MX9708857A - Forma iii cristalina de la sal de calcio hemi del acido (r-(r*,r*)-2-(4-fluorofenil)-beta-delta-dihidroxi-5-(1-metil -etil-)-3-fenil-4-((fenilamino)carbonil)-1h-pirrole-1-heptan oico(atorvastatina). - Google Patents

Forma iii cristalina de la sal de calcio hemi del acido (r-(r*,r*)-2-(4-fluorofenil)-beta-delta-dihidroxi-5-(1-metil -etil-)-3-fenil-4-((fenilamino)carbonil)-1h-pirrole-1-heptan oico(atorvastatina).

Info

Publication number
MX9708857A
MX9708857A MX9708857A MX9708857A MX9708857A MX 9708857 A MX9708857 A MX 9708857A MX 9708857 A MX9708857 A MX 9708857A MX 9708857 A MX9708857 A MX 9708857A MX 9708857 A MX9708857 A MX 9708857A
Authority
MX
Mexico
Prior art keywords
phenylamino
fluorophenyl
pyrrole
dihydroxy
delta
Prior art date
Application number
MX9708857A
Other languages
English (en)
Inventor
Ann T Mckenzie
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21696105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9708857(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of MX9708857A publication Critical patent/MX9708857A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

Se describe una forma cristalina nueva de la sal de calcio hemi del ácido (R-(R*,R*)-2-(4-florofenil)-beta-delta-dihidroxi-5 -(1-metil-etil-)-3-fenil-4-((fenilamino)carbonil)- 1H-pirrole-1-heptanoico diseñada de la forma II que se caracteriza por la difraccion de polvos de Rayos X y/o NMR en estado solido, así como los métodos para la preparacion y composicion farmacéutica de la misma, la cual es util como agente para tratar hiperlipidemia e hipercolesterolemia.
MX9708857A 1995-07-17 1996-07-08 Forma iii cristalina de la sal de calcio hemi del acido (r-(r*,r*)-2-(4-fluorofenil)-beta-delta-dihidroxi-5-(1-metil -etil-)-3-fenil-4-((fenilamino)carbonil)-1h-pirrole-1-heptan oico(atorvastatina). MX9708857A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US145495P 1995-07-17 1995-07-17
PCT/US1996/011367 WO1997003958A1 (en) 1995-07-17 1996-07-08 Form iii crystalline (r-(r*,r*)-2-(4-fluorophenyl)-beta-delta-dihydroxy-5-(1-methyl-ethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)

Publications (1)

Publication Number Publication Date
MX9708857A true MX9708857A (es) 1998-03-31

Family

ID=21696105

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9708857A MX9708857A (es) 1995-07-17 1996-07-08 Forma iii cristalina de la sal de calcio hemi del acido (r-(r*,r*)-2-(4-fluorofenil)-beta-delta-dihidroxi-5-(1-metil -etil-)-3-fenil-4-((fenilamino)carbonil)-1h-pirrole-1-heptan oico(atorvastatina).

Country Status (33)

Country Link
US (1) US6121461A (es)
JP (1) JP3296563B2 (es)
KR (1) KR100431039B1 (es)
CN (1) CN1081632C (es)
AT (1) ATE207465T1 (es)
AU (1) AU725368B2 (es)
BG (1) BG63629B1 (es)
BR (1) BR9610567A (es)
CA (1) CA2220458C (es)
CO (1) CO4700442A1 (es)
CZ (1) CZ294109B6 (es)
DK (1) DK0848704T3 (es)
EA (1) EA000505B1 (es)
EE (1) EE03607B1 (es)
ES (1) ES2166456T3 (es)
GE (1) GEP20002028B (es)
HK (1) HK1018053A1 (es)
HR (1) HRP960313B1 (es)
HU (1) HU223598B1 (es)
ID (1) ID16158A (es)
IL (3) IL122162A (es)
MX (1) MX9708857A (es)
MY (1) MY118398A (es)
NO (1) NO309899B1 (es)
NZ (1) NZ312906A (es)
PE (1) PE1798A1 (es)
PL (1) PL192244B1 (es)
RO (1) RO120068B1 (es)
SK (1) SK284201B6 (es)
TW (1) TW401399B (es)
UA (1) UA44796C2 (es)
WO (1) WO1997003958A1 (es)
ZA (1) ZA966045B (es)

