HK1015380A1 - Peptides and compounds that bind to a thrombopoietin receptor - Google Patents

Peptides and compounds that bind to a thrombopoietin receptor

Info

Publication number
HK1015380A1
HK1015380A1 HK99100309A HK99100309A HK1015380A1 HK 1015380 A1 HK1015380 A1 HK 1015380A1 HK 99100309 A HK99100309 A HK 99100309A HK 99100309 A HK99100309 A HK 99100309A HK 1015380 A1 HK1015380 A1 HK 1015380A1
Authority
HK
Hong Kong
Prior art keywords
peptides
bind
compounds
thrombopoietin receptor
thrombopoietin
Prior art date
Application number
HK99100309A
Other languages
English (en)
Inventor
William J Dower
Ronald W Barret
Steven E Cwirla
David J Duffin
Christian M Gates
Sherril S Heselden
Larry C Mattheakis
Peter J Schatz
Christopher R Wagstrom
Nicholas C Wrighton
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of HK1015380A1 publication Critical patent/HK1015380A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
HK99100309A 1995-06-07 1999-01-22 Peptides and compounds that bind to a thrombopoietin receptor HK1015380A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48530195A 1995-06-07 1995-06-07
US47812895A 1995-06-07 1995-06-07
PCT/US1996/009623 WO1996040750A1 (en) 1995-06-07 1996-06-07 Peptides and compounds that bind to a thrombopoietin receptor

Publications (1)

Publication Number Publication Date
HK1015380A1 true HK1015380A1 (en) 1999-10-15

Family

ID=27045796

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99100309A HK1015380A1 (en) 1995-06-07 1999-01-22 Peptides and compounds that bind to a thrombopoietin receptor

Country Status (27)

