PE7898A1 - Peptidos compuestos que se ligan al receptor de trombopoietina - Google Patents

Peptidos compuestos que se ligan al receptor de trombopoietina

Info

Publication number
PE7898A1
PE7898A1 PE1996000437A PE00043796A PE7898A1 PE 7898 A1 PE7898 A1 PE 7898A1 PE 1996000437 A PE1996000437 A PE 1996000437A PE 00043796 A PE00043796 A PE 00043796A PE 7898 A1 PE7898 A1 PE 7898A1
Authority
PE
Peru
Prior art keywords
thrombopoietine
receptor
rent
trp
link
Prior art date
Application number
PE1996000437A
Other languages
English (en)
Inventor
William J Dower
Steven E Cwirla
Sherril S Johnson
David J Duffin
Christopher R Wagstrom
Peter J Schatz
Larry C Mattheakis
Nicholas C Wrighton
Ronald W Barrett
Christian M Gates
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE7898A1 publication Critical patent/PE7898A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

CARACTERIZADOS POR UNA SECUENCIA CICLIZADA O DIMERIZADA DE AMINOACIDOS, QUE COMPRENDE: CX2X3X4X5X6X7 O X9X8GX1X2X3X4X5WX7, EN DONDE PREFERENTEMENTE: X1 ES P; X2 ES T; X3 ES L; X4 Y X6 SON R; X5 ES E o Q; X7 ES I o L; X8 ES D, E o K; X9 ES A o I; EN DONDE: P ES Pro, T ES Thr, L ES Leu, R ES Arg, G ES GLY, E ES Glu, Q ES Gln, I ES Yle, D ES Asp, K ES Lys, A ES Ala, C ES Cys, W ES Trp, S ES Ser, F ES Phe, W ES Trp; ESTA SECUENCIA PREFERENTEMENTE COMPRENDE: CADGPTLREWISFC O IEGPTLRQWLAARA, EN DONDE: A) OPCIONALMENTE, LOS ENLACES PEPTIDICOS HAN SIDO REEMPLAZADOS POR GRUPOS: -CH2-O-CONR-, -CH2-SO2-NR-, -CH2-NR-, -CO-NR6, -NHCO-NH- O UN ENLACE FOSFONATO; B) N-TERMINAL ES -NRR1, -NR-COR, -NR-COOR, -NR-SO2-R O UN GRUPO SUCCINAMIDA, BENCILOXICARBONILO-NH- OPCIONALMENTE SUSTITUIDO POR 1; 2 o 3 ALQUILO INFERIOR, ALCOXI INFERIOR, Cl o Br; C) C-TERMINAL ES -COR2, EN DONDE R2 ES OH, ALCOXI INFERIOR O NR3R4, EN DONDE: R3 Y R4 SON H, ALQUILO INFERIOR O NR3R4 FORMAN UN PEPTIDO CICLICO; ADEMAS R Y R1 SON H O ALQUILO INFERIOR;Y R6 ES ALQUILO INFERIOR. ESTOS PEPTIDOS PRESENTAN: 1) UN PESO MOLECULAR MENOR A 8 000 DALTONS; 2) UNA AFINIDAD DE ENLACE AL RECEPTOR DE TROMBOPOIETINA, EN IC50 DE NO MAS DE 100�m, SIENDO USADOS EN CASOS DE TROMBOCITOPENIA RESULTANTE DE QUIMIOTERAPIA, DE TERAPIA DE RADIACION O DE TRANSFUSIONES DE MEDULA OSEA
PE1996000437A 1995-06-07 1996-06-07 Peptidos compuestos que se ligan al receptor de trombopoietina PE7898A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48530195A 1995-06-07 1995-06-07
US47812895A 1995-06-07 1995-06-07

Publications (1)

Publication Number Publication Date
PE7898A1 true PE7898A1 (es) 1998-03-05

Family

ID=27045796

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000437A PE7898A1 (es) 1995-06-07 1996-06-07 Peptidos compuestos que se ligan al receptor de trombopoietina

Country Status (27)

