YU35802A - Polimorfni oblik atorvastatin kalcijuma - Google Patents

Polimorfni oblik atorvastatin kalcijuma

Info

Publication number
YU35802A
YU35802A YU35802A YUP35802A YU35802A YU 35802 A YU35802 A YU 35802A YU 35802 A YU35802 A YU 35802A YU P35802 A YUP35802 A YU P35802A YU 35802 A YU35802 A YU 35802A
Authority
YU
Yugoslavia
Prior art keywords
atorvastatin calcium
polymorphic form
new
preparing
processes
Prior art date
Application number
YU35802A
Other languages
English (en)
Inventor
Ari Ayalon
Michal Levinger
Sofia Roytblat
Valerie Niddam
Revital Lifshitz
Original Assignee
Teva Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.
Publication of YU35802A publication Critical patent/YU35802A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Abstract

Predmetni pronalazak se odnosi na atorvastatin kalcijum, korisno sredstvo za smanjivanje nivoa holesterola u krvi. Opisani su novi oblik V atorvastatin kalcijuma, postupci za pripremanje novog oblika, kao i farmaceutski preparati i oblici za doziranje koji sadrže novi oblik.[The present invention relates to atorvastatin calcium, a useful agent for lowering serum cholesterol levels. New atorvastatin calcium Form V, processes for preparing the new form, and pharmaceutical compositions and dosage forms containing the new form are disclosed.
YU35802A 1999-11-17 2000-11-16 Polimorfni oblik atorvastatin kalcijuma YU35802A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16615399P 1999-11-17 1999-11-17

Publications (1)

Publication Number Publication Date
YU35802A true YU35802A (sh) 2005-07-19

Family

ID=22602039

Family Applications (1)

Application Number Title Priority Date Filing Date
YU35802A YU35802A (sh) 1999-11-17 2000-11-16 Polimorfni oblik atorvastatin kalcijuma

Country Status (20)