Country Link
US (2) US6083913A (xx)
EP (4) EP0885242B1 (xx)
JP (1) JP3059218B2 (xx)
KR (1) KR100436680B1 (xx)
CN (2) CN1315870C (xx)
AR (1) AR003431A1 (xx)
AT (1) ATE390439T1 (xx)
BR (1) BR9608587A (xx)
CA (2) CA2223449C (xx)
CZ (1) CZ291749B6 (xx)
DE (1) DE69637473T2 (xx)
DK (1) DK0885242T3 (xx)
EA (1) EA001220B1 (xx)
ES (1) ES2303338T3 (xx)
HK (1) HK1015380A1 (xx)
HU (1) HU227678B1 (xx)
IL (1) IL122102A (xx)
MX (1) MX9709315A (xx)
NO (2) NO317737B1 (xx)
NZ (1) NZ310778A (xx)
PE (1) PE7898A1 (xx)
PL (1) PL188795B1 (xx)
PT (1) PT885242E (xx)
TR (1) TR199701526T1 (xx)
TW (1) TW518341B (xx)
WO (1) WO1996040750A1 (xx)
ZA (1) ZA964814B (xx)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
DK0885242T3 (da) * 1995-06-07 2008-07-14 Glaxo Group Ltd Peptider og forbindelser, der binder til en trombopoietinreceptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6172210B1 (en) * 1996-04-02 2001-01-09 Blood Center Research Foundation DNA encoding phospholipid scramblase
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
US6593456B1 (en) * 1996-11-06 2003-07-15 The Regents Of The University Of California Tumor necrosis factor receptor releasing enzyme
US6930084B1 (en) 1996-11-06 2005-08-16 The Regents Of The University Of California Treating arthritis with TNF receptor releasing enzyme
US6121416A (en) 1997-04-04 2000-09-19 Genentech, Inc. Insulin-like growth factor agonist molecules
US6420518B1 (en) 1997-04-04 2002-07-16 Genetech, Inc. Insulin-like growth factor agonist molecules
WO1999052877A1 (en) * 1998-04-14 1999-10-21 Smithkline Beecham Corporation Receptor ligands
CN1810832B (zh) * 1998-10-23 2012-12-12 麒麟-安姆根有限公司 与MPl受体结合并具有血小板生成活性的模拟二聚体血小板生成素肽
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
EP1141014B1 (en) 1999-01-06 2004-12-08 Genentech, Inc. Insulin-like growth factor (igf) i mutant variant
US6911314B2 (en) 1999-05-14 2005-06-28 The Regents Of The University Of California Screening for drugs that affect TNF receptor releasing enzyme
EP1216037A2 (en) 1999-09-21 2002-06-26 Emory University Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents
TWI284639B (en) 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
EP1282437B1 (en) 2000-05-16 2008-03-19 Genentech, Inc. Treatment of cartilage disorders
CY2010012I2 (el) 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
WO2001092211A1 (fr) * 2000-05-30 2001-12-06 Chugai Seiyaku Kabushiki Kaisha Composes possedant des activites analogues a celles de la thrombopoietine
ATE544785T1 (de) 2000-12-05 2012-02-15 Alexion Pharma Inc Rationell entworfene antikörper
US7396917B2 (en) 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
US6958213B2 (en) 2000-12-12 2005-10-25 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function
EP1361220A4 (en) 2001-01-26 2005-09-07 Shionogi & Co CYCLIC COMPOUNDS WITH THROMBOPOIETIN RECEPTAGONISM
WO2002078612A2 (en) * 2001-04-02 2002-10-10 Euro-Celtique S.A. Thrombopoietin (tpo) synthebody for stimulation of platelet production
US7332474B2 (en) * 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
US20030093229A1 (en) * 2001-11-06 2003-05-15 Wang Ho Chris Meichung System and method for improved computer drug design
ES2416304T3 (es) * 2002-01-18 2013-07-31 Astellas Pharma Inc. Derivado de 2-acilaminotiazol o sal del mismo
US20040009944A1 (en) * 2002-05-10 2004-01-15 Inex Pharmaceuticals Corporation Methylated immunostimulatory oligonucleotides and methods of using the same
TWI280128B (en) 2002-05-22 2007-05-01 Smithkline Beecham Corp 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)
US20040028661A1 (en) * 2002-08-07 2004-02-12 Bartelmez Stephen H. Expansion of cells using thrombopoietin and anti-transforming growth factor-beta
US7851503B2 (en) 2002-08-14 2010-12-14 Nissan Chemical Industries, Ltd. Thrombopoetin receptor activator and process for producing the same
CA2499625A1 (en) 2002-09-18 2004-04-01 Ortho-Mcneil Pharmaceutical, Inc. Methods of increasing platelet and hematopoietic stem cell production
FI20021762A0 (fi) * 2002-10-03 2002-10-03 Karyon Oy Ab Ltd Uusia terapeuttisia aineita ja valmisteita
TWI324593B (en) 2002-10-09 2010-05-11 Nissan Chemical Ind Ltd Pyrazolone compounds and thrombopoietin receptor activator
US7736909B2 (en) * 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
MXPA05012313A (es) * 2003-05-12 2006-04-18 Affymax Inc Peptidos que se unen al receptor de eritropoyetina.
EP1628686A2 (en) 2003-05-12 2006-03-01 Affymax, Inc. Spacer moiety for poly (ethylene glycol)-modified peptides
ATE428727T1 (de) 2003-05-12 2009-05-15 Affymax Inc Neue, an den erythropoietinrezeptor bindende peptide
BRPI0411160A (pt) * 2003-05-12 2006-07-11 Affymax Inc novos compostos modificados com poli(glicol etilênico) e usos dos mesmos
