SK284755B6 - Baktérie Lactobacillus helveticus produkujúce kyselinu mliečnu s vysokou produktivitou tripeptidu, fermentovaný mliečny výrobok a spôsob jeho výroby - Google Patents
Baktérie Lactobacillus helveticus produkujúce kyselinu mliečnu s vysokou produktivitou tripeptidu, fermentovaný mliečny výrobok a spôsob jeho výroby Download PDFInfo
- Publication number
- SK284755B6 SK284755B6 SK435-2000A SK4352000A SK284755B6 SK 284755 B6 SK284755 B6 SK 284755B6 SK 4352000 A SK4352000 A SK 4352000A SK 284755 B6 SK284755 B6 SK 284755B6
- Authority
- SK
- Slovakia
- Prior art keywords
- pro
- lactic acid
- milk
- fermented
- strain
- Prior art date
Links
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title claims abstract description 172
- 239000004310 lactic acid Substances 0.000 title claims abstract description 68
- 235000014655 lactic acid Nutrition 0.000 title claims abstract description 68
- 240000002605 Lactobacillus helveticus Species 0.000 title claims abstract description 23
- 238000004519 manufacturing process Methods 0.000 title claims description 11
- 235000014048 cultured milk product Nutrition 0.000 title abstract 3
- 241000894006 Bacteria Species 0.000 claims abstract description 51
- DOFAQXCYFQKSHT-SRVKXCTJSA-N Val-Pro-Pro Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(O)=O)CCC1 DOFAQXCYFQKSHT-SRVKXCTJSA-N 0.000 claims abstract description 51
- 230000000694 effects Effects 0.000 claims abstract description 28
- 238000000855 fermentation Methods 0.000 claims abstract description 28
- 230000004151 fermentation Effects 0.000 claims abstract description 28
- 235000013336 milk Nutrition 0.000 claims abstract description 21
- 239000008267 milk Substances 0.000 claims abstract description 21
- 210000004080 milk Anatomy 0.000 claims abstract description 21
- 108010015385 valyl-prolyl-proline Proteins 0.000 claims abstract description 18
- 235000020244 animal milk Nutrition 0.000 claims abstract description 15
- 235000013861 fat-free Nutrition 0.000 claims abstract description 14
- 239000007787 solid Substances 0.000 claims abstract description 11
- FQYQMFCIJNWDQZ-CYDGBPFRSA-N Ile-Pro-Pro Chemical compound CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(O)=O)CCC1 FQYQMFCIJNWDQZ-CYDGBPFRSA-N 0.000 claims abstract description 10
- 108010031424 isoleucyl-prolyl-proline Proteins 0.000 claims abstract description 7
- 230000000721 bacterilogical effect Effects 0.000 claims abstract description 4
- 229960000448 lactic acid Drugs 0.000 claims description 82
- 235000015140 cultured milk Nutrition 0.000 claims description 45
- 235000021001 fermented dairy product Nutrition 0.000 claims description 28
- 235000013967 Lactobacillus helveticus Nutrition 0.000 claims description 18
- 229940054346 lactobacillus helveticus Drugs 0.000 claims description 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 18
- 239000012634 fragment Substances 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 17
- 101710089384 Extracellular protease Proteins 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 14
- 239000013611 chromosomal DNA Substances 0.000 claims description 12
- 235000015097 nutrients Nutrition 0.000 claims description 11
- 230000015572 biosynthetic process Effects 0.000 claims description 10
- 235000018102 proteins Nutrition 0.000 claims description 10
- 102000004169 proteins and genes Human genes 0.000 claims description 10
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 238000005516 engineering process Methods 0.000 claims description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims description 6
- 235000013365 dairy product Nutrition 0.000 claims description 6
- 239000008103 glucose Substances 0.000 claims description 6
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 5
