SV2017005605A - Moduladores cot y metodos de uso de los mismos - Google Patents

Moduladores cot y metodos de uso de los mismos

Info

Publication number
SV2017005605A
SV2017005605A SV2017005605A SV2017005605A SV2017005605A SV 2017005605 A SV2017005605 A SV 2017005605A SV 2017005605 A SV2017005605 A SV 2017005605A SV 2017005605 A SV2017005605 A SV 2017005605A SV 2017005605 A SV2017005605 A SV 2017005605A
Authority
SV
El Salvador
Prior art keywords
methods
same
cot
modulators
cot modulators
Prior art date
Application number
SV2017005605A
Other languages
English (en)
Spanish (es)
Inventor
Elizabeth M Bacon
Gayatri Balan
Chien- Hung Chou
Christopher T Clark
Jeromy J Cottell
Musong Kim
Thorsten A Kirschberg
John O Link
Gary Phillips
Scott D Schroeder
Neil H Squires
Kirk L Stevens
James G Taylor
William J Watkins
Nathan E Wright
Sheila M Zipfel
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of SV2017005605A publication Critical patent/SV2017005605A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
SV2017005605A 2015-07-06 2017-12-22 Moduladores cot y metodos de uso de los mismos SV2017005605A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562189158P 2015-07-06 2015-07-06
US201562269060P 2015-12-17 2015-12-17

Publications (1)

Publication Number Publication Date
SV2017005605A true SV2017005605A (es) 2018-07-18

Family

ID=56411943

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2017005605A SV2017005605A (es) 2015-07-06 2017-12-22 Moduladores cot y metodos de uso de los mismos

Country Status (41)