Country Link
EP (3) EP1235799B1 (sh)
JP (2) JP2003514798A (sh)
KR (1) KR20020063190A (sh)
CN (1) CN1423634A (sh)
AT (2) ATE288893T1 (sh)
AU (1) AU783002B2 (sh)
CA (1) CA2392096C (sh)
CZ (1) CZ20021642A3 (sh)
DE (2) DE60044884D1 (sh)
ES (2) ES2234699T3 (sh)
HR (1) HRP20020429B8 (sh)
HU (1) HUP0203257A3 (sh)
IL (2) IL149681A0 (sh)
PL (1) PL355805A1 (sh)
PT (2) PT1235799E (sh)
SI (2) SI1535613T1 (sh)
SK (1) SK286789B6 (sh)
WO (1) WO2001036384A1 (sh)
YU (1) YU35802A (sh)
ZA (1) ZA200203755B (sh)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
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CN1535139A (zh) 2000-11-03 2004-10-06 ������ҩ��ҵ���޹�˾ 阿伐他丁半钙形式ⅶ
IL156055A0 (en) * 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
US7501450B2 (en) 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
PL365312A1 (en) * 2000-12-27 2004-12-27 Teva Pharmaceutical Industries Ltd Crystalline forms of atorvastatin
WO2002057229A1 (en) * 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
GEP20053546B (en) 2001-06-29 2005-06-10 Warner Lambert Co Crystalline Forms of 'R-(R*,R*)!-2-(4- Fluorophenyl)-Beta, Delta-Dihydroxy-5-(1-Methylethyl)-3-Phenyl-4-'Phenylamino) Carbonyl!-1H-Pyrrole-1-Heptanoic Acid Calcium Salt (2:1) (Atorvastatin)
US7074818B2 (en) 2001-07-30 2006-07-11 Dr. Reddy's Laboratories Limited Crystalline forms VI and VII of Atorvastatin calcium
CN100471836C (zh) 2001-07-30 2009-03-25 雷迪实验室有限公司 托伐他汀钙晶型vi和vii
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
CA2475864A1 (en) * 2002-02-15 2003-08-28 Teva Pharmaceutical Industries Ltd. Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation, as well as novel processes for preparing atorvastatin hemi-calcium forms i, viii and ix
CA2475123A1 (en) 2002-02-19 2003-08-28 Teva Pharmaceutical Industries Ltd. Desolvating solvates of atorvastatin hemi-calcium
DK1515717T3 (da) * 2002-06-13 2009-02-09 Novartis Ag Calciumsalte af indolafledte statiner
GB0218781D0 (en) * 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
WO2004050618A2 (en) * 2002-11-28 2004-06-17 Teva Pharmaceutical Industries Ltd. Crystalline form f of atorvastatin hemi-calcium salt
EP1424324A1 (en) * 2002-11-28 2004-06-02 Teva Pharmaceutical Industries Limited Crystalline form F of Atorvastatin hemi-calcium salt
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
US7790197B2 (en) 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US7655692B2 (en) 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
CA2465693A1 (en) * 2003-06-12 2004-12-12 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
CA2649054A1 (en) 2004-05-05 2005-11-10 Pfizer Products Inc. Salt forms of [r-(r*,r*)]-2-(4-fluorophenyl)-.beta., .delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid
CA2672554C (en) * 2004-07-20 2012-01-03 Warner-Lambert Company Llc Novel forms of [r-(r*,r*)]-2-(4-fluorophenyl).beta.,.delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1)
DE202005020841U1 (de) 2004-09-28 2006-08-31 Teva Pharmaceutical Industries Ltd. Formen von Atorvastatin-Calcium, die im wesentlichen frei von Verunreinigungen sind
US20060106230A1 (en) 2004-10-18 2006-05-18 Michael Pinchasov Processes for preparing amorphous atorvastatin hemi-calcium
US7939675B2 (en) 2004-10-28 2011-05-10 Pfizer, Inc. Process for forming amorphous atorvastatin
WO2006048894A1 (en) * 2004-11-05 2006-05-11 Morepen Laboratories Limited Novel crystalline forms of atorvastatin calcium and processes for preparing them.
AU2005305460B2 (en) 2004-11-22 2011-04-21 Dexcel Pharma Technologies Ltd. Stable atorvastatin formulations
CA2499047A1 (en) 2005-03-01 2006-09-01 Apotex Pharmachem Inc. Process for producing atorvastatin hemicalcium
BRPI0614279A2 (pt) 2005-08-15 2012-11-06 Arrow Int Ltd atorvastatina sódica cristalina e amorfa
CN101268047B (zh) 2005-08-15 2012-11-07 箭锋国际有限公司 结晶和无定形阿托伐他汀钠
CA2547216A1 (en) 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
EP1808162A1 (en) 2005-11-21 2007-07-18 Teva Pharmaceutical Industries Ltd. Atorvastatin pharmaceutical formulation
DE602006014193D1 (de) 2005-11-21 2010-06-17 Warner Lambert Co Neue formen von är-(r*,r*)ü-2-(4-fluorphenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-ä(phenylamino)carbonylü-1h-pyrrol-1-heptansäure-magnesium
EP1923057A1 (en) 2005-11-21 2008-05-21 Teva Pharmaceutical Industries Ltd Atorvastatin pharmaceutical formulation
CN101370774A (zh) * 2005-12-13 2009-02-18 特瓦制药工业有限公司 阿托伐他汀半钙的晶形及其制备方法
EP1810667A1 (en) 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
AU2007219107B2 (en) * 2006-02-22 2012-12-06 Mylan Laboratories Ltd. New crystalline form of Atorvastatin hemi-calcium
WO2008108572A1 (en) * 2007-03-02 2008-09-12 Dong-A Pharm. Co., Ltd. Novel crystal forms of pyrrolylheptanoic acid derivatives
AU2008272685B2 (en) 2007-06-29 2013-04-18 Generics [Uk] Limited Process for introduction of hydroxyethoxy side chain in bosentan
US20100260851A1 (en) * 2007-07-11 2010-10-14 Actavis Group Ptc Ehf Novel Polymorph of Atorvastatin Calcium and Use Thereof for the Preparation of Amorphous Atorvastatin Calcium
JP2011500780A (ja) 2007-10-24 2011-01-06 ジェネリクス・（ユーケー）・リミテッド 新規結晶形
ES2650247T3 (es) 2008-02-08 2018-01-17 Generics [Uk] Limited Procedimiento de preparación del bosentán
CA2741928A1 (en) 2008-11-03 2010-06-03 Generics [Uk] Limited Hplc method for the analysis of bosentan and related substances and use of these substances as reference standards and markers
EP2327682A1 (en) * 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
WO2010069593A1 (en) * 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
CZ201039A3 (cs) 2010-01-19 2011-07-27 Zentiva, K. S Zpusob prumyslové výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu) s vysokým specifickým povrchem a jeho použití v lékové forme
KR20120011249A (ko) * 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
CN102249978A (zh) * 2011-06-09 2011-11-23 浙江金立源药业有限公司 阿托伐他汀钙的ky晶型及制备方法
CN103483238B (zh) * 2013-08-20 2014-12-31 蚌埠丰原医药科技发展有限公司 阿托伐他汀钙三水合物的制备方法
KR102381295B1 (ko) 2013-11-15 2022-03-31 아케비아 테라퓨틱스 인코포레이티드 ｛[5-(3-클로로페닐)-3-하이드록시피리딘-2-카보닐]아미노｝아세트산의 고체형, 이의 조성물 및 용도
CN104945300B (zh) * 2015-06-17 2017-05-10 北京嘉林药业股份有限公司 一种ⅰ型阿托伐他汀钙的纯化方法
CN105085362B (zh) * 2015-09-18 2018-01-05 浙江海森药业有限公司 高纯度结晶型阿托伐他汀钙的制备方法