Country Link
US (2) US6083913A (es)
EP (4) EP2055712A1 (es)
JP (1) JP3059218B2 (es)
KR (1) KR100436680B1 (es)
CN (2) CN1315870C (es)
AR (1) AR003431A1 (es)
AT (1) ATE390439T1 (es)
BR (1) BR9608587A (es)
CA (2) CA2223449C (es)
CZ (1) CZ291749B6 (es)
DE (1) DE69637473T2 (es)
DK (1) DK0885242T3 (es)
EA (1) EA001220B1 (es)
ES (1) ES2303338T3 (es)
HK (1) HK1015380A1 (es)
HU (1) HU227678B1 (es)
IL (1) IL122102A (es)
MX (1) MX9709315A (es)
NO (2) NO317737B1 (es)
NZ (1) NZ310778A (es)
PE (1) PE7898A1 (es)
PL (1) PL188795B1 (es)
PT (1) PT885242E (es)
TR (1) TR199701526T1 (es)
TW (1) TW518341B (es)
WO (1) WO1996040750A1 (es)
ZA (1) ZA964814B (es)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
CA2223449C (en) * 1995-06-07 2008-10-07 Glaxo Group Limited Peptides and compounds that bind to the thrombopoietin receptor
US6172210B1 (en) * 1996-04-02 2001-01-09 Blood Center Research Foundation DNA encoding phospholipid scramblase
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
US6930084B1 (en) 1996-11-06 2005-08-16 The Regents Of The University Of California Treating arthritis with TNF receptor releasing enzyme
US6593456B1 (en) 1996-11-06 2003-07-15 The Regents Of The University Of California Tumor necrosis factor receptor releasing enzyme
US6121416A (en) 1997-04-04 2000-09-19 Genentech, Inc. Insulin-like growth factor agonist molecules
US6420518B1 (en) 1997-04-04 2002-07-16 Genetech, Inc. Insulin-like growth factor agonist molecules
US20030069177A1 (en) 2000-05-16 2003-04-10 Genentech, Inc. Method for treating cartilage disorders
WO1999052877A1 (en) * 1998-04-14 1999-10-21 Smithkline Beecham Corporation Receptor ligands
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
CN1810832B (zh) * 1998-10-23 2012-12-12 麒麟-安姆根有限公司 与MPl受体结合并具有血小板生成活性的模拟二聚体血小板生成素肽
EP1141014B1 (en) 1999-01-06 2004-12-08 Genentech, Inc. Insulin-like growth factor (igf) i mutant variant
US6911314B2 (en) 1999-05-14 2005-06-28 The Regents Of The University Of California Screening for drugs that affect TNF receptor releasing enzyme
WO2001021259A2 (en) 1999-09-21 2001-03-29 Emory University Use and compositions for treating platelet-related disorders using anagrelide
TWI284639B (en) 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
CY2010012I2 (el) 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
WO2001092211A1 (fr) * 2000-05-30 2001-12-06 Chugai Seiyaku Kabushiki Kaisha Composes possedant des activites analogues a celles de la thrombopoietine
US7396917B2 (en) * 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
ES2258558T3 (es) * 2000-12-05 2006-09-01 Alexion Pharmaceuticals, Inc. Anticuerpos diseñados racionalmente.
US6958213B2 (en) 2000-12-12 2005-10-25 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function
US7169931B2 (en) 2001-01-26 2007-01-30 Shionogi & Co., Ltd. Cyclic compounds exhibiting thrombopoietin receptor agonism
WO2002078612A2 (en) * 2001-04-02 2002-10-10 Euro-Celtique S.A. Thrombopoietin (tpo) synthebody for stimulation of platelet production
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
AU2002363522A1 (en) * 2001-11-06 2003-05-19 Ho Chris Meichung Wang System and method for improved computer drug design
SI1466912T1 (sl) * 2002-01-18 2013-08-30 Astellas Pharma Inc. Derivat 2-acilaminotiazola ali njegova sol
US20040009944A1 (en) * 2002-05-10 2004-01-15 Inex Pharmaceuticals Corporation Methylated immunostimulatory oligonucleotides and methods of using the same
MY142390A (en) 2002-05-22 2010-11-30 Glaxosmithkline Llc 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine)
US20040028661A1 (en) * 2002-08-07 2004-02-12 Bartelmez Stephen H. Expansion of cells using thrombopoietin and anti-transforming growth factor-beta
CA2495184A1 (en) 2002-08-14 2004-02-26 Nissan Chemical Industries, Ltd. Thrombopoietin receptor activators and process for their production
MXPA05003057A (es) * 2002-09-18 2006-04-18 Johnson & Johnson Metodos para aumentar la produccion de celulas madre hematopoyeticas y plaquetas.
FI20021762A0 (fi) * 2002-10-03 2002-10-03 Karyon Oy Ab Ltd Uusia terapeuttisia aineita ja valmisteita
TWI324593B (en) 2002-10-09 2010-05-11 Nissan Chemical Ind Ltd Pyrazolone compounds and thrombopoietin receptor activator
US7736909B2 (en) * 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
EP1626983B8 (en) * 2003-05-12 2010-12-22 Affymax, Inc. Novel poly (ethylene glycol) modified erythropoietin agonists and uses thereof
SI1629007T1 (sl) 2003-05-12 2009-10-31 Affymax Inc Novi peptidi, ki se veĹľejo na eritropoetinski receptor
WO2004101611A2 (en) * 2003-05-12 2004-11-25 Affymax, Inc. Peptides that bind to the erythropoietin receptor
EP1628686A2 (en) 2003-05-12 2006-03-01 Affymax, Inc. Spacer moiety for poly (ethylene glycol)-modified peptides
WO2004108078A2 (en) * 2003-06-02 2004-12-16 Alexion Pharmaceuticals Inc. Rationally designed antibodies