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 5
- 108091008146 restriction endonucleases Proteins 0.000 claims description 5
- 235000021262 sour milk Nutrition 0.000 claims description 5
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 4
- 244000068988 Glycine max Species 0.000 claims description 4
- 235000010469 Glycine max Nutrition 0.000 claims description 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 4
- 235000021307 Triticum Nutrition 0.000 claims description 4
- 241000209140 Triticum Species 0.000 claims description 4
- 240000008042 Zea mays Species 0.000 claims description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 4
- 239000005018 casein Substances 0.000 claims description 4
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 4
- 235000021240 caseins Nutrition 0.000 claims description 4
- 235000013402 health food Nutrition 0.000 claims description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 3
- 102000016938 Catalase Human genes 0.000 claims description 3
- 108010053835 Catalase Proteins 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 3
- 229930091371 Fructose Natural products 0.000 claims description 3
- 239000005715 Fructose Substances 0.000 claims description 3
- 238000003794 Gram staining Methods 0.000 claims description 3
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- 229910002651 NO3 Inorganic materials 0.000 claims description 3
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 3
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims description 3
- NGFMICBWJRZIBI-JZRPKSSGSA-N Salicin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O1)c1c(CO)cccc1 NGFMICBWJRZIBI-JZRPKSSGSA-N 0.000 claims description 3
- 108010073771 Soybean Proteins Proteins 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 3
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims description 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 3
- 230000009603 aerobic growth Effects 0.000 claims description 3
- NGFMICBWJRZIBI-UHFFFAOYSA-N alpha-salicin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UHFFFAOYSA-N 0.000 claims description 3
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 3
- 230000015556 catabolic process Effects 0.000 claims description 3
- 235000005822 corn Nutrition 0.000 claims description 3
- 238000006731 degradation reaction Methods 0.000 claims description 3
- 229930182830 galactose Natural products 0.000 claims description 3
- 229930195733 hydrocarbon Natural products 0.000 claims description 3
- 150000002430 hydrocarbons Chemical class 0.000 claims description 3
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims description 3
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- 230000000877 morphologic effect Effects 0.000 claims description 3
- 230000001766 physiological effect Effects 0.000 claims description 3
- NGFMICBWJRZIBI-UJPOAAIJSA-N salicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UJPOAAIJSA-N 0.000 claims description 3
- 229940120668 salicin Drugs 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 229940001941 soy protein Drugs 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- PLXMOAALOJOTIY-FPTXNFDTSA-N Aesculin Natural products OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1Oc2cc3C=CC(=O)Oc3cc2O PLXMOAALOJOTIY-FPTXNFDTSA-N 0.000 claims description 2
- WNBCMONIPIJTSB-BGNCJLHMSA-N Cichoriin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1)c1c(O)cc2c(OC(=O)C=C2)c1 WNBCMONIPIJTSB-BGNCJLHMSA-N 0.000 claims description 2
- 235000013351 cheese Nutrition 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 229940093496 esculin Drugs 0.000 claims description 2
- AWRMZKLXZLNBBK-UHFFFAOYSA-N esculin Natural products OC1OC(COc2cc3C=CC(=O)Oc3cc2O)C(O)C(O)C1O AWRMZKLXZLNBBK-UHFFFAOYSA-N 0.000 claims description 2
