NO984369L - Immunmodulering ved Õ anvende B7-bindende og CD40-bindende molkyler - Google Patents
Immunmodulering ved Õ anvende B7-bindende og CD40-bindende molkylerInfo
- Publication number
- NO984369L NO984369L NO984369A NO984369A NO984369L NO 984369 L NO984369 L NO 984369L NO 984369 A NO984369 A NO 984369A NO 984369 A NO984369 A NO 984369A NO 984369 L NO984369 L NO 984369L
- Authority
- NO
- Norway
- Prior art keywords
- binding
- endogenous
- molecules
- ligand
- immune modulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Transplantation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1375196P | 1996-03-20 | 1996-03-20 | |
PCT/US1997/004248 WO1997034633A1 (en) | 1996-03-20 | 1997-03-20 | Methods for inhibiting an immune response by blocking the gp39/cd40 and ctla4/cd28/b7 pathways and compositions for use therewith |
Publications (3)
Publication Number | Publication Date |
---|---|
NO984369D0 NO984369D0 (no) | 1998-09-18 |
NO984369L true NO984369L (no) | 1998-11-18 |
NO326922B1 NO326922B1 (no) | 2009-03-16 |
Family
ID=21761563
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19984369A NO326922B1 (no) | 1996-03-20 | 1998-09-18 | Anvendelse av en forste loselig og en andre loselig ligand for fremstilling av en farmasoytisk belanding. |
Country Status (13)
Country | Link |
---|---|
US (4) | US5916560A (no) |
EP (1) | EP0892643B2 (no) |
JP (1) | JP4751493B2 (no) |
AT (1) | ATE219376T1 (no) |
AU (1) | AU710998B2 (no) |
CA (1) | CA2246352C (no) |
DE (1) | DE69713499T3 (no) |
DK (1) | DK0892643T4 (no) |
ES (1) | ES2177967T5 (no) |
IL (1) | IL125928A (no) |
NO (1) | NO326922B1 (no) |
PT (1) | PT892643E (no) |
WO (1) | WO1997034633A1 (no) |
Families Citing this family (68)
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US6887471B1 (en) | 1991-06-27 | 2005-05-03 | Bristol-Myers Squibb Company | Method to inhibit T cell interactions with soluble B7 |
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US5397703A (en) | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
US6340459B1 (en) | 1995-12-01 | 2002-01-22 | The Trustees Of Columbia University In The City Of New York | Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients |
EP0892643B2 (en) * | 1996-03-20 | 2009-09-02 | Bristol-Myers Squibb Company | Methods for inhibiting an immune response by blocking the gp39/cd40 and ctla4/cd28/b7 pathways and compositions for use therewith |
DE69837322T2 (de) * | 1997-01-10 | 2007-11-22 | Biogen Idec Ma Inc., Cambridge | Verfahren zur therapeutischen verabreichung von anti-cd40l-mitteln |
ZA98533B (en) * | 1997-01-31 | 1999-07-22 | Bristol Myers Squibb Co | Soluble CTLA4 mutant molecules and uses thereof. |
US20030219863A1 (en) * | 1997-01-31 | 2003-11-27 | Bristol-Myers Squibb Company | Soluble CTLA4 mutant molecules and uses thereof |
BR9809641A (pt) * | 1997-05-17 | 2000-07-11 | Biogen Inc | Uso de um interruptor de ligação cd40:cd154 para evitar respostas imunes inadaptadas, particularmente rejeição a enxerto |
CA2291338A1 (en) * | 1997-06-11 | 1998-12-17 | Wisconsin Alumni Research Foundation | Composition and method to prevent graft rejection and other counter-adaptive t lymphocyte mediated immune responses |
WO1998058669A2 (en) * | 1997-06-20 | 1998-12-30 | Biogen, Inc. | Cd154 blockade therapy for pancreatic islet tissue transplantation |
US6955811B2 (en) * | 1997-11-07 | 2005-10-18 | Trillium Therapeutics Inc. | Methods of inhibiting immune response suppression by administering antibodies to OX-2 |
US7223729B2 (en) * | 1997-11-07 | 2007-05-29 | Trillium Therapeutics Inc. | Methods of treating allergy by administering a CD200 protein |
DK1032662T3 (da) | 1997-11-07 | 2006-07-03 | Trillium Therapeutics Inc | Fremgangsmåder og sammensætninger til immunmodulation |
JP2002502824A (ja) * | 1998-02-04 | 2002-01-29 | ザ・ジェネラル・ホスピタル・コーポレイション | 同種移植における補刺激遮断および混合キメラ現象 |
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CN1161129C (zh) * | 1998-07-30 | 2004-08-11 | 明尼苏达州立大学董事会 | 用gp39拮抗剂离体处理同种异体和异种T-细胞 |
