ES2183185T3 - Procedimiento para preparar tetraazamacrociclos. - Google Patents

Procedimiento para preparar tetraazamacrociclos.

Info

Publication number
ES2183185T3
ES2183185T3 ES97928162T ES97928162T ES2183185T3 ES 2183185 T3 ES2183185 T3 ES 2183185T3 ES 97928162 T ES97928162 T ES 97928162T ES 97928162 T ES97928162 T ES 97928162T ES 2183185 T3 ES2183185 T3 ES 2183185T3
Authority
ES
Spain
Prior art keywords
procedure
tetraazamacrociclos
prepare
resulting compound
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97928162T
Other languages
English (en)
Inventor
Maria Argese
Giorgio Ripa
Alessandro Scala
Vittorio Valle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Application granted granted Critical
Publication of ES2183185T3 publication Critical patent/ES2183185T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA PREPARACION DE TETRAAZAMACROCICLOS DE FORMULA GENERAL (I) EN LA QUE N, P Y Q PUEDEN SER INDEPENDIENTEMENTE 0 O 1, Y QUE INCLUYE LOS PASOS SIGUIENTES: A) CONDENSACION DE POLIAMINAS CON UN DERIVADO GLIOXAL; B) CONDENSACION DEL COMPUESTO RESULTANTE CON UN AGENTE ALQUILANTE; C) OXIDACION DEL COMPUESTO RESULTANTE CON UN AGENTE OXIDANTE, PARA DAR UNA MEZCLA DE PRODUCTOS OXIDADOS QUE SE SOMETE A D) HIDROLISIS EN SOLUCION ACUOSA ACIDA, PARA OBTENER EL COMPUESTO DE FORMULA (I).
ES97928162T 1996-06-21 1997-06-09 Procedimiento para preparar tetraazamacrociclos. Expired - Lifetime ES2183185T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI001257A IT1284046B1 (it) 1996-06-21 1996-06-21 Processo per la preparazione di tetraazamacrocicli

Publications (1)

Publication Number Publication Date
ES2183185T3 true ES2183185T3 (es) 2003-03-16

Family

ID=11374458

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97928162T Expired - Lifetime ES2183185T3 (es) 1996-06-21 1997-06-09 Procedimiento para preparar tetraazamacrociclos.

Country Status (16)

