TR199701526T1 - Bir trombopoietin reseptörüne baglanan peptitler ve bilesikler. - Google Patents
Bir trombopoietin reseptörüne baglanan peptitler ve bilesikler.Info
- Publication number
- TR199701526T1 TR199701526T1 TR97/01526T TR9701526T TR199701526T1 TR 199701526 T1 TR199701526 T1 TR 199701526T1 TR 97/01526 T TR97/01526 T TR 97/01526T TR 9701526 T TR9701526 T TR 9701526T TR 199701526 T1 TR199701526 T1 TR 199701526T1
- Authority
- TR
- Turkey
- Prior art keywords
- peptides
- bind
- thrombopoietin receptor
- compounds
- peptide mimetics
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Trombopoietin reseptörüne baglanan ve onu etkinlestiren peptitler ve peptit mimetikleri. Bu peptitler ve peptit mimetikleri hematolojik bozukluklari ve özellikle kemoterapi, radyasyon tedavisi veya kemik iligi transfüzyonlarindan kaynaklanan trombositopeniyi tedavi etmeye yönelik yöntemlerde, ayrica isaretlenmis peptitlerin ve peptit mimetiklerinin kullanildigi tani yöntemlerinde yararlidir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48530195A | 1995-06-07 | 1995-06-07 | |
US47812895A | 1995-06-07 | 1995-06-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR199701526T1 true TR199701526T1 (tr) | 1998-03-21 |
Family
ID=27045796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR97/01526T TR199701526T1 (tr) | 1995-06-07 | 1996-06-07 | Bir trombopoietin reseptörüne baglanan peptitler ve bilesikler. |
Country Status (27)
Country | Link |
---|---|
US (2) | US6083913A (tr) |
EP (4) | EP1961760A3 (tr) |
JP (1) | JP3059218B2 (tr) |
KR (1) | KR100436680B1 (tr) |
CN (2) | CN1315870C (tr) |
AR (1) | AR003431A1 (tr) |
AT (1) | ATE390439T1 (tr) |
BR (1) | BR9608587A (tr) |
CA (2) | CA2636432C (tr) |
CZ (1) | CZ291749B6 (tr) |
DE (1) | DE69637473T2 (tr) |
DK (1) | DK0885242T3 (tr) |
EA (1) | EA001220B1 (tr) |
ES (1) | ES2303338T3 (tr) |
HK (1) | HK1015380A1 (tr) |
HU (1) | HU227678B1 (tr) |
IL (1) | IL122102A (tr) |
MX (1) | MX9709315A (tr) |
NO (2) | NO317737B1 (tr) |
NZ (1) | NZ310778A (tr) |
PE (1) | PE7898A1 (tr) |
PL (1) | PL188795B1 (tr) |
PT (1) | PT885242E (tr) |
TR (1) | TR199701526T1 (tr) |
TW (1) | TW518341B (tr) |
WO (1) | WO1996040750A1 (tr) |
ZA (1) | ZA964814B (tr) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
US6251864B1 (en) | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
EP1961760A3 (en) * | 1995-06-07 | 2008-09-03 | Glaxo Group Limited | Peptides and compounds that bind to a thrombopoietin receptor |
US6172210B1 (en) * | 1996-04-02 | 2001-01-09 | Blood Center Research Foundation | DNA encoding phospholipid scramblase |
US7091311B2 (en) * | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
US6930084B1 (en) | 1996-11-06 | 2005-08-16 | The Regents Of The University Of California | Treating arthritis with TNF receptor releasing enzyme |
US6593456B1 (en) * | 1996-11-06 | 2003-07-15 | The Regents Of The University Of California | Tumor necrosis factor receptor releasing enzyme |
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
JP2002511569A (ja) * | 1998-04-14 | 2002-04-16 | スミスクライン・ビーチャム・コーポレイション | 受容体リガンド |
MEP42108A (en) * | 1998-10-23 | 2011-02-10 | Kiren Amgen Inc | Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