WO2004108078A2 (en) * 2003-06-02 2004-12-16 Alexion Pharmaceuticals Inc. Rationally designed antibodies
WO2005014561A1 (ja) 2003-08-12 2005-02-17 Shionogi & Co., Ltd. トロンボポエチン受容体アゴニスト作用を有する化合物
US7723295B2 (en) * 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
MXPA06002292A (es) * 2003-08-28 2006-09-04 Johnson & Johnson Peptidos y compuestos que se unen a un receptor.
TW200526638A (en) 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
US20060210542A1 (en) * 2004-08-16 2006-09-21 Yurkow Edward J Use of TPO mimetic compounds and pharmaceutical compositions in the treatment of anemia
CN100432102C (zh) * 2004-09-30 2008-11-12 百瑞全球有限公司 血小板增进蛋白及其应用
JP2008519858A (ja) * 2004-11-11 2008-06-12 アフィーマックス・インコーポレイテッド エリスロポエチンレセプターに結合する新規ペプチド
WO2006062685A2 (en) * 2004-11-11 2006-06-15 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
RU2395505C2 (ru) 2004-12-08 2010-07-27 Ниссан Кемикал Индастриз, ЛТД 3-этилиденгидразино-замещенные гетероциклические соединения в качестве активаторов рецептора тромбопоэтина
CA2590204C (en) 2004-12-14 2012-12-04 Nissan Chemical Industries, Ltd. Amide compounds and thrombopoietin receptor activators
US8258258B2 (en) 2005-03-10 2012-09-04 Biontech Ag Dimeric or multimeric microproteins
US8324159B2 (en) * 2005-06-03 2012-12-04 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US7550433B2 (en) * 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US7919461B2 (en) 2005-06-03 2011-04-05 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
WO2006136450A2 (en) * 2005-06-23 2006-12-28 Aplagen Gmbh Supravalent compounds
AU2006270801B2 (en) 2005-07-15 2011-12-22 Nissan Chemical Industries, Ltd. Thiophene compounds and thrombopoietin receptor activators
US7960425B2 (en) 2005-07-20 2011-06-14 Nissan Chemical Industries, Ltd. Pyrazole compounds and thrombopoietin receptor activators
EP1947101A4 (en) 2005-11-07 2009-09-16 Nissan Chemical Ind Ltd HYDRAZIDE COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR
AU2006313491B2 (en) * 2005-11-08 2011-01-06 Astellas Pharma Inc. Compositions and methods for treating thrombocytopenia
US7879318B2 (en) * 2006-01-23 2011-02-01 Mcw Research Foundation, Inc. Method of reducing the effects of ischemia by administration of a thrombopoietin receptor ligand
EP2025671A4 (en) 2006-06-07 2011-04-06 Nissan Chemical Ind Ltd NITROGENIC HETEROCYCLIC COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR
CA2660283C (en) * 2006-08-08 2014-11-18 Akarx, Inc. 2-acylaminothiazole compositions and methods for increasing blood platlelet levels in humans
EP2118127A4 (en) * 2007-01-31 2010-12-01 Affymax Inc NICKET-BASED LINKER FOR BONDING MODIFYING GROUPS OF POLYPEPTIDES AND OTHER MACROMOLECULES
ECSP077628A (es) 2007-05-03 2008-12-30 Smithkline Beechman Corp Nueva composición farmacéutica
US20090054332A1 (en) * 2007-06-21 2009-02-26 Conjuchem Biotechnologies, Inc. Thombopoietin peptide conjugates
AU2008283357B2 (en) 2007-07-31 2011-08-11 Shionogi & Co., Ltd. Pharmaceutical composition containing optically active compound having thrombopoietin receptor agonist activity and intermediate thereof
WO2009029682A1 (en) * 2007-08-28 2009-03-05 Rigel Pharmaceuticals, Inc. Combination therapy with syk kinase inhibitor
US8278057B2 (en) * 2007-09-14 2012-10-02 Nestec S.A. Addressable antibody arrays and methods of use
US8637455B2 (en) * 2007-10-22 2014-01-28 Affinergy, Llc Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces
CN101481352A (zh) 2008-01-10 2009-07-15 上海恒瑞医药有限公司 双环取代吡唑酮偶氮类衍生物、其制备方法及其在医药上的应用
MX2011008936A (es) 2009-02-24 2011-09-21 Alexion Pharma Inc Anticuerpos que contienen peptidos terapeuticos mimeticos de tpo/epo.
ES2605593T3 (es) 2009-05-29 2017-03-15 Novartis Ag Métodos de administración de compuestos agonistas de trombopoyetina
CN102449481B (zh) * 2009-05-29 2016-05-25 德克萨斯大学系统董事会 用于分离和处理自身免疫性t细胞的类肽配体
AU2010256880B2 (en) * 2009-06-02 2015-01-22 Opko Health, Inc. Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases
WO2011047257A1 (en) * 2009-10-16 2011-04-21 The Board Of Regents Of The University Of Texas System Compositions and methods for producing cyclic peptoid libraries
EP2492262B1 (en) 2009-10-23 2016-04-20 Nissan Chemical Industries, Ltd. Fused heterocyclic compound and thrombopoietin receptor activator
WO2011098095A1 (en) 2010-02-09 2011-08-18 Aplagen Gmbh Peptides binding the tpo receptor
CN104045715B (zh) * 2013-03-15 2018-05-01 兰州大学 二聚体化融合蛋白的制备及应用
TN2017000084A1 (en) * 2014-09-11 2018-07-04 Bristol Myers Squibb Co Macrocyclic inhibitors of the pd-1/pd-l1 and cd80 (b7-1)/pd-li protein/protein interactions
BR112020001367A2 (pt) * 2017-07-26 2020-08-11 Janssen Pharmaceutica N.V. métodos de proteção da integridade vascular induzida por terapia de radiação direcionada
JPWO2021112249A1 (xx) 2019-12-06 2021-06-10

