HUP9904166A2 - Eljárás florfenikol intermedierek előállítására - Google Patents
Eljárás florfenikol intermedierek előállításáraInfo
- Publication number
- HUP9904166A2 HUP9904166A2 HU9904166A HUP9904166A HUP9904166A2 HU P9904166 A2 HUP9904166 A2 HU P9904166A2 HU 9904166 A HU9904166 A HU 9904166A HU P9904166 A HUP9904166 A HU P9904166A HU P9904166 A2 HUP9904166 A2 HU P9904166A2
- Authority
- HU
- Hungary
- Prior art keywords
- florfenicol
- preparing intermediates
- intermediates
- carbon
- alkyl
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 title 1
- 229960003760 florfenicol Drugs 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- QSLPNSWXUQHVLP-UHFFFAOYSA-N $l^{1}-sulfanylmethane Chemical compound [S]C QSLPNSWXUQHVLP-UHFFFAOYSA-N 0.000 abstract 1
- MFMZCAORNQSRKY-UHFFFAOYSA-N 2,3-dihydro-1,2,5-oxadiazole Chemical group C1NON=C1 MFMZCAORNQSRKY-UHFFFAOYSA-N 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/28—Nitrogen atoms not forming part of a nitro radical
Abstract
A találmány tárgyát a flőrfenikől, azaz (R-(R*, S*)]-2,2-diklór-N-[1-(flűőr-metil)-2-hidrőxi-2-(4-metilszűlfőnil-fenil)-etil]-acetamid (I)általánős képletű intermedierek -, ahől R H, NO2, CH3S, CH3SO2 vagy 4-6 szénatőmős alkilcsőpőrt; R'' arl-, halőgénaril-, benzil-, szűbsztitűált benzil-, 1-6 szénatőmősalkil-, 3-7 szénatőmős ciklőalkil- és halőgén-alkilcsőpőrt; és azőxazőlingyűrű kőnfigűrációja 4R-transz - előállítására szőlgáló újeljárás képezi. ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/699,271 US5663361A (en) | 1996-08-19 | 1996-08-19 | Process for preparing intermediates to florfenicol |
PCT/US1997/014205 WO1998007709A1 (en) | 1996-08-19 | 1997-08-18 | Process for preparing intermediates to florfenicol |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP9904166A2 true HUP9904166A2 (hu) | 2000-05-28 |
HUP9904166A3 HUP9904166A3 (en) | 2001-11-28 |
HU229610B1 HU229610B1 (en) | 2014-03-28 |
Family
ID=24808601
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9904166A HU229610B1 (en) | 1996-08-19 | 1997-08-18 | Process for preparing intermediates of florfenicol |
Country Status (31)
Country | Link |
---|---|
US (1) | US5663361A (hu) |
EP (1) | EP0922040B2 (hu) |
JP (1) | JP3274868B2 (hu) |
KR (1) | KR100286851B1 (hu) |
CN (1) | CN1097583C (hu) |
AR (1) | AR008298A1 (hu) |
AT (1) | ATE283847T1 (hu) |
AU (1) | AU714495B2 (hu) |
BR (1) | BR9711318B1 (hu) |
CA (1) | CA2264116C (hu) |
CO (1) | CO4560550A1 (hu) |
CZ (1) | CZ297915B6 (hu) |
DE (1) | DE69731835T3 (hu) |
DK (1) | DK0922040T3 (hu) |
ES (1) | ES2234026T5 (hu) |
HK (1) | HK1017890A1 (hu) |
HU (1) | HU229610B1 (hu) |
ID (1) | ID18047A (hu) |
IL (1) | IL128574A (hu) |
MY (1) | MY115679A (hu) |
NO (1) | NO312962B1 (hu) |
NZ (1) | NZ334111A (hu) |
PE (1) | PE99798A1 (hu) |
PL (2) | PL196454B1 (hu) |
PT (1) | PT922040E (hu) |
SI (1) | SI0922040T1 (hu) |
SK (1) | SK286124B6 (hu) |
TR (2) | TR200800474T2 (hu) |
TW (1) | TW381075B (hu) |
WO (1) | WO1998007709A1 (hu) |
ZA (1) | ZA977406B (hu) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1173933C (zh) * | 2001-06-01 | 2004-11-03 | 中国科学院上海有机化学研究所 | 一种从l型取代苯丝氨酸酯制备d-(-)-苏式1-r-取代苯基-2-二氯乙酰氨基-3-氟-1-丙醇的方法 |
BR0308289A (pt) * | 2002-03-08 | 2005-01-11 | Schering Plough Ltd | Antibióticos do tipo florfenicol |
TW200505425A (en) * | 2003-05-29 | 2005-02-16 | Schering Plough Ltd | Compositions and method for treating infection in cattle and swine |