PT1141014E (pt) | 1999-01-06 | 2005-04-29 | Genentech Inc | Variante mutante do factor de crescimento semelhante a insulina (igf-i) |
US6911314B2 (en) | 1999-05-14 | 2005-06-28 | The Regents Of The University Of California | Screening for drugs that affect TNF receptor releasing enzyme |
EP1216037A2 (en) | 1999-09-21 | 2002-06-26 | Emory University | Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents |
TWI284639B (en) | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
EP1282437B1 (en) | 2000-05-16 | 2008-03-19 | Genentech, Inc. | Treatment of cartilage disorders |
CY2010012I2 (el) | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
AU2001260661A1 (en) * | 2000-05-30 | 2001-12-11 | Chugai Seiyaku Kabushiki Kaisha | Compounds exhibiting thrombopoietin-like activities |
EP1642910B1 (en) * | 2000-12-05 | 2012-02-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
US7396917B2 (en) * | 2000-12-05 | 2008-07-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
US6958213B2 (en) | 2000-12-12 | 2005-10-25 | Alligator Bioscience Ab | Method for in vitro molecular evolution of protein function |
JP4145654B2 (ja) | 2001-01-26 | 2008-09-03 | 塩野義製薬株式会社 | トロンボポエチン受容体アゴニスト作用を有する環状化合物 |
AU2002307062A1 (en) * | 2001-04-02 | 2002-10-15 | Purdue Pharma L.P. | Thrombopoietin (tpo) synthebody for stimulation of platelet production |
US7332474B2 (en) | 2001-10-11 | 2008-02-19 | Amgen Inc. | Peptides and related compounds having thrombopoietic activity |
US20030093229A1 (en) * | 2001-11-06 | 2003-05-15 | Wang Ho Chris Meichung | System and method for improved computer drug design |
CA2472711C (en) * | 2002-01-18 | 2012-03-20 | Yamanouchi Pharmaceutical Co., Ltd. | 2-acylaminothiazole derivative or salt thereof |
US20040009944A1 (en) * | 2002-05-10 | 2004-01-15 | Inex Pharmaceuticals Corporation | Methylated immunostimulatory oligonucleotides and methods of using the same |
AR040083A1 (es) | 2002-05-22 | 2005-03-16 | Smithkline Beecham Corp | Compuesto bis-(monoetanolamina) del acido 3'-[(2z)-[1-(3,4-dimetilfenil) -1,5-dihidro-3-metil-5-oxo-4h-pirazol-4-iliden] hidrazino] -2'-hidroxi-[1,1'-bifenil]-3-carboxilico, procedimiento para prepararlo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion farmac |
US20040028661A1 (en) * | 2002-08-07 | 2004-02-12 | Bartelmez Stephen H. | Expansion of cells using thrombopoietin and anti-transforming growth factor-beta |
US7851503B2 (en) | 2002-08-14 | 2010-12-14 | Nissan Chemical Industries, Ltd. | Thrombopoetin receptor activator and process for producing the same |
PT1542714E (pt) | 2002-09-18 | 2014-06-23 | Janssen Pharmaceuticals Inc | Métodos para aumentar a produção de células estaminais plaquetárias e hematopoiéticas |
FI20021762A0 (fi) * | 2002-10-03 | 2002-10-03 | Karyon Oy Ab Ltd | Uusia terapeuttisia aineita ja valmisteita |
TWI324593B (en) | 2002-10-09 | 2010-05-11 | Nissan Chemical Ind Ltd | Pyrazolone compounds and thrombopoietin receptor activator |
US7736909B2 (en) * | 2003-01-09 | 2010-06-15 | Board Of Regents, The University Of Texas System | Methods and compositions comprising capture agents |
