SK283663B6 - Spôsob prípravy kyseliny (S)-3-(aminometyl)-5-metylhexánovej - Google Patents

Spôsob prípravy kyseliny (S)-3-(aminometyl)-5-metylhexánovej Download PDF

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Publication number
SK283663B6
SK283663B6 SK1621-97A SK162197A SK283663B6 SK 283663 B6 SK283663 B6 SK 283663B6 SK 162197 A SK162197 A SK 162197A SK 283663 B6 SK283663 B6 SK 283663B6
Authority
SK
Slovakia
Prior art keywords
acid
carbamoylmethyl
methylhexanoic acid
methylhexanoic
reacting
Prior art date
Application number
SK1621-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK162197A3 (en
Inventor
Brian Keith Huckabee
Denis Martin Sobieray
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of SK162197A3 publication Critical patent/SK162197A3/sk
Publication of SK283663B6 publication Critical patent/SK283663B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK1621-97A 1995-06-02 1996-04-26 Spôsob prípravy kyseliny (S)-3-(aminometyl)-5-metylhexánovej SK283663B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/458,950 US5616793A (en) 1995-06-02 1995-06-02 Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
PCT/US1996/005831 WO1996038405A1 (en) 1995-06-02 1996-04-26 Methods of making (s)-3-(aminomethyl)-5-methylhexanoic acid

Publications (2)

Publication Number Publication Date
SK162197A3 SK162197A3 (en) 1998-10-07
SK283663B6 true SK283663B6 (sk) 2003-11-04

Family

ID=23822760

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1621-97A SK283663B6 (sk) 1995-06-02 1996-04-26 Spôsob prípravy kyseliny (S)-3-(aminometyl)-5-metylhexánovej

Country Status (16)

Country Link
US (2) US5616793A (da)
EP (1) EP0828704B1 (da)
JP (1) JP3965440B2 (da)
AT (1) ATE214361T1 (da)
AU (1) AU699982B2 (da)
CZ (1) CZ297631B6 (da)
DE (1) DE69619809T2 (da)
DK (1) DK0828704T3 (da)
EE (1) EE03964B1 (da)
ES (1) ES2173279T3 (da)
HU (1) HUP9802090A3 (da)
NZ (1) NZ307030A (da)
PL (1) PL185034B1 (da)
PT (1) PT828704E (da)
SK (1) SK283663B6 (da)
WO (1) WO1996038405A1 (da)

