HUP9900921A2 - Trombopoietin-receptorhoz kötődő peptidek és vegyületek - Google Patents

Trombopoietin-receptorhoz kötődő peptidek és vegyületek

Info

Publication number
HUP9900921A2
HUP9900921A2 HU9900921A HUP9900921A HUP9900921A2 HU P9900921 A2 HUP9900921 A2 HU P9900921A2 HU 9900921 A HU9900921 A HU 9900921A HU P9900921 A HUP9900921 A HU P9900921A HU P9900921 A2 HUP9900921 A2 HU P9900921A2
Authority
HU
Hungary
Prior art keywords
thrombopoietin receptor
peptides
bind
compounds
approximately
Prior art date
Application number
HU9900921A
Other languages
English (en)
Inventor
Ronald W. Barret
Steven E. Cwirla
William J. Dower
David J. Duffin
Christian M. Gates
Sherril S. Johnson
Larry C. Mattheakis
Peter J. Schatz
Christopher R. Wagstrom
Nicholas C. Wrighton
Original Assignee
Glaxo Group Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd. filed Critical Glaxo Group Ltd.
Publication of HUP9900921A2 publication Critical patent/HUP9900921A2/hu
Publication of HUP9900921A3 publication Critical patent/HUP9900921A3/hu
Publication of HU227678B1 publication Critical patent/HU227678B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A találmány szerinti peptidek és peptidmimetikűmők - amelyek 1)móltömege kisebb, mint körülbelül 8000 daltőn és 2) trőmbőpőietin-receptőrhőz való kötődési aktivitásűk IC50 értéke nem nagyőbb, mintkörülbelül 100 mmől/l - trőmbőpőietin-receptőrhőz kötődve aztaktiválják. Fenti tűlajdőnságűk következtében hematőlógiairendellenességek, különösen kemőterápia, sűgárterápia és csőntvelő-transzfúzió eredetű trőmbőcitőpénia kezelésére, valamint jelzetfőrmában diagnősztikai eljárásőkban alkalmazhatók. ŕ
HU9900921A 1995-06-07 1996-06-07 Peptides and compounds that bind to a thrombopoietin receptor HU227678B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47812895A 1995-06-07 1995-06-07
US48530195A 1995-06-07 1995-06-07
PCT/US1996/009623 WO1996040750A1 (en) 1995-06-07 1996-06-07 Peptides and compounds that bind to a thrombopoietin receptor

Publications (3)

Publication Number Publication Date
HUP9900921A2 true HUP9900921A2 (hu) 1999-07-28
HUP9900921A3 HUP9900921A3 (en) 1999-11-29
HU227678B1 HU227678B1 (en) 2011-11-28

Family

ID=27045796

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900921A HU227678B1 (en) 1995-06-07 1996-06-07 Peptides and compounds that bind to a thrombopoietin receptor

Country Status (27)

Country Link
US (2) US6083913A (hu)
EP (4) EP2338897A1 (hu)
JP (1) JP3059218B2 (hu)
KR (1) KR100436680B1 (hu)
CN (2) CN1966520B (hu)
AR (1) AR003431A1 (hu)
AT (1) ATE390439T1 (hu)
BR (1) BR9608587A (hu)
CA (2) CA2223449C (hu)
CZ (1) CZ291749B6 (hu)
DE (1) DE69637473T2 (hu)
DK (1) DK0885242T3 (hu)
EA (1) EA001220B1 (hu)
ES (1) ES2303338T3 (hu)
HK (1) HK1015380A1 (hu)
HU (1) HU227678B1 (hu)
IL (1) IL122102A (hu)
MX (1) MX9709315A (hu)
NO (2) NO317737B1 (hu)
NZ (1) NZ310778A (hu)
PE (1) PE7898A1 (hu)
PL (1) PL188795B1 (hu)
PT (1) PT885242E (hu)
TR (1) TR199701526T1 (hu)
TW (1) TW518341B (hu)
WO (1) WO1996040750A1 (hu)
ZA (1) ZA964814B (hu)

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US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
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US5932546A (en) * 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
US8157793B2 (en) 2006-10-25 2012-04-17 Terumo Kabushiki Kaisha Manipulator for medical use
JP2023049441A (ja) 2021-09-29 2023-04-10 トヨタ紡織株式会社 乗物用シート

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CA2636432A1 (en) 1996-12-19
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AR003431A1 (es) 1998-08-05
CA2636432C (en) 2012-01-03
NO20041296L (no) 1998-02-05
KR100436680B1 (ko) 2004-09-18
NO975705D0 (no) 1997-12-05
TW518341B (en) 2003-01-21
EP0885242A4 (en) 2000-03-22
DK0885242T3 (da) 2008-07-14
PL323917A1 (en) 1998-04-27
CN1192749A (zh) 1998-09-09
CA2223449C (en) 2008-10-07
DE69637473T2 (de) 2009-05-07
MX9709315A (es) 1998-08-30
NO317737B1 (no) 2004-12-13
ZA964814B (en) 1998-02-09
CA2223449A1 (en) 1996-12-19
EA199700359A1 (ru) 1998-10-29
NO331550B1 (no) 2012-01-23
TR199701526T1 (xx) 1998-03-21
CN1966520B (zh) 2012-07-11
EA001220B1 (ru) 2000-12-25
AU6163496A (en) 1996-12-30
ES2303338T3 (es) 2008-08-01
US6083913A (en) 2000-07-04
US6465430B1 (en) 2002-10-15
DE69637473D1 (de) 2008-05-08
HU227678B1 (en) 2011-11-28
PL188795B1 (pl) 2005-04-29
IL122102A0 (en) 1998-04-05
CZ389797A3 (cs) 1998-06-17
EP0885242A1 (en) 1998-12-23
KR19990022576A (ko) 1999-03-25
AU704215B2 (en) 1999-04-15
JP3059218B2 (ja) 2000-07-04
CN1966520A (zh) 2007-05-23
PT885242E (pt) 2008-06-18
NO975705L (no) 1998-02-05
IL122102A (en) 2002-07-25
PE7898A1 (es) 1998-03-05
EP0885242B1 (en) 2008-03-26
EP2055712A1 (en) 2009-05-06
HUP9900921A3 (en) 1999-11-29
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BR9608587A (pt) 1999-01-05
EP1961760A2 (en) 2008-08-27
JPH10507776A (ja) 1998-07-28
HK1015380A1 (en) 1999-10-15
EP2338897A1 (en) 2011-06-29
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CN1315870C (zh) 2007-05-16
ATE390439T1 (de) 2008-04-15

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