ES2183185T3 - Procedimiento para preparar tetraazamacrociclos. - Google Patents
Procedimiento para preparar tetraazamacrociclos.Info
- Publication number
- ES2183185T3 ES2183185T3 ES97928162T ES97928162T ES2183185T3 ES 2183185 T3 ES2183185 T3 ES 2183185T3 ES 97928162 T ES97928162 T ES 97928162T ES 97928162 T ES97928162 T ES 97928162T ES 2183185 T3 ES2183185 T3 ES 2183185T3
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- tetraazamacrociclos
- prepare
- resulting compound
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO PARA LA PREPARACION DE TETRAAZAMACROCICLOS DE FORMULA GENERAL (I) EN LA QUE N, P Y Q PUEDEN SER INDEPENDIENTEMENTE 0 O 1, Y QUE INCLUYE LOS PASOS SIGUIENTES: A) CONDENSACION DE POLIAMINAS CON UN DERIVADO GLIOXAL; B) CONDENSACION DEL COMPUESTO RESULTANTE CON UN AGENTE ALQUILANTE; C) OXIDACION DEL COMPUESTO RESULTANTE CON UN AGENTE OXIDANTE, PARA DAR UNA MEZCLA DE PRODUCTOS OXIDADOS QUE SE SOMETE A D) HIDROLISIS EN SOLUCION ACUOSA ACIDA, PARA OBTENER EL COMPUESTO DE FORMULA (I).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI001257A IT1284046B1 (it) | 1996-06-21 | 1996-06-21 | Processo per la preparazione di tetraazamacrocicli |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2183185T3 true ES2183185T3 (es) | 2003-03-16 |
Family
ID=11374458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97928162T Expired - Lifetime ES2183185T3 (es) | 1996-06-21 | 1997-06-09 | Procedimiento para preparar tetraazamacrociclos. |
Country Status (16)
Country | Link |
---|---|
US (3) | US5880281A (es) |
EP (1) | EP0914320B1 (es) |
JP (1) | JP4308323B2 (es) |
CN (1) | CN1083442C (es) |
AT (1) | ATE223389T1 (es) |
AU (1) | AU3256497A (es) |
CA (1) | CA2258768C (es) |
CZ (1) | CZ295406B6 (es) |
DE (1) | DE69715211T2 (es) |
ES (1) | ES2183185T3 (es) |
HU (1) | HU223439B1 (es) |
IN (1) | IN183348B (es) |
IT (1) | IT1284046B1 (es) |
NO (1) | NO310621B1 (es) |
WO (1) | WO1997049691A1 (es) |
ZA (1) | ZA975425B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1284046B1 (it) * | 1996-06-21 | 1998-05-08 | Bracco Spa | Processo per la preparazione di tetraazamacrocicli |
IT1290457B1 (it) * | 1997-04-04 | 1998-12-03 | Bracco Spa | Processo per la preparazione di tetraazamacrocicli |
IT1291673B1 (it) * | 1997-04-28 | 1999-01-19 | Bracco Spa | Processo per la preparazione di 1,4,7,10 - tetraazaciclododecano |
IT1293777B1 (it) * | 1997-07-25 | 1999-03-10 | Bracco Spa | Processo per la preparazione di tetraazamacrocicli |
DE19809542A1 (de) * | 1998-03-05 | 1999-09-09 | Clariant Gmbh | Quaternäre polycyclische Polyammoniumsalze und Verfahren zu deren Herstellung |
DE19809543A1 (de) * | 1998-03-05 | 1999-09-09 | Clariant Gmbh | Verfahren zur Herstellung von makropolycyclischen Polymaninen |
DE19856481C1 (de) * | 1998-12-02 | 2000-07-06 | Schering Ag | Verfahren zur Herstellung von Cyclen |
US6156890A (en) * | 1999-01-15 | 2000-12-05 | Schering Aktiengesellschaft | Process for the production of cyclene |