US7601746B2 (en) 2003-08-12 2009-10-13 Shionogi & Co., Ltd. Compounds exhibiting thrombopoietin receptor agonism
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
SG131110A1 (en) * 2003-08-28 2007-04-26 Ortho Mcneil Pharm Inc Peptides and compounds that bind to thrombopoietin receptors
TW200526638A (en) 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
US20060210542A1 (en) * 2004-08-16 2006-09-21 Yurkow Edward J Use of TPO mimetic compounds and pharmaceutical compositions in the treatment of anemia
CN100432102C (zh) * 2004-09-30 2008-11-12 百瑞全球有限公司 血小板增进蛋白及其应用
WO2006062685A2 (en) * 2004-11-11 2006-06-15 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
CA2587382A1 (en) * 2004-11-11 2006-06-08 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
CA2588979C (en) 2004-12-08 2013-01-22 Nissan Chemical Industries, Ltd. 3-ethylidenehydrazino substituted heterocyclic compounds as thrombopoietin receptor activators
RU2401259C2 (ru) 2004-12-14 2010-10-10 Ниссан Кемикал Индастриз, ЛТД Амидные соединения и активаторы рецептора тромбопоэтина
CA2600749C (en) 2005-03-10 2014-04-15 Nascacell Ip Gmbh Dimeric or multimeric microproteins
US7919461B2 (en) 2005-06-03 2011-04-05 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US7550433B2 (en) 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US8324159B2 (en) * 2005-06-03 2012-12-04 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
WO2006136450A2 (en) * 2005-06-23 2006-12-28 Aplagen Gmbh Supravalent compounds
JP5071375B2 (ja) 2005-07-15 2012-11-14 日産化学工業株式会社 チオフェン化合物及びトロンボポエチンレセプター活性化剤
KR101290484B1 (ko) 2005-07-20 2013-07-26 닛산 가가쿠 고교 가부시키 가이샤 피라졸 화합물 및 트롬보포이에틴 수용체 활성화제
JP5205967B2 (ja) 2005-11-07 2013-06-05 日産化学工業株式会社 ヒドラジド化合物及びトロンボポエチンレセプター活性化剤
US20070203153A1 (en) * 2005-11-08 2007-08-30 Astellas Pharma Inc. Compositions and methods for treating thrombocytopenia
US7879318B2 (en) * 2006-01-23 2011-02-01 Mcw Research Foundation, Inc. Method of reducing the effects of ischemia by administration of a thrombopoietin receptor ligand
WO2007142308A1 (ja) 2006-06-07 2007-12-13 Nissan Chemical Industries, Ltd. 含窒素ヘテロ環化合物及びトロンボポエチンレセプター活性化剤
EP2452674B1 (en) * 2006-08-08 2014-03-26 Akarx, Inc. Compositions and methods for increasing blood platelet levels in humans
EP2118127A4 (en) 2007-01-31 2010-12-01 Affymax Inc NICKET-BASED LINKER FOR BONDING MODIFYING GROUPS OF POLYPEPTIDES AND OTHER MACROMOLECULES
ECSP077628A (es) 2007-05-03 2008-12-30 Smithkline Beechman Corp Nueva composición farmacéutica
WO2008157824A2 (en) * 2007-06-21 2008-12-24 Conjuchem Biotechnologies Inc. Thrombopoietin peptide conjugates
KR20100027243A (ko) 2007-07-31 2010-03-10 시오노기세이야쿠가부시키가이샤 트롬보포이에틴 수용체 아고니스트 작용을 갖는 광학 활성인 화합물을 함유하는 의약 조성물 및 그 중간체
WO2009029682A1 (en) * 2007-08-28 2009-03-05 Rigel Pharmaceuticals, Inc. Combination therapy with syk kinase inhibitor
US8278057B2 (en) * 2007-09-14 2012-10-02 Nestec S.A. Addressable antibody arrays and methods of use
US8637455B2 (en) * 2007-10-22 2014-01-28 Affinergy, Llc Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces
CN101481352A (zh) 2008-01-10 2009-07-15 上海恒瑞医药有限公司 双环取代吡唑酮偶氮类衍生物、其制备方法及其在医药上的应用
KR20110122846A (ko) 2009-02-24 2011-11-11 알렉시온 파마슈티칼스, 인코포레이티드 치료용 ｔｐｏ/ｅｐｏ 모방 펩티드를 포함하는 항체
ES2782898T3 (es) 2009-05-29 2020-09-16 Novartis Ag Métodos de administración de compuestos agonistas de la trombopoyetina
US20100303835A1 (en) * 2009-05-29 2010-12-02 The Board Of Regents Of The University Of Texas System Peptoid ligands for isolation and treatment of autoimmune t-cells
CA2764153C (en) * 2009-06-02 2021-07-27 The Board Of Regents Of The University Of Texas System Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases
EP2488543A1 (en) * 2009-10-16 2012-08-22 The Board of Regents of The University of Texas System Compositions and methods for producing cyclic peptoid libraries
US8889732B2 (en) 2009-10-23 2014-11-18 Nissan Chemical Industries, Ltd. Fused heterocyclic compounds and thrombopoietin receptor activators
WO2011098095A1 (en) 2010-02-09 2011-08-18 Aplagen Gmbh Peptides binding the tpo receptor
CN104045715B (zh) * 2013-03-15 2018-05-01 兰州大学 二聚体化融合蛋白的制备及应用
MA40132B1 (fr) * 2014-09-11 2019-04-30 Bristol Myers Squibb Co Inhibiteurs macrocycliques des interactions protéine/protéine pd-1/pd-l1 et cd80(b7-1)/pd-li
US20200164039A1 (en) * 2017-07-26 2020-05-28 Janssen Pharmaceutica Nv Methods of protecting vascular integrity induced by targeted radiation therapy
EP4071178A1 (en) 2019-12-06 2022-10-12 Ajinomoto Co., Inc. Method for producing peptide having physiological activity, and peptide comprising short linker
BR112023018676A2 (pt) 2021-03-18 2023-10-10 Seagen Inc Conjugado anticorpo-fármaco, composição farmacêutica, métodos de tratamento de uma doença ou condição e de um câncer, e, composição de conjugado ligante-fármaco