DE602004028725D1 (de) | 2003-05-12 | 2010-09-30 | Affymax Inc | Neue poly(ethylenglycol) modifizierte erythropoietinagonisten und deren verwendungen |
MXPA05012313A (es) * | 2003-05-12 | 2006-04-18 | Affymax Inc | Peptidos que se unen al receptor de eritropoyetina. |
KR101163683B1 (ko) | 2003-05-12 | 2012-07-10 | 아피맥스, 인크. | 에리스로포이에틴 수용체에 결합하는 신규의 펩티드 |
US7919118B2 (en) | 2003-05-12 | 2011-04-05 | Affymax, Inc. | Spacer moiety for poly (ethylene glycol) modified peptide based compounds |
WO2004108078A2 (en) * | 2003-06-02 | 2004-12-16 | Alexion Pharmaceuticals Inc. | Rationally designed antibodies |
EP1655291B1 (en) | 2003-08-12 | 2016-08-03 | Shionogi & Co., Ltd. | Compounds having thrombopoietin receptor agonism |
PL1675606T3 (pl) * | 2003-08-28 | 2017-08-31 | Janssen Pharmaceuticals, Inc. | Peptydy i związki, które wiążą się z receptorami trombopoetyny |
US7723295B2 (en) | 2003-08-28 | 2010-05-25 | Ortho-Mcneil Pharmaceutical, Inc. | Peptides and compounds that bind to a receptor |
TW200526638A (en) | 2003-10-22 | 2005-08-16 | Smithkline Beecham Corp | 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline |
US20060210542A1 (en) * | 2004-08-16 | 2006-09-21 | Yurkow Edward J | Use of TPO mimetic compounds and pharmaceutical compositions in the treatment of anemia |
CN100432102C (zh) * | 2004-09-30 | 2008-11-12 | 百瑞全球有限公司 | 血小板增进蛋白及其应用 |
WO2006060148A2 (en) * | 2004-11-11 | 2006-06-08 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
WO2006062685A2 (en) * | 2004-11-11 | 2006-06-15 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
EP1819692A1 (en) | 2004-12-08 | 2007-08-22 | Nissan Chemical Industries, Ltd. | 3-ethylidenehydrazino substituted heterocyclic compounds as thrombopoietin receptor activators |
EP1845090A4 (en) | 2004-12-14 | 2009-11-11 | Nissan Chemical Ind Ltd | AMIDE COMPOUND AND THROMBOPOIETINE RECEPTOR ACTIVATOR |
WO2006094813A2 (en) | 2005-03-10 | 2006-09-14 | Nascacell Technologies Ag. | Dimeric or multimeric microproteins |
US8324159B2 (en) * | 2005-06-03 | 2012-12-04 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US7550433B2 (en) * | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US7919461B2 (en) | 2005-06-03 | 2011-04-05 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
EA200800109A1 (ru) * | 2005-06-23 | 2008-06-30 | Аплаген Гмбх | Суправалентные соединения |
AU2006270801B2 (en) | 2005-07-15 | 2011-12-22 | Nissan Chemical Industries, Ltd. | Thiophene compounds and thrombopoietin receptor activators |
WO2007011056A1 (en) | 2005-07-20 | 2007-01-25 | Nissan Chemical Industries, Ltd. | Pyrazole compounds and thrombopoietin receptor activators |
JP5205967B2 (ja) | 2005-11-07 | 2013-06-05 | 日産化学工業株式会社 | ヒドラジド化合物及びトロンボポエチンレセプター活性化剤 |
KR20080074166A (ko) * | 2005-11-08 | 2008-08-12 | 아스테라스 세이야쿠 가부시키가이샤 | 혈소판감소증을 치료하는 조성물 및 방법 |
US7879318B2 (en) | 2006-01-23 | 2011-02-01 | Mcw Research Foundation, Inc. | Method of reducing the effects of ischemia by administration of a thrombopoietin receptor ligand |
WO2007142308A1 (ja) | 2006-06-07 | 2007-12-13 | Nissan Chemical Industries, Ltd. | 含窒素ヘテロ環化合物及びトロンボポエチンレセプター活性化剤 |
EP2452674B1 (en) * | 2006-08-08 | 2014-03-26 | Akarx, Inc. | Compositions and methods for increasing blood platelet levels in humans |
