NO984369D0 - Immunmodulering ved Õ anvende B7-bindende og CD40-bindende molkyler - Google Patents
Immunmodulering ved Õ anvende B7-bindende og CD40-bindende molkylerInfo
- Publication number
- NO984369D0 NO984369D0 NO984369A NO984369A NO984369D0 NO 984369 D0 NO984369 D0 NO 984369D0 NO 984369 A NO984369 A NO 984369A NO 984369 A NO984369 A NO 984369A NO 984369 D0 NO984369 D0 NO 984369D0
- Authority
- NO
- Norway
- Prior art keywords
- binding
- endogenous
- molecules
- ligand
- immune modulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1375196P | 1996-03-20 | 1996-03-20 | |
PCT/US1997/004248 WO1997034633A1 (en) | 1996-03-20 | 1997-03-20 | Methods for inhibiting an immune response by blocking the gp39/cd40 and ctla4/cd28/b7 pathways and compositions for use therewith |
Publications (3)
Publication Number | Publication Date |
---|---|
NO984369D0 true NO984369D0 (no) | 1998-09-18 |
NO984369L NO984369L (no) | 1998-11-18 |
NO326922B1 NO326922B1 (no) | 2009-03-16 |
Family
ID=21761563
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19984369A NO326922B1 (no) | 1996-03-20 | 1998-09-18 | Anvendelse av en forste loselig og en andre loselig ligand for fremstilling av en farmasoytisk belanding. |
Country Status (13)
Country | Link |
---|---|
US (4) | US5916560A (no) |
EP (1) | EP0892643B2 (no) |
JP (1) | JP4751493B2 (no) |
AT (1) | ATE219376T1 (no) |
AU (1) | AU710998B2 (no) |
CA (1) | CA2246352C (no) |
DE (1) | DE69713499T3 (no) |
DK (1) | DK0892643T4 (no) |
ES (1) | ES2177967T5 (no) |
IL (1) | IL125928A (no) |
NO (1) | NO326922B1 (no) |
PT (1) | PT892643E (no) |
WO (1) | WO1997034633A1 (no) |
Families Citing this family (68)
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US6887471B1 (en) * | 1991-06-27 | 2005-05-03 | Bristol-Myers Squibb Company | Method to inhibit T cell interactions with soluble B7 |
US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
US5397703A (en) | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
US6340459B1 (en) | 1995-12-01 | 2002-01-22 | The Trustees Of Columbia University In The City Of New York | Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients |
JP4751493B2 (ja) * | 1996-03-20 | 2011-08-17 | ブリストル−マイヤーズ スクイッブ カンパニー | Gp39/cd40およびctla4/cd28/b7経路のブロックによって免疫反応を阻止する方法およびそれに使用する組成物 |
KR20000070035A (ko) * | 1997-01-10 | 2000-11-25 | 아스트루 마이클 제이 | 치료를 위한 항cd40l 화합물의 투여 방법 |
US20030219863A1 (en) * | 1997-01-31 | 2003-11-27 | Bristol-Myers Squibb Company | Soluble CTLA4 mutant molecules and uses thereof |
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NZ500974A (en) * | 1997-05-17 | 2001-06-29 | Biogen Inc | Use of a CD40:CD154 binding interruptor to prevent counter adaptive immune responses in graft rejection |
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CN1651919A (zh) * | 1997-06-20 | 2005-08-10 | 拜奥根有限公司 | 结合cd154的单克隆抗体抑制产生胰岛素的组织移植物的排斥的用途 |
US6955811B2 (en) * | 1997-11-07 | 2005-10-18 | Trillium Therapeutics Inc. | Methods of inhibiting immune response suppression by administering antibodies to OX-2 |
AU748587B2 (en) | 1997-11-07 | 2002-06-06 | Trillium Therapeutics Inc | Methods and compositions for immunomodulation |
US7223729B2 (en) * | 1997-11-07 | 2007-05-29 | Trillium Therapeutics Inc. | Methods of treating allergy by administering a CD200 protein |
JP2002502824A (ja) | 1998-02-04 | 2002-01-29 | ザ・ジェネラル・ホスピタル・コーポレイション | 同種移植における補刺激遮断および混合キメラ現象 |
US6841347B1 (en) | 1998-02-05 | 2005-01-11 | The General Hospital Corporation | In vivo construction of DNA libraries |
GB9809280D0 (en) * | 1998-04-30 | 1998-07-01 | Rpms Technology Ltd | Immunosupression |
AU764015C (en) * | 1998-07-30 | 2006-03-16 | Regents Of The University Of Minnesota | Ex vivo treatment of allogeneic and xenogeneic T-cells with gp39 antagonists |
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WO2000039294A1 (en) * | 1998-12-24 | 2000-07-06 | Novartis Ag | Porcine cells incapable of expressing cd40 antigen, for xenotransplantation |
EP2039368A3 (en) | 1999-04-30 | 2009-04-01 | La Jolla Institute For Allergy And Immunology | Methods for preventing reactivation of latent virus and controlling virus replication |
CA2372603C (en) | 1999-05-07 | 2015-11-17 | Genentech, Inc. | Treatment of autoimmune diseases with antagonists which bind to b cell surface markers |
