SK286124B6 - Spôsob prípravy medziproduktov florfenikolu - Google Patents

Spôsob prípravy medziproduktov florfenikolu Download PDF

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Publication number
SK286124B6
SK286124B6 SK199-99A SK19999A SK286124B6 SK 286124 B6 SK286124 B6 SK 286124B6 SK 19999 A SK19999 A SK 19999A SK 286124 B6 SK286124 B6 SK 286124B6
Authority
SK
Slovakia
Prior art keywords
compound
formula
benzyl
alkyl
general formula
Prior art date
Application number
SK199-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK19999A3 (en
Inventor
James C. Towson
Dhiru B. Vashi
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24808601&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK286124(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of SK19999A3 publication Critical patent/SK19999A3/sk
Publication of SK286124B6 publication Critical patent/SK286124B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK199-99A 1996-08-19 1997-08-18 Spôsob prípravy medziproduktov florfenikolu SK286124B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/699,271 US5663361A (en) 1996-08-19 1996-08-19 Process for preparing intermediates to florfenicol
PCT/US1997/014205 WO1998007709A1 (en) 1996-08-19 1997-08-18 Process for preparing intermediates to florfenicol

Publications (2)

Publication Number Publication Date
SK19999A3 SK19999A3 (en) 2000-02-14
SK286124B6 true SK286124B6 (sk) 2008-04-07

Family

ID=24808601

Family Applications (1)

Application Number Title Priority Date Filing Date
SK199-99A SK286124B6 (sk) 1996-08-19 1997-08-18 Spôsob prípravy medziproduktov florfenikolu

Country Status (31)

Country Link
US (1) US5663361A (pt)
EP (1) EP0922040B2 (pt)
JP (1) JP3274868B2 (pt)
KR (1) KR100286851B1 (pt)
CN (1) CN1097583C (pt)
AR (1) AR008298A1 (pt)
AT (1) ATE283847T1 (pt)
AU (1) AU714495B2 (pt)
BR (1) BR9711318B1 (pt)
CA (1) CA2264116C (pt)
CO (1) CO4560550A1 (pt)
CZ (1) CZ297915B6 (pt)
DE (1) DE69731835T3 (pt)
DK (1) DK0922040T3 (pt)
ES (1) ES2234026T5 (pt)
HK (1) HK1017890A1 (pt)
HU (1) HU229610B1 (pt)
ID (1) ID18047A (pt)
IL (1) IL128574A (pt)
MY (1) MY115679A (pt)
NO (1) NO312962B1 (pt)
NZ (1) NZ334111A (pt)
PE (1) PE99798A1 (pt)
PL (2) PL196454B1 (pt)
PT (1) PT922040E (pt)
SI (1) SI0922040T1 (pt)
SK (1) SK286124B6 (pt)
TR (2) TR199900354T2 (pt)
TW (1) TW381075B (pt)
WO (1) WO1998007709A1 (pt)
ZA (1) ZA977406B (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1173933C (zh) * 2001-06-01 2004-11-03 中国科学院上海有机化学研究所 一种从l型取代苯丝氨酸酯制备d－（－）－苏式1－r－取代苯基－2－二氯乙酰氨基－3－氟－1－丙醇的方法
CN1649829A (zh) * 2002-03-08 2005-08-03 先灵-普劳有限公司 新型氟苯尼考类抗生素
PE20050386A1 (es) * 2003-05-29 2005-06-23 Schering Plough Ltd Composiciones farmaceuticas de florfenicol
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
US7126005B2 (en) * 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
CN102499928A (zh) 2004-08-13 2012-06-20 先灵-普劳有限公司 包含抗菌素、三唑和皮质类固醇的药物制剂
MX2007003378A (es) 2004-09-23 2007-05-10 Schering Plough Ltd Control de parasitos en animales mediante el uso de nuevos derivados de trifluorometansulfonanilida oxima eter.
WO2006055565A2 (en) * 2004-11-19 2006-05-26 Schering-Plough Ltd. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives
AU2005318187B2 (en) * 2004-12-21 2010-12-16 Intervet International B.V. Injectable veterinary composition
JP2008545788A (ja) * 2005-06-09 2008-12-18 シェーリング−プラウ・リミテッド Ｎ−［（フェニルオキシ）フェニル］−１，１，１−トリフルオロメタンスルホンアミドおよびｎ−［（フェニルスルファニル）フェニル）］−１，１，１−トリフルオロメタンスルホンアミド誘導体による動物中の寄生生物の制御
TW200800924A (en) * 2005-09-07 2008-01-01 Schering Plough Ltd A process for preparing oxazolidine protected aminodiol compounds useful as intermediates to florfenicol
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
CA2672586A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
US8044230B2 (en) * 2006-12-13 2011-10-25 Intervet Inc. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
AR066265A1 (es) * 2007-04-27 2009-08-05 Schering Plough Ltd Compuestos y metodos para mejorar la solubilidad de florfenicol y antibioticos estructuralmente relacionados por medio del uso de ciclodextrinas. composicion. complejo. kit. metodo de tratamiento.
MX2009013016A (es) * 2007-05-30 2010-02-17 Schering Plough Ltd Un procedimiento para preparar compuestos de aminodiol oxazolina-protegidos utiles como intermediarios para florfenicol.
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
CN101743000A (zh) 2007-06-27 2010-06-16 杜邦公司 动物虫害控制方法
CA2693922A1 (en) * 2007-07-25 2009-01-29 Intervet International B.V. Process for preparing oxazolidine-and oxazolidinone-aminodiols
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
KR20100085162A (ko) * 2007-11-09 2010-07-28 인터벳 인터내셔널 비.브이. 속방성 고체 제형, 제조 및 이의 용도
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
WO2010014566A2 (en) * 2008-07-30 2010-02-04 Intervet International B.V. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
AU2010279574A1 (en) 2009-08-05 2012-02-09 E. I. Du Pont De Nemours And Company Mesoionic pesticides
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
JP2013501063A (ja) 2009-08-05 2013-01-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー メソイオン性殺虫剤
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
ES2566402T3 (es) 2010-05-27 2016-04-12 E. I. Du Pont De Nemours And Company Forma cristalina de 4-[5-[3-cloro-5-(trifluorometil)fenil]-4,5-dihidro-5-(trifluorometil)-3-isoxazolil]-N-[2-oxo-2-[(2,2,2-trifluoroetil)amino]etil]-1-naftalenocarboxamida
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN102911133B (zh) * 2012-10-31 2014-07-02 绍兴民生医药有限公司 (4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103254147B (zh) * 2013-04-19 2016-04-06 浙江科技学院 一种d-苏式-2-(二氯甲基)-4,5-二氢-5-[对-（甲砜基）苯基]-4-噁唑甲醇的制备方法
CN106278964B (zh) * 2016-07-31 2018-01-16 浙江润康药业有限公司 氟苯尼考的制备方法
CN106631872A (zh) * 2016-12-13 2017-05-10 浙江普洛家园药业有限公司 一种氟苯尼考类似物中间体的合成方法
CN110272856B (zh) * 2019-05-08 2022-05-03 江南大学 一种表达d-苏氨酸醛缩酶的重组菌及其构建方法与应用
CN117466787B (zh) * 2023-12-28 2024-03-22 山东国邦药业有限公司 一种氟苯尼考中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2759001A (en) * 1952-03-01 1956-08-14 Parke Davis & Co Process for the production of delta2-oxazolines
US4361557A (en) * 1980-01-28 1982-11-30 Schering Corporation 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor
EP0677511A3 (en) * 1983-06-02 1996-07-24 Zambon Spa Intermediates for the production of 1-phenyl-1-hydroxy-2-amino-3-fluoropropane derivatives.
US4876352A (en) * 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
EP0405104A1 (en) † 1989-05-15 1991-01-02 Schering Corporation Process for preparing antibacterial compounds and intermediates thereto
ATE115123T1 (de) * 1990-10-25 1994-12-15 Schering Corp Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte.

