SK284201B6 - Kryštalická forma III hydrátu atorvastatínu, to je semivápenatej soli kyseliny [(R)-(R*,R*)-2-(4-fluórfenyl)-beta, delta-dihydroxy-5-(1-metyletyl)-3-fenyl-4-((fenylamino)- karbonyl)-1H-pyrol-1-heptánovej, farmaceutická kompozícia obsahujúca túto kryštalickú formu a táto kryštalická forma na použitie ako liečivo - Google Patents

Kryštalická forma III hydrátu atorvastatínu, to je semivápenatej soli kyseliny [(R)-(R*,R*)-2-(4-fluórfenyl)-beta, delta-dihydroxy-5-(1-metyletyl)-3-fenyl-4-((fenylamino)- karbonyl)-1H-pyrol-1-heptánovej, farmaceutická kompozícia obsahujúca túto kryštalickú formu a táto kryštalická forma na použitie ako liečivo Download PDF

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Publication number
SK284201B6
SK284201B6 SK59-98A SK5998A SK284201B6 SK 284201 B6 SK284201 B6 SK 284201B6 SK 5998 A SK5998 A SK 5998A SK 284201 B6 SK284201 B6 SK 284201B6
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SK
Slovakia
Prior art keywords
crystalline form
atorvastatin
form iii
atorvastatin hydrate
fluorophenyl
Prior art date
Application number
SK59-98A
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English (en)
Slovak (sk)
Other versions
SK5998A3 (en
Inventor
Ann T. Mckenzie
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Warner-Lambert Company
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Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of SK5998A3 publication Critical patent/SK5998A3/sk
Publication of SK284201B6 publication Critical patent/SK284201B6/sk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK59-98A 1995-07-17 1996-07-08 Kryštalická forma III hydrátu atorvastatínu, to je semivápenatej soli kyseliny [(R)-(R*,R*)-2-(4-fluórfenyl)-beta, delta-dihydroxy-5-(1-metyletyl)-3-fenyl-4-((fenylamino)- karbonyl)-1H-pyrol-1-heptánovej, farmaceutická kompozícia obsahujúca túto kryštalickú formu a táto kryštalická forma na použitie ako liečivo SK284201B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US145495P 1995-07-17 1995-07-17
PCT/US1996/011367 WO1997003958A1 (en) 1995-07-17 1996-07-08 Form iii crystalline (r-(r*,r*)-2-(4-fluorophenyl)-beta-delta-dihydroxy-5-(1-methyl-ethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)

Publications (2)

Publication Number Publication Date
SK5998A3 SK5998A3 (en) 1998-05-06
SK284201B6 true SK284201B6 (sk) 2004-10-05

Family

ID=21696105

Family Applications (1)

Application Number Title Priority Date Filing Date
SK59-98A SK284201B6 (sk) 1995-07-17 1996-07-08 Kryštalická forma III hydrátu atorvastatínu, to je semivápenatej soli kyseliny [(R)-(R*,R*)-2-(4-fluórfenyl)-beta, delta-dihydroxy-5-(1-metyletyl)-3-fenyl-4-((fenylamino)- karbonyl)-1H-pyrol-1-heptánovej, farmaceutická kompozícia obsahujúca túto kryštalickú formu a táto kryštalická forma na použitie ako liečivo

Country Status (33)