ATE363290T1 (de) * | 1999-10-04 | 2007-06-15 | Novartis Vaccines & Diagnostic | Cd40 antagonist zur behandlung von psoriasis |
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US20030211107A1 (en) * | 2002-01-31 | 2003-11-13 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
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US20040058445A1 (en) * | 2001-04-26 | 2004-03-25 | Ledbetter Jeffrey Alan | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB |
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US20030219436A1 (en) * | 2002-03-15 | 2003-11-27 | Ledbetter Jeffrey A. | Compositions and methods to regulate an immune response using CD83 gene expressed in tumors and using soluble CD83-Ig fusion protein |
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US7541164B2 (en) * | 2002-12-23 | 2009-06-02 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
US7754209B2 (en) | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
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WO2005018668A1 (en) * | 2003-08-25 | 2005-03-03 | Pangenetics B.V. | Method of inducing immune tolerance |
CN105012953B (zh) | 2005-07-25 | 2018-06-22 | 阿普泰沃研发有限责任公司 | 用cd37-特异性和cd20-特异性结合分子减少b-细胞 |
CN103690947A (zh) | 2006-01-12 | 2014-04-02 | 阿莱克申药物公司 | 抗ox-2/cd200的抗体及其用途 |
RU2487888C2 (ru) | 2006-06-12 | 2013-07-20 | ЭМЕРДЖЕНТ ПРОДАКТ ДИВЕЛОПМЕНТ СИЭТЛ, ЭлЭлСи | Одноцепочечные мультивалентные связывающие белки с эффекторной функцией |
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PT2699601T (pt) | 2011-04-21 | 2018-04-05 | Domantis Ltd | Polipéptidos de anticorpo que antagonizam cd40 |
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CN116059378A (zh) | 2014-12-10 | 2023-05-05 | 明尼苏达大学董事会 | 用于治疗疾病的遗传修饰的细胞、组织和器官 |
CA2999138C (en) | 2015-09-21 | 2024-05-21 | Aptevo Research And Development Llc | Cd3 binding polypeptides |
EP3468356A4 (en) * | 2016-06-14 | 2020-02-26 | Regents Of The University Of Minnesota | GENETICALLY MODIFIED CELLS, TISSUES AND ORGANS FOR THE TREATMENT OF A DISEASE |
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-
1997
- 1997-03-20 JP JP53360197A patent/JP4751493B2/ja not_active Expired - Lifetime
- 1997-03-20 AU AU23310/97A patent/AU710998B2/en not_active Ceased
- 1997-03-20 ES ES97916037T patent/ES2177967T5/es not_active Expired - Lifetime
- 1997-03-20 CA CA2246352A patent/CA2246352C/en not_active Expired - Lifetime
- 1997-03-20 EP EP97916037A patent/EP0892643B2/en not_active Expired - Lifetime
- 1997-03-20 AT AT97916037T patent/ATE219376T1/de active
- 1997-03-20 WO PCT/US1997/004248 patent/WO1997034633A1/en active IP Right Grant
- 1997-03-20 DK DK97916037T patent/DK0892643T4/da active
- 1997-03-20 DE DE69713499T patent/DE69713499T3/de not_active Expired - Lifetime
- 1997-03-20 IL IL12592897A patent/IL125928A/en not_active IP Right Cessation
- 1997-03-20 US US08/821,400 patent/US5916560A/en not_active Expired - Lifetime
- 1997-03-20 PT PT97916037T patent/PT892643E/pt unknown
-
1998
- 1998-09-18 NO NO19984369A patent/NO326922B1/no not_active IP Right Cessation
-
2001
- 2001-05-22 US US09/862,255 patent/US20020031510A1/en not_active Abandoned
-
2005
- 2005-01-04 US US11/028,793 patent/US20050202011A1/en not_active Abandoned
-
2008
- 2008-09-10 US US12/207,997 patent/US20090186037A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE69713499D1 (de) | 2002-07-25 |
ATE219376T1 (de) | 2002-07-15 |
NO984369L (no) | 1998-11-18 |
WO1997034633A1 (en) | 1997-09-25 |
DE69713499T3 (de) | 2010-05-06 |
PT892643E (pt) | 2002-09-30 |
US5916560A (en) | 1999-06-29 |
EP0892643B2 (en) | 2009-09-02 |
AU710998B2 (en) | 1999-10-07 |
US20050202011A1 (en) | 2005-09-15 |
NO326922B1 (no) | 2009-03-16 |
ES2177967T3 (es) | 2002-12-16 |
IL125928A0 (en) | 1999-04-11 |
IL125928A (en) | 2002-11-10 |
JP2001518066A (ja) | 2001-10-09 |
EP0892643A1 (en) | 1999-01-27 |
US20020031510A1 (en) | 2002-03-14 |
JP4751493B2 (ja) | 2011-08-17 |
ES2177967T5 (es) | 2009-12-17 |
AU2331097A (en) | 1997-10-10 |
CA2246352C (en) | 2011-11-08 |
CA2246352A1 (en) | 1997-09-25 |
DK0892643T3 (da) | 2002-10-14 |
EP0892643B1 (en) | 2002-06-19 |
DK0892643T4 (da) | 2009-12-14 |
DE69713499T2 (de) | 2003-01-30 |
US20090186037A1 (en) | 2009-07-23 |
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