Also Published As

Publication number Publication date
PL331644A1 (en) 1999-08-02
NO312962B1 (no) 2002-07-22
PL196454B1 (pl) 2008-01-31
CO4560550A1 (es) 1998-02-10
AR008298A1 (es) 1999-12-29
ZA977406B (en) 1998-02-18
CN1097583C (zh) 2003-01-01
SK19999A3 (en) 2000-02-14
ES2234026T3 (es) 2005-06-16
DE69731835T3 (de) 2013-12-05
DE69731835T2 (de) 2005-07-21
IL128574A0 (en) 2000-01-31
DK0922040T3 (da) 2005-04-04
US5663361A (en) 1997-09-02
EP0922040A1 (en) 1999-06-16
CA2264116A1 (en) 1998-02-26
PL198553B1 (pl) 2008-06-30
AU714495B2 (en) 2000-01-06
HK1017890A1 (en) 1999-12-03
ID18047A (id) 1998-02-19
DE69731835D1 (de) 2005-01-05
CA2264116C (en) 2002-07-02
PE99798A1 (es) 1998-12-28
CZ54099A3 (cs) 1999-07-14
EP0922040B2 (en) 2013-07-17
HUP9904166A3 (en) 2001-11-28
IL128574A (en) 2002-04-21
TR200800474T2 (tr) 2008-04-21
JP2000501424A (ja) 2000-02-08
BR9711318A (pt) 1999-08-17
TR199900354T2 (xx) 1999-05-21
KR100286851B1 (ko) 2001-04-16
NZ334111A (en) 1999-10-28
SI0922040T1 (en) 2005-02-28
NO990756L (no) 1999-02-18
WO1998007709A1 (en) 1998-02-26
HUP9904166A2 (hu) 2000-05-28
TW381075B (en) 2000-02-01
CN1233244A (zh) 1999-10-27
KR20000068178A (ko) 2000-11-25
AU4063897A (en) 1998-03-06
ATE283847T1 (de) 2004-12-15
HU229610B1 (en) 2014-03-28
BR9711318B1 (pt) 2009-01-13
NO990756D0 (no) 1999-02-18
CZ297915B6 (cs) 2007-04-25
JP3274868B2 (ja) 2002-04-15
PT922040E (pt) 2005-02-28
EP0922040B1 (en) 2004-12-01
ES2234026T5 (es) 2013-11-12
MY115679A (en) 2003-08-30

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Legal Events

Date Code Title Description
TC4A Change of owner's name

Owner name: MERCK SHARP & DOHME CORP., RAHWAY, NJ, US

Effective date: 20121108

MK4A Expiry of patent

Expiry date: 20170818