- 235000013322 soy milk Nutrition 0.000 claims description 2
- 235000013618 yogurt Nutrition 0.000 claims description 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 1
- 235000021067 refined food Nutrition 0.000 claims 1
- 235000011497 sour milk drink Nutrition 0.000 claims 1
- 235000013305 food Nutrition 0.000 abstract description 5
- 230000001077 hypotensive effect Effects 0.000 abstract description 5
- 102000035195 Peptidases Human genes 0.000 abstract description 4
- 108091005804 Peptidases Proteins 0.000 abstract description 4
- 235000013361 beverage Nutrition 0.000 abstract description 4
- 230000002180 anti-stress Effects 0.000 abstract description 3
- 230000001747 exhibiting effect Effects 0.000 abstract description 2
- 235000019833 protease Nutrition 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002609 medium Substances 0.000 description 24
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 description 19
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 description 19
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 17
- 230000002401 inhibitory effect Effects 0.000 description 16
- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 description 13
- 102000004196 processed proteins & peptides Human genes 0.000 description 13
- 102100026819 Inositol polyphosphate 1-phosphatase Human genes 0.000 description 12
- 239000000047 product Substances 0.000 description 11
- 239000005862 Whey Substances 0.000 description 10
- 102000007544 Whey Proteins Human genes 0.000 description 10
- 108010046377 Whey Proteins Proteins 0.000 description 10
- 235000020183 skimmed milk Nutrition 0.000 description 9
- 238000012216 screening Methods 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 238000001962 electrophoresis Methods 0.000 description 6
- 241000186660 Lactobacillus Species 0.000 description 5
- 238000002835 absorbance Methods 0.000 description 5
- 229940039696 lactobacillus Drugs 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 235000020247 cow milk Nutrition 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000701959 Escherichia virus Lambda Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical class C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 2
- 102000014171 Milk Proteins Human genes 0.000 description 2
- 108010011756 Milk Proteins Proteins 0.000 description 2
- QIAFMBKCNZACKA-UHFFFAOYSA-N N-benzoylglycine Chemical compound OC(=O)CNC(=O)C1=CC=CC=C1 QIAFMBKCNZACKA-UHFFFAOYSA-N 0.000 description 2
- 239000011543 agarose gel Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- 235000021551 crystal sugar Nutrition 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000012737 fresh medium Substances 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 235000020251 goat milk Nutrition 0.000 description 2
- 235000020252 horse milk Nutrition 0.000 description 2
- 239000003999 initiator Substances 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- 238000011699 spontaneously hypertensive rat Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000020125 yoghurt-based beverage Nutrition 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- DHCLVCXQIBBOPH-UHFFFAOYSA-N Glycerol 2-phosphate Chemical compound OCC(CO)OP(O)(O)=O DHCLVCXQIBBOPH-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 108010070551 Meat Proteins Proteins 0.000 description 1
- 102000007079 Peptide Fragments Human genes 0.000 description 1
- 108010033276 Peptide Fragments Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- XHCADAYNFIFUHF-TVKJYDDYSA-N esculin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC2=C1OC(=O)C=C2 XHCADAYNFIFUHF-TVKJYDDYSA-N 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 239000008371 vanilla flavor Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