Country Link
US (8) US20170008905A1 (show.php)
EP (4) EP3896064B1 (show.php)
JP (6) JP6430060B2 (show.php)
KR (5) KR102073641B1 (show.php)
CN (4) CN109879859B (show.php)
AU (5) AU2016290820B2 (show.php)
BR (1) BR102016015656B1 (show.php)
CA (1) CA2971640C (show.php)
CL (1) CL2017003356A1 (show.php)
CO (1) CO2017013351A2 (show.php)
CR (1) CR20170599A (show.php)
CU (1) CU20170172A7 (show.php)
CY (1) CY1121750T1 (show.php)
DK (1) DK3191470T3 (show.php)
DO (1) DOP2017000311A (show.php)
EA (1) EA036788B1 (show.php)
EC (1) ECSP17084635A (show.php)
ES (3) ES2872076T3 (show.php)
HR (1) HRP20190853T1 (show.php)
HU (1) HUE043310T2 (show.php)
IL (4) IL274568B (show.php)
LT (1) LT3191470T (show.php)
MA (1) MA39422B1 (show.php)
ME (1) ME03425B (show.php)
MX (1) MX370984B (show.php)
MY (1) MY196173A (show.php)
NZ (2) NZ738525A (show.php)
PE (1) PE20180462A1 (show.php)
PH (2) PH12018500031B1 (show.php)
PL (3) PL3456717T3 (show.php)
PT (3) PT3191470T (show.php)
RS (1) RS58639B1 (show.php)
SA (1) SA517381350B1 (show.php)
SG (1) SG11201702041PA (show.php)
SI (3) SI3456717T1 (show.php)
SM (1) SMT201900244T1 (show.php)
SV (1) SV2017005605A (show.php)
TW (3) TWI748539B (show.php)
UA (1) UA123010C2 (show.php)
UY (1) UY36771A (show.php)
WO (1) WO2017007689A1 (show.php)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012278976B2 (en) 2011-07-06 2017-05-11 Gilead Sciences, Inc. Compounds for the treatment of HIV
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
PT3319955T (pt) 2015-07-06 2021-01-05 Gilead Sciences Inc 6-amino-quinolino-3-carbonitrilos como moduladores de cot
HRP20190853T1 (hr) * 2015-07-06 2019-06-28 Gilead Sciences, Inc. Cot modulatori i postupci za njihovu upotrebu
JP6776378B2 (ja) 2016-06-30 2020-10-28 ギリアード サイエンシーズ， インコーポレイテッド Ｃｏｔモジュレーターとしての４，６−ジアミノキナゾリン類およびその使用方法
TWI853404B (zh) * 2016-08-19 2024-08-21 美商基利科學股份有限公司 治療性化合物
EA036921B1 (ru) * 2017-02-10 2021-01-15 Джилид Сайэнс, Инк. Терапевтические соединения, которые можно применять для профилактического или терапевтического лечения инфекции вирусом вич
CN108794516A (zh) * 2017-04-26 2018-11-13 上海时莱生物技术有限公司 硼酸和硼酸酯类化合物及其制备方法和用途
TW202024061A (zh) 2017-08-17 2020-07-01 美商基利科學股份有限公司 Hiv蛋白質膜抑制劑之固體形式
AR112412A1 (es) 2017-08-17 2019-10-23 Gilead Sciences Inc Formas de sal de colina de un inhibidor de la cápside del vih
US20200275661A1 (en) * 2017-09-26 2020-09-03 Nippon Soda Co., Ltd. Quinoline compound, and agricultural and horticultural fungicide
AU2019221568B2 (en) 2018-02-15 2021-04-22 Gilead Sciences, Inc. Pyridine derivatives and their use for treating HIV infection
TWI823164B (zh) 2018-02-16 2023-11-21 美商基利科學股份有限公司 用於製備有療效化合物之方法及中間物
US11760701B2 (en) 2018-02-27 2023-09-19 The Research Foundation For The State University Of New Yrok Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
CN110294660B (zh) * 2018-03-23 2021-09-24 中国农业大学 一种含碳碳三键和/或碳氮三键的不饱和有机化合物的还原氘化方法
CN108658996A (zh) * 2018-06-25 2018-10-16 中国药科大学 一种氘代Fiduxosin的制备方法
