IL116325A - Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazoles and substituted 4-(2,3-dihydro-1h-inden-1-yl)-1h-imidazoles the optically active isomers thereof and racemic mixtures thereof their preparation and pharmaceutical compositions containing them - Google Patents

Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazoles and substituted 4-(2,3-dihydro-1h-inden-1-yl)-1h-imidazoles the optically active isomers thereof and racemic mixtures thereof their preparation and pharmaceutical compositions containing them

Info

Publication number
IL116325A
IL116325A IL11632595A IL11632595A IL116325A IL 116325 A IL116325 A IL 116325A IL 11632595 A IL11632595 A IL 11632595A IL 11632595 A IL11632595 A IL 11632595A IL 116325 A IL116325 A IL 116325A
Authority
IL
Israel
Prior art keywords
imidazoles
substituted
naphthalenyl
inden
tetrahydro
Prior art date
Application number
IL11632595A
Other languages
English (en)
Other versions
IL116325A0 (en
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of IL116325A0 publication Critical patent/IL116325A0/xx
Publication of IL116325A publication Critical patent/IL116325A/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11632595A 1994-12-14 1995-12-11 Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazoles and substituted 4-(2,3-dihydro-1h-inden-1-yl)-1h-imidazoles the optically active isomers thereof and racemic mixtures thereof their preparation and pharmaceutical compositions containing them IL116325A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9425211.1A GB9425211D0 (en) 1994-12-14 1994-12-14 Substituted 1H-imidazoles

Publications (2)

Publication Number Publication Date
IL116325A0 IL116325A0 (en) 1996-03-31
IL116325A true IL116325A (en) 1999-10-28

Family

ID=10765918

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11632595A IL116325A (en) 1994-12-14 1995-12-11 Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazoles and substituted 4-(2,3-dihydro-1h-inden-1-yl)-1h-imidazoles the optically active isomers thereof and racemic mixtures thereof their preparation and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (1) US5658938A (OSRAM)
EP (1) EP0717037A1 (OSRAM)
JP (1) JPH08208622A (OSRAM)
KR (1) KR960022474A (OSRAM)
CN (1) CN1054376C (OSRAM)
AR (1) AR002257A1 (OSRAM)
AU (1) AU693614B2 (OSRAM)
BG (1) BG63043B1 (OSRAM)
BR (1) BR9505815A (OSRAM)
CA (1) CA2165133A1 (OSRAM)
CZ (1) CZ327195A3 (OSRAM)
EE (1) EE9500064A (OSRAM)
FI (1) FI955927L (OSRAM)
GB (1) GB9425211D0 (OSRAM)
HU (1) HUT73980A (OSRAM)
IL (1) IL116325A (OSRAM)
IS (1) IS4311A (OSRAM)
MX (1) MX9505063A (OSRAM)
NO (1) NO305316B1 (OSRAM)
NZ (1) NZ280646A (OSRAM)
PL (1) PL311736A1 (OSRAM)
RO (1) RO113346B1 (OSRAM)
RU (1) RU2156239C2 (OSRAM)
SK (1) SK155095A3 (OSRAM)
TW (1) TW303362B (OSRAM)
ZA (1) ZA9510554B (OSRAM)

