CO4560550A1 - Proceso para preparar intermediarios de florfenicol - Google Patents

Proceso para preparar intermediarios de florfenicol

Info

Publication number
CO4560550A1
CO4560550A1 CO97047276A CO97047276A CO4560550A1 CO 4560550 A1 CO4560550 A1 CO 4560550A1 CO 97047276 A CO97047276 A CO 97047276A CO 97047276 A CO97047276 A CO 97047276A CO 4560550 A1 CO4560550 A1 CO 4560550A1
Authority
CO
Colombia
Prior art keywords
compound
formula
alkyl
see
prepare
Prior art date
Application number
CO97047276A
Other languages
English (en)
Inventor
James C Towson
B Vashi Dhiru
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24808601&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO4560550(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of CO4560550A1 publication Critical patent/CO4560550A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. UN PROCESO PARA PREPARAR UN COMPUESTO DE FORMULA (I);VER FIGURA I DONDE R ES H,NO2,CH3S,CH3SO2,O C4 A C6 ALQUILO Y RANDm ES ARILO, HALOARILO, BENCILO, BENCILO SUSTITUIDO, C1 A C6 ALQUILO C3 A C7 CICLOALQUILO, HALOALQUILO Y LA CONFIGURACION DEL ANILLO OXANO- LIDINA ES 4R TRANS: QUE COMPRENDE: A) CONTACTAR UN COMPUESTO DE FORMULA II: VER FIGURA II DONDE R ESCOMO DESCRIBE ANTERIORMENTE, Y R ES H, C1 A C6 ALQUILO, C3 A C7 CICLOALQUILO, BENCILO, BENCILO SUSUTITUIDO O ARILO; CON UN AGENTE REDUCTOR TAL COMO BOHIDRURO DE POTASIO, EN UN RECIPIENTE DE REACCION ADECUADO, PARA OBTENER UN COMPUESTO DE FORMULA III: VER FIGURA III DONDE R ES COMO SE DESCRIBE ANTERIORMENTE, Y B) LUEGO REACCIONA EN EL MISMO RECIPIENTE DE REACCION ADECUADO, PARA OBTENER UN COMPUESTO DE LA FORMULA IV: R´´---C=N PARA OBTENER UN COMPUESTO DE FORMULA I. 2. UN PROCESO DE ACUERDO CON LA REIVINDICACION 1 DONDE EL AGENTE REDUCTOR ES BOHIDURO DE POTASIO. O
CO97047276A 1996-08-19 1997-08-15 Proceso para preparar intermediarios de florfenicol CO4560550A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/699,271 US5663361A (en) 1996-08-19 1996-08-19 Process for preparing intermediates to florfenicol

Publications (1)

Publication Number Publication Date
CO4560550A1 true CO4560550A1 (es) 1998-02-10

Family

ID=24808601

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97047276A CO4560550A1 (es) 1996-08-19 1997-08-15 Proceso para preparar intermediarios de florfenicol

Country Status (31)

Country Link
US (1) US5663361A (es)
EP (1) EP0922040B2 (es)
JP (1) JP3274868B2 (es)
KR (1) KR100286851B1 (es)
CN (1) CN1097583C (es)
AR (1) AR008298A1 (es)
AT (1) ATE283847T1 (es)
AU (1) AU714495B2 (es)
BR (1) BR9711318B1 (es)
CA (1) CA2264116C (es)
CO (1) CO4560550A1 (es)
CZ (1) CZ297915B6 (es)
DE (1) DE69731835T3 (es)
DK (1) DK0922040T3 (es)
ES (1) ES2234026T5 (es)
HK (1) HK1017890A1 (es)
HU (1) HU229610B1 (es)
ID (1) ID18047A (es)
IL (1) IL128574A (es)
MY (1) MY115679A (es)
NO (1) NO312962B1 (es)
NZ (1) NZ334111A (es)
PE (1) PE99798A1 (es)
PL (2) PL198553B1 (es)
PT (1) PT922040E (es)
SI (1) SI0922040T1 (es)
SK (1) SK286124B6 (es)
TR (2) TR199900354T2 (es)
TW (1) TW381075B (es)
WO (1) WO1998007709A1 (es)
ZA (1) ZA977406B (es)

Families Citing this family (40)