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Also Published As

Publication number Publication date
PL355805A1 (en) 2004-05-17
DE60018100T2 (de) 2005-09-15
AU1617301A (en) 2001-05-30
CN1423634A (zh) 2003-06-11
SI1535613T1 (sl) 2010-12-31
KR20020063190A (ko) 2002-08-01
CA2392096C (en) 2008-07-15
JP2003514798A (ja) 2003-04-22
ZA200203755B (en) 2004-05-26
HRP20020429B1 (en) 2006-05-31
CA2392096A1 (en) 2001-05-25
SI1235799T1 (en) 2005-06-30
PT1535613E (pt) 2010-10-04
ATE288893T1 (de) 2005-02-15
ES2234699T3 (es) 2005-07-01
EP2206497A1 (en) 2010-07-14
CZ20021642A3 (cs) 2003-05-14
WO2001036384A1 (en) 2001-05-25
HRP20020429B8 (en) 2007-03-31
JP2009102439A (ja) 2009-05-14
EP1235799A1 (en) 2002-09-04
IL149681A (en) 2007-06-17
HUP0203257A2 (hu) 2003-01-28
EP1535613B1 (en) 2010-08-25
AU783002B2 (en) 2005-09-15
EP1535613A3 (en) 2005-08-31
EP1235799A4 (en) 2003-05-28
SK286789B6 (sk) 2009-05-07
SK6742002A3 (en) 2003-05-02
HUP0203257A3 (en) 2003-05-28
EP1235799B1 (en) 2005-02-09
IL149681A0 (en) 2002-11-10
ES2349364T3 (es) 2010-12-30
DE60018100D1 (en) 2005-03-17
PT1235799E (pt) 2005-05-31
HRP20020429A2 (en) 2004-04-30
DE60044884D1 (de) 2010-10-07
ATE478665T1 (de) 2010-09-15
EP1535613A2 (en) 2005-06-01

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