Country Link
US (3) US5880281A (es)
EP (1) EP0914320B1 (es)
JP (1) JP4308323B2 (es)
CN (1) CN1083442C (es)
AT (1) ATE223389T1 (es)
AU (1) AU3256497A (es)
CA (1) CA2258768C (es)
CZ (1) CZ295406B6 (es)
DE (1) DE69715211T2 (es)
ES (1) ES2183185T3 (es)
HU (1) HU223439B1 (es)
IN (1) IN183348B (es)
IT (1) IT1284046B1 (es)
NO (1) NO310621B1 (es)
WO (1) WO1997049691A1 (es)
ZA (1) ZA975425B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1284046B1 (it) * 1996-06-21 1998-05-08 Bracco Spa Processo per la preparazione di tetraazamacrocicli
IT1290457B1 (it) * 1997-04-04 1998-12-03 Bracco Spa Processo per la preparazione di tetraazamacrocicli
IT1291673B1 (it) * 1997-04-28 1999-01-19 Bracco Spa Processo per la preparazione di 1,4,7,10 - tetraazaciclododecano
IT1293777B1 (it) * 1997-07-25 1999-03-10 Bracco Spa Processo per la preparazione di tetraazamacrocicli
DE19809542A1 (de) * 1998-03-05 1999-09-09 Clariant Gmbh Quaternäre polycyclische Polyammoniumsalze und Verfahren zu deren Herstellung
DE19809543A1 (de) * 1998-03-05 1999-09-09 Clariant Gmbh Verfahren zur Herstellung von makropolycyclischen Polymaninen
DE19856481C1 (de) * 1998-12-02 2000-07-06 Schering Ag Verfahren zur Herstellung von Cyclen
US6156890A (en) * 1999-01-15 2000-12-05 Schering Aktiengesellschaft Process for the production of cyclene
IT1309601B1 (it) * 1999-03-09 2002-01-24 Bracco Spa Processo per la preparazione di 1,4,7,10 tetraazaciclododecano.
US6685914B1 (en) * 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US7067111B1 (en) * 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
EP2316494A1 (en) * 2000-06-02 2011-05-04 Board Of Regents, The University Of Texas Ethylenedicysteine (EC)-neomycin conjugates and their use in tissue specific disease imaging
FR2810035B1 (fr) * 2000-06-13 2004-04-16 Air Liquide Procede de preparation de tetraaza macrocycles et nouveaux composes
FR2856063B1 (fr) * 2003-06-13 2005-10-07 Air Liquide Procede de preparation du cis-8b-methyldecahydro-2a,4a,6a, 8a-tetraazacyclopenta[fg]acenaphthylene,ou du cis-decahydro-2a,4a,6a,8a-tetraazacyclopenta[fg] acenaphthylene, du cyclene, et de cyclenes fonctionnalises
US7498432B2 (en) 2003-06-25 2009-03-03 Board Of Trustees Of Michigan State University Method of synthesis of 1, 4, 7, 10, 13, 16, 21, 24-octaazabicyclo [8.8.8] hexacosane (1) and 1, 4, 7, 10, 13, 16, 21, 24-octaazabicyclo [8.8.8] hexacosa, 4, 6, 13, 15, 21, 23-hexaene (2)
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
DE102004003710A1 (de) * 2004-01-24 2005-08-11 Clariant Gmbh Verwendung von Übergangsmetallkomplexen als Bleichkatalysatoren in Wasch- und Reinigungsmitteln
US8758723B2 (en) * 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
US20100104511A1 (en) * 2006-11-22 2010-04-29 The Board Of Regents Of The University Of Texas System Methods and compositions using chelator-antibody conjugates
WO2008119036A2 (en) 2007-03-27 2008-10-02 Radiomedix Inc. Compositions for targeted imaging and therapy
US11473032B2 (en) 2010-02-02 2022-10-18 Fuchs Petrolub Se Constant velocity joint having a boot
EP2721045B1 (en) 2011-06-20 2017-04-12 Radiomedix Inc. Compositions, methods of synthesis and use of carbohydrate targeted agents
CN103360333B (zh) * 2013-07-22 2016-03-30 厦门市华兴化工有限公司 一种高纯度轮环藤宁的制备方法
CN104387336B (zh) * 2014-10-24 2016-04-27 上海应用技术学院 1,4,7,10-四氮杂环十二烷及其纳滤膜的制备方法
IL271681A (en) 2018-07-18 2020-01-30 Vyripharm Entpr Llc Systems and methods for integrated and comprehensive management of cannabis products
CN113956262B (zh) * 2021-10-18 2023-03-07 苏州百灵威超精细材料有限公司 一种四氮杂环烷类化合物及其中间体的合成方法
CN113801123B (zh) * 2021-10-18 2022-12-09 苏州百灵威超精细材料有限公司 一种1,4,8,11-四氮杂环十四烷类化合物及其中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3485818A (en) * 1968-04-05 1969-12-23 Jerome B Thompson 1,4,7,10-tetraazacyclododecene and 1,4,7,10,13 - pentaazacyclopentadecene and process for their manufacture
US3932451A (en) * 1973-11-27 1976-01-13 E. I. Du Pont De Nemours & Company 1,4,7,10-Tetraazatetracyclo[5.5.1.04,13.010,13 ]tridecane and its conjugate acids
FR2654102B1 (fr) * 1989-11-09 1992-01-10 Air Liquide Procede de synthese de derives polyazotes cycliques.
US5587451A (en) * 1993-11-26 1996-12-24 The Dow Chemical Company Process for preparing polyazamacrocycles
GB9504922D0 (en) * 1995-03-10 1995-04-26 Nycomed As Process
IT1284046B1 (it) * 1996-06-21 1998-05-08 Bracco Spa Processo per la preparazione di tetraazamacrocicli

Also Published As

Publication number Publication date
IN183348B (es) 1999-11-27
ATE223389T1 (de) 2002-09-15
US5880281A (en) 1999-03-09
CZ421098A3 (cs) 1999-06-16
US6013793A (en) 2000-01-11
ITMI961257A0 (es) 1996-06-21
IT1284046B1 (it) 1998-05-08
DE69715211D1 (de) 2002-10-10
WO1997049691A1 (en) 1997-12-31
AU3256497A (en) 1998-01-14
CZ295406B6 (cs) 2005-08-17
NO985992D0 (no) 1998-12-18
NO310621B1 (no) 2001-07-30
CA2258768A1 (en) 1997-12-31
CN1083442C (zh) 2002-04-24
CN1222147A (zh) 1999-07-07
EP0914320A1 (en) 1999-05-12
DE69715211T2 (de) 2003-08-07
EP0914320B1 (en) 2002-09-04
HU223439B1 (hu) 2004-07-28
JP4308323B2 (ja) 2009-08-05
HUP9903380A3 (en) 2001-07-30
NO985992L (no) 1999-02-22
ITMI961257A1 (it) 1997-12-21
ZA975425B (en) 1998-01-26
US6114521A (en) 2000-09-05
CA2258768C (en) 2009-03-10
JP2000512642A (ja) 2000-09-26

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