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1319315A (en) 1969-06-19 1973-06-06 Citizen Watch Co Ltd Calendar timepiece
US3940475A (en) 1970-06-11 1976-02-24 Biological Developments, Inc. Radioimmune method of assaying quantitatively for a hapten
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
NO812612L (no) 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4612132A (en) 1984-07-20 1986-09-16 Chevron Research Company Modified succinimides
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5326558A (en) 1989-08-08 1994-07-05 Genetics Institute, Inc. Megakaryocytopoietic factor
IL96477A0 (en) 1989-12-01 1991-08-16 Amgen Inc Megakaryocyte production
DK167813B1 (da) * 1989-12-07 1993-12-20 Carlbiotech Ltd As Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
US5571508A (en) 1989-12-18 1996-11-05 Amrad Corporation Limited Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor
US5141851A (en) * 1990-04-18 1992-08-25 Board Of Regents, The University Of Texas System Isolated farnesyl protein transferase enzyme
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5250732A (en) 1991-07-18 1993-10-05 Genentech, Inc. Ketamine analogues for treatment of thrombocytopenia
WO1993006121A1 (en) 1991-09-18 1993-04-01 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5359115A (en) 1992-03-26 1994-10-25 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
WO1993025221A1 (en) 1992-06-11 1993-12-23 Alkermes Controlled Therapeutics, Inc. Erythropoietin drug delivery system
US5420328A (en) 1992-09-11 1995-05-30 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
US5358934A (en) * 1992-12-11 1994-10-25 The United States Of America As Represented By The Secretary Of Agriculture Materials and methods for control of pests
US5354934A (en) 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
EP0722331A4 (en) 1993-08-25 1997-10-01 Systemix Inc METHOD FOR PRODUCING A POPULATION OF HIGHLY ENRICHED HEMATOPOIETIC STEM CELLS
WO1995011992A1 (en) 1993-10-27 1995-05-04 The Regents Of The University Of California Antiviral compounds
WO1995011922A1 (en) 1993-10-29 1995-05-04 Affymax Technologies N.V. In vitro peptide and antibody display libraries
SG47030A1 (en) 1994-01-03 1998-03-20 Genentech Inc Thrombopoietin
SG79882A1 (en) 1994-02-14 2001-04-17 Kirin Brewery Protein having tpo activity
AU1843595A (en) 1994-02-14 1995-08-29 University Of Washington Methods for stimulating erythropoiesis using thrombopoietin
WO1995021919A2 (en) * 1994-02-14 1995-08-17 Kirin Brewery Company, Limited Protein having tpo activity
WO1995021920A1 (en) 1994-02-14 1995-08-17 Zymogenetics, Inc. Hematopoietic protein and materials and methods for making it
DK0690127T3 (da) 1994-03-31 1999-05-03 Amgen Inc Sammensætninger og fremgangsmåder til stimulering af megakaryocytvækst og -differentiering
US5571686A (en) 1994-04-14 1996-11-05 Massachusetts Institute Of Technology Method of using megapoietin for prolonging the survival & viability of platlets
WO1996017062A1 (en) * 1994-11-30 1996-06-06 Zymogenetics, Inc. Low molecular weight thrombopoietin
US5641655A (en) 1994-11-30 1997-06-24 Zymogenetics, Inc. Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
CA2223449C (en) * 1995-06-07 2008-10-07 Glaxo Group Limited Peptides and compounds that bind to the thrombopoietin receptor
US5932546A (en) * 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
US8157793B2 (en) 2006-10-25 2012-04-17 Terumo Kabushiki Kaisha Manipulator for medical use
JP2023049441A (ja) 2021-09-29 2023-04-10 トヨタ紡織株式会社 乗物用シート