- A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/137—Thickening substances
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/147—Helveticus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dairy Products (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9277949A JP3028411B2 (ja) | 1997-09-26 | 1997-09-26 | トリペプチド高生産性ラクトバチルス・ヘルベチカス乳酸菌 |
| PCT/JP1998/000481 WO1999016862A1 (fr) | 1997-09-26 | 1998-02-05 | Bacterie du genre lactobacillus helveticus ayant une grande capacite de production de tripeptides, produit laitier fermente et son procede de preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK4352000A3 SK4352000A3 (en) | 2001-05-10 |
| SK284755B6 true SK284755B6 (sk) | 2005-11-03 |
Family
ID=17590526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK435-2000A SK284755B6 (sk) | 1997-09-26 | 1998-02-05 | Baktérie Lactobacillus helveticus produkujúce kyselinu mliečnu s vysokou produktivitou tripeptidu, fermentovaný mliečny výrobok a spôsob jeho výroby |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6534304B1 (en:Method) |
| EP (1) | EP1016709B1 (en:Method) |
| JP (1) | JP3028411B2 (en:Method) |
| KR (1) | KR100404154B1 (en:Method) |
| CN (1) | CN1149279C (en:Method) |
| AR (1) | AR017153A1 (en:Method) |
| AT (1) | ATE294230T1 (en:Method) |
| AU (1) | AU734422B2 (en:Method) |
| BG (1) | BG64422B1 (en:Method) |
| BR (1) | BR9813218A (en:Method) |
| CA (1) | CA2304985C (en:Method) |
| CZ (1) | CZ291067B6 (en:Method) |
| DE (1) | DE69829983T2 (en:Method) |
| ES (1) | ES2237834T3 (en:Method) |
| HU (1) | HU225980B1 (en:Method) |
| IN (1) | IN188418B (en:Method) |
| MY (1) | MY118157A (en:Method) |
| PL (1) | PL188675B1 (en:Method) |
| PT (1) | PT1016709E (en:Method) |
| SK (1) | SK284755B6 (en:Method) |
| TR (1) | TR200000854T2 (en:Method) |
| TW (1) | TW526268B (en:Method) |
| WO (1) | WO1999016862A1 (en:Method) |
| ZA (1) | ZA988659B (en:Method) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102012016127A1 (de) | 2011-08-31 | 2013-02-28 | Daniel Elias | Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60022859T3 (de) | 1999-01-11 | 2010-05-06 | Calpis Co., Ltd. | Verfahren zur herstellung von sauermilch enthaltend ein inhibitionspeptid fuer ein angiotensin konvertierendes enzym sowie ein verfahren zur herstellung von milchserum |
| FR2793257B1 (fr) | 1999-05-06 | 2001-07-27 | Gervais Danone Sa | Bacteries lactiques a proprietes anxiolytiques, et leurs utilisations |
| FI113741B (fi) * | 1999-11-01 | 2004-06-15 | Valio Oy | Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi |
| JP4633876B2 (ja) * | 1999-11-11 | 2011-02-16 | カルピス株式会社 | トリペプチドの製造方法 |
| FI112031B (fi) | 2002-02-25 | 2003-10-31 | Valio Oy | Biologisesti aktiivisen tuotteen uusi käyttö |
| EP1492409A2 (en) * | 2002-04-03 | 2005-01-05 | Chr. Hansen A/S | Peptides with anti-hypertensive properties |
| AU2003260281B2 (en) * | 2002-08-09 | 2007-11-29 | Chr. Hansen A/S | Process for preparing peptides with anti-hypertensive properties |
| WO2004060073A1 (en) | 2003-01-06 | 2004-07-22 | Unilever N.V. | Fermented milk product comprising tripeptide vpp and/or ipp |
| TWI328457B (en) * | 2003-03-18 | 2010-08-11 | Suntory Holdings Ltd | Angiotensin-converting enzyme inhibitory peptides |
| US7718171B2 (en) | 2003-04-07 | 2010-05-18 | Chr. Hansen A/S | Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus |
| ZA200507880B (en) * | 2003-05-05 | 2006-12-27 | Unilever Plc | Hydrolysed casein product comprising tripeptides IPP and/or VPP |
| JP4680571B2 (ja) * | 2003-12-25 | 2011-05-11 | カルピス株式会社 | 経口摂取用保湿剤 |
| TW200533299A (en) * | 2004-03-31 | 2005-10-16 | Calpis Co Ltd | Functional food for improving endogenous rhythm of melatonin secretion, and functional food for improving circadian rhythm |