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1319315A (en) 1969-06-19 1973-06-06 Citizen Watch Co Ltd Calendar timepiece
US3940475A (en) 1970-06-11 1976-02-24 Biological Developments, Inc. Radioimmune method of assaying quantitatively for a hapten
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
NO812612L (no) 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4612132A (en) 1984-07-20 1986-09-16 Chevron Research Company Modified succinimides
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5326558A (en) 1989-08-08 1994-07-05 Genetics Institute, Inc. Megakaryocytopoietic factor
IL96477A0 (en) 1989-12-01 1991-08-16 Amgen Inc Megakaryocyte production
DK167813B1 (da) * 1989-12-07 1993-12-20 Carlbiotech Ltd As Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
US5571508A (en) 1989-12-18 1996-11-05 Amrad Corporation Limited Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor
US5141851A (en) * 1990-04-18 1992-08-25 Board Of Regents, The University Of Texas System Isolated farnesyl protein transferase enzyme
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5250732A (en) 1991-07-18 1993-10-05 Genentech, Inc. Ketamine analogues for treatment of thrombocytopenia
AU669489B2 (en) 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5359115A (en) 1992-03-26 1994-10-25 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
ES2181691T5 (es) 1992-06-11 2007-10-01 Alkermes Controlled Therapeutics, Inc. Sistema de distribucion de proteina eritropoyetina.
US5420328A (en) 1992-09-11 1995-05-30 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
EP0673387B1 (en) * 1992-12-11 1999-09-22 University Of Florida Materials and methods for control of pests
US5354934A (en) 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
AU685506B2 (en) 1993-08-25 1998-01-22 Systemix, Inc. Method for producing a highly enriched population of hematopoietic stem cells
AU7843394A (en) 1993-10-27 1995-05-22 Regents Of The University Of California, The Antiviral compounds
AU8124694A (en) 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
GB2285446B (en) 1994-01-03 1999-07-28 Genentech Inc Thrombopoietin
WO1995021919A2 (en) * 1994-02-14 1995-08-17 Kirin Brewery Company, Limited Protein having tpo activity
JPH09508797A (ja) 1994-02-14 1997-09-09 ザイモジェネティクス，インコーポレイティド 造血タンパク質及びそれを製造するための材料及び方法
CA2169173C (en) 1994-02-14 2002-10-15 Kenneth Kaushansky Methods for stimulating erythropoiesis using thrombopoietin
EP0668352A1 (en) 1994-02-14 1995-08-23 Kirin Brewery Company, Ltd. Protein having TPO activity
US5766581A (en) 1994-03-31 1998-06-16 Amgen Inc. Method for treating mammals with monopegylated proteins that stimulates megakaryocyte growth and differentiation
US5571686A (en) 1994-04-14 1996-11-05 Massachusetts Institute Of Technology Method of using megapoietin for prolonging the survival & viability of platlets
WO1996017062A1 (en) * 1994-11-30 1996-06-06 Zymogenetics, Inc. Low molecular weight thrombopoietin
US5641655A (en) 1994-11-30 1997-06-24 Zymogenetics, Inc. Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide
DK0885242T3 (da) * 1995-06-07 2008-07-14 Glaxo Group Ltd Peptider og forbindelser, der binder til en trombopoietinreceptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5932546A (en) * 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
US8157793B2 (en) 2006-10-25 2012-04-17 Terumo Kabushiki Kaisha Manipulator for medical use