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AR003431A1 (es) 1998-08-05
CZ389797A3 (cs) 1998-06-17
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NO317737B1 (no) 2004-12-13
KR100436680B1 (ko) 2004-09-18
HUP9900921A3 (en) 1999-11-29
NZ310778A (en) 1999-10-28
WO1996040750A1 (en) 1996-12-19
IL122102A (en) 2002-07-25
CA2636432A1 (en) 1996-12-19
TW518341B (en) 2003-01-21
TR199701526T1 (xx) 1998-03-21
EP2055712A1 (en) 2009-05-06
KR19990022576A (ko) 1999-03-25
DE69637473D1 (de) 2008-05-08
PL323917A1 (en) 1998-04-27
US6465430B1 (en) 2002-10-15
ATE390439T1 (de) 2008-04-15
CN1315870C (zh) 2007-05-16
PL188795B1 (pl) 2005-04-29
EP0885242A4 (en) 2000-03-22
IL122102A0 (en) 1998-04-05
AU6163496A (en) 1996-12-30
CZ291749B6 (cs) 2003-05-14
DE69637473T2 (de) 2009-05-07
CA2223449C (en) 2008-10-07
NO331550B1 (no) 2012-01-23
HU227678B1 (en) 2011-11-28
CN1966520B (zh) 2012-07-11
MX9709315A (es) 1998-08-30
PT885242E (pt) 2008-06-18
DK0885242T3 (da) 2008-07-14
JPH10507776A (ja) 1998-07-28
EP0885242B1 (en) 2008-03-26
NO20041296L (no) 1998-02-05
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CN1966520A (zh) 2007-05-23
AU704215B2 (en) 1999-04-15
HUP9900921A2 (hu) 1999-07-28
EA001220B1 (ru) 2000-12-25
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CN1192749A (zh) 1998-09-09
ZA964814B (en) 1998-02-09
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CA2636432C (en) 2012-01-03
HK1015380A1 (en) 1999-10-15
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EA199700359A1 (ru) 1998-10-29
EP1961760A2 (en) 2008-08-27
JP3059218B2 (ja) 2000-07-04
US6083913A (en) 2000-07-04
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CA2223449A1 (en) 1996-12-19
NO975705L (no) 1998-02-05

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