| US20070224285A1 (en) * | 2004-03-31 | 2007-09-27 | Calpis Co., Ltd | Agent for Preventing or Suppressing Hepatopathy and Functional Food for Preventing or Suppressing Hepatopathy |
| WO2006004105A1 (ja) * | 2004-07-05 | 2006-01-12 | Calpis Co., Ltd. | ペプチド混合物の製造法、抗高血圧ペプチド含有発酵乳の製造法及び抗高血圧ペプチド製剤の製造法 |
| JP2008511593A (ja) | 2004-09-03 | 2008-04-17 | セーホーエル．ハンセン アクティーゼルスカブ | 受容体リガンドを含む発酵乳又は植物性タンパク質及びその使用 |
| WO2006095764A1 (ja) * | 2005-03-09 | 2006-09-14 | Calpis Co., Ltd. | 皮膚における紫外線感受性抑制剤及び機能性飲食品 |
| AU2006260100A1 (en) * | 2005-06-24 | 2006-12-28 | Calpis Co., Ltd. | Promoter of differentiation and keratinization of epidermic cell and functional beverage/food for promotion of keratinization of epidermis |
| CN1903052B (zh) * | 2005-07-26 | 2010-04-28 | 天津科技大学 | 具有酪蛋白磷酸肽、抗血管紧张素转化酶肽和低聚半乳糖乳清粉的制备方法 |
| CN101272693B (zh) * | 2005-07-26 | 2012-08-01 | 卡尔皮斯株式会社 | 发酵乳的制造方法和发酵乳饮料食品 |
| BRPI0707837A2 (pt) | 2006-02-14 | 2011-05-10 | Calpis Co Ltd | "agente para prevenÇço de arteriosclerose, agente para supressço de espessamento vascular da Íntima e agente para melhoria da funÇço endotelial vascular" |
| EP1992353B1 (en) * | 2006-02-14 | 2014-05-07 | Calpis Co., Ltd. | Vasodilator |
| PT1820849E (pt) | 2006-02-20 | 2009-04-24 | Gervais Danone Sa | Novas estirpes de lactobacillus helveticus |
| ATE503388T1 (de) * | 2006-02-20 | 2011-04-15 | Gervais Danone Sa | Neue lactobacillus helveticus stämme |
| EP1820850B1 (fr) * | 2006-02-20 | 2009-02-25 | Compagnie Gervais Danone | Nouvelles souches de lactobacillus helveticus |
| ATE548445T1 (de) | 2006-02-20 | 2012-03-15 | Gervais Danone Sa | Laktose nicht fermentierende lactobacillus helveticus |
| AU2006343802A1 (en) * | 2006-05-15 | 2007-11-22 | Valio Ltd | New use of therapeutically useful peptides |
| EP2034848B1 (en) | 2006-06-16 | 2016-10-19 | DuPont Nutrition Biosciences ApS | Streptococcus thermophilus bacterium |
| CN101678051B (zh) | 2006-09-04 | 2012-12-12 | 雪印惠乳业株式会社 | 促进血中脂连蛋白浓度增加及/或抑制其减少的制剂及内脏脂肪蓄积抑制剂 |
| JP2008214253A (ja) | 2007-03-02 | 2008-09-18 | Snow Brand Milk Prod Co Ltd | 内臓脂肪減少剤 |
| CA2681746C (en) * | 2007-03-27 | 2014-04-29 | Calpis Co., Ltd. | Prophylactic agent for heart failure |
| TWI414305B (zh) * | 2007-03-27 | 2013-11-11 | Calpis Co Ltd | 腎衰竭預防劑 |
| CN102098923B (zh) * | 2008-06-12 | 2014-01-15 | 雀巢产品技术援助有限公司 | 用于产生降血压肽的瑞士乳杆菌菌株 |
| ATE544350T1 (de) * | 2008-12-29 | 2012-02-15 | Unilever Nv | GEFRORENE SÜßWARENPRODUKTE UND GETRÄNKE, DIE THEOBROMIN UND KOFFEIN ENTHALTEN |
| WO2011095389A1 (en) * | 2010-02-04 | 2011-08-11 | Unilever Nv | Use of theobromine for lowering central blood pressure |
| CA2798911C (en) | 2010-05-19 | 2018-07-03 | Unilever Plc | Theobromine for increasing hdl-cholesterol |
| JP2010183918A (ja) * | 2010-06-01 | 2010-08-26 | Calpis Co Ltd | トリペプチドの製造方法 |
| JP5797891B2 (ja) * | 2010-11-09 | 2015-10-21 | カルピス株式会社 | Ｎｏｎ−ｄｉｐｐｅｒ型血圧日内変動による疾病発症リスク軽減剤 |
| WO2012063826A1 (ja) * | 2010-11-09 | 2012-05-18 | カルピス株式会社 | 高タンパク質分解活性を有するラクトバチルス・ヘルベティカス菌 |
| RU2453593C1 (ru) * | 2011-04-21 | 2012-06-20 | Общество с ограниченной ответственностью "Бифилюкс" | Штамм lactobacillus helveticus, используемый для получения продукции, содержащей лактобактерии |
| US20120328735A1 (en) * | 2011-06-24 | 2012-12-27 | Naoto Uchida | Process for preparing casein-derived peptides by fermentation of lactic acid bacteria |
| BR112015003239B1 (pt) | 2012-08-22 | 2020-10-27 | Kraft Foods Group Brands Llc | queijo processado incluindo antimicrobianos naturais e método para produção de um queijo processado tendo antimicrobianos naturais |
| CN102960444A (zh) * | 2012-11-19 | 2013-03-13 | 陕西科技大学 | 一种基于瑞士乳杆菌发酵的含ace抑制肽的羊奶的制备方法 |
| CN104450574B (zh) * | 2014-12-10 | 2017-05-10 | 生合生物科技（南京）有限公司 | 一种瑞士乳杆菌lh43及其制作乳酸菌饮料的方法 |