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CN101687811A (zh) * 2007-07-03 2010-03-31 弗·哈夫曼-拉罗切有限公司 4-咪唑啉类及其作为抗抑郁剂的应用
BRPI0813837A2 (pt) * 2007-07-27 2015-01-06 Hoffmann La Roche 2-azetidinametanoaminas e 2-pirrolidinametanoaminas como ligantes de taar
EP2182935A1 (en) * 2007-08-02 2010-05-12 F. Hoffmann-Roche AG The use of benzamide derivatives for the treatment of cns disorders
WO2009019149A1 (en) * 2007-08-03 2009-02-12 F. Hoffmann-La Roche Ag Pyridinecarboxamide and benzamide derivatives as taar1 ligands
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
WO2009105504A2 (en) 2008-02-21 2009-08-27 Schering Corporation Functionally selective alpha2c adrenoreceptor agonists
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
CN102083805A (zh) * 2008-07-24 2011-06-01 弗·哈夫曼-拉罗切有限公司 4,5-二氢-唑-2-基衍生物
US20110190247A1 (en) * 2008-08-04 2011-08-04 Schering Corporation Cyclopropylchromene derivatives as modulators of the alpha-2c receptor
TW201026691A (en) 2008-10-07 2010-07-16 Schering Corp Biaryl spiroaminooxazoline analogues as alpha2C adrenergic receptor modulators
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) * 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
US8673950B2 (en) 2010-11-02 2014-03-18 Hoffmann-Laroche Inc. Dihydrooxazol-2-amine derivatives
US8802673B2 (en) 2011-03-24 2014-08-12 Hoffmann-La Roche Inc Heterocyclic amine derivatives
US9073911B2 (en) 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
US9029370B2 (en) 2011-06-10 2015-05-12 Hoffmann-La Roche Inc. Substituted benzamide derivatives
ES2554843T3 (es) 2012-01-12 2015-12-23 F. Hoffmann-La Roche Ag Derivados heterocíclicos como receptores asociados de trazas de amina (TAARs)
PE20150735A1 (es) 2012-09-14 2015-05-17 Hoffmann La Roche Derivados de pirazol-carboxamida como moduladores de taar para uso en el tratamiento de numerosos desordenes, tales como depresion, diabetes y enfermedad de parkinson
RU2637938C2 (ru) 2012-09-17 2017-12-08 Ф. Хоффманн-Ля Рош Аг Производные триазолкарбоксамида
WO2015165085A1 (en) 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Morpholin-pyridine derivatives
CN106470994B (zh) 2014-08-27 2019-09-24 豪夫迈·罗氏有限公司 用于治疗cns疾病的取代的吡嗪并[2,1-a]异喹啉衍生物
BR112017000160A2 (pt) 2014-08-27 2017-10-31 Hoffmann La Roche derivados de azetidina substituidos como ligantes de taar
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KR102537050B1 (ko) 2016-03-17 2023-05-26 에프. 호프만-라 로슈 아게 Taar의 작용제로서 활성을 갖는 5-에틸-4-메틸-피라졸-3-카복스아미드 유도체
CN116496261B (zh) * 2023-03-09 2025-06-27 中国人民解放军军事科学院军事医学研究院 4-(1h)-咪唑类衍生物及其医药用途
CN118684628B (zh) * 2024-05-20 2025-06-17 中国人民解放军军事科学院军事医学研究院 取代二氢茚基咪唑类化合物及其制备方法和用途

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Also Published As

Publication number Publication date
AU4036895A (en) 1996-06-20
CA2165133A1 (en) 1996-06-15
HU9503549D0 (en) 1996-02-28
IS4311A (is) 1996-06-15
US5658938A (en) 1997-08-19
AR002257A1 (es) 1998-03-11
RO113346B1 (ro) 1998-06-30
TW303362B (OSRAM) 1997-04-21
GB9425211D0 (en) 1995-02-15
BR9505815A (pt) 1998-01-06
CN1054376C (zh) 2000-07-12
MX9505063A (es) 1997-01-31
SK155095A3 (en) 1997-02-05
AU693614B2 (en) 1998-07-02
KR960022474A (ko) 1996-07-18
CZ327195A3 (en) 1996-07-17
PL311736A1 (en) 1996-06-24
FI955927A7 (fi) 1996-06-15
CN1133837A (zh) 1996-10-23
NO955034D0 (no) 1995-12-12
NO305316B1 (no) 1999-05-10
FI955927L (fi) 1996-06-15
EE9500064A (et) 1996-06-17
BG100208A (bg) 1996-07-31
JPH08208622A (ja) 1996-08-13
NZ280646A (en) 1996-08-27
HUT73980A (en) 1996-10-28
EP0717037A1 (fr) 1996-06-19
ZA9510554B (en) 1996-06-13
IL116325A0 (en) 1996-03-31
RU2156239C2 (ru) 2000-09-20
NO955034L (no) 1996-06-17
FI955927A0 (fi) 1995-12-11
BG63043B1 (bg) 2001-02-28

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