TWI814350B (zh) 2018-07-16 2023-09-01 美商基利科學股份有限公司 用於治療hiv之蛋白殼抑制劑
TWI770527B (zh) * 2019-06-14 2022-07-11 美商基利科學股份有限公司 Cot 調節劑及其使用方法
KR102854071B1 (ko) 2019-08-09 2025-09-02 이도르시아 파마슈티컬스 리미티드 (헤테로)아릴-메틸-티오-베타-d-갈락토피라노시드 유도체
KR102863667B1 (ko) 2019-08-09 2025-09-23 이도르시아 파마슈티컬스 리미티드 (2-아세트아미딜)티오-베타-d-갈락토피라노시드 유도체
BR112021026829A2 (pt) 2019-08-15 2022-02-22 Idorsia Pharmaceuticals Ltd Composto, composição farmacêutica, uso de um composto, e, método para a profilaxia ou tratamento de fibrose de órgãos; doenças e distúrbios hepáticos; doenças e distúrbios cardiovasculares; doenças proliferativas celulares e cânceres; doenças e distúrbios inflamatórios e autoimunes; doenças e distúrbios do trato gastrointestinal; doenças e distúrbios pancreáticos; doenças e distúrbios associados à angiogênese anormal; doenças e distúrbios associados ao cérebro; dor neuropática e neuropatia periférica; doenças e distúrbios oculares; lesão renal aguda e doença renal crônica; doenças e distúrbios pulmonares intersticiais; ou rejeição ao transplante
KR102824799B1 (ko) 2019-08-29 2025-06-24 이도르시아 파마슈티컬스 리미티드 알파-d-갈락토피라노시드 유도체
EP4065116B1 (en) 2019-11-26 2026-01-21 Gilead Sciences, Inc. Capsid inhibitors for the prevention of hiv
US11655237B2 (en) 2020-03-30 2023-05-23 Gilead Sciences, Inc. Solid forms of a Cot inhibitor compound
AU2021245924B2 (en) * 2020-04-02 2024-02-29 Gilead Sciences, Inc. Process for preparing a Cot inhibitor compound
TWI858267B (zh) 2020-06-25 2024-10-11 美商基利科學股份有限公司 用於治療hiv之蛋白殼抑制劑
MX2023004033A (es) 2020-10-06 2023-04-27 Idorsia Pharmaceuticals Ltd Espiro derivados de alfa-d-galactopiranosidos.
KR20230104190A (ko) 2020-11-02 2023-07-07 이도르시아 파마슈티컬스 리미티드 갈렉틴-3 억제 2-히드록시시클로알칸-1-카르바모일 유도체
ES3032987T3 (en) 2021-02-09 2025-07-29 Idorsia Pharmaceuticals Ltd Hydroxyheterocycloalkane-carbamoyl derivatives
US20240109930A1 (en) 2021-03-03 2024-04-04 Idorsia Pharmaceuticals Ltd Triazolyl-methyl substituted alpha-d-galactopyranoside derivatives
TW202345826A (zh) * 2021-06-04 2023-12-01 美商基利科學股份有限公司 治療nash之方法
WO2022261404A1 (en) * 2021-06-11 2022-12-15 Neuronascent, Inc. Methods and compositions for lipid formulation of lipophilic small molecule therapies of the heterocyclic type
AU2022403012B2 (en) 2021-12-03 2026-02-12 Gilead Sciences, Inc. Therapeutic compounds for hiv virus infection
CA3237155A1 (en) 2021-12-03 2023-06-08 Zhimin Du Therapeutic compounds for hiv virus infection
SI4440702T1 (sl) 2021-12-03 2025-09-30 Gilead Sciences, Inc. Terapevtske spojine za okužbo z virusom hiv
WO2024245157A1 (zh) * 2023-05-30 2024-12-05 浙江星浩澎博医药有限公司 氮杂喹啉环衍生物
AU2024282281A1 (en) * 2023-06-02 2026-01-15 Westol, Llc 2,8-dihydroxyquinoline glucuronide derivatives with enhanced properties for use as anticancer, antiviral, antimicrobial, and other therapeutic applications
WO2025020886A1 (zh) * 2023-07-27 2025-01-30 浙江星浩澎博医药有限公司 氮杂喹唑啉环衍生物及其用途
KR102732584B1 (ko) 2024-03-28 2024-11-21 (주)신한티이씨 전기 배전반의 화재 위험 감지 및 진압용 소화 장치