| RU2577112C1 (ru) * | 2014-12-25 | 2016-03-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Горский государственный аграрный университет" | Штамм lactobacillus helveticus вкпм в-11175, полученный на доступных питательных средах |
| CN107674848A (zh) * | 2017-09-20 | 2018-02-09 | 云南乍甸乳业有限责任公司 | 一种酸奶发酵菌种的制备方法 |
| CN111227049B (zh) * | 2018-11-29 | 2022-08-12 | 内蒙古伊利实业集团股份有限公司 | 一种维持褐色植物基酸奶货架期内组织状态稳定性的方法 |
| CN109517763B (zh) * | 2018-12-27 | 2022-03-22 | 内蒙古农业大学 | 瑞士乳杆菌h11及其应用 |
| CN110226687A (zh) * | 2019-06-12 | 2019-09-13 | 宁波依萃健生物科技有限公司 | 一种解酒护肝组合物及制备方法 |
| PL3845069T3 (pl) * | 2019-12-30 | 2023-01-30 | Compagnie Gervais Danone | Ujemny względem sacharozy streptococcus thermophilus do zastosowania do wytwarzania wyrobów fermentowanych |
| CN111979286B (zh) * | 2020-08-31 | 2021-11-26 | 鲁东大学 | 一种发酵法与酶法联合制备贝类高f值寡肽的方法 |
| CN112616925A (zh) * | 2020-12-30 | 2021-04-09 | 光明乳业股份有限公司 | 一种双蛋白发酵乳及其制备方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3846560A (en) * | 1971-07-22 | 1974-11-05 | Quaker Oats Co | Process of making a base for protein beverages |
| US3876806A (en) * | 1971-10-14 | 1975-04-08 | Quaker Oats Co | Process for the preparation of acid soluble polypeptides and carbonated beverages containing same |
| US4107334A (en) * | 1976-10-13 | 1978-08-15 | Pfizer Inc. | Modified protein |
| CH636248A5 (fr) * | 1979-03-09 | 1983-05-31 | Nestle Sa | Procede de preparation d'un hydrolysat de proteines purifie. |
| JPS60262561A (ja) * | 1984-06-08 | 1985-12-25 | House Food Ind Co Ltd | 大豆蛋白質水溶液の処理方法 |
| US4585757A (en) * | 1984-07-27 | 1986-04-29 | Texas Tech University Health Sciences Center | Hypotensive active peptides |
| US4687840A (en) * | 1986-02-11 | 1987-08-18 | Texas Tech University Health Sciences Center | Hypotensive active peptides |
| GB8823429D0 (en) * | 1988-10-05 | 1988-11-09 | Agricultural Genetics Co | Method for accelerated ripening of cheddar & related hard type cheese |
| DD300815A5 (de) * | 1989-07-07 | 1992-08-06 | Nestle Sa | Proteinhydrolyse |
| NL9000422A (nl) * | 1990-02-21 | 1991-09-16 | Nl Zuivelonderzoek Inst | Werkwijze voor de bereiding van een gefermenteerd melkprodukt. |
| DE69124274T2 (de) * | 1990-02-27 | 1997-08-14 | Agency Ind Science Techn | Oligopeptide, sie enthaltende pharmazeutische und Futterzusammensetzung und Benützung von Oligopeptiden |
| EP0457565B1 (en) * | 1990-05-18 | 1997-07-30 | Morinaga Milk Industry Co., Ltd. | Milk-protein hydrolyzates and compositions for use as hair and skin treating agent |
| JP2571734B2 (ja) * | 1991-08-23 | 1997-01-16 | 株式会社ヤクルト本社 | 乳酸菌飲料 |
| US5486461A (en) * | 1991-11-08 | 1996-01-23 | Novo Nordisk A/S | Casein hydrolyzate and method for production of such casein hydrolyzate |
| FI94088C (fi) * | 1992-03-13 | 1995-07-25 | Valio Oy | Menetelmä fenyylialaniinin poistamiseksi proteiinipitoisista koostumuksista |
| US5418218A (en) * | 1992-07-10 | 1995-05-23 | The University Of Maryland At Baltimore | Histidyl-proline diketopiperazine (cyclo his-pro) a cns-active pharmacologic agent |
| JP2782142B2 (ja) * | 1992-07-23 | 1998-07-30 | カルピス株式会社 | アンジオテンシン変換酵素阻害剤及びその製造法 |
| JP2782153B2 (ja) * | 1992-11-09 | 1998-07-30 | カルピス株式会社 | アンジオテンシン変換酵素阻害ペプチドの製造法 |
| US5656268A (en) * | 1995-04-21 | 1997-08-12 | Sorodsky; Michael | Biological product |
| US5618689A (en) * | 1995-05-25 | 1997-04-08 | Nestec S.A. | Enhanced procedures for preparing food hydrolysates |
| AU5764098A (en) * | 1996-12-23 | 1998-07-17 | Gist-Brocades B.V. | Method for producing a protein hydrolysate |
| US6221423B1 (en) * | 1998-04-13 | 2001-04-24 | Protein Technologies Int'l Inc. | Short-chained peptide material |
| AU2001245537A1 (en) | 2000-03-10 | 2001-09-24 | Monsanto Company | Anti-hypertensive peptides |
