PL3398598T3 - Pochodne sulfonoamidowe oraz sposoby ich wytwarzania i zastosowanie - Google Patents
Pochodne sulfonoamidowe oraz sposoby ich wytwarzania i zastosowanieInfo
- Publication number
- PL3398598T3 PL3398598T3 PL16881237.8T PL16881237T PL3398598T3 PL 3398598 T3 PL3398598 T3 PL 3398598T3 PL 16881237 T PL16881237 T PL 16881237T PL 3398598 T3 PL3398598 T3 PL 3398598T3
- Authority
- PL
- Poland
- Prior art keywords
- preparation
- sulfonamide derivative
- sulfonamide
- derivative
- Prior art date
Links
- HFFXLYHRNRKAPM-UHFFFAOYSA-N 2,4,5-trichloro-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C(=CC(Cl)=C(Cl)C=2)Cl)=N1 HFFXLYHRNRKAPM-UHFFFAOYSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511029249 | 2015-12-31 | ||
| PCT/CN2016/112896 WO2017114448A1 (zh) | 2015-12-31 | 2016-12-29 | 磺酰胺衍生物及其制备方法与应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3398598T3 true PL3398598T3 (pl) | 2022-08-22 |
Family
ID=59225913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16881237.8T PL3398598T3 (pl) | 2015-12-31 | 2016-12-29 | Pochodne sulfonoamidowe oraz sposoby ich wytwarzania i zastosowanie |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11149008B2 (pl) |
| EP (1) | EP3398598B1 (pl) |
| JP (1) | JP6804540B2 (pl) |
| KR (1) | KR102264012B1 (pl) |
| CN (1) | CN106928198B (pl) |
| AU (1) | AU2016382372B2 (pl) |
| CA (1) | CA3010326C (pl) |
| DK (1) | DK3398598T3 (pl) |
| ES (1) | ES2920888T3 (pl) |
| PL (1) | PL3398598T3 (pl) |
| PT (1) | PT3398598T (pl) |
| WO (1) | WO2017114448A1 (pl) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS58639B1 (sr) | 2015-07-06 | 2019-05-31 | Gilead Sciences Inc | Cot modulatori i postupci za njihovu upotrebu |
| CN109705071B (zh) * | 2017-10-25 | 2020-11-13 | 成都先导药物开发股份有限公司 | Hdac抑制剂及其制备方法和用途 |
| CN108299255B (zh) * | 2018-02-11 | 2020-05-19 | 山东大学 | 组蛋白去乙酰化酶8选择性抑制剂及其制备方法和应用 |
| TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
| KR102924836B1 (ko) | 2020-03-30 | 2026-02-09 | 길리애드 사이언시즈, 인코포레이티드 | Cot 억제제 화합물, (S)-6-(((1-(바이사이클로[1.1.1]펜탄-1-일)-1H-1,2,3-트라이아졸-4-일)2-메틸-1-옥소-1,2-다이하이드로아이소퀴놀린-5-일)메틸)))아미노8-클로로-(네오펜틸아미노)퀴놀린-3-카르보니트릴의 고체 형태 |
| WO2021202688A1 (en) | 2020-04-02 | 2021-10-07 | Gilead Sciences, Inc. | Process for preparing a cot inhibitor compound |
| CA3253074A1 (en) * | 2022-05-20 | 2025-07-08 | Sichuan Huiyu Pharmaceutical Co., Ltd. | Hydroxyamide derivative and its use |
| CN116803983A (zh) * | 2022-05-26 | 2023-09-26 | 杭州师范大学 | 一种组蛋白去乙酰化酶和热休克蛋白110KDa双靶点抑制剂及应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040090979A (ko) * | 2002-03-13 | 2004-10-27 | 얀센 파마슈티카 엔.브이. | 히스톤 데아세틸레이즈의 신규한 억제제 |
| WO2004013324A1 (ja) * | 2002-08-01 | 2004-02-12 | Mochida Pharmaceutical Co., Ltd. | 結晶性新規トリプターゼおよびその利用 |
| US7345043B2 (en) * | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
| ITFI20050041A1 (it) * | 2005-03-15 | 2006-09-16 | Menarini Internat Operations Luxembourg Sa | Idrossammati come inibitori dell'istone deacelitasi, loro preparazione e formulazioni farmaceutiche che li contengono |
| US8642660B2 (en) * | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| KR20110040911A (ko) * | 2008-07-14 | 2011-04-20 | 노파르티스 아게 | 선택적 히드록삼산계 ｍｍｐ-12 및 ｍｍｐ-13 억제제 |
| US9914717B2 (en) * | 2012-12-20 | 2018-03-13 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| WO2016107541A1 (zh) * | 2014-12-29 | 2016-07-07 | 成都先导药物开发有限公司 | 吡咯酰胺类化合物及其制备方法与用途 |
-
2016
- 2016-12-29 WO PCT/CN2016/112896 patent/WO2017114448A1/zh not_active Ceased
- 2016-12-29 ES ES16881237T patent/ES2920888T3/es active Active
- 2016-12-29 CN CN201611243758.3A patent/CN106928198B/zh active Active
- 2016-12-29 KR KR1020187019144A patent/KR102264012B1/ko active Active
- 2016-12-29 US US16/067,097 patent/US11149008B2/en active Active
- 2016-12-29 EP EP16881237.8A patent/EP3398598B1/en active Active
- 2016-12-29 PT PT168812378T patent/PT3398598T/pt unknown
- 2016-12-29 JP JP2018534705A patent/JP6804540B2/ja active Active
- 2016-12-29 PL PL16881237.8T patent/PL3398598T3/pl unknown
- 2016-12-29 CA CA3010326A patent/CA3010326C/en active Active
- 2016-12-29 AU AU2016382372A patent/AU2016382372B2/en active Active
- 2016-12-29 DK DK16881237.8T patent/DK3398598T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| US11149008B2 (en) | 2021-10-19 |
| EP3398598B1 (en) | 2022-04-06 |
| EP3398598A1 (en) | 2018-11-07 |
| AU2016382372A1 (en) | 2018-07-19 |
| KR102264012B1 (ko) | 2021-06-10 |
| JP2019501919A (ja) | 2019-01-24 |
| CN106928198A (zh) | 2017-07-07 |
| ES2920888T3 (es) | 2022-08-11 |
| AU2016382372B2 (en) | 2019-09-19 |
| DK3398598T3 (da) | 2022-07-11 |
| US20190031612A1 (en) | 2019-01-31 |
| JP6804540B2 (ja) | 2020-12-23 |
| CA3010326A1 (en) | 2017-07-06 |
| KR20180086258A (ko) | 2018-07-30 |
| CN106928198B (zh) | 2020-07-28 |
| WO2017114448A1 (zh) | 2017-07-06 |
| EP3398598A4 (en) | 2018-11-07 |
| CA3010326C (en) | 2020-07-14 |
| PT3398598T (pt) | 2022-07-12 |
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