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3930837A (en) 1971-12-31 1976-01-06 Ici Australia Limited 3-chloro-5-acetamidaisoquinoline as a herbicide
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
NL7800191A (nl) 1977-01-10 1978-07-12 Ciba Geigy Anthelmintisch preparaat.
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US5364620A (en) 1983-12-22 1994-11-15 Elan Corporation, Plc Controlled absorption diltiazem formulation for once daily administration
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US4992445A (en) 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
US5001139A (en) 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
US4902514A (en) 1988-07-21 1990-02-20 Alza Corporation Dosage form for administering nilvadipine for treating cardiovascular symptoms
JP2634438B2 (ja) 1988-07-26 1997-07-23 三井東圧化学株式会社 不斉ビスオキサゾリルピリジン誘導体およびその製造方法
DE4014171A1 (de) 1990-05-03 1991-11-07 Basf Ag Cyanochinolinverbindungen
GB9310700D0 (en) 1993-05-24 1993-07-07 Zeneca Ltd Novel composition
UA73073C2 (uk) * 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
NZ503079A (en) 1997-08-28 2002-07-26 Nissan Chemical Ind Ltd Cyanoacrylate-containing antibacterial and antifungal agents, algicides and antifouling agents
WO2000002887A2 (en) 1998-07-10 2000-01-20 Massachusetts Institute Of Technology Ligands for metals and metal-catalyzed processes
ES2457396T3 (es) 1998-09-29 2014-04-25 Wyeth Holdings Llc 3-Cianoquinolinas sustituidas como inhibidores de las proteínas tirosina quinasas
RS81904A (sr) 2002-03-20 2007-02-05 Bristol-Myers Squibb Company, Fosfatni prolekovi fluorooksindola
ES2297386T3 (es) 2003-03-03 2008-05-01 F. Hoffmann-La Roche Ag Tetrahidroisoquinolinas 2,5-sustituidas para uso como moduladores de 5-ht6.
CN1835923A (zh) 2003-08-19 2006-09-20 惠氏控股公司 制备4－氨基－3－喹啉腈的方法
US7399865B2 (en) 2003-09-15 2008-07-15 Wyeth Protein tyrosine kinase enzyme inhibitors
TW200529846A (en) * 2004-02-20 2005-09-16 Wyeth Corp 3-quinolinecarbonitrile protein kinase inhibitors
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
AU2006247315A1 (en) 2005-05-18 2006-11-23 Wyeth 4, 6-diamino-[1,7] naphthyridine-3-carbonitrile inhibitors of Tpl2 kinase and methods of making and using the same
AU2006247520A1 (en) 2005-05-18 2006-11-23 Wyeth 3-cyanoquinoline inhibitors of TPL2 kinase and methods of making and using the same
CN101365684A (zh) 2005-10-28 2009-02-11 艾博特公司 抑制trpv1受体的吲唑衍生物
JP5255559B2 (ja) 2006-03-31 2013-08-07 アボット・ラボラトリーズ インダゾール化合物
ES2481442T3 (es) 2006-11-09 2014-07-30 Probiodrug Ag Inhibidores novedosos de glutaminil ciclasa
CN101583601B (zh) 2007-01-17 2013-06-05 香港科技大学 作为褪黑素受体mt1和mt2的亚型选择性激动剂的异喹诺酮化合物
GB0820856D0 (en) 2008-11-14 2008-12-24 Univ Leuven Kath Novel inhibitors of flavivirus replication
TWI598347B (zh) 2009-07-13 2017-09-11 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
GB0922302D0 (en) 2009-12-22 2010-02-03 Imp Innovations Ltd Compounds
BR112012022801B8 (pt) 2010-03-09 2019-10-29 Dana Farber Cancer Inst Inc método de identificar um indivíduo que tem câncer que é provável beneficiar-se do tratamento com uma terapia de combinação com um inibidor de raf e um segundo inibidor e uso de um inibidor de raf e um segundo inibidor para a fabricação de um medicamento para tratar câncer
KR101562347B1 (ko) * 2010-06-09 2015-10-22 티안진 헤메이 바이오-텍 컴퍼니 리미티드 시아노퀴놀린 유도체
US9453021B2 (en) 2011-05-10 2016-09-27 Kyowa Hakko Kirin Co., Ltd. Pyrimidodiazepinone compound
CN103957711A (zh) 2011-07-04 2014-07-30 拜耳知识产权有限责任公司 取代的异喹啉酮、异喹啉二酮、异喹啉三酮和二氢异喹啉酮或其各自的盐作为活性剂对抗植物非生物胁迫的用途