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PT934061E (pt) 1996-07-24 2003-10-31 Warner Lambert Co Isobutilgaba e seus derivados para o tratamento da dor
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EP1543831A1 (en) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Pregabalin composition
DE602005002253T2 (de) * 2004-03-12 2008-05-29 Warner-Lambert Company Llc C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin
CN102102114B (zh) * 2004-06-21 2013-08-14 沃尼尔·朗伯有限责任公司 普瑞巴林和相关化合物的制备
CN101160281A (zh) * 2005-04-06 2008-04-09 特瓦制药工业有限公司 结晶形态的普瑞巴林
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US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
MX2007000525A (es) * 2005-05-10 2007-03-28 Teva Pharma Pregabalina libre de acido isobutilglutarico y un proceso para la preparacion de ella.
EP1879852A1 (en) * 2005-05-10 2008-01-23 Teva Pharmaceutical Industries Ltd Pregabalin free of lactam and a process for preparation thereof
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ATE523484T1 (de) * 2005-05-10 2011-09-15 Teva Pharma Optische lösung a us 3-carbamoylmethyl-5-methyl- hexansäure
CN100410242C (zh) * 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
WO2007035890A1 (en) * 2005-09-19 2007-03-29 Teva Pharmaceutical Industries Ltd. An asymmetric synthesis of ( s ) - ( + ) -3- (aminomethyl) -5-methylhexanoic acid
NL2000281C2 (nl) * 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
KR20080016658A (ko) * 2006-04-24 2008-02-21 테바 파마슈티컬 인더스트리즈 리미티드 3-이소부틸글루타르산의 합성 방법
WO2007139933A2 (en) * 2006-05-24 2007-12-06 Teva Pharmaceutical Industries Ltd. Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
WO2007143152A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
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ITMI20061297A1 (it) * 2006-07-04 2008-01-05 Laboratorio Chimico Int Spa Procedimento per la preparazione della'acido (r)-(-)-3-(carbamoilmetil)-5-metilesanoico e del pregabalin e intermedi di sintesi
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WO2009004643A2 (en) * 2007-05-08 2009-01-08 Cadila Healthcare Limited An improved process for preparation of (s)-pregabalin and intermediates thereof
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KR20090101462A (ko) * 2007-10-03 2009-09-28 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
JP5234901B2 (ja) * 2007-10-04 2013-07-10 学校法人東京理科大学 不斉触媒マイケル反応生成物の製造方法
CA2706381C (en) * 2007-11-30 2016-11-01 Medichem, S.A. Processes for preparing a substituted gamma-amino acid
ITMI20072262A1 (it) * 2007-12-03 2009-06-04 Dipharma Francis Srl Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico
US20100312010A1 (en) * 2007-12-18 2010-12-09 Watson Pharma Private Limited Process for the Preparation of (S)-Pregabalin
US20110144383A1 (en) * 2008-02-18 2011-06-16 Matrix Laboratories Limited Process for preparing (s)-3-(aminomethyl)-5-methylhexanoic acid
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US20100087525A1 (en) * 2008-06-23 2010-04-08 Lilach Hedvati Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
EP2213659A1 (en) 2009-01-29 2010-08-04 The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin Intermediates in the Enantioselective Synthesis of 3-(Aminomethyl)-5-Methyl-Hexanoic Acid
CN101987826A (zh) * 2009-08-04 2011-03-23 铜陵凯顺生物科技有限公司 一种(3s)-3-氨甲基-5-甲基己酸的合成方法
CN102126979A (zh) * 2009-12-15 2011-07-20 中国科学院成都有机化学有限公司 一种光学纯的3-(氨甲酰甲基)-5-甲基己酸的制备方法