Families Citing this family (75)

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CZ294108B6 (cs) 1995-07-17 2004-10-13 Warner@Lambertácompany Krystalická forma I hydrátu atorvastatinuŹ tj@ semivápenaté soli kyseliny [R@}RgŹRgB]@}@fluorfenylB@betaŹdelta@dihydroxy@Q@}�@methylethylB@fenyl[}fenylaminoBkarbonyl]@�H@pyrrol@�@heptanové
US6569461B1 (en) 1999-03-08 2003-05-27 Merck & Co., Inc. Dihydroxy open-acid and salts of HMG-CoA reductase inhibitors
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US7411075B1 (en) 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
JP2003514798A (ja) * 1999-11-17 2003-04-22 テバ ファーマシューティカル インダストリーズ リミティド アトルバスタチンカルシウムの多形
SI20425A (sl) 1999-12-10 2001-06-30 LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. Priprava amorfnega atorvastatina
MXPA02004078A (es) * 1999-12-17 2002-10-11 Warner Lambert Res & Dev Un proceso a escala industrial para producir sal de hemi calcio de trihidrato de atorvastatin cristalino.
CA2391357C (en) * 1999-12-17 2009-01-06 Warner Lambert Research And Development Ireland Limited A process for producing crystalline atorvastatin calcium
HUP0303765A2 (hu) * 2000-11-03 2004-03-01 Teva Pharmaceutical Industries Ltd. Atorvastatin-hemi-kalcium VII forma és eljárás az előállítására
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LT5196B (lt) 2000-11-30 2005-02-25 Teva Pharmaceutical Industries Ltd. Naujos atorvastatino pusiau kalcio kristalinės formos ir jų gavimo būdai, taip pat ir nauji kitų formų gavimo būdai
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
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US6476235B2 (en) 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
EP1724256A3 (en) 2001-01-09 2007-03-21 Warner-Lambert Company LLC Novel process for the synthesis of 5-(4-fluorphenyl)-1-2(2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl)-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
WO2002057229A1 (en) 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) * 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
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EP2292600A1 (en) * 2001-07-30 2011-03-09 Dr. Reddy's Laboratories Ltd. Crystaline forms VI and VII of atorvastatin calcium
US7074818B2 (en) 2001-07-30 2006-07-11 Dr. Reddy's Laboratories Limited Crystalline forms VI and VII of Atorvastatin calcium
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US20060020137A1 (en) * 2001-11-29 2006-01-26 Limor Tessler Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
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CZ201039A3 (cs) 2010-01-19 2011-07-27 Zentiva, K. S Zpusob prumyslové výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu) s vysokým specifickým povrchem a jeho použití v lékové forme
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CN103288702B (zh) * 2010-12-03 2015-09-16 上海科州药物研发有限公司 一种阿托伐他汀氨基酸盐的制备方法
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CN103483238B (zh) * 2013-08-20 2014-12-31 蚌埠丰原医药科技发展有限公司 阿托伐他汀钙三水合物的制备方法
CN106432033B (zh) * 2016-10-21 2018-07-27 江苏阿尔法药业有限公司 一种无定形阿托伐他汀钙的制备方法
KR101723783B1 (ko) 2017-02-24 2017-04-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법

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Also Published As

Publication number Publication date
EA199800129A1 (ru) 1998-08-27
CN1081632C (zh) 2002-03-27
ZA966045B (en) 1997-02-04
IL128863A (en) 2006-09-05
AU725368B2 (en) 2000-10-12
PL192244B1 (pl) 2006-09-29
CN1190957A (zh) 1998-08-19
JP3296563B2 (ja) 2002-07-02
IL122162A0 (en) 1998-04-05
PE1798A1 (es) 1998-03-04
EE03607B1 (et) 2002-02-15
ES2166456T3 (es) 2002-04-16
IL128863A0 (en) 2000-01-31
KR100431039B1 (ko) 2004-08-25
MY118398A (en) 2004-10-30
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