SK284201B6 - Kryštalická forma III hydrátu atorvastatínu, to je semivápenatej soli kyseliny [(R)-(R*,R*)-2-(4-fluórfenyl)-beta, delta-dihydroxy-5-(1-metyletyl)-3-fenyl-4-((fenylamino)- karbonyl)-1H-pyrol-1-heptánovej, farmaceutická kompozícia obsahujúca túto kryštalickú formu a táto kryštalická forma na použitie ako liečivo - Google Patents

Kryštalická forma III hydrátu atorvastatínu, to je semivápenatej soli kyseliny [(R)-(R*,R*)-2-(4-fluórfenyl)-beta, delta-dihydroxy-5-(1-metyletyl)-3-fenyl-4-((fenylamino)- karbonyl)-1H-pyrol-1-heptánovej, farmaceutická kompozícia obsahujúca túto kryštalickú formu a táto kryštalická forma na použitie ako liečivo Download PDF

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Publication number
SK284201B6
SK284201B6 SK59-98A SK5998A SK284201B6 SK 284201 B6 SK284201 B6 SK 284201B6 SK 5998 A SK5998 A SK 5998A SK 284201 B6 SK284201 B6 SK 284201B6
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SK
Slovakia
Prior art keywords
crystalline form
atorvastatin
form iii
atorvastatin hydrate
fluorophenyl
Prior art date
Application number
SK59-98A
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English (en)
Slovak (sk)
Other versions
SK5998A3 (en
Inventor
Ann T. Mckenzie
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Warner-Lambert Company
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Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of SK5998A3 publication Critical patent/SK5998A3/sk
Publication of SK284201B6 publication Critical patent/SK284201B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK59-98A 1995-07-17 1996-07-08 Kryštalická forma III hydrátu atorvastatínu, to je semivápenatej soli kyseliny [(R)-(R*,R*)-2-(4-fluórfenyl)-beta, delta-dihydroxy-5-(1-metyletyl)-3-fenyl-4-((fenylamino)- karbonyl)-1H-pyrol-1-heptánovej, farmaceutická kompozícia obsahujúca túto kryštalickú formu a táto kryštalická forma na použitie ako liečivo SK284201B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US145495P 1995-07-17 1995-07-17
PCT/US1996/011367 WO1997003958A1 (en) 1995-07-17 1996-07-08 Form iii crystalline (r-(r*,r*)-2-(4-fluorophenyl)-beta-delta-dihydroxy-5-(1-methyl-ethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)

Publications (2)

Publication Number Publication Date
SK5998A3 SK5998A3 (en) 1998-05-06
SK284201B6 true SK284201B6 (sk) 2004-10-05

Family

ID=21696105

Family Applications (1)

Application Number Title Priority Date Filing Date
SK59-98A SK284201B6 (sk) 1995-07-17 1996-07-08 Kryštalická forma III hydrátu atorvastatínu, to je semivápenatej soli kyseliny [(R)-(R*,R*)-2-(4-fluórfenyl)-beta, delta-dihydroxy-5-(1-metyletyl)-3-fenyl-4-((fenylamino)- karbonyl)-1H-pyrol-1-heptánovej, farmaceutická kompozícia obsahujúca túto kryštalickú formu a táto kryštalická forma na použitie ako liečivo

Country Status (33)

Country Link
US (1) US6121461A (es)
JP (1) JP3296563B2 (es)
KR (1) KR100431039B1 (es)
CN (1) CN1081632C (es)
AT (1) ATE207465T1 (es)
AU (1) AU725368B2 (es)
BG (1) BG63629B1 (es)
BR (1) BR9610567A (es)
CA (1) CA2220458C (es)
CO (1) CO4700442A1 (es)
CZ (1) CZ294109B6 (es)
DK (1) DK0848704T3 (es)
EA (1) EA000505B1 (es)
EE (1) EE03607B1 (es)
ES (1) ES2166456T3 (es)
GE (1) GEP20002028B (es)
HK (1) HK1018053A1 (es)
HR (1) HRP960313B1 (es)
HU (1) HU223598B1 (es)
ID (1) ID16158A (es)
IL (3) IL122162A (es)
MX (1) MX9708857A (es)
MY (1) MY118398A (es)
NO (1) NO309899B1 (es)
NZ (1) NZ312906A (es)
PE (1) PE1798A1 (es)
PL (1) PL192244B1 (es)
RO (1) RO120068B1 (es)
SK (1) SK284201B6 (es)
TW (1) TW401399B (es)
UA (1) UA44796C2 (es)
WO (1) WO1997003958A1 (es)
ZA (1) ZA966045B (es)

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FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
IL128862A (en) 1995-07-17 2007-12-03 Warner Lambert Co [R - (R * R *)] - 2 - (4 - fluorophenyl) - ß, d - dihydroxy - 5 - (1 - methyl - ethyl) 3 - phenyl - 4 - [(phenamino) carbonyl)] - 1H - Pyrol - 1 - Patenoic acid Hydrogen salt Hydrogen crystalline (Atorostatin) Crystalline hydrate
US6569461B1 (en) 1999-03-08 2003-05-27 Merck & Co., Inc. Dihydroxy open-acid and salts of HMG-CoA reductase inhibitors
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EP1724256A3 (en) 2001-01-09 2007-03-21 Warner-Lambert Company LLC Novel process for the synthesis of 5-(4-fluorphenyl)-1-2(2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl)-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
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SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) * 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
EA005317B1 (ru) 2001-06-29 2004-12-30 УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си Кристаллические формы [r-(r*,r*)]-2-(4-фторфенил)-бета, дельта-дигидрокси-5-(1-метилэтил)-3-фенил-4-[(фениламино)карбонил]-1h-пиррол-1-гептановой кислоты кальциевой соли (2:1) (аторвастатин)
EP1414796A1 (en) * 2001-07-30 2004-05-06 Dr. Reddy's Laboratories Ltd. Crystalline forms vi and vii of atorvastatin calcium
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UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
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ITMI20020907A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione della forma amorfa del sale di calcio della atorvastatina
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KR20120011249A (ko) 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
CN102424663B (zh) * 2010-12-03 2013-08-14 天津滨江药物研发有限公司 一种阿托伐他汀氨基酸盐及其制备方法
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CN106432033B (zh) * 2016-10-21 2018-07-27 江苏阿尔法药业有限公司 一种无定形阿托伐他汀钙的制备方法
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Publication number Publication date
CN1190957A (zh) 1998-08-19
CZ12398A3 (cs) 1998-06-17
JP3296563B2 (ja) 2002-07-02
IL128863A0 (en) 2000-01-31
IL177378A0 (en) 2006-12-10
MX9708857A (es) 1998-03-31
NZ312906A (en) 2000-12-22
RO120068B1 (ro) 2005-08-30
PL192244B1 (pl) 2006-09-29
CA2220458A1 (en) 1997-02-06
CN1081632C (zh) 2002-03-27
KR19990029044A (ko) 1999-04-15
BG102186A (en) 1998-10-30
HRP960313A2 (en) 1998-04-30
HK1018053A1 (en) 1999-12-10
ES2166456T3 (es) 2002-04-16
HUP9901687A3 (en) 2000-04-28
PE1798A1 (es) 1998-03-04
NO980208L (no) 1998-01-16
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