IT1309601B1 (it) * | 1999-03-09 | 2002-01-24 | Bracco Spa | Processo per la preparazione di 1,4,7,10 tetraazaciclododecano. |
US6685914B1 (en) * | 1999-09-13 | 2004-02-03 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants for metallopharmaceuticals |
US7067111B1 (en) * | 1999-10-25 | 2006-06-27 | Board Of Regents, University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
EP2316494A1 (en) * | 2000-06-02 | 2011-05-04 | Board Of Regents, The University Of Texas | Ethylenedicysteine (EC)-neomycin conjugates and their use in tissue specific disease imaging |
FR2810035B1 (fr) * | 2000-06-13 | 2004-04-16 | Air Liquide | Procede de preparation de tetraaza macrocycles et nouveaux composes |
FR2856063B1 (fr) * | 2003-06-13 | 2005-10-07 | Air Liquide | Procede de preparation du cis-8b-methyldecahydro-2a,4a,6a, 8a-tetraazacyclopenta[fg]acenaphthylene,ou du cis-decahydro-2a,4a,6a,8a-tetraazacyclopenta[fg] acenaphthylene, du cyclene, et de cyclenes fonctionnalises |
US7498432B2 (en) | 2003-06-25 | 2009-03-03 | Board Of Trustees Of Michigan State University | Method of synthesis of 1, 4, 7, 10, 13, 16, 21, 24-octaazabicyclo [8.8.8] hexacosane (1) and 1, 4, 7, 10, 13, 16, 21, 24-octaazabicyclo [8.8.8] hexacosa, 4, 6, 13, 15, 21, 23-hexaene (2) |
US9050378B2 (en) * | 2003-12-10 | 2015-06-09 | Board Of Regents, The University Of Texas System | N2S2 chelate-targeting ligand conjugates |
DE102004003710A1 (de) * | 2004-01-24 | 2005-08-11 | Clariant Gmbh | Verwendung von Übergangsmetallkomplexen als Bleichkatalysatoren in Wasch- und Reinigungsmitteln |
US8758723B2 (en) * | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
US10925977B2 (en) | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
US20100104511A1 (en) * | 2006-11-22 | 2010-04-29 | The Board Of Regents Of The University Of Texas System | Methods and compositions using chelator-antibody conjugates |
WO2008119036A2 (en) | 2007-03-27 | 2008-10-02 | Radiomedix Inc. | Compositions for targeted imaging and therapy |
US11473032B2 (en) | 2010-02-02 | 2022-10-18 | Fuchs Petrolub Se | Constant velocity joint having a boot |
EP2721045B1 (en) | 2011-06-20 | 2017-04-12 | Radiomedix Inc. | Compositions, methods of synthesis and use of carbohydrate targeted agents |
CN103360333B (zh) * | 2013-07-22 | 2016-03-30 | 厦门市华兴化工有限公司 | 一种高纯度轮环藤宁的制备方法 |
CN104387336B (zh) * | 2014-10-24 | 2016-04-27 | 上海应用技术学院 | 1,4,7,10-四氮杂环十二烷及其纳滤膜的制备方法 |
IL271681A (en) | 2018-07-18 | 2020-01-30 | Vyripharm Entpr Llc | Systems and methods for integrated and comprehensive management of cannabis products |
CN113956262B (zh) * | 2021-10-18 | 2023-03-07 | 苏州百灵威超精细材料有限公司 | 一种四氮杂环烷类化合物及其中间体的合成方法 |
CN113801123B (zh) * | 2021-10-18 | 2022-12-09 | 苏州百灵威超精细材料有限公司 | 一种1,4,8,11-四氮杂环十四烷类化合物及其中间体的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3485818A (en) * | 1968-04-05 | 1969-12-23 | Jerome B Thompson | 1,4,7,10-tetraazacyclododecene and 1,4,7,10,13 - pentaazacyclopentadecene and process for their manufacture |