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CN1173933C (zh) * 2001-06-01 2004-11-03 中国科学院上海有机化学研究所 一种从l型取代苯丝氨酸酯制备d－（－）－苏式1－r－取代苯基－2－二氯乙酰氨基－3－氟－1－丙醇的方法
CA2478048A1 (en) * 2002-03-08 2003-09-25 Schering-Plough, Ltd. Novel florfenicol-type antibiotics
AR044437A1 (es) 2003-05-29 2005-09-14 Schering Plough Ltd Composiciones y metodo para el tratamiento de infecciones en ganado vacuno y porcino
US7439268B2 (en) 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
US7126005B2 (en) * 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
NZ553119A (en) 2004-08-13 2010-11-26 Schering Plough Ltd Pharmaceutical formulation comprising an antibiotic, a triazole and a corticosteroid
KR20070054691A (ko) 2004-09-23 2007-05-29 쉐링-프라우 리미티드 신규한 트리플루오로메탄설폰아미드 옥심 에테르 유도체를사용하여 동물의 기생충 방제
WO2006055565A2 (en) * 2004-11-19 2006-05-26 Schering-Plough Ltd. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives
JP5017122B2 (ja) * 2004-12-21 2012-09-05 インターベツト・インターナシヨナル・ベー・ベー 注射可能な獣医学組成物
WO2006135648A2 (en) * 2005-06-09 2006-12-21 Schering-Plough Ltd. Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
ES2459205T3 (es) * 2005-09-07 2014-05-08 Intervet International Bv Proceso para preparar compuestos de oxazolidina éster y su conversión en florfenicol
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
CA2672795A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
WO2008076259A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
JP2010525059A (ja) * 2007-04-27 2010-07-22 シェーリング−プラウ・リミテッド シクロデキストリンを用いてフロルフェニコールおよび構造的に関連する抗生物質の溶解度を高めるための化合物および方法
PE20090758A1 (es) * 2007-05-30 2009-06-24 Schering Plough Ltd Un proceso para la preparacion de compuestos de aminodiol protegidos con oxazolina, utiles como intermediarios para florfenicol
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
CN101743000A (zh) 2007-06-27 2010-06-16 杜邦公司 动物虫害控制方法
EP2173726A2 (en) * 2007-07-25 2010-04-14 Intervet International B.V. Process for preparing oxazolidine- and oxazolidinone-aminodiols
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
AU2008324852A1 (en) * 2007-11-09 2009-05-14 Intervet International B.V. Fast release solid formulation, preparation and use thereof
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
KR20110038723A (ko) * 2008-07-30 2011-04-14 인터벳 인터내셔널 비.브이. 플로르페니콜에 대한 중간체로서 유용한 옥사졸린-보호된 아미노디올 화합물의 제조 방법
CN102574815A (zh) 2009-08-05 2012-07-11 杜邦公司 介离子杀虫剂
MX2012001651A (es) 2009-08-05 2012-03-16 Du Pont Pesticidas mesoionicos.
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
US8598087B2 (en) 2010-05-27 2013-12-03 E. I. Du Pont De Nemours And Company Crystalline form of 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-0X0-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1- naph-thalenecarboxamide
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN102911133B (zh) * 2012-10-31 2014-07-02 绍兴民生医药有限公司 (4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103254147B (zh) * 2013-04-19 2016-04-06 浙江科技学院 一种d-苏式-2-(二氯甲基)-4,5-二氢-5-[对-（甲砜基）苯基]-4-噁唑甲醇的制备方法
CN106278964B (zh) * 2016-07-31 2018-01-16 浙江润康药业有限公司 氟苯尼考的制备方法
CN106631872A (zh) * 2016-12-13 2017-05-10 浙江普洛家园药业有限公司 一种氟苯尼考类似物中间体的合成方法
CN110272856B (zh) * 2019-05-08 2022-05-03 江南大学 一种表达d-苏氨酸醛缩酶的重组菌及其构建方法与应用
CN117466787B (zh) * 2023-12-28 2024-03-22 山东国邦药业有限公司 一种氟苯尼考中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2759001A (en) * 1952-03-01 1956-08-14 Parke Davis & Co Process for the production of delta2-oxazolines
US4361557A (en) * 1980-01-28 1982-11-30 Schering Corporation 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor
EP0678506A3 (en) * 1983-06-02 1996-07-24 Zambon Spa Intermediates for the preparation of 1-phenyl-1-hydroxy-2-amino-3-fluoropropane derivatives.
US4876352A (en) * 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
KR920701469A (ko) † 1989-05-15 1992-08-11 스테이너 브이. 캔스태드 향균성 화합물 및 이의 중간물질의 제조방법
HU212617B (en) * 1990-10-25 1996-09-30 Schering Corp Process for preparating florfenicol and its analogs thereto

Also Published As

Publication number Publication date
PL198553B1 (pl) 2008-06-30
HUP9904166A3 (en) 2001-11-28
ES2234026T3 (es) 2005-06-16
DE69731835T2 (de) 2005-07-21
SK286124B6 (sk) 2008-04-07
JP3274868B2 (ja) 2002-04-15
PL196454B1 (pl) 2008-01-31
SK19999A3 (en) 2000-02-14
ATE283847T1 (de) 2004-12-15
AU4063897A (en) 1998-03-06
KR100286851B1 (ko) 2001-04-16
NZ334111A (en) 1999-10-28
PE99798A1 (es) 1998-12-28
TW381075B (en) 2000-02-01
ZA977406B (en) 1998-02-18
DE69731835T3 (de) 2013-12-05
KR20000068178A (ko) 2000-11-25
HK1017890A1 (en) 1999-12-03
ES2234026T5 (es) 2013-11-12
CN1097583C (zh) 2003-01-01
CZ54099A3 (cs) 1999-07-14
EP0922040B1 (en) 2004-12-01
PT922040E (pt) 2005-02-28
US5663361A (en) 1997-09-02
MY115679A (en) 2003-08-30
BR9711318B1 (pt) 2009-01-13
CZ297915B6 (cs) 2007-04-25
NO312962B1 (no) 2002-07-22
WO1998007709A1 (en) 1998-02-26
CA2264116A1 (en) 1998-02-26
NO990756L (no) 1999-02-18
EP0922040A1 (en) 1999-06-16
TR200800474T2 (tr) 2008-04-21
CA2264116C (en) 2002-07-02
HUP9904166A2 (hu) 2000-05-28
SI0922040T1 (en) 2005-02-28
CN1233244A (zh) 1999-10-27
TR199900354T2 (xx) 1999-05-21
EP0922040B2 (en) 2013-07-17
AR008298A1 (es) 1999-12-29
AU714495B2 (en) 2000-01-06
ID18047A (id) 1998-02-19
DE69731835D1 (de) 2005-01-05
IL128574A (en) 2002-04-21
BR9711318A (pt) 1999-08-17
IL128574A0 (en) 2000-01-31
PL331644A1 (en) 1999-08-02
NO990756D0 (no) 1999-02-18
HU229610B1 (en) 2014-03-28
JP2000501424A (ja) 2000-02-08
DK0922040T3 (da) 2005-04-04

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