JP2010520855A (ja) | 2007-01-31 | 2010-06-17 | アフィーマックス・インコーポレイテッド | 修飾基をポリペプチドおよびその他の高分子に結合するための窒素ベースのリンカー |
ECSP077628A (es) | 2007-05-03 | 2008-12-30 | Smithkline Beechman Corp | Nueva composición farmacéutica |
WO2008157824A2 (en) * | 2007-06-21 | 2008-12-24 | Conjuchem Biotechnologies Inc. | Thrombopoietin peptide conjugates |
KR20100027243A (ko) | 2007-07-31 | 2010-03-10 | 시오노기세이야쿠가부시키가이샤 | 트롬보포이에틴 수용체 아고니스트 작용을 갖는 광학 활성인 화합물을 함유하는 의약 조성물 및 그 중간체 |
WO2009029682A1 (en) * | 2007-08-28 | 2009-03-05 | Rigel Pharmaceuticals, Inc. | Combination therapy with syk kinase inhibitor |
US8278057B2 (en) * | 2007-09-14 | 2012-10-02 | Nestec S.A. | Addressable antibody arrays and methods of use |
US8637455B2 (en) * | 2007-10-22 | 2014-01-28 | Affinergy, Llc | Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces |
CN101481352A (zh) | 2008-01-10 | 2009-07-15 | 上海恒瑞医药有限公司 | 双环取代吡唑酮偶氮类衍生物、其制备方法及其在医药上的应用 |
NZ603712A (en) | 2009-02-24 | 2014-05-30 | Alexion Pharma Inc | Antibodies containing therapeutic tpo/epo mimetic peptides |
EP3127427B1 (en) | 2009-05-29 | 2020-01-08 | Novartis Ag | Methods of administration of thrombopoietin agonist compounds |
JP5991916B2 (ja) * | 2009-05-29 | 2016-09-14 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | 自己免疫性t細胞の単離および処理のためのペプトイドリガンド |
AU2010256880B2 (en) * | 2009-06-02 | 2015-01-22 | Opko Health, Inc. | Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases |
TW201124726A (en) * | 2009-10-16 | 2011-07-16 | Univ Texas | Compositions and methods for producing coded peptoid libraries |
EP2492262B1 (en) | 2009-10-23 | 2016-04-20 | Nissan Chemical Industries, Ltd. | Fused heterocyclic compound and thrombopoietin receptor activator |
WO2011098095A1 (en) | 2010-02-09 | 2011-08-18 | Aplagen Gmbh | Peptides binding the tpo receptor |
CN104045715B (zh) * | 2013-03-15 | 2018-05-01 | 兰州大学 | 二聚体化融合蛋白的制备及应用 |
MX2017003201A (es) * | 2014-09-11 | 2017-05-23 | Bristol Myers Squibb Co | Inhibidores macrociclicos de las interacciones proteina/proteina de muerte programada 1 (pd-1)/pd-l1 y cd80(b7-1)/pd-l1. |
EP3658191A1 (en) * | 2017-07-26 | 2020-06-03 | Janssen Pharmaceutica NV | Methods of protecting vascular integrity induced by targeted radiation therapy |
CN114787198A (zh) | 2019-12-06 | 2022-07-22 | 味之素株式会社 | 具有生理活性的肽的制造方法以及包含短链接头的肽 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2046920B1 (tr) | 1969-06-19 | 1974-05-03 | Citizen Watch Co Ltd | |
US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
NO812612L (no) | 1980-08-06 | 1982-02-08 | Ferring Pharma Ltd | Enzym-inhibitorer. |
US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
US4612132A (en) | 1984-07-20 | 1986-09-16 | Chevron Research Company | Modified succinimides |
EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5326558A (en) | 1989-08-08 | 1994-07-05 | Genetics Institute, Inc. | Megakaryocytopoietic factor |
IL96477A0 (en) | 1989-12-01 | 1991-08-16 | Amgen Inc | Megakaryocyte production |
DK167813B1 (da) * | 1989-12-07 | 1993-12-20 | Carlbiotech Ltd As | Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat |
US5571508A (en) | 1989-12-18 | 1996-11-05 | Amrad Corporation Limited | Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor |
US5141851A (en) * | 1990-04-18 | 1992-08-25 | Board Of Regents, The University Of Texas System | Isolated farnesyl protein transferase enzyme |
US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
US5250732A (en) | 1991-07-18 | 1993-10-05 | Genentech, Inc. | Ketamine analogues for treatment of thrombocytopenia |
US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
CA2118806A1 (en) | 1991-09-18 | 1993-04-01 | William J. Dower | Method of synthesizing diverse collections of oligomers |
US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
US5359115A (en) | 1992-03-26 | 1994-10-25 | Affymax Technologies, N.V. | Methods for the synthesis of phosphonate esters |
ATE222500T1 (de) | 1992-06-11 | 2002-09-15 | Alkermes Inc | Enythropoietin enthaltendes arzneimittelabgabesystem |
US5420328A (en) | 1992-09-11 | 1995-05-30 | Affymax Technologies, N.V. | Methods for the synthesis of phosphonate esters |
EP0673387B1 (en) * | 1992-12-11 | 1999-09-22 | University Of Florida | Materials and methods for control of pests |
US5354934A (en) | 1993-02-04 | 1994-10-11 | Amgen Inc. | Pulmonary administration of erythropoietin |
AU685506B2 (en) | 1993-08-25 | 1998-01-22 | Systemix, Inc. | Method for producing a highly enriched population of hematopoietic stem cells |
WO1995011992A1 (en) | 1993-10-27 | 1995-05-04 | The Regents Of The University Of California | Antiviral compounds |
AU8124694A (en) | 1993-10-29 | 1995-05-22 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
GB2285446B (en) | 1994-01-03 | 1999-07-28 | Genentech Inc | Thrombopoietin |
WO1995021919A2 (en) * | 1994-02-14 | 1995-08-17 | Kirin Brewery Company, Limited | Protein having tpo activity |
SG79882A1 (en) | 1994-02-14 | 2001-04-17 | Kirin Brewery | Protein having tpo activity |
AU1843595A (en) | 1994-02-14 | 1995-08-29 | University Of Washington | Methods for stimulating erythropoiesis using thrombopoietin |
CA2183266A1 (en) | 1994-02-14 | 1995-08-17 | Richard D. Holly | Hematopoietic protein and materials and methods for making it |
RO115788B1 (ro) | 1994-03-31 | 2000-06-30 | Amgen Inc. | Polipeptidă mgdf, derivat de polipeptidă mgdf, polipeptidă mgdf mono-pegilată şi procedee de obţinere a acestora |
US5571686A (en) | 1994-04-14 | 1996-11-05 | Massachusetts Institute Of Technology | Method of using megapoietin for prolonging the survival & viability of platlets |
AU4163196A (en) * | 1994-11-30 | 1996-06-19 | Zymogenetics Inc. | Low molecular weight thrombopoietin |
US5641655A (en) | 1994-11-30 | 1997-06-24 | Zymogenetics, Inc. | Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide |
US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
EP1961760A3 (en) * | 1995-06-07 | 2008-09-03 | Glaxo Group Limited | Peptides and compounds that bind to a thrombopoietin receptor |
US5932546A (en) * | 1996-10-04 | 1999-08-03 | Glaxo Wellcome Inc. | Peptides and compounds that bind to the thrombopoietin receptor |
US8157793B2 (en) | 2006-10-25 | 2012-04-17 | Terumo Kabushiki Kaisha | Manipulator for medical use |
JP2023049441A (ja) | 2021-09-29 | 2023-04-10 | トヨタ紡織株式会社 | 乗物用シート |
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1996
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