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
PT2772482E (pt) 2011-10-27 2016-06-03 Taisho Pharmaceutical Co Ltd Derivados de azole
TWI582095B (zh) 2011-11-11 2017-05-11 基利阿波羅有限責任公司 Ａｃｃ抑制劑及彼等之用途
UY34573A (es) 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
CN103483363B (zh) 2012-06-13 2016-12-21 上海赛迦化工产品有限公司 多样性的手性氨基硼酸及其制备方法和应用
WO2014064215A1 (en) 2012-10-24 2014-05-01 INSERM (Institut National de la Santé et de la Recherche Médicale) TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL
CN103408572B (zh) 2013-07-12 2015-12-02 上海工程技术大学 手性氨基硼酸衍生物及其制备方法和应用
EP3080072A4 (en) 2013-12-12 2017-07-19 Kalyra Pharmaceuticals, inc. Bicyclic alkyl compounds and synthesis
WO2015134710A1 (en) 2014-03-07 2015-09-11 Kalyra Pharmaceuticals, Inc. Propellane derivates and synthesis
US9701661B2 (en) * 2014-07-11 2017-07-11 Northwestern University 2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase
US10308609B2 (en) 2014-09-17 2019-06-04 Zeno Royalties & Milestones, LLC Bicyclic compounds
KR20190035960A (ko) 2014-09-24 2019-04-03 길리애드 사이언시즈, 인코포레이티드 간 질환의 치료 방법
TWI749934B (zh) 2014-12-23 2021-12-11 美商基利科學股份有限公司 製備2-氟-4-甲基-5-(4-環丙基-1h-咪唑-1-基)苯甲酸之方法
MA41252A (fr) 2014-12-23 2017-10-31 Gilead Sciences Inc Formes solides d'un inhibiteur d'ask 1
EA201791258A1 (ru) 2015-01-09 2017-12-29 Джилид Аполло, Ллс Комбинированная терапия с применением ингибитора ацетил-коа-карбоксилазы (acc) для лечения неалкогольной жировой болезни печени
CA2974004A1 (en) 2015-01-16 2016-07-21 3M Innovative Properties Company Systems and methods for selecting grid actions to improve grid outcomes
PT3319955T (pt) 2015-07-06 2021-01-05 Gilead Sciences Inc 6-amino-quinolino-3-carbonitrilos como moduladores de cot
HRP20190853T1 (hr) 2015-07-06 2019-06-28 Gilead Sciences, Inc. Cot modulatori i postupci za njihovu upotrebu
PL3398598T3 (pl) 2015-12-31 2022-08-22 Hitgen Inc. Pochodne sulfonoamidowe oraz sposoby ich wytwarzania i zastosowanie
EP4364795A3 (en) 2016-03-02 2024-08-14 Gilead Apollo, LLC Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
EP3473715B1 (en) 2016-06-21 2021-08-04 PHC Holdings Corporation Catalase inhibitor and method for measuring analyte using catalase inhibitor
JP6776378B2 (ja) 2016-06-30 2020-10-28 ギリアード サイエンシーズ， インコーポレイテッド Ｃｏｔモジュレーターとしての４，６−ジアミノキナゾリン類およびその使用方法
CN106512014A (zh) 2016-10-27 2017-03-22 武汉大学 肿瘤进展位点2在治疗脂肪肝和ⅱ型糖尿病中的功能和应用
CA3053956C (en) 2017-03-03 2024-04-23 Gilead Sciences, Inc. Processes for preparing acc inhibitors and solid forms thereof
EP4122464B1 (en) 2017-03-28 2024-05-15 Gilead Sciences, Inc. Therapeutic combinations for treating liver diseases
AU2018250614A1 (en) 2017-04-12 2019-10-17 Gilead Sciences, Inc. Methods of treating liver disease
TWI814744B (zh) 2017-10-06 2023-09-11 美商基利科學股份有限公司 包含acc抑制劑之組合療法
WO2020172075A1 (en) 2019-02-19 2020-08-27 Gilead Sciences, Inc. Solid forms of fxr agonists
US20220143153A1 (en) 2019-03-08 2022-05-12 The Regents Of The University Of California Compositions and methods for treating acne
TWI770527B (zh) 2019-06-14 2022-07-11 美商基利科學股份有限公司 Cot 調節劑及其使用方法
AR119594A1 (es) 2019-08-09 2021-12-29 Gilead Sciences Inc Derivados de tienopirimidina como inhibidores acc y usos de los mismos
US11655237B2 (en) 2020-03-30 2023-05-23 Gilead Sciences, Inc. Solid forms of a Cot inhibitor compound
AU2021245924B2 (en) 2020-04-02 2024-02-29 Gilead Sciences, Inc. Process for preparing a Cot inhibitor compound
TW202345826A (zh) 2021-06-04 2023-12-01 美商基利科學股份有限公司 治療nash之方法