WO2011077463A1 (en) * 2009-12-24 2011-06-30 Msn Laboratories Limited Process for preparing pregabalin and its intermediate
ES2362913B1 (es) 2009-12-24 2012-05-24 Moehs Iberica S.L. Nuevo método para la preparación de (s)-pregabalina.
WO2011078172A1 (ja) * 2009-12-25 2011-06-30 株式会社カネカ 光学活性３－置換グルタル酸モノアミドの製造法
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
KR101306585B1 (ko) * 2011-04-14 2013-09-10 한국외국어대학교 연구산학협력단 프레가발린의 제조방법
EP2700645A4 (en) 2011-04-20 2014-09-24 Kemphys Ltd SILICONE-CONTAINING CARBOXYLENE DERIVATIVE
BR112014012595A2 (pt) 2011-11-24 2017-06-06 Lupin Ltd processo de racemização de ácido (s)-3-carbamoilmetil-5-metil-hexanoico
CN102863326A (zh) * 2012-03-20 2013-01-09 常州制药厂有限公司 一种抗癫痫药物中间体的制备方法
CN104781264A (zh) 2012-10-18 2015-07-15 有限会社肯菲思 含有硅的羧酸衍生物
CN102898320A (zh) * 2012-10-26 2013-01-30 浙江省天台县奥锐特药业有限公司 (3r)-(-)-3-(2-乙酰氨基)-5-甲基己酸的制备方法
EP2916832B1 (en) 2012-11-07 2019-01-16 Hikal Limited A process for the preparation of pregabalin
CN102964263B (zh) * 2012-11-29 2014-12-03 太仓市茜泾化工有限公司 一种(±)-3-(氨甲酰基)-5-甲基己酸的制备方法
CN103980144B (zh) * 2014-05-16 2018-08-17 浙江华海药业股份有限公司 一种普瑞巴林中间体母液的套用方法
CN104086439B (zh) * 2014-06-30 2018-11-16 浙江华海药业股份有限公司 一种pregabalin中间体拆分剂(R)-(+)-α-苯乙胺的回收方法
CN104356016B (zh) * 2014-10-24 2019-08-23 浙江华海药业股份有限公司 一种用回收制备3-异丁基戊二酸单酰胺的方法
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
CN104496832A (zh) * 2014-11-21 2015-04-08 浙江美诺华药物化学有限公司 一种普瑞巴林的合成方法
CN104557577B (zh) * 2014-12-26 2016-08-17 上海臣邦医药科技有限公司 高纯度(+)-普瑞巴林和(-)-普瑞巴林的制备方法
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CN104803868B (zh) * 2015-03-27 2020-10-02 浙江华海药业股份有限公司 一种回收3-异丁基戊二酸单酰胺的方法
CN104803869A (zh) * 2015-03-27 2015-07-29 浙江华海药业股份有限公司 一种无溶剂反应制备3-异丁基戊二酸单酰胺的方法
CN104803871B (zh) * 2015-05-12 2021-03-05 浙江华海药业股份有限公司 一种制备普瑞巴林中间体的方法
CN104892441A (zh) * 2015-05-22 2015-09-09 浙江华海药业股份有限公司 一种制备普瑞巴林异构体r-普瑞巴林的方法
US10561602B2 (en) 2015-05-26 2020-02-18 Isa Odidi Controlled extended release pregabalin
WO2017019791A1 (en) 2015-07-27 2017-02-02 Teva Pharmaceuticals International Gmbh Synthesis of (s)-pregabalin
CN105481712A (zh) * 2015-11-30 2016-04-13 常州市阳光药业有限公司 普瑞巴林中间体拆分母液的消旋回收方法
WO2019193607A1 (en) * 2018-04-04 2019-10-10 Msn Laboratories Private Limited, R&D Center An improved process for the preparation of pregabalin
CN108912004B (zh) * 2018-08-01 2021-05-07 宏冠生物药业有限公司 一种普瑞巴林中间体的合成方法
CN109942446B (zh) * 2019-04-17 2021-09-07 黄冈鲁班药业股份有限公司 一种普瑞巴林的制备方法
CN112062689A (zh) * 2019-06-11 2020-12-11 太仓市茜泾化工有限公司 一种r-3-（氨甲酰基）-5-甲基己酸的制备方法
CN113045468A (zh) * 2019-12-26 2021-06-29 上虞京新药业有限公司 一种布瓦西坦中间体的制备方法
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Also Published As

Publication number Publication date
DE69619809D1 (de) 2002-04-18
DE69619809T2 (de) 2002-09-26
AU5577896A (en) 1996-12-18
ATE214361T1 (de) 2002-03-15
ES2173279T3 (es) 2002-10-16
NZ307030A (en) 1999-02-25
HUP9802090A3 (en) 1999-08-30
EE03964B1 (et) 2003-02-17
PL323563A1 (en) 1998-04-14
PT828704E (pt) 2002-08-30
CZ297631B6 (cs) 2007-02-14
EP0828704B1 (en) 2002-03-13
SK162197A3 (en) 1998-10-07
US5629447A (en) 1997-05-13
AU699982B2 (en) 1998-12-17
EP0828704A1 (en) 1998-03-18
DK0828704T3 (da) 2002-07-01
WO1996038405A1 (en) 1996-12-05
JP3965440B2 (ja) 2007-08-29
EE9700311A (et) 1998-06-15
JPH11506098A (ja) 1999-06-02
HUP9802090A2 (hu) 1998-12-28
CZ374297A3 (cs) 1998-10-14
US5616793A (en) 1997-04-01
PL185034B1 (pl) 2003-02-28

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Effective date: 20090426