A (pt) 1998-01-06
EP0717037A1 (fr) 1996-06-19
CZ327195A3 (en) 1996-07-17
CN1133837A (zh) 1996-10-23
KR960022474A (ko) 1996-07-18
BG100208A (bg) 1996-07-31
HUT73980A (en) 1996-10-28
RO113346B1 (ro) 1998-06-30
HU9503549D0 (en) 1996-02-28
FI955927L (fi) 1996-06-15
US5658938A (en) 1997-08-19
IS4311A (is) 1996-06-15
RU2156239C2 (ru) 2000-09-20
CA2165133A1 (en) 1996-06-15

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