| AU2001247334A1 (en) | 2000-03-10 | 2001-09-24 | Monsanto Company | Novel peptides with anti-hypertensive activity |
| CA2391063A1 (en) | 2000-03-13 | 2001-09-20 | Hiroshi Miyakawa | Protein hydrolyzate, manufacuring method therefor, and foods and drinks containing the protein hydrolyzate |
| US20030040475A1 (en) | 2001-01-16 | 2003-02-27 | Yasuhiro Toba | Agents for improving lipid metabolism and reducing high blood pressure |
| US6815426B2 (en) | 2001-02-16 | 2004-11-09 | E. I. Du Pont De Nemours And Company | Angiogenesis-inhibitory tripeptides, compositions and their methods of use |
| EP1365656A1 (en) | 2001-03-09 | 2003-12-03 | Unilever N.V. | Fermented milk product |
| US6589574B2 (en) | 2001-03-19 | 2003-07-08 | Council Of Scientific & Industrial Research | Process for preparation of protein-hydrolysate from milk protein |
-
1997
- 1997-09-26 JP JP9277949A patent/JP3028411B2/ja not_active Expired - Lifetime
-
1998
- 1998-02-05 TR TR2000/00854T patent/TR200000854T2/xx unknown
- 1998-02-05 CA CA002304985A patent/CA2304985C/en not_active Expired - Fee Related
- 1998-02-05 WO PCT/JP1998/000481 patent/WO1999016862A1/ja active IP Right Grant
- 1998-02-05 EP EP98901520A patent/EP1016709B1/en not_active Expired - Lifetime
- 1998-02-05 ES ES98901520T patent/ES2237834T3/es not_active Expired - Lifetime
- 1998-02-05 PL PL98339343A patent/PL188675B1/pl unknown
- 1998-02-05 SK SK435-2000A patent/SK284755B6/sk not_active IP Right Cessation
- 1998-02-05 CZ CZ20001082A patent/CZ291067B6/cs not_active IP Right Cessation
- 1998-02-05 KR KR10-2000-7003224A patent/KR100404154B1/ko not_active Expired - Fee Related
- 1998-02-05 PT PT98901520T patent/PT1016709E/pt unknown
- 1998-02-05 US US09/508,840 patent/US6534304B1/en not_active Expired - Fee Related
- 1998-02-05 AU AU57802/98A patent/AU734422B2/en not_active Ceased
- 1998-02-05 AT AT98901520T patent/ATE294230T1/de active
- 1998-02-05 HU HU0003744A patent/HU225980B1/hu not_active IP Right Cessation
- 1998-02-05 DE DE69829983T patent/DE69829983T2/de not_active Expired - Lifetime
- 1998-02-05 CN CNB988115301A patent/CN1149279C/zh not_active Expired - Fee Related
- 1998-02-05 BR BR9813218-0A patent/BR9813218A/pt not_active Application Discontinuation
- 1998-09-17 IN IN2795DE1998 patent/IN188418B/en unknown
- 1998-09-22 TW TW087115782A patent/TW526268B/zh not_active IP Right Cessation
- 1998-09-23 MY MYPI98004363A patent/MY118157A/en unknown
- 1998-09-25 AR ARP980104806A patent/AR017153A1/es active IP Right Grant
- 1998-09-25 ZA ZA988659A patent/ZA988659B/xx unknown
-
2000
- 2000-04-26 BG BG104382A patent/BG64422B1/bg unknown
-
2002
- 2002-12-05 US US10/310,628 patent/US7282354B2/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102012016127A1 (de) | 2011-08-31 | 2013-02-28 | Daniel Elias | Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels |
| DE202012012998U1 (de) | 2011-08-31 | 2014-06-13 | Daniel Elias | Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SK284755B6 (sk) | Baktérie Lactobacillus helveticus produkujúce kyselinu mliečnu s vysokou produktivitou tripeptidu, fermentovaný mliečny výrobok a spôsob jeho výroby | |
| RU2276689C2 (ru) | Способ получения продукта, содержащего гипотензивные пептиды, продукт, полученный способом, и пищевой продукт | |
| CN101421390B (zh) | 不发酵乳糖的瑞士乳杆菌菌株 | |
| CN102098923A (zh) | 用于产生降血压肽的瑞士乳杆菌菌株 | |
| MXPA00002575A (en) | Lactobacillus helveticus bacterium having high capability of producing tripeptide, fermented milk product, and process for preparing the same | |
| PL241893B1 (pl) | Sposób przeprowadzenia selekcji mikroorganizmów proteolitycznych, sposób wytwarzania hydrolizatu białek serwatkowych, zawierającego bioaktywne peptydy i hydrolizat białek serwatkowych |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20130205 |