US7439268B2 (en) * | 2003-07-18 | 2008-10-21 | Idexx Laboratories | Compositions containing prodrugs of florfenicol and methods of use |
US20050049210A1 (en) * | 2003-08-27 | 2005-03-03 | Idexx Laboratories, Inc. | Methods for the controlled delivery of pharmacologically active compounds |
US7126005B2 (en) * | 2003-10-06 | 2006-10-24 | Aurobindo Pharma Limited | Process for preparing florfenicol |
AU2005272925B2 (en) * | 2004-08-13 | 2011-02-10 | Intervet International B.V. | Pharmaceutical formulation comprising an antibiotic, a triazole and a corticosteroid |
EP1799636B1 (en) | 2004-09-23 | 2008-08-27 | Schering-Plough Ltd. | Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives |
US7705038B2 (en) * | 2004-11-19 | 2010-04-27 | Intervet, Inc. | Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives |
PL1830885T3 (pl) * | 2004-12-21 | 2009-04-30 | Intervet Int Bv | Iniekcyjna kompozycja weterynaryjna zawierająca florfenikol |
CA2609574A1 (en) * | 2005-06-09 | 2006-12-21 | Schering-Plough Ltd. | Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives |
TW200800924A (en) * | 2005-09-07 | 2008-01-01 | Schering Plough Ltd | A process for preparing oxazolidine protected aminodiol compounds useful as intermediates to florfenicol |
US8119667B2 (en) * | 2005-12-29 | 2012-02-21 | Schering-Plough Animal Health Corporation | Carbonates of fenicol antibiotics |
US7518017B2 (en) | 2006-02-17 | 2009-04-14 | Idexx Laboratories | Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds |
US20070238700A1 (en) * | 2006-04-10 | 2007-10-11 | Winzenberg Kevin N | N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites |
MX2009006467A (es) * | 2006-12-13 | 2009-08-21 | Schering Plough Ltd | Profarmacos solubles en agua de cloranfenicol, tiamfenicol y analogos de los mismos. |
WO2008076259A1 (en) * | 2006-12-13 | 2008-06-26 | Schering-Plough Ltd. | Water-soluble prodrugs of florfenicol and its analogs |
CA2685264A1 (en) * | 2007-04-27 | 2008-11-06 | Schering-Plough Ltd. | Compounds and methods for enhancing solubility of florfenicol and structurally-related antibiotics using cyclodextrins |
US20080319200A1 (en) * | 2007-05-30 | 2008-12-25 | Schering-Plough Animal Health Corp. | Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol |
TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
MX368680B (es) | 2007-06-27 | 2019-10-11 | Du Pont | Administración subcutánea de un derivado de isoxazol-benzamida para usarse en un método para proteger un mamífero de una pulga. |
JP2010534667A (ja) * | 2007-07-25 | 2010-11-11 | インターベツト・インターナシヨナル・ベー・ベー | オキサゾリジンおよびオキサゾリジノンアミノジオール類ならびに関連中間体を調製するためのプロセス |
US7550625B2 (en) * | 2007-10-19 | 2009-06-23 | Idexx Laboratories | Esters of florfenicol |
BRPI0818906A2 (pt) * | 2007-11-09 | 2015-05-12 | Intervet Int Bv | Formulação sólida de liberação rápida, preparação e uso da mesma |
TWI401023B (zh) | 2008-02-06 | 2013-07-11 | Du Pont | 中離子農藥 |
WO2010014566A2 (en) * | 2008-07-30 | 2010-02-04 | Intervet International B.V. | Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol |
JP2013501059A (ja) | 2009-08-05 | 2013-01-10 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | メソイオン性殺虫剤 |
UA110924C2 (uk) | 2009-08-05 | 2016-03-10 | Е. І. Дю Пон Де Немур Енд Компані | Мезоіонні пестициди |
UA107804C2 (en) | 2009-08-05 | 2015-02-25 | Du Pont | Mixtures of pesticides mezoionnyh |
MX2012001646A (es) | 2009-08-05 | 2012-03-21 | Du Pont | Pesticidas mesoionicos. |
BRPI1002023A2 (pt) | 2010-03-01 | 2011-10-25 | Nanocore Biotecnologia S A | forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas |
CA2799963C (en) | 2010-05-27 | 2018-01-23 | E. I. Du Pont De Nemours And Company | Crystalline form of 4- [5 - [3 -chloro-5 - (trifluoromethyl) phenyl] -4,5 -dihydro-5 - (trifluoromethyl) -3 - isoxazolyl] -n- [2-0x0-2- [(2,2,2-trifluoroethyl)amino]ethyl] -1-naphthalenecarboxamide |
WO2012087630A1 (en) | 2010-12-20 | 2012-06-28 | E.I. Du Pont De Nemours And Company | Pyridine and pyrimidine compounds for controlling invertebrate |
WO2013158422A1 (en) | 2012-04-17 | 2013-10-24 | E. I. Du Pont De Nemours And Company | Heterocyclic compounds for controlling invertebrate pests |
CN102911133B (zh) * | 2012-10-31 | 2014-07-02 | 绍兴民生医药有限公司 | (4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法 |
CN103254147B (zh) * | 2013-04-19 | 2016-04-06 | 浙江科技学院 | 一种d-苏式-2-(二氯甲基)-4,5-二氢-5-[对-(甲砜基)苯基]-4-噁唑甲醇的制备方法 |
CN106278964B (zh) * | 2016-07-31 | 2018-01-16 | 浙江润康药业有限公司 | 氟苯尼考的制备方法 |
CN106631872A (zh) * | 2016-12-13 | 2017-05-10 | 浙江普洛家园药业有限公司 | 一种氟苯尼考类似物中间体的合成方法 |
CN110272856B (zh) * | 2019-05-08 | 2022-05-03 | 江南大学 | 一种表达d-苏氨酸醛缩酶的重组菌及其构建方法与应用 |
CN117466787B (zh) * | 2023-12-28 | 2024-03-22 | 山东国邦药业有限公司 | 一种氟苯尼考中间体的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2759001A (en) * | 1952-03-01 | 1956-08-14 | Parke Davis & Co | Process for the production of delta2-oxazolines |
US4361557A (en) * | 1980-01-28 | 1982-11-30 | Schering Corporation | 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor |
EP0678506A3 (en) * | 1983-06-02 | 1996-07-24 | Zambon Spa | Intermediates for the preparation of 1-phenyl-1-hydroxy-2-amino-3-fluoropropane derivatives. |
US4876352A (en) * | 1988-09-14 | 1989-10-24 | Schering Corporation | Pressurized fluorination of hydroxy alkyl groups |
KR920701469A (ko) † | 1989-05-15 | 1992-08-11 | 스테이너 브이. 캔스태드 | 향균성 화합물 및 이의 중간물질의 제조방법 |
AU646910B2 (en) * | 1990-10-25 | 1994-03-10 | Schering Corporation | Process for preparing florfenicol, its analogs and oxazoline intermediates thereto |
-
1996
- 1996-08-19 US US08/699,271 patent/US5663361A/en not_active Expired - Lifetime
-
1997
- 1997-08-15 CO CO97047276A patent/CO4560550A1/es unknown
- 1997-08-15 AR ARP970103736A patent/AR008298A1/es not_active Application Discontinuation
- 1997-08-18 PL PL331644A patent/PL196454B1/pl not_active IP Right Cessation
- 1997-08-18 MY MYPI97003778A patent/MY115679A/en unknown
- 1997-08-18 PT PT97938263T patent/PT922040E/pt unknown
- 1997-08-18 HU HU9904166A patent/HU229610B1/hu unknown
- 1997-08-18 EP EP97938263.7A patent/EP0922040B2/en not_active Expired - Lifetime
- 1997-08-18 JP JP51080598A patent/JP3274868B2/ja not_active Expired - Lifetime
- 1997-08-18 BR BRPI9711318-2A patent/BR9711318B1/pt not_active IP Right Cessation
- 1997-08-18 IL IL12857497A patent/IL128574A/en not_active IP Right Cessation
- 1997-08-18 CN CN97198768A patent/CN1097583C/zh not_active Expired - Lifetime
- 1997-08-18 ZA ZA9707406A patent/ZA977406B/xx unknown
- 1997-08-18 PL PL378741A patent/PL198553B1/pl not_active IP Right Cessation
- 1997-08-18 CA CA002264116A patent/CA2264116C/en not_active Expired - Lifetime
- 1997-08-18 TR TR2008/00474T patent/TR200800474T2/xx unknown
- 1997-08-18 SK SK199-99A patent/SK286124B6/sk not_active IP Right Cessation
- 1997-08-18 PE PE1997000728A patent/PE99798A1/es not_active Application Discontinuation
- 1997-08-18 AU AU40638/97A patent/AU714495B2/en not_active Expired
- 1997-08-18 ES ES97938263T patent/ES2234026T5/es not_active Expired - Lifetime