MXPA01002898A (es) * | 1998-09-21 | 2002-06-04 | Genetics Inst | Metodos de modulacion descendente de la respuesta inmune a proteinas terapeuticas. |
WO2000039294A1 (en) * | 1998-12-24 | 2000-07-06 | Novartis Ag | Porcine cells incapable of expressing cd40 antigen, for xenotransplantation |
EP2039368A3 (en) | 1999-04-30 | 2009-04-01 | La Jolla Institute For Allergy And Immunology | Methods for preventing reactivation of latent virus and controlling virus replication |
PL200134B1 (pl) | 1999-05-07 | 2008-12-31 | Genentech Inc | Zastosowanie przeciwciała anty-CD20 |
JP2003510371A (ja) * | 1999-10-04 | 2003-03-18 | カイロン コーポレイション | 乾癬を処置するためのcd40アンタゴニスト |
US20020028178A1 (en) * | 2000-07-12 | 2002-03-07 | Nabil Hanna | Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
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AU2701895A (en) * | 1994-06-07 | 1996-01-05 | Regents Of The University Of Minnesota | Methods for inhibiting antigen specific t cell responses |
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US5872154A (en) * | 1995-02-24 | 1999-02-16 | The Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant adenovirus |
US5652224A (en) * | 1995-02-24 | 1997-07-29 | The Trustees Of The University Of Pennsylvania | Methods and compositions for gene therapy for the treatment of defects in lipoprotein metabolism |
ES2236735T4 (es) * | 1995-06-05 | 2007-03-01 | University Of Washington | Procedimiento de prolongacion de la expresion de un gen de interes usando moleculas ctla4 solubles. |
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EP0892643B2 (en) * | 1996-03-20 | 2009-09-02 | Bristol-Myers Squibb Company | Methods for inhibiting an immune response by blocking the gp39/cd40 and ctla4/cd28/b7 pathways and compositions for use therewith |
US20030219863A1 (en) * | 1997-01-31 | 2003-11-27 | Bristol-Myers Squibb Company | Soluble CTLA4 mutant molecules and uses thereof |
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-
1997
- 1997-03-20 EP EP97916037A patent/EP0892643B2/en not_active Expired - Lifetime
- 1997-03-20 US US08/821,400 patent/US5916560A/en not_active Expired - Lifetime
- 1997-03-20 DK DK97916037T patent/DK0892643T4/da active
- 1997-03-20 AU AU23310/97A patent/AU710998B2/en not_active Ceased
- 1997-03-20 PT PT97916037T patent/PT892643E/pt unknown
- 1997-03-20 IL IL12592897A patent/IL125928A/en not_active IP Right Cessation
- 1997-03-20 JP JP53360197A patent/JP4751493B2/ja not_active Expired - Lifetime
- 1997-03-20 CA CA2246352A patent/CA2246352C/en not_active Expired - Lifetime
- 1997-03-20 DE DE69713499T patent/DE69713499T3/de not_active Expired - Lifetime
- 1997-03-20 ES ES97916037T patent/ES2177967T5/es not_active Expired - Lifetime
- 1997-03-20 AT AT97916037T patent/ATE219376T1/de active
- 1997-03-20 WO PCT/US1997/004248 patent/WO1997034633A1/en active IP Right Grant
-
1998
- 1998-09-18 NO NO19984369A patent/NO326922B1/no not_active IP Right Cessation
-
2001
- 2001-05-22 US US09/862,255 patent/US20020031510A1/en not_active Abandoned
-
2005
- 2005-01-04 US US11/028,793 patent/US20050202011A1/en not_active Abandoned
-
2008
- 2008-09-10 US US12/207,997 patent/US20090186037A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU710998B2 (en) | 1999-10-07 |
ES2177967T5 (es) | 2009-12-17 |
ES2177967T3 (es) | 2002-12-16 |
IL125928A0 (en) | 1999-04-11 |
ATE219376T1 (de) | 2002-07-15 |
DE69713499D1 (de) | 2002-07-25 |
IL125928A (en) | 2002-11-10 |
EP0892643A1 (en) | 1999-01-27 |
US20090186037A1 (en) | 2009-07-23 |
EP0892643B2 (en) | 2009-09-02 |
US5916560A (en) | 1999-06-29 |
DE69713499T2 (de) | 2003-01-30 |
DK0892643T3 (da) | 2002-10-14 |
US20050202011A1 (en) | 2005-09-15 |
PT892643E (pt) | 2002-09-30 |
AU2331097A (en) | 1997-10-10 |
WO1997034633A1 (en) | 1997-09-25 |
DK0892643T4 (da) | 2009-12-14 |
US20020031510A1 (en) | 2002-03-14 |
NO984369D0 (no) | 1998-09-18 |
DE69713499T3 (de) | 2010-05-06 |
CA2246352C (en) | 2011-11-08 |
JP4751493B2 (ja) | 2011-08-17 |
JP2001518066A (ja) | 2001-10-09 |
EP0892643B1 (en) | 2002-06-19 |
CA2246352A1 (en) | 1997-09-25 |
NO326922B1 (no) | 2009-03-16 |
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