US3932451A (en) * | 1973-11-27 | 1976-01-13 | E. I. Du Pont De Nemours & Company | 1,4,7,10-Tetraazatetracyclo[5.5.1.04,13.010,13 ]tridecane and its conjugate acids |
FR2654102B1 (fr) * | 1989-11-09 | 1992-01-10 | Air Liquide | Procede de synthese de derives polyazotes cycliques. |
US5587451A (en) * | 1993-11-26 | 1996-12-24 | The Dow Chemical Company | Process for preparing polyazamacrocycles |
GB9504922D0 (en) * | 1995-03-10 | 1995-04-26 | Nycomed As | Process |
IT1284046B1 (it) * | 1996-06-21 | 1998-05-08 | Bracco Spa | Processo per la preparazione di tetraazamacrocicli |
-
1996
- 1996-06-21 IT IT96MI001257A patent/IT1284046B1/it active IP Right Grant
-
1997
- 1997-06-09 EP EP97928162A patent/EP0914320B1/en not_active Expired - Lifetime
- 1997-06-09 CA CA002258768A patent/CA2258768C/en not_active Expired - Lifetime
- 1997-06-09 ES ES97928162T patent/ES2183185T3/es not_active Expired - Lifetime
- 1997-06-09 HU HU9903380A patent/HU223439B1/hu active IP Right Grant
- 1997-06-09 WO PCT/EP1997/002987 patent/WO1997049691A1/en active IP Right Grant
- 1997-06-09 JP JP50219498A patent/JP4308323B2/ja not_active Expired - Lifetime
- 1997-06-09 AU AU32564/97A patent/AU3256497A/en not_active Abandoned
- 1997-06-09 CN CN97195647A patent/CN1083442C/zh not_active Expired - Lifetime
- 1997-06-09 AT AT97928162T patent/ATE223389T1/de not_active IP Right Cessation
- 1997-06-09 CZ CZ19984210A patent/CZ295406B6/cs not_active IP Right Cessation
- 1997-06-09 DE DE69715211T patent/DE69715211T2/de not_active Expired - Lifetime
- 1997-06-19 US US08/878,508 patent/US5880281A/en not_active Expired - Lifetime
- 1997-06-19 IN IN1333MA1997 patent/IN183348B/en unknown
- 1997-06-19 ZA ZA9705425A patent/ZA975425B/xx unknown
-
1998
- 1998-12-02 US US09/203,604 patent/US6013793A/en not_active Expired - Lifetime
- 1998-12-02 US US09/203,595 patent/US6114521A/en not_active Expired - Lifetime
- 1998-12-18 NO NO19985992A patent/NO310621B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IN183348B (es) | 1999-11-27 |
ATE223389T1 (de) | 2002-09-15 |
US5880281A (en) | 1999-03-09 |
CZ421098A3 (cs) | 1999-06-16 |
US6013793A (en) | 2000-01-11 |
ITMI961257A0 (es) | 1996-06-21 |
IT1284046B1 (it) | 1998-05-08 |
DE69715211D1 (de) | 2002-10-10 |
WO1997049691A1 (en) | 1997-12-31 |
AU3256497A (en) | 1998-01-14 |
CZ295406B6 (cs) | 2005-08-17 |
NO985992D0 (no) | 1998-12-18 |
NO310621B1 (no) | 2001-07-30 |
CA2258768A1 (en) | 1997-12-31 |
CN1083442C (zh) | 2002-04-24 |
CN1222147A (zh) | 1999-07-07 |
EP0914320A1 (en) | 1999-05-12 |
DE69715211T2 (de) | 2003-08-07 |
EP0914320B1 (en) | 2002-09-04 |
HU223439B1 (hu) | 2004-07-28 |
JP4308323B2 (ja) | 2009-08-05 |
HUP9903380A3 (en) | 2001-07-30 |
NO985992L (no) | 1999-02-22 |
ITMI961257A1 (it) | 1997-12-21 |
ZA975425B (en) | 1998-01-26 |
US6114521A (en) | 2000-09-05 |
CA2258768C (en) | 2009-03-10 |
JP2000512642A (ja) | 2000-09-26 |
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