- 1997-08-18 TR TR1999/00354T patent/TR199900354T2/xx unknown
- 1997-08-18 DK DK97938263T patent/DK0922040T3/da active
- 1997-08-18 NZ NZ334111A patent/NZ334111A/en not_active IP Right Cessation
- 1997-08-18 DE DE69731835T patent/DE69731835T3/de not_active Expired - Lifetime
- 1997-08-18 ID IDP972887A patent/ID18047A/id unknown
- 1997-08-18 CZ CZ0054099A patent/CZ297915B6/cs not_active IP Right Cessation
- 1997-08-18 AT AT97938263T patent/ATE283847T1/de active
- 1997-08-18 SI SI9730688T patent/SI0922040T1/xx unknown
- 1997-08-18 WO PCT/US1997/014205 patent/WO1998007709A1/en active Application Filing
- 1997-08-19 TW TW086111823A patent/TW381075B/zh not_active IP Right Cessation
-
1999
- 1999-02-18 NO NO19990756A patent/NO312962B1/no not_active IP Right Cessation
- 1999-02-18 KR KR1019997001290A patent/KR100286851B1/ko not_active IP Right Cessation
- 1999-07-10 HK HK99102946A patent/HK1017890A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP9904166A2 (hu) | Eljárás florfenikol intermedierek előállítására | |
FR2446834A1 (fr) | Octahydro-pyrazolo(3,4-g)quinoleines utiles comme intermediaires de synthese | |
HUP0000527A2 (hu) | Eljárás tolterodin előállítására és az intermedier | |
HUP0000437A2 (hu) | Peszticid hatású ciklusos iminek, intermedierjeik, előállításuk és alkalmazásuk | |
BR9809111A (pt) | Novos intermediários e processo para sua preparação | |
ES2160534B1 (es) | Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo. | |
NO1996014I1 (no) | 4-cyano-3-fluormetyl-N-(3-p-fluorfenylsulfonyl-2-hydroksy-2-metylpropionyl)-anilin | |
TR199901366T2 (xx) | Prostaglandin agonistleriyle kemik kitlesindeki kayb�n �nlenmesi / onar�lmas�. | |
SE8204347D0 (sv) | N-phenylpyrazole derivatives useful as herbicides | |
DE69420421T2 (de) | Zwischenprodukte für die Herstellung einer substituierten 2,5-Diamino-3-hydroxyhexan. | |
SE7905910L (sv) | Sammansatt keramikgasturbinskovel | |
DE69709956T2 (de) | Verwendung einer ni-basislegierung für kompositrohre für verbrennungsanlage | |
BR9809113A (pt) | Novos intermediários e processo para sua preparação | |
HUP9802257A2 (hu) | Szelektív béta3 adrenerg agonisták, előállításuk és a vegyületeket tartalmazó gyógyszerkészítmények | |
FI875596A (fi) | Foerfarande foer framstaellning av tienyletylaminer och aeven ditienyletylaminer. | |
ES2143058T3 (es) | Procedimiento de preparacion de un 2,5-diamino-3-hidroxihexano sustituido. | |
ES2123277T3 (es) | Derivados de sacarina. | |
HUP0004565A2 (hu) | Szubsztituált krománszármazékok, intermedierjeik és azokat tartalmazó gyógyszerkészítmények | |
GB9710726D0 (en) | Compound | |
BR9805040A (pt) | Composição de catalisador para a polimerização de olefinas. | |
ES521624A0 (es) | Procedimiento para la obtencion de fenoxipropionatos sustituidos. | |
YU48628B (sh) | Pregradni prsten za modernizovanje snopa cevi cevnog izmenjivača toplote, snop cevi cevnog izmenjivača toplote i postupak za modernizovanje snopa cevi | |
ES516319A0 (es) | "procedimiento para la preparacion de n-(3-trimetilestannilalquilen)-n'-fenilsulfonil y respectivamente-benzoil-ureas". | |
FR2412536A1 (fr) | 2,3-dicyanopyrazines utilisables comme herbicides | |
AR223186A1 (es) | Procedimiento para la preparacion de n-(metil-2-pirrolidinilmetil)-2,3-dimetoxi-5-metilsulfamoil benzamida y sus derivados |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC9A | Change of name, address |
Owner name: MERCK SHARP & DOHME CORP., US Free format text: FORMER OWNER(S): SCHERING CORP., US |