Also Published As

Publication number Publication date
US6083913A (en) 2000-07-04
NO317737B1 (no) 2004-12-13
CA2223449A1 (en) 1996-12-19
KR19990022576A (ko) 1999-03-25
AU6163496A (en) 1996-12-30
DK0885242T3 (da) 2008-07-14
CN1315870C (zh) 2007-05-16
KR100436680B1 (ko) 2004-09-18
EP0885242B1 (en) 2008-03-26
EP0885242A4 (en) 2000-03-22
HU227678B1 (en) 2011-11-28
CA2636432A1 (en) 1996-12-19
EP1961760A2 (en) 2008-08-27
DE69637473D1 (de) 2008-05-08
HUP9900921A2 (hu) 1999-07-28
NO975705D0 (no) 1997-12-05
ES2303338T3 (es) 2008-08-01
ZA964814B (en) 1998-02-09
AR003431A1 (es) 1998-08-05
WO1996040750A1 (en) 1996-12-19
AU704215B2 (en) 1999-04-15
DE69637473T2 (de) 2009-05-07
CN1192749A (zh) 1998-09-09
JP3059218B2 (ja) 2000-07-04
PE7898A1 (es) 1998-03-05
EP1961760A3 (en) 2008-09-03
NO20041296L (no) 1998-02-05
JPH10507776A (ja) 1998-07-28
CZ389797A3 (cs) 1998-06-17
EP2055712A1 (en) 2009-05-06
PT885242E (pt) 2008-06-18
TW518341B (en) 2003-01-21
EA199700359A1 (ru) 1998-10-29
EP0885242A1 (en) 1998-12-23
CA2636432C (en) 2012-01-03
MX9709315A (es) 1998-08-30
EA001220B1 (ru) 2000-12-25
EP2338897A1 (en) 2011-06-29
CZ291749B6 (cs) 2003-05-14
CN1966520B (zh) 2012-07-11
US6465430B1 (en) 2002-10-15
ATE390439T1 (de) 2008-04-15
NO331550B1 (no) 2012-01-23
IL122102A (en) 2002-07-25
CN1966520A (zh) 2007-05-23
BR9608587A (pt) 1999-01-05
NO975705L (no) 1998-02-05
NZ310778A (en) 1999-10-28
PL188795B1 (pl) 2005-04-29
CA2223449C (en) 2008-10-07
IL122102A0 (en) 1998-04-05
HUP9900921A3 (en) 1999-11-29
PL323917A1 (en) 1998-04-27
TR199701526T1 (xx) 1998-03-21

Similar Documents

Publication Publication Date Title
NZ310778A (en) Peptides and compounds that bind to a thrombopoietin receptor
HRP970683B1 (en) Peptides and compounds that bind to a receptor
AU6046696A (en) Peptides and compounds that bind to a receptor
ZA95788B (en) Peptides and compounds that bind to the IL-1 receptor
GB9519419D0 (en) Particulate materials
GB9712410D0 (en) Peptides and compounds that bind to the il-5 receptor
IL131045A0 (en) Peptide comprising a t-cell epitope specific to collagne ii
GB2304670B (en) A bale wrapping system
GB2300164B (en) Pedal cycles
GB9509170D0 (en) Particulate dispenser
GB2300371B (en) Particulate dispenser
GB9712383D0 (en) Peptides and compounds that bind to the IL-5 receptor
AU2003200308A1 (en) Peptides and compounds that bind to the IL-5 receptor
AU2003200384A1 (en) Peptides and compounds that bind to the IL-5 receptor
GB9503429D0 (en) Specific binding materials
GB2308391B (en) A wire compactor
KR0111007Y1 (en) A file cover
GB2301649B (en) Distributing particulate material
GB9508569D0 (en) Particulate composite material
GB9517429D0 (en) A bale wrapping system
GB2325445B (en) Pedal cycles
IL112699A0 (en) Antibodies to tbp-II
ZA963388B (en) A pharmaceutical composition
GB9511176D0 (en) Distributing particulate material
AU125582S (en) A packing clip

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20160606