Also Published As

Publication number Publication date
AU2022204050B2 (en) 2024-04-18
AU2016290820A1 (en) 2018-01-18
EA036788B1 (ru) 2020-12-21
TW202114673A (zh) 2021-04-16
US11905299B2 (en) 2024-02-20
MY196173A (en) 2023-03-17
JP2022082816A (ja) 2022-06-02
EP3896064B1 (en) 2025-05-21
PL3191470T3 (pl) 2019-08-30
JP2019178178A (ja) 2019-10-17
KR102443575B1 (ko) 2022-09-16
PT3896064T (pt) 2025-07-03
IL293770B2 (en) 2023-07-01
KR20190045416A (ko) 2019-05-02
US9878995B2 (en) 2018-01-30
PL3896064T3 (pl) 2025-09-08
SA517381350B1 (ar) 2021-03-11
PT3191470T (pt) 2019-06-05
EA201792613A1 (ru) 2018-06-29
CA2971640C (en) 2020-09-22
EP3456717A1 (en) 2019-03-20
SI3896064T1 (sl) 2025-07-31
IL293770B1 (en) 2023-03-01
ES2872076T3 (es) 2021-11-02
TW201712005A (zh) 2017-04-01
US11066414B2 (en) 2021-07-20
EP4613332A2 (en) 2025-09-10
EP3191470B1 (en) 2019-02-27
SI3456717T1 (sl) 2021-08-31
NZ750707A (en) 2023-09-29
KR20240008398A (ko) 2024-01-18
CN119143730A (zh) 2024-12-17
BR102016015656B1 (pt) 2021-11-03
EP3896064A1 (en) 2021-10-20
IL293770A (en) 2022-08-01
US20200123172A1 (en) 2020-04-23
DOP2017000311A (es) 2018-01-15
ES3034100T3 (en) 2025-08-13
UA123010C2 (uk) 2021-02-03
JP2021042252A (ja) 2021-03-18
PT3456717T (pt) 2021-05-26
PL3456717T3 (pl) 2021-10-25
US20170152240A1 (en) 2017-06-01
AU2024204902A1 (en) 2024-08-01
WO2017007689A1 (en) 2017-01-12
AU2016290820B2 (en) 2019-03-07
AU2020257055B2 (en) 2022-03-31
EP4613332A3 (en) 2025-12-10
IL256433B (en) 2019-06-30
HRP20190853T1 (hr) 2019-06-28
JP7138155B2 (ja) 2022-09-15
MX2017004737A (es) 2017-06-19
PH12018500031A1 (en) 2018-07-09
EP3191470A1 (en) 2017-07-19
US20240254137A1 (en) 2024-08-01
CN107922390B (zh) 2019-05-10
ME03425B (me) 2020-01-20
CR20170599A (es) 2018-02-28
AU2019203122A1 (en) 2019-05-30
KR102073641B1 (ko) 2020-02-05
JP6781221B2 (ja) 2020-11-04
CN109879859B (zh) 2022-01-25
TWI699361B (zh) 2020-07-21
JP6430060B2 (ja) 2018-11-28
MA39422B1 (fr) 2019-03-29
KR20180022982A (ko) 2018-03-06
BR102016015656A2 (pt) 2020-09-24
KR101974793B1 (ko) 2019-05-02
AU2022204050A1 (en) 2022-06-30
CN107922390A (zh) 2018-04-17
ECSP17084635A (es) 2018-01-31
IL274568B (en) 2022-07-01
AU2020257055A1 (en) 2020-11-12
CO2017013351A2 (es) 2018-05-21
JP6906021B2 (ja) 2021-07-21
JP2018520161A (ja) 2018-07-26
CN109879859A (zh) 2019-06-14
MA39422A (fr) 2017-07-19
CU20170172A7 (es) 2018-06-05
DK3191470T3 (en) 2019-04-15
AU2019203122B2 (en) 2020-10-01
US20170008905A1 (en) 2017-01-12
IL266995A (en) 2019-07-31
CL2017003356A1 (es) 2018-07-06
JP2018193405A (ja) 2018-12-06
US20230002407A1 (en) 2023-01-05
US20190248807A1 (en) 2019-08-15
ES2734713T3 (es) 2019-12-11
SI3191470T1 (sl) 2019-04-30
TWI634112B (zh) 2018-09-01
PH12020551397A1 (en) 2021-08-16
CY1121750T1 (el) 2020-07-31
US20250346609A1 (en) 2025-11-13
SMT201900244T1 (it) 2019-05-10
HUE043310T2 (hu) 2019-08-28
US20180237455A1 (en) 2018-08-23
MX370984B (es) 2020-01-09
KR20220129667A (ko) 2022-09-23
NZ738525A (en) 2019-03-29
TW201908305A (zh) 2019-03-01
KR20200013120A (ko) 2020-02-05
CN114380799B (zh) 2024-10-01
RS58639B1 (sr) 2019-05-31
TWI748539B (zh) 2021-12-01
SG11201702041PA (en) 2017-04-27
EP3456717B1 (en) 2021-03-17
IL266995B (en) 2020-05-31
IL274568A (en) 2020-06-30
CA2971640A1 (en) 2017-01-12
PH12018500031B1 (en) 2018-07-09
IL256433A (en) 2018-02-28
LT3191470T (lt) 2019-05-10
CN114380799A (zh) 2022-04-22
JP2024100865A (ja) 2024-07-26
UY36771A (es) 2017-01-31
PE20180462A1 (es) 2018-03-06

Similar Documents

Publication Publication Date Title
SV2017005605A (es) Moduladores cot y metodos de uso de los mismos
MX2017007585A (es) Anticuerpos anti-c10orf54 y usos de los mismos.
MX388018B (es) Anticuerpos anti-pd1 y métodos de uso.
MX2020009461A (es) Anticuerpos anti-proteína que contiene dominio de inmunologlubina rfig elacionado con el receptor de poliovirus (pvrig) y métodos de uso.
UY34876A (es) Anticuerpos anti-egfr y usos de los mismos
MX2016005631A (es) Anticuerpos anti-alfa-sinucleina y metodos de uso.
CR20150618A (es) Anticuerpos receptores de antitransferina y métodos de uso
MX2015017341A (es) Anticuerpos anti-factor del complemento c1q y uso de los mismos.
BR112016002391A2 (pt) composições tópicas e métodos de uso das mesmas
MX2017017124A (es) 6-amino-quinolin-3-carbonitrilos como moduladores de cancer osaka tiroides (cot).
BR112017000456A2 (pt) composições antivirais tópicas e métodos de uso das mesmas
DOP2023000172A (es) Moduladores de cot y métodos de uso de los mismos
AU366605S (en) Theater seat
BR112016017402A2 (pt) fusões anti-pcsk9~glp-1 e métodos para uso
CO7020877A2 (es) Anticuerpos anti-asic1 y usos de los mismos
UY35475A (es) 4-amino-6-(piridil y 2-fenilsustituido)-picolinatos y 6-amino-2-(piridil y 2-fenilsustituido)-pirimidin-4-carboxilatos novedosos y su uso como herbicidas
AU366606S (en) Theater seat
AU366604S (en) Theater seat
ECSP18050673A (es) Formulaciones de giberelina en solución concentrada
AU366623S (en) Theater seat
AR121189A2 (es) Anticuerpos anti-tigit y métodos de uso
EA202092495A1 (ru) МОДУЛЯТОРЫ Cot И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
TWD169258S (zh) 蹦床
AU351525S (en) Light fitting
AU351524S (en) Light fitting