Country Link
US (1) US6121461A (da)
JP (1) JP3296563B2 (da)
KR (1) KR100431039B1 (da)
CN (1) CN1081632C (da)
AT (1) ATE207465T1 (da)
AU (1) AU725368B2 (da)
BG (1) BG63629B1 (da)
BR (1) BR9610567A (da)
CA (1) CA2220458C (da)
CO (1) CO4700442A1 (da)
CZ (1) CZ294109B6 (da)
DK (1) DK0848704T3 (da)
EA (1) EA000505B1 (da)
EE (1) EE03607B1 (da)
ES (1) ES2166456T3 (da)
GE (1) GEP20002028B (da)
HK (1) HK1018053A1 (da)
HR (1) HRP960313B1 (da)
HU (1) HU223598B1 (da)
ID (1) ID16158A (da)
IL (3) IL122162A (da)
MX (1) MX9708857A (da)
MY (1) MY118398A (da)
NO (1) NO309899B1 (da)
NZ (1) NZ312906A (da)
PE (1) PE1798A1 (da)
PL (1) PL192244B1 (da)
RO (1) RO120068B1 (da)
SK (1) SK284201B6 (da)
TW (1) TW401399B (da)
UA (1) UA44796C2 (da)
WO (1) WO1997003958A1 (da)
ZA (1) ZA966045B (da)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
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FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
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US6569461B1 (en) 1999-03-08 2003-05-27 Merck & Co., Inc. Dihydroxy open-acid and salts of HMG-CoA reductase inhibitors
IN191236B (da) 1999-05-25 2003-10-11 Ranbaxy Lab Ltd
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SI20425A (sl) 1999-12-10 2001-06-30 LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. Priprava amorfnega atorvastatina
DE60026737T2 (de) * 1999-12-17 2006-09-21 Pfizer Science And Technology Ireland Ltd., Dun Laoghaire Verfahren zur herstellung von kristallin atorvastin kalcium
MXPA02004078A (es) * 1999-12-17 2002-10-11 Warner Lambert Res & Dev Un proceso a escala industrial para producir sal de hemi calcio de trihidrato de atorvastatin cristalino.
CA2426632C (en) 2000-11-03 2008-08-05 Teva Pharmaceutical Industries, Ltd. Atorvastatin hemi-calcium form vii
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US7501450B2 (en) * 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
ATE420070T1 (de) 2000-12-27 2009-01-15 Teva Pharma Kristalline formen von atorvastatin
EP1734034A3 (en) 2001-01-09 2007-01-03 Warner-Lambert Company LLC Carboxylic acid salts of beta-alanine esters or -amides
US6476235B2 (en) 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
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SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) * 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
EE200300597A (et) 2001-06-29 2004-02-16 Warner-Lambert Company Llc [R-(R*,R*)]-2-(4-fluorofenüül)-beeta, delta-dihüdroksü-5-(1-metüületüül)-3-fenüül-4-[fenüülamino)karbonüül]-1H-pürrool-1-hepta anhappe kaltsiumsoola (2:1) (atorvastatiini) kristallilised vormid
US7074818B2 (en) 2001-07-30 2006-07-11 Dr. Reddy's Laboratories Limited Crystalline forms VI and VII of Atorvastatin calcium
CZ2004126A3 (cs) * 2001-07-30 2004-12-15 Dr. Reddy's Laboratories Limited Krystalické formy VI. A VII. vápenaté soli atorvastatinu
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US20060020137A1 (en) * 2001-11-29 2006-01-26 Limor Tessler Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
CZ296967B6 (cs) 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
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ATE452871T1 (de) 2002-03-18 2010-01-15 Biocon Ltd Amorphe hmg-coa-reduktase-inhibitoren mit gewünschter teilchengrösse
ITMI20020907A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione della forma amorfa del sale di calcio della atorvastatina
CN100357289C (zh) * 2002-08-06 2007-12-26 沃尼尔·朗伯有限责任公司 制备5-(4-氟苯基)-1-[2-((2r,4r)-4-羟基-6-氧代-四氢-吡喃-2-基)乙基]-2-异丙基-4-苯基-1h-吡咯-3-羧酸苯基酰胺的方法
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HRP20020885B1 (en) * 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
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CA2547216A1 (en) 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
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US20070265456A1 (en) * 2006-05-09 2007-11-15 Judith Aronhime Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
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US8115015B2 (en) * 2009-01-26 2012-02-14 Cadila Healthcare Limited Process for the preparation of amorphous atorvastatin calcium
CZ201039A3 (cs) 2010-01-19 2011-07-27 Zentiva, K. S Zpusob prumyslové výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu) s vysokým specifickým povrchem a jeho použití v lékové forme
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CN103274985B (zh) * 2010-12-03 2016-03-09 上海科州药物研发有限公司 一种阿托伐他汀氨基酸盐
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CN103483238B (zh) * 2013-08-20 2014-12-31 蚌埠丰原医药科技发展有限公司 阿托伐他汀钙三水合物的制备方法
CN106432033B (zh) * 2016-10-21 2018-07-27 江苏阿尔法药业有限公司 一种无定形阿托伐他汀钙的制备方法
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BR9610567A (pt) 1999-07-06
CA2220458A1 (en) 1997-02-06
EA000505B1 (ru) 1999-10-28
HK1018053A1 (en) 1999-12-10
CN1190957A (zh) 1998-08-19
EA199800129A1 (ru) 1998-08-27
EE9800016A (et) 1998-08-17
NZ312906A (en) 2000-12-22
HRP960313B1 (en) 2002-08-31
ID16158A (id) 1997-09-11
IL122162A (en) 1999-07-14
MY118398A (en) 2004-10-30
NO980208D0 (no) 1998-01-16
GEP20002028B (en) 2000-04-10
DK0848704T3 (da) 2002-02-04
UA44796C2 (uk) 2002-03-15
CA2220458C (en) 2002-09-24
NO309899B1 (no) 2001-04-17
BG102186A (en) 1998-10-30
HUP9901687A3 (en) 2000-04-28
CZ294109B6 (cs) 2004-10-13
CN1081632C (zh) 2002-03-27
AU